Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [797]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 15204-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15204-1-AP, RRID:AB_2292610
- Product name
- CHOP; GADD153 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CHOP; GADD153 antibody (Cat. #15204-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hsph1 alleviates hypoxia-glucose deprivation-induced cardiomyocyte damage by regulating endoplasmic reticulum stress.
After Traumatic Brain Injury, EPHA4 Enhances Endoplasmic Reticulum Stress to Promote M1 Microglial Polarization Through the MAPK Signaling Pathway.
Meningeal lymphatic vessel dysfunction exacerbates brain injury in CVST mice via endoplasmic reticulum and oxidative stress pathways.
A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells.
Electroacupuncture reduces calcium influx and inhibits endoplasmic reticulum stress by inhibiting the PKCδ-TRPA1 pathway to promote motor function recovery after spinal cord injury.
Nur77 attenuates Paneth cell necroptosis-induced intestinal inflammation through regulating endoplasmic reticulum homeostasis in sepsis.
CYR61 promotes obesity-induced kidney injury by activating endoplasmic reticulum stress.
Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress response.
Inhibition of α-1,3-mannosyltransferase sensitizes head and neck squamous cell carcinomas to cetuximab via endoplasmic reticulum stress.
A novel MMP13 frameshift variant causes short stature via enhanced MMP13-HSPA5 interaction and activated endoplasmic reticulum stress.
PERK-eIF2alpha-mediated translational inhibition of MCL-1 contributes to potential 2-deoxy-D-glucose and BAD mimetic combinatorial cancer therapy.
Endoplasmic reticulum stress-induced CHOP activation mediates NLRP3 inflammasome-dependent pyroptosis in BDE-47-induced cognitive dysfunction.
Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction.
Dissecting Complex Interactions Between Ferroptosis and the Proteasome.
Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips.
Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma.
MSMO1 promotes chemotherapy resistance through modulation of T-MAS metabolism via PERK/elF2α/ATF4/CHOP pathway.
ASCC3 promotes chemosensitivity in colorectal cancer cells.
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.
African swine fever virus MGF_110-8L promotes host cell autophagy and suppresses interferon signaling by activating the unfolded protein response.
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
Tetramethylpyrazine mitigates ER-stress-driven ATF4/CHOP apoptosis to protect dopaminergic neurons in cellular and MPTP models of Parkinson's disease.
LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells.
SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma.
Differential Toxicity of Water-Soluble Versus Water-Insoluble Components of Cowshed PM2.5 on Ovarian Granulosa Cells and the Regulatory Role of Txnip in Overall Toxicity.
Detection of factors related to ROS and ERS in the reproductive organs of hibernating Daurian ground squirrels (Spermophilus dauricus)†.
Citicoline Triggers Proteome Remodeling and Proteostatic Adaptation: Evidence from Shotgun Proteomics.
Multi-omics-informed hydrogel design: modulating IL-6 to reduce endoplasmic reticulum stress in bone regeneration.
Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress.
DNA damage-inducible transcript 3-mediated endoplasmic reticulum stress drives manganese-induced apoptosis in bovine testicular Leydig cells.
Characterization of Novel Decenoic Acid Derivatives Exhibiting Cytotoxic Activity Against T98G Glioma Cells Under a Serum- and Glucose-deprived Condition.
Paris polyphylla Smith var. yunnanensis-derived saponins potentiate the antitumor activity of GPX4 inhibitors.
Mazdutide Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Endoplasmic Reticulum Stress, Improving Lipid Metabolism and Alleviating Inflammation.
Integrative analysis of single-cell RNA sequencing, bulk RNA sequencing, and proteomic data identified NOTCH3 as a hub gene contributing to human intervertebral disc fibrosis.
Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cells.
Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbates endoplasmic reticulum stress in lupus nephritis.
SMG6's PIN (PilT N-Terminus) Domain Is Required for Nonsense-Mediated mRNA Decay (NMD) In Vivo.
Hesperetin, Acting Through Inhibition of c-Jun Signaling, Mitigates Hypomyelinating Disease-Associated Stop-Loss Claudin-11-Induced Defective Morphogenesis in Oligodendroglial FBD-102b Cells.
