Antibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations
- Western blot [1]
- Flow cytometry [1]
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Validation data
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- Product number
- 15386-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15386-1-AP, RRID:AB_10755144
- Product name
- Connexin-43 antibody
- Antibody type
- Polyclonal
- Description
- Connexin-43 antibody (Cat. #15386-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Centrosome amplification promotes cell invasion via cell-cell contact disruption and Rap-1 activation.
A novel role of SIRT2 in regulating gap junction communications via connexin-43 in bovine cumulus-oocyte complexes.
Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation.
Wilms' tumour 1 (WT1) negatively regulates the expression of connexin 43 via a non-canonical Wnt signalling pathway in cultured bovine Sertoli cells.
Cx43 and AKAP95 regulate G1/S conversion by competitively binding to cyclin E1/E2 in lung cancer cells.
MicroRNA-1298-5p inhibits cell proliferation and the invasiveness of bladder cancer cells via down-regulation of connexin 43.
Trimetazidine Attenuates Exhaustive Exercise-Induced Myocardial Injury in Rats via Regulation of the Nrf2/NF-κB Signaling Pathway.
Vinculin anchors contractile actin to the cardiomyocyte adherens junction.
Bone marrow mesenchymal stem cells overexpressing GATA-4 improve cardiac function following myocardial infarction.
Biomimetic electrical stimulation induces rat bone marrow mesenchymal stem cells to differentiate into cardiomyocyte-like cells via TGF-beta 1 in vitro.
Senescence-related deterioration of intercellular junctions in the peritoneal mesothelium promotes the transmesothelial invasion of ovarian cancer cells.
Targeting the mDia Formin-Assembled Cytoskeleton Is an Effective Anti-Invasion Strategy in Adult High-Grade Glioma Patient-Derived Neurospheres.
Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells.
The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics.
Human skeletal muscle-derived stem/progenitor cells modified with connexin-43 prevent arrhythmia in rat post-infarction hearts and influence gene expression in the myocardium.
Renal Denervation Effects on Myocardial Fibrosis and Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy.
Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway.
Selenium (Na(2)SeO(3)) Upregulates Expression of Immune Genes and Blood-Testis Barrier Constituent Proteins of Bovine Sertoli Cell In Vitro.
Selective increase of cardiomyocyte derived extracellular vesicles after experimental myocardial infarction and functional effects on the endothelium.
Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in Mice.
Aquaporin 4 Silencing Aggravates Hydrocephalus Induced by Injection of Autologous Blood in Rats.
Loureirin B promotes insulin secretion through inhibition of K(ATP) channel and influx of intracellular calcium.
Sodium Selenite inhibits mitophagy, downregulation and mislocalization of blood-testis barrier proteins of bovine Sertoli cell exposed to microcystin-leucine arginine (MC-LR) via TLR4/NF-kB and mitochondrial signaling pathways blockage.
Visualization of Annular Gap Junction Vesicle Processing: The Interplay Between Annular Gap Junctions and Mitochondria.
Expression of Connexin43 in Cerebral Arteries of Patients with Moyamoya Disease.
Aloe-Emodin Relieves High-Fat Diet Induced QT Prolongation via MiR-1 Inhibition and IK1 Up-Regulation in Rats.
The Proangiogenic Capabilities of Malignant Ascites Generated by Aggressive Ovarian Tumors.
Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells.
Very-Low-Density Lipoprotein of Metabolic Syndrome Modulates Gap Junctions and Slows Cardiac Conduction.
Involvement of interstitial cells of Cajal in bladder dysfunction in mice with experimental autoimmune encephalomyelitis.
MicroRNA-19b Downregulates Gap Junction Protein Alpha1 and Synergizes with MicroRNA-1 in Viral Myocarditis.
All-trans retinoic acid enhances bystander effect of suicide gene therapy in the treatment of breast cancer.
GATA-3 augmentation down-regulates Connexin43 in Helicobacter pylori associated gastric carcinogenesis.
Insulin-like growth factor binding protein 4 enhances cardiomyocytes induction in murine-induced pluripotent stem cells.
