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- Antibody Data
- Antigen structure
- References [41]
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- Validations
- Immunohistochemistry [2]
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- Product number
- 55131-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Collagen Type IV antibody
- Antibody type
- Polyclonal
- Description
- Collagen Type IV antibody (Cat. #55131-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1ΔHBS in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling.
Engineering microvasculature by 3D bioprinting of prevascularized spheroids in photo-crosslinkable gelatin.
Patterned vascularization in a directional ice-templated scaffold of decellularized matrix.
Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients.
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.
circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis.
Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation.
Human Tissue Kallikrein 1 Improves Erectile Dysfunction of Streptozotocin-Induced Diabetic Rats by Inhibition of Excessive Oxidative Stress and Activation of the PI3K/AKT/eNOS Pathway.
Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway.
Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy.
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Melatonin ameliorates hyperglycaemia-induced renal inflammation by inhibiting the activation of TLR4 and TGF-β1/Smad3 signalling pathway.
SHCBP1 Promotes Papillary Thyroid Carcinoma Carcinogenesis and Progression Through Promoting Formation of Integrin and Collagen and Maintaining Cell Stemness.
FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model.
Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.
Neointimal hyperplasia in the inferior vena cava of adenine-induced chronic kidney disease rats with aortocaval fistulas.
Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.
The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial-mesenchymal transition in human renal tubular epithelial cells.
Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis.
Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress.
Transplantation of adipose-derived stem cells overexpressing inducible nitric oxide synthase ameliorates diabetes mellitus-induced erectile dysfunction in rats.
Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway.
lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis.
Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca2+/CAMK II/ERK/NF-κB signaling pathway.
Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy.
Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.
Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury.
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.
SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.
5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats.
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy.
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway.
Wang D, Zhao T, Zhao Y, Yin Y, Huang Y, Cheng Z, Wang B, Liu S, Pan M, Sun D, Wang Z, Zhu G
Frontiers in pharmacology 2021;12:690535
Frontiers in pharmacology 2021;12:690535
Engineering microvasculature by 3D bioprinting of prevascularized spheroids in photo-crosslinkable gelatin.
De Moor L, Smet J, Plovyt M, Bekaert B, Vercruysse C, Asadian M, De Geyter N, Van Vlierberghe S, Dubruel P, Declercq H
Biofabrication 2021 Sep 21;13(4)
Biofabrication 2021 Sep 21;13(4)
Patterned vascularization in a directional ice-templated scaffold of decellularized matrix.
Shen L, Song X, Xu Y, Tian R, Wang Y, Li P, Li J, Bai H, Zhu H, Wang D
Engineering in life sciences 2021 Oct;21(10):683-692
Engineering in life sciences 2021 Oct;21(10):683-692
Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients.
Zhou Z, Liu XQ, Zhang SQ, Qi XM, Zhang Q, Yard B, Wu YG
Amino acids 2021 May;53(5):687-700
Amino acids 2021 May;53(5):687-700
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Liu J, Li X, Lu S, Zheng X, Zhang X, Zhao W
Annals of translational medicine 2021 Mar;9(6):492
Annals of translational medicine 2021 Mar;9(6):492
Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.
Xiao Y, Deng J, Li C, Gong X, Gui Z, Huang J, Zhang Y, Liu Y, Ye X, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153488
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153488
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Zhao B, Li S, Guo Z, Chen Z, Zhang X, Xu C, Chen J, Wei C
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.
Liu K, Zhao X, Qi X, Hou DL, Li HB, Gu YH, Xu QL
European journal of medicinal chemistry 2021 Jun 5;218:113388
European journal of medicinal chemistry 2021 Jun 5;218:113388
circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis.
Wen S, Li S, Li L, Fan Q
Biological & pharmaceutical bulletin 2020;43(3):558-564
Biological & pharmaceutical bulletin 2020;43(3):558-564
Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation.
Zhang Y, Tao C, Xuan C, Jiang J, Cao W
Oxidative medicine and cellular longevity 2020;2020:9542165
Oxidative medicine and cellular longevity 2020;2020:9542165
Human Tissue Kallikrein 1 Improves Erectile Dysfunction of Streptozotocin-Induced Diabetic Rats by Inhibition of Excessive Oxidative Stress and Activation of the PI3K/AKT/eNOS Pathway.
