Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 12672-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12672-1-AP, RRID:AB_10639526
- Product name
- SHCBP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SHCBP1 antibody (Cat. #12672-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Knockout of Shcbp1 sensitizes immunotherapy by regulating α-SMA positive cancer-associated fibroblasts.
SHCBP1 contributes to the proliferation and self‑renewal of cervical cancer cells and activation of the NF‑κB signaling pathway through EIF5A.
Rucaparib inhibits lung adenocarcinoma cell proliferation and migration via the SHCBP1/CDK1 pathway.
CDC20 is a potential target gene to inhibit the tumorigenesis of MDCK cells.
Effects of Shenkang Pills on Early-Stage Diabetic Nephropathy in db/db Mice via Inhibiting AURKB/RacGAP1/RhoA Signaling Pathway.
Functional roles of the SHCBP1 and KIF23 interaction in modulating the cell-cycle and cisplatin resistance of head and neck squamous cell carcinoma.
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.
SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.
SHCBP1 regulates STAT3/c-Myc signaling activation to promote tumor progression in penile cancer.
FGF13 interaction with SHCBP1 activates AKT-GSK3α/β signaling and promotes the proliferation of A549 cells.
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis.
Measles virus nonstructural C protein modulates viral RNA polymerase activity by interacting with host protein SHCBP1.
Gu Q, Ma Z, Wang Q, Dai Y, Shi W, Jiao Z
Molecular carcinogenesis 2024 Apr;63(4):601-616
Molecular carcinogenesis 2024 Apr;63(4):601-616
SHCBP1 contributes to the proliferation and self‑renewal of cervical cancer cells and activation of the NF‑κB signaling pathway through EIF5A.
Deng B, Li A, Zhu Y, Zhou Y, Fei J, Miao Y
Oncology letters 2023 Jun;25(6):246
Oncology letters 2023 Jun;25(6):246
Rucaparib inhibits lung adenocarcinoma cell proliferation and migration via the SHCBP1/CDK1 pathway.
Dai Y, Hu C, Zhou H, Liu W, Lai W, Xu R, Liao J, Wang J, Li G, Zhang R
The FEBS journal 2023 Dec;290(24):5720-5743
The FEBS journal 2023 Dec;290(24):5720-5743
CDC20 is a potential target gene to inhibit the tumorigenesis of MDCK cells.
Liu Z, Pei M, Liu G, Qiu Z, Wang S, Qiao Z, Wang J, Jin D, Zhang J, Duan K, Nian X, Ma Z, Yang X
Biologicals : journal of the International Association of Biological Standardization 2023 Aug;83:101697
Biologicals : journal of the International Association of Biological Standardization 2023 Aug;83:101697
Effects of Shenkang Pills on Early-Stage Diabetic Nephropathy in db/db Mice via Inhibiting AURKB/RacGAP1/RhoA Signaling Pathway.
Wang F, Fan J, Pei T, He Z, Zhang J, Ju L, Han Z, Wang M, Xiao W
Frontiers in pharmacology 2022;13:781806
Frontiers in pharmacology 2022;13:781806
Functional roles of the SHCBP1 and KIF23 interaction in modulating the cell-cycle and cisplatin resistance of head and neck squamous cell carcinoma.
Sun Y, Pan H, He Y, Hu C, Gu Y
Head & neck 2022 Mar;44(3):591-605
Head & neck 2022 Mar;44(3):591-605
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.
Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J, Kiziltug E, Kundishora AJ, Koundal S, Pedram MZ, Torres-Fernández LA, Händler K, De Domenico E, Becker M, Ulas T, Juranek SA, Cuevas E, Hao LT, Jux B, Sousa AMM, Liu F, Kim SK, Li M, Yang Y, Takeo Y, Duque A, Nelson-Williams C, Ha Y, Selvaganesan K, Robert SM, Singh AK, Allington G, Furey CG, Timberlake AT, Reeves BC, Smith H, Dunbar A, DeSpenza T Jr, Goto J, Marlier A, Moreno-De-Luca A, Yu X, Butler WE, Carter BS, Lake EMR, Constable RT, Rakic P, Lin H, Deniz E, Benveniste H, Malvankar NS, Estrada-Veras JI, Walsh CA, Alper SL, Schultze JL, Paeschke K, Doetzlhofer A, Wulczyn FG, Jin SC, Lifton RP, Sestan N, Kolanus W, Kahle KT
Nature neuroscience 2022 Apr;25(4):458-473
Nature neuroscience 2022 Apr;25(4):458-473
SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.
Yang C, Hu JF, Zhan Q, Wang ZW, Li G, Pan JJ, Huang L, Liao CY, Huang Y, Tian YF, Shen BY, Chen JZ, Wang YD, Chen S
Genomics 2021 Mar;113(2):827-842
Genomics 2021 Mar;113(2):827-842
SHCBP1 regulates STAT3/c-Myc signaling activation to promote tumor progression in penile cancer.
Mo M, Tong S, Yin H, Jin Z, Zu X, Hu X
American journal of cancer research 2020;10(10):3138-3156
American journal of cancer research 2020;10(10):3138-3156
FGF13 interaction with SHCBP1 activates AKT-GSK3α/β signaling and promotes the proliferation of A549 cells.
Lu H, Yin M, Wang L, Cheng J, Cheng W, An H, Zhang T
Cancer biology & therapy 2020 Nov 1;21(11):1014-1024
Cancer biology & therapy 2020 Nov 1;21(11):1014-1024
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
Huang H, Cai H, Zhang L, Hua Z, Shi J, Wei Y
International immunopharmacology 2020 Mar;80:106123
International immunopharmacology 2020 Mar;80:106123
SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis.
Peng C, Zhao H, Song Y, Chen W, Wang X, Liu X, Zhang C, Zhao J, Li J, Cheng G, Wu D, Gao C, Wang X
Journal of experimental & clinical cancer research : CR 2017 Oct 11;36(1):141
Journal of experimental & clinical cancer research : CR 2017 Oct 11;36(1):141
Measles virus nonstructural C protein modulates viral RNA polymerase activity by interacting with host protein SHCBP1.
Ito M, Iwasaki M, Takeda M, Nakamura T, Yanagi Y, Ohno S
Journal of virology 2013 Sep;87(17):9633-42
Journal of virology 2013 Sep;87(17):9633-42
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 12672-1-AP(SHCBP1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human tonsillitis using 12672-1-AP(SHCBP1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SHCBP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SHCBP1. This antibody recognizes human, mouse antigen. The SHCBP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.