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.
Ageing promotes metastasis via activation of the integrated stress response.
Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.
Endoplasmic reticulum stress-mediated epithelial-mesenchymal transition contributes to cardiac biomarker-induced kidney injury.
Inhibition of N-Terminal Acetyltransferase C Mitigates Endoplasmic Reticulum Stress-Mediated Muscle Atrophy in Cancer Cachexia.
The Bufei Nashen Pill Alleviates COPD by Targeting Endoplasmic Reticulum Stress Through the PERK/eIF2α Signaling Pathway.
Sortilin is Associated with PGRN-Mediated Endoplasmic Reticulum Stress and Activation of Microglia in a Rat Model of Degenerative Cervical Myelopathy.
Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple-Negative Breast Cancer by Disrupting the Hippo-YAP/TEAD4-PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation.
Sunitinib induces immunogenic cell death through eIF2α phosphorylation to potentiate immunotherapy in HCC.
Cardiac and brain pathological alterations with potential biomarker screening in stress-related fatalities.
Pathogenic mechanisms of amyotrophic lateral sclerosis-linked VAPB P56S mutation in the degeneration of corticospinal motor neurons.
Pentadecyl, an Active Component of Microalgae, Ameliorates Endoplasmic Reticulum Stress and Blue Light-Induced Cell Death in Mouse Retina-Derived 661W Cells.
CB1 Receptor Agonist ACEA Resists ER Stress-Mediated Apoptosis via CB1R-Independent Mechanism.
Qizhi Kebitong Formula Ameliorates Sciatic Nerve Injury in Streptozocin-induced Diabetic Mice through PERK/ATF4/CHOP Endoplasmic Reticulum Stress Signaling Pathway.
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling.
Leonurine Attenuates CCl(4)-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway.
Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway.
Huanglian Jiedu Decoction Alleviates Myocardial Ischemia-Reperfusion Injury via AKT-Mediated Regulation of Endoplasmic Reticulum Stress.
Semaphorin 6D Alleviates Osteoarthritis by Inhibiting NLRP3 Inflammasome Activation and Endoplasmic Reticulum Stress.
Volatile Oil From Acorus Gramineus Rhizoma Synergizes with Crebanine to Alleviate Oxidative Stress and Endoplasmic Reticulum Stress in Myocardial Ischemia-Reperfusion Injury by Suppressing GRP78-PERK/ATF6-CHOP and MAPK-NF-κB-TNF-α Signaling Pathways.
Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk.
Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways.
Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus.
Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis.
Endoplasmic reticulum stress aggravates ferroptosis via PERK/ATF4/HSPA5 pathway in UUO-induced renal fibrosis.
Polymethoxyflavones extracted from Bauhinia championii alleviate LPS-induced acute lung injury by ameliorating endoplasmic reticulum stress.
Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway.
Bioinformatics-based identification of mirdametinib as a potential therapeutic target for idiopathic pulmonary fibrosis associated with endoplasmic reticulum stress.
Quercetin diminishes scleral ER stress and protein misfolding: High throughput transcriptome analysis in form-deprivation myopia of Guinea pigs.
Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation.
Unveiling the HSP90 inhibitor mediated effects on endoplasmic reticulum stress and redox signaling:from a cancer inhibitor to retinal degeneration catalyst.
Unraveling the molecular mechanisms of paraquat toxicity: The interplay of ATF4, ferroptosis, and endoplasmic reticulum stress.
PMAIP1 mediates endoplasmic reticulum stress in human dental pulp stem cells during pulpitis pathogenesis.
Short-term high-dose gemcitabine induces PERK-mediated immunogenic cell death and potentiates antitumor immunity in bladder cancer.
Excessive mitochondrial stress response triggers neuronal injury through the persistent eIF2α phosphorylation in mice exposed to manganese.
Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca(2 +) ]i stability.
PADI1 aggravates endoplasmic reticulum stress in trophoblast cells by inhibiting the FAK-ERK signaling pathway.
RCN3 functions as a tumor promoter in colorectal cancer by modulating the GRP78-PI3K-AKT signaling pathway.