Prakash A, Paunikar S, Webber M, McDermott E, Vellanki SH, Thompson K, Dockery P, Jahns H, Brown JAL, Hopkins AM, Bourke E
Journal of cell science 2023 Nov 1;136(21)
Journal of cell science 2023 Nov 1;136(21)
A novel role of SIRT2 in regulating gap junction communications via connexin-43 in bovine cumulus-oocyte complexes.
Xu D, He H, Liu D, Geng G, Li Q
Journal of cellular physiology 2020 Oct;235(10):7332-7343
Journal of cellular physiology 2020 Oct;235(10):7332-7343
Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation.
Wang Y, Yao F, Wang L, Li Z, Ren Z, Li D, Zhang M, Han L, Wang SQ, Zhou B, Wang L
Nature communications 2020 May 22;11(1):2585
Nature communications 2020 May 22;11(1):2585
Wilms' tumour 1 (WT1) negatively regulates the expression of connexin 43 via a non-canonical Wnt signalling pathway in cultured bovine Sertoli cells.
Wang X, Wang Z, Adeniran SO, Huang F, Ma M, Zhang H, Li X, Zheng P, Zhang G
Reproduction, fertility, and development 2020 Mar;32(5):522-530
Reproduction, fertility, and development 2020 Mar;32(5):522-530
Cx43 and AKAP95 regulate G1/S conversion by competitively binding to cyclin E1/E2 in lung cancer cells.
Chen R, Chen Y, Yuan Y, Zou X, Sun Q, Lin H, Chen X, Liu M, Deng Z, Yao Y, Guo D, Zhang Y
Thoracic cancer 2020 Jun;11(6):1594-1602
Thoracic cancer 2020 Jun;11(6):1594-1602
MicroRNA-1298-5p inhibits cell proliferation and the invasiveness of bladder cancer cells via down-regulation of connexin 43.
Li G, Sun L, Mu Z, Liu S, Qu H, Xie Q, Hu B
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):227-237
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):227-237
Trimetazidine Attenuates Exhaustive Exercise-Induced Myocardial Injury in Rats via Regulation of the Nrf2/NF-κB Signaling Pathway.
Zhang H, Liu M, Zhang Y, Li X
Frontiers in pharmacology 2019;10:175
Frontiers in pharmacology 2019;10:175
Vinculin anchors contractile actin to the cardiomyocyte adherens junction.
Merkel CD, Li Y, Raza Q, Stolz DB, Kwiatkowski AV
Molecular biology of the cell 2019 Oct 1;30(21):2639-2650
Molecular biology of the cell 2019 Oct 1;30(21):2639-2650
Bone marrow mesenchymal stem cells overexpressing GATA-4 improve cardiac function following myocardial infarction.
He JG, Li HR, Li BB, Xie QL, Yan D, Wang XJ
Perfusion 2019 Nov;34(8):696-704
Perfusion 2019 Nov;34(8):696-704
Biomimetic electrical stimulation induces rat bone marrow mesenchymal stem cells to differentiate into cardiomyocyte-like cells via TGF-beta 1 in vitro.
He X, Li L, Tang M, Zeng Y, Li H, Yu X
Progress in biophysics and molecular biology 2019 Nov;148:47-53
Progress in biophysics and molecular biology 2019 Nov;148:47-53
Senescence-related deterioration of intercellular junctions in the peritoneal mesothelium promotes the transmesothelial invasion of ovarian cancer cells.
Pakuła M, Witucka A, Uruski P, Radziemski A, Moszyński R, Szpurek D, Maksin K, Woźniak A, Sajdak S, Tykarski A, Mikuła-Pietrasik J, Książek K
Scientific reports 2019 May 20;9(1):7587
Scientific reports 2019 May 20;9(1):7587
Targeting the mDia Formin-Assembled Cytoskeleton Is an Effective Anti-Invasion Strategy in Adult High-Grade Glioma Patient-Derived Neurospheres.
Pettee KM, Becker KN, Alberts AS, Reinard KA, Schroeder JL, Eisenmann KM
Cancers 2019 Mar 20;11(3)
Cancers 2019 Mar 20;11(3)
Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells.