Luan Y, Cui K, Tang Z, Ruan Y, Liu K, Wang T, Chen Z, Wang S, Liu J
Oxidative medicine and cellular longevity 2020;2020:6834236
Oxidative medicine and cellular longevity 2020;2020:6834236
Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway.
Li X, Zou Y, Xing J, Fu YY, Wang KY, Wan PZ, Zhai XY
Oxidative medicine and cellular longevity 2020;2020:6286984
Oxidative medicine and cellular longevity 2020;2020:6286984
Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy.
Zheng ZC, Zhu W, Lei L, Liu XQ, Wu YG
Drug design, development and therapy 2020;14:4135-4148
Drug design, development and therapy 2020;14:4135-4148
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Ndibalema AR, Kabuye D, Wen S, Li L, Li X, Fan Q
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Melatonin ameliorates hyperglycaemia-induced renal inflammation by inhibiting the activation of TLR4 and TGF-β1/Smad3 signalling pathway.
Wei J, Wang Y, Qi X, Fan Z, Wu Y
American journal of translational research 2020;12(5):1584-1599
American journal of translational research 2020;12(5):1584-1599
SHCBP1 Promotes Papillary Thyroid Carcinoma Carcinogenesis and Progression Through Promoting Formation of Integrin and Collagen and Maintaining Cell Stemness.
Geng H, Guo M, Xu W, Zang X, Wu T, Teng F, Wang Y, Liu X, Wang X, Sun Q, Liang J
Frontiers in endocrinology 2020;11:613879
Frontiers in endocrinology 2020;11:613879
FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model.
Wang Z, Higashikawa K, Yasui H, Kuge Y, Ohno Y, Kihara A, Midori YA, Houkin K, Kawabori M
Translational stroke research 2020 Oct;11(5):1103-1116
Translational stroke research 2020 Oct;11(5):1103-1116
Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.
Liu B, Zhang S, Wang W, Yun Z, Lv L, Chai M, Wu Z, Zhu Y, Ma J, Leng L
ACS biomaterials science & engineering 2020 Oct 12;6(10):5720-5733
ACS biomaterials science & engineering 2020 Oct 12;6(10):5720-5733
Neointimal hyperplasia in the inferior vena cava of adenine-induced chronic kidney disease rats with aortocaval fistulas.
Du J, Liang L, Liu S, Yang X, Cao S, Zhang H, Su H, Gong X, Chen Q, Kong X, Xu D
Clinical and experimental nephrology 2020 Nov;24(11):1007-1014
Clinical and experimental nephrology 2020 Nov;24(11):1007-1014
Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.
Li G, Lin J, Peng Y, Qin K, Wen L, Zhao T, Feng Q
Phytotherapy research : PTR 2020 Jun;34(6):1421-1435
Phytotherapy research : PTR 2020 Jun;34(6):1421-1435
The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial-mesenchymal transition in human renal tubular epithelial cells.
Li L, Xu L, Wen S, Yang Y, Li X, Fan Q
Journal of cellular physiology 2020 Jul;235(7-8):5787-5795
Journal of cellular physiology 2020 Jul;235(7-8):5787-5795
Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.
Tan Y, Li Y, Zhou F, Guo J, Wang T, Shi Y, Yang Y, Lu J, Pei G
Journal of pharmacological sciences 2020 Jul;143(3):165-175
Journal of pharmacological sciences 2020 Jul;143(3):165-175
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Jiang ZH, Tang YZ, Song HN, Yang M, Li B, Ni CL
International journal of molecular medicine 2020 Jan;45(1):45-52
International journal of molecular medicine 2020 Jan;45(1):45-52
Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis.
Xu J, Xiang P, Liu L, Sun J, Ye S
The Journal of pharmacy and pharmacology 2020 Aug;72(8):1101-1109
The Journal of pharmacy and pharmacology 2020 Aug;72(8):1101-1109
Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
Fan Z, Qi X, Yang W, Xia L, Wu Y
Archives of medical research 2020 Aug;51(6):524-534
Archives of medical research 2020 Aug;51(6):524-534
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
Huang K, Zhao X
Experimental cell research 2020 Aug 15;393(2):112100
Experimental cell research 2020 Aug 15;393(2):112100
Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress.