Baicalin inhibits LPS-induced apoptosis and inflammation in WI- 38 cells by promoting FOXA2/TRIM27 Interaction: Implications for pediatric pneumonia mechanisms.
Maresin1 ameliorates osseointegration in type 2 diabetes mellitus by promoting FAM134B-mediated ER-phagy in osteoblasts.
Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury.
Usenamine A, an RGS2 inhibitor, exerts anti-NSCLC activity and enhances cytotoxicity of gemcitabine by inducing ER stress and Notch1-mediated autophagy.
IL-6/KIAA1429 promotes ferroptosis resistance in endometrial cancer through m6A modification of DDIT3.
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Intestinal Epithelial-Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78-mediated Endoplasmic Reticulum Stress.
Legionella pneumophila Effector Protein LegU1 Mediates the Ubiquitination of Endoplasmic Reticulum Chaperone BiP.
Combination of B-AP15 and HSP90 inhibitor tanespimycin induces ROS-mediated cytotoxicity in human lung cancer cells.
Rab26-mediated lysosomal translocation of eEF1A alleviates myocardial hypertrophy and cardiac remodeling.
An endoplasmic reticulum-targeting photodynamic AMPK agonist activates breast cancer immunotherapy through promoting immunogenic cell death and downregulation of PD-L1.
Astragalin induces immunogenic cell death in liver cancer by targeting NQO2 to promote ROS-mediated endoplasmic reticulum stress pathway.
Mechanistic and target study of anthraquinone modifier KA-4c triggering endoplasmic reticulum stress to inhibit triple-negative breast cancer cells.
Identification and validation of BCL11A as a neural and immune vulnerability factor in pancreatic adenocarcinoma.
Hydrogen sulfide alleviates vascular smooth muscle cell senescence by inhibiting endoplasmic reticulum stress.
Novel Disulfiram-Loaded Metal-Organic Nanoparticles Inhibit Tumor Growth and Induce Immunogenic Cell Death of Triple-Negative Breast Cancer Cells.
RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease.
Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury.
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Programmable initiation of mRNA translation by trans-RNA.
Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation.
Quercetin alleviated cadmium-induced oxidative stress, endoplasmic reticulum stress, and autophagy in chicken kidneys.
Overexpression of Heme Oxygenase 1 Enhances the Neuroprotective Effects of Exosomes in Subarachnoid Hemorrhage by Suppressing Oxidative Stress and Endoplasmic Reticulum Stress.
SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound.
Apolipoprotein B100 acts as a tumor suppressor in ovarian cancer via lipid/ER stress axis-induced blockade of autophagy.
Simulated microgravity activates autophagy expression in the rat retina.
Loss of ADAMTS5 promotes vascular calcification via versican/integrin β1/FAK signal.
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
FAM134B-mediated ER-phagy alleviates alcohol-related liver fibrosis by reducing endoplasmic reticulum stress.
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production.
HDAC4 regulates apoptosis in Acan-Cre(ERT2);HDAC4(d) (/d) mice with osteoarthritis by downregulating ATF4.
GRP78 Nanobody-Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy.
Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury.
TRAF3IP3 Induces ER Stress-Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation.
Dihydrotanshinone I potentiates the anti-tumor activity of cisplatin by activating ROS-mediated ER stress through targeting HSPD1 in lung cancer cells.
HNF4A Regulated APEH Deficiency Promotes UPR Activation in Diabetic Kidney Disease.
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson's Disease.
Potential mechanisms by which Jiawei Lianpu Yin inhibits Helicobacter pylori colonization and alleviates gastric mucosal inflammation and damage: Integrated transcriptomics, network pharmacology, and experimental validation.
NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors.
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants.
5-Azacytidine inhibits endoplasmic reticulum stress and apoptosis of nucleus pulposus cells by preserving PPARγ via promoter demethylation.
Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice.
Cryoshocked Adipocytes Mediated Dual-Modal Strategy Combining Photodynamic Therapy and Triptolide Palmitate for Pulmonary Metastatic Melanoma Treatment.
Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway.
Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor.
Clemastine fumarate alleviates endoplasmic reticulum stress through the Nur77/GFPT2/CHOP pathway after ischemia/reperfusion in rat hearts.
Androgen receptor alleviates doxorubicin-induced endoplasmic reticulum stress and myocardial injury by interacting with SERCA2a.
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Citrinin-Induced Intestinal Onset of Pyroptosis via the IP3R1-GRP75-VDAC1 Complex-Mediated Mitochondrial Oxidative Stress.
Triclosan Caused Oocyte Meiotic Arrest by Modulating Oxidative Stress, Organelle Dysfunctions, Autophagy, and Apoptosis in Pigs.
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation Underlie Silver Nanoparticles-Induced Neurologic Deficits in Adult Mice.
Polygonatum cyrtonema polysaccharide alleviates dopaminergic neuron apoptosis in Parkinson's disease mouse model via inhibiting oxidative stress and endoplasmic reticulum stress.
Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress-regulated neuronal apoptosis in APP/PS1 transgenic mice.
Alterations of retinal autophagy after a blast simulated microgravity in rats.
Unfolded protein response-activated NLRP3 inflammasome contributes to pyroptotic and apoptotic podocyte injury in diabetic kidney disease via the CHOP-TXNIP axis.
Nimbolide Targeting SIRT1 Protects Against Acetaminophen-Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.
Transcriptional regulation of solute carrier family 6 member 9 gene.
Endoplasmic reticulum stress induces trophoblast pyroptosis via regulating CYLD during labor initiation.
Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice.
SREBF1 mediates immunoparalysis of dendritic cells in sepsis by regulating lipid metabolism and endoplasmic reticulum stress.
Eeyarestatin I (ESI)-induced ERAD inhibition exhibits anti-cancer activity through multiple mechanisms in human colorectal cancer cells.
Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress.
SERP1 Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting ER Stress-Mediated Apoptosis.
Ubiquitination of ALOX15 regulates endoplasmic reticulum stress in Schwann cells and experimental autoimmune neuritis (EAN) models.
Calcium Fructoborate Improves Knee Osteoarthritis in Rats by Activating Hedgehog Signaling Through DDIT3.
Constitutive Hepatic mTORC1 Activation Aggravates Alcohol-Induced Liver Injury via Endoplasmic Reticulum Stress-Mediated Ferroptosis.
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
Koumine mediates the generation of mtROS through the IP3R1-GRP75-VDAC1 complex to improve Citrinin induced intestinal inflammation.
PERK inhibition with GSK2606414 in zebrafish evokes developmental defects consistent with Wolcott-Rallison syndrome phenotypes.
Zika virus non-structural protein NS2A mediated endoplasmic reticulum stress through interacting with Sarco/endoplasmic reticulum Ca(2+)-ATPase 2.
Reactive oxygen species regulate adipose-osteogenic lineage commitment of human mesenchymal stem cells by modulating gene expression of C/EBP homology protein and aldo-keto reductase family 1 member A1.
DDX3X promotes endoplasmic reticulum protein reprogramming via interaction with ERN1 to amplify cerebral ischemia/reperfusion injury.
Glycosylation of ceramide synthase 6 is required for its activity.
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells.
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
Best1 mitigates ER stress induced by the increased cellular microenvironment stiffness in epilepsy.
Anti-lung cancer synergy of low-dose doxorubicin and PD-L1 blocker co-delivered via mild photothermia-responsive black phosphorus.
Toosendanin alleviates acute lung injury by reducing pulmonary vascular barrier dysfunction mediated by endoplasmic reticulum stress through mTOR.
Caveolin 1 in bovine liver is associated with fatty acid-induced lipid accumulation and the endoplasmic reticulum unfolded protein response: Role in fatty liver development.
IL-17A exacerbates synovial inflammation in osteoarthritis via activation of endoplasmic reticulum stress.
PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response.
LINC00626 drives tamoxifen resistance in breast cancer cells by interaction with UPF1.
CUMS induces depressive-like behaviors and cognition impairment by activating the ERS-NLRP3 signaling pathway in mice.