Adegoke EO, Adeniran SO, Zeng Y, Wang X, Wang H, Wang C, Zhang H, Zheng P, Zhang G
Journal of applied toxicology : JAT 2019 Jun;39(6):832-843
Journal of applied toxicology : JAT 2019 Jun;39(6):832-843
The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics.
Li Y, Merkel CD, Zeng X, Heier JA, Cantrell PS, Sun M, Stolz DB, Watkins SC, Yates NA, Kwiatkowski AV
Journal of cell science 2019 Feb 11;132(3)
Journal of cell science 2019 Feb 11;132(3)
Human skeletal muscle-derived stem/progenitor cells modified with connexin-43 prevent arrhythmia in rat post-infarction hearts and influence gene expression in the myocardium.
Rugowska A, Wiernicki B, Maczewski M, Mackiewicz U, Chojnacka K, Bednarek-Rajewska K, Kluk A, Majewski P, Kolanowski T, Malcher A, Rozwadowska N, Kurpisz M
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2019 Dec;70(6)
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2019 Dec;70(6)
Renal Denervation Effects on Myocardial Fibrosis and Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy.
Zhang B, Li X, Chen C, Jiang W, Lu D, Liu Q, Wang K, Yan Y, Jiang Z, Geng J, Xu H, Shan Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2471-2479
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2471-2479
Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway.
Adegoke EO, Wang C, Machebe NS, Wang X, Wang H, Adeniran SO, Zhang H, Zheng P, Zhang G
Environmental toxicology and pharmacology 2018 Oct;63:115-126
Environmental toxicology and pharmacology 2018 Oct;63:115-126
Selenium (Na(2)SeO(3)) Upregulates Expression of Immune Genes and Blood-Testis Barrier Constituent Proteins of Bovine Sertoli Cell In Vitro.
Adegoke EO, Wang X, Wang H, Wang C, Zhang H, Zhang G
Biological trace element research 2018 Oct;185(2):332-343
Biological trace element research 2018 Oct;185(2):332-343
Selective increase of cardiomyocyte derived extracellular vesicles after experimental myocardial infarction and functional effects on the endothelium.
Rodriguez JA, Orbe J, Saenz-Pipaon G, Abizanda G, Gebara N, Radulescu F, Azcarate PM, Alonso-Perez L, Merino D, Prosper F, Paramo JA, Roncal C
Thrombosis research 2018 Oct;170:1-9
Thrombosis research 2018 Oct;170:1-9
Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in Mice.
Li J, Wang S, Bai J, Yang XL, Zhang YL, Che YL, Li HH, Yang YZ
Hypertension (Dallas, Tex. : 1979) 2018 May;71(5):866-876
Hypertension (Dallas, Tex. : 1979) 2018 May;71(5):866-876
Aquaporin 4 Silencing Aggravates Hydrocephalus Induced by Injection of Autologous Blood in Rats.
Guo J, Mi X, Zhan R, Li M, Wei L, Sun J
Medical science monitor : international medical journal of experimental and clinical research 2018 Jun 20;24:4204-4212
Medical science monitor : international medical journal of experimental and clinical research 2018 Jun 20;24:4204-4212
Loureirin B promotes insulin secretion through inhibition of K(ATP) channel and influx of intracellular calcium.
Sha Y, Zhang Y, Cao J, Qian K, Niu B, Chen Q
Journal of cellular biochemistry 2018 Feb;119(2):2012-2021
Journal of cellular biochemistry 2018 Feb;119(2):2012-2021
Sodium Selenite inhibits mitophagy, downregulation and mislocalization of blood-testis barrier proteins of bovine Sertoli cell exposed to microcystin-leucine arginine (MC-LR) via TLR4/NF-kB and mitochondrial signaling pathways blockage.