Schwörer S, Berisa M, Violante S, Qin W, Zhu J, Hendrickson RC, Cross JR, Thompson CB
The EMBO journal 2020 Apr 15;39(8):e103334
The EMBO journal 2020 Apr 15;39(8):e103334
Transplantation of adipose-derived stem cells overexpressing inducible nitric oxide synthase ameliorates diabetes mellitus-induced erectile dysfunction in rats.
Zhang Y, Yang J, Zhuan L, Zang G, Wang T, Liu J
PeerJ 2019;7:e7507
PeerJ 2019;7:e7507
Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway.
Ma TK, Xu L, Lu LX, Cao X, Li X, Li LL, Wang X, Fan QL
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:2597-2608
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:2597-2608
lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis.
Ge Y, Wang J, Wu D, Zhou Y, Qiu S, Chen J, Zhu X, Xiang X, Li H, Zhang D
Molecular therapy. Nucleic acids 2019 Sep 6;17:741-753
Molecular therapy. Nucleic acids 2019 Sep 6;17:741-753
Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca2+/CAMK II/ERK/NF-κB signaling pathway.
Ding XW, Sun X, Shen XF, Lu Y, Wang JQ, Sun ZR, Miao CH, Chen JW
Acta pharmacologica Sinica 2019 Oct;40(10):1303-1313
Acta pharmacologica Sinica 2019 Oct;40(10):1303-1313
Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy.
Shang J, Wang L, Zhang Y, Zhang S, Ning L, Zhao J, Cheng G, Liu D, Xiao J, Zhao Z
Journal of cellular and molecular medicine 2019 May;23(5):3417-3428
Journal of cellular and molecular medicine 2019 May;23(5):3417-3428
Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.
Wang T, Fu X, Jin T, Zhang L, Liu B, Wu Y, Xu F, Wang X, Ye K, Zhang W, Ye L
EBioMedicine 2019 Jul;45:168-180
EBioMedicine 2019 Jul;45:168-180
Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury.
Liu L, Li Y, Wang Z, Ding F, Cheng Z, Xu Q, Cai Y, Limbu MH, Yang Y, Liu B, Chen P
Experimental cell research 2018 Sep 15;370(2):198-207
Experimental cell research 2018 Sep 15;370(2):198-207
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.
Li A, Peng R, Sun Y, Liu H, Peng H, Zhang Z
Cell death & disease 2018 May 1;9(5):461
Cell death & disease 2018 May 1;9(5):461
SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.
Sun JX, Chang TF, Li MH, Sun LJ, Yan XC, Yang ZY, Liu Y, Xu WQ, Lv Y, Su JB, Liang L, Han H, Dou GR, Wang YS
Angiogenesis 2018 Aug;21(3):635-652
Angiogenesis 2018 Aug;21(3):635-652
5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats.
Quesada A, O'Valle F, Montoro-Molina S, Gómez-Morales M, Caba-Molina M, González JF, de Gracia MC, Osuna A, Vargas F, Wangensteen R
Bioscience reports 2018 Apr 27;38(2)
Bioscience reports 2018 Apr 27;38(2)
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Sun D, Liu Y, Wang H, Deng F, Zhang Y, Zhao S, Ma X, Wu H, Sun G
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy.
Yi H, Peng R, Zhang LY, Sun Y, Peng HM, Liu HD, Yu LJ, Li AL, Zhang YJ, Jiang WH, Zhang Z
Cell death & disease 2017 Feb 2;8(2):e2583
Cell death & disease 2017 Feb 2;8(2):e2583
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway.
Li XY, Wang SS, Han Z, Han F, Chang YP, Yang Y, Xue M, Sun B, Chen LM
Molecular therapy. Nucleic acids 2017 Dec 15;9:48-56
Molecular therapy. Nucleic acids 2017 Dec 15;9:48-56
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Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Collagen Type IV antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Collagen Type IV. This antibody recognizes human antigen. The Collagen Type IV antibody has been validated for the following applications: ELISA, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human kidney tissue slide using 55131-1-AP( COL4A2 Antibody) at dilution of 1:50 (under 10x lens)
- Other comments
- IHC