Adegoke EO, Xue W, Machebe NS, Adeniran SO, Hao W, Chen W, Han Z, Guixue Z, Peng Z
Ecotoxicology and environmental safety 2018 Dec 30;166:165-175
Ecotoxicology and environmental safety 2018 Dec 30;166:165-175
Visualization of Annular Gap Junction Vesicle Processing: The Interplay Between Annular Gap Junctions and Mitochondria.
Bell CL, Shakespeare TI, Smith AR, Murray SA
International journal of molecular sciences 2018 Dec 22;20(1)
International journal of molecular sciences 2018 Dec 22;20(1)
Expression of Connexin43 in Cerebral Arteries of Patients with Moyamoya Disease.
Liao J, Hong T, Xu J, Zeng E, Tang B, Lai W
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018 Apr;27(4):1107-1114
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018 Apr;27(4):1107-1114
Aloe-Emodin Relieves High-Fat Diet Induced QT Prolongation via MiR-1 Inhibition and IK1 Up-Regulation in Rats.
Bai Y, Su Z, Sun H, Zhao W, Chen X, Hang P, Zhu W, Du Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1961-1973
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1961-1973
The Proangiogenic Capabilities of Malignant Ascites Generated by Aggressive Ovarian Tumors.
Mikuła-Pietrasik J, Uruski P, Szubert S, Maksin K, Moszyński R, Szpurek D, Woźniak A, Sajdak S, Tykarski A, Książek K
BioMed research international 2017;2017:2592496
BioMed research international 2017;2017:2592496
Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells.
Mikuła-Pietrasik J, Uruski P, Pakuła M, Maksin K, Szubert S, Woźniak A, Naumowicz E, Szpurek D, Tykarski A, Książek K
Free radical biology & medicine 2017 Sep;110:270-279
Free radical biology & medicine 2017 Sep;110:270-279
Very-Low-Density Lipoprotein of Metabolic Syndrome Modulates Gap Junctions and Slows Cardiac Conduction.
Lee HC, Chen CC, Tsai WC, Lin HT, Shiao YL, Sheu SH, Wu BN, Chen CH, Lai WT
Scientific reports 2017 Sep 21;7(1):12050
Scientific reports 2017 Sep 21;7(1):12050
Involvement of interstitial cells of Cajal in bladder dysfunction in mice with experimental autoimmune encephalomyelitis.
Jin Z, Ding Y, Xue R, Jia Z, Huang Z, Ding Y, Gu C, Yang J
International urology and nephrology 2017 Aug;49(8):1353-1359
International urology and nephrology 2017 Aug;49(8):1353-1359
MicroRNA-19b Downregulates Gap Junction Protein Alpha1 and Synergizes with MicroRNA-1 in Viral Myocarditis.
Lin J, Xue A, Li L, Li B, Li Y, Shen Y, Sun N, Chen R, Xu H, Zhao Z
International journal of molecular sciences 2016 May 18;17(5)
International journal of molecular sciences 2016 May 18;17(5)
All-trans retinoic acid enhances bystander effect of suicide gene therapy in the treatment of breast cancer.
Kong H, Liu X, Yang L, Qi K, Zhang H, Zhang J, Huang Z, Wang H
Oncology reports 2016 Mar;35(3):1868-74
Oncology reports 2016 Mar;35(3):1868-74
GATA-3 augmentation down-regulates Connexin43 in Helicobacter pylori associated gastric carcinogenesis.
Liu X, Cao K, Xu C, Hu T, Zhou L, Cao D, Xiao J, Luo L, Guo Y, Qi Y
Cancer biology & therapy 2015;16(6):987-96
Cancer biology & therapy 2015;16(6):987-96
Insulin-like growth factor binding protein 4 enhances cardiomyocytes induction in murine-induced pluripotent stem cells.
Xue Y, Yan Y, Gong H, Fang B, Zhou Y, Ding Z, Yin P, Zhang G, Ye Y, Yang C, Ge J, Zou Y
Journal of cellular biochemistry 2014 Sep;115(9):1495-504
Journal of cellular biochemistry 2014 Sep;115(9):1495-504
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15386-1-AP(GJA1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Connexin-43 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Connexin-43. This antibody recognizes human,mouse,rat antigen. The Connexin-43 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.