More than just DNA damage: Pt(ΙΙ)-NHC complexes derived from 4,5-diarylimidazoles augment immunogenic cell death.
Piperine inhibits the proliferation of colorectal adenocarcinoma by regulating ARL3-mediated endoplasmic reticulum stress.
Daphnetin ameliorates diabetic cardiomyopathy by regulating inflammation and endoplasmic reticulum stress-induced apoptosis.
PRDM16 in thermogenic adipocytes mediates an inter-organ protective signaling against alcohol-associated liver disease.
MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis.
Role of MFN2 in bovine embryonic development and the mitigation of ER stress.
Targeting ceramide transfer protein sensitizes AML to FLT3 inhibitors via a GRP78-ATF6-CHOP axis.
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Sephin1 suppresses ER stress-induced cell death by inhibiting the formation of PP2A holoenzyme.
Sulfonated albumin from hepatocytes accelerates liver fibrosis in nonalcoholic fatty liver disease through endoplasmic reticulum stress.
Yinchen-Gancao decoction ameliorated NASH in mice by reducing hepatic lipid accumulation, inhibiting hepatic inflammatory and endoplasmic reticulum stress.
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis.
6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling.
WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of TMEM176A.
Study on the effect of HMGB1 on immune cells isolated from SLE mice.
Unlocking the potential of atractylenolide II: Mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay.
Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells.
Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca(2+) Imbalance.
An Enhanced Cancer Immunogenic Cell Death Strategy: Fibrate-Oxaliplatin(IV) Conjugates with Modulating Tumor Immune Microenvironment.
Effects of psychosocial stress on myocardial injury by modulating endoplasmic reticulum stress-induced autophagy and inflammation.
Cochlear endoplasmic reticulum stress causes connexin 26 degradation is involved in age-related hearing loss.
Knockdown of FXYD2 inhibits mepivacaine-induced cardiomyocyte injury by activating the PI3K/AKT signaling pathway.
A combination of ethanol and arachidonic acid promotes steatosis and endoplasmic reticulum stress and impairs mitochondrial respiration in H9c2 cardiomyoblasts.
A study on the mechanism by which BCAT1 influences the formation of intracranial aneurysms by regulating autophagy through endoplasmic reticulum stress.
E7386 Enhances Lenvatinib's Antitumor Activity in Preclinical Models and Human Hepatocellular Carcinoma.
Carboxypeptidase D deficiency causes hearing loss amenable to treatment.
Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU Through Smoothing Endoplasmic Reticulum Stress-Mediated Autophagic Flux.
Yinchenhao Decoction Combined with Praziquantel Ameliorates Inflammation and Hepatic Fibrosis in Schistosoma japonicum-Infected Mice.
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response.
The structural characteristics of cellular phospholipid acyl chains required for ABCA1-mediated HDL formation.
Protective effect of β-carotene against lipopolysaccharide-induced meiotic maturation defects in porcine cumulus-oocytes complexes.
Cadmium induces autophagy via IRE1 signaling pathway activated by Ca(2 +) in GC-2spd cells.
Cardiopulmonary Bypass-Induced IL-17A Aggravates Caspase-12-Dependent Neuronal Apoptosis Through the Act1-IRE1-JNK1 Pathway.
Isolation and Characterization of a Novel Porcine Teschovirus 2 Strain: Incomplete PERK-Mediated Unfolded Protein Response Supports Viral Replication.
In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma.
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
The endoplasmic reticulum stress-ferroptosis reciprocal signaling orchestrates anti-tumor effect of anlotinib in anaplastic thyroid cancer.
Pyrotinib targeted EGFR/GRP78 mediated cell apoptosis in high EGFR gene copy number gastric cancer.
Glia maturation factor-β in hepatocytes enhances liver regeneration and mitigates steatosis and ballooning in zebrafish.
Mitochondrial damage and ER stress in CB1 receptor antagonist-induced apoptosis in human neuroblastoma SH-SY5Y cells.
NOD2 promotes sepsis-induced neuroinflammation by increasing brain endoplasmic reticulum stress mediated by LACC1.
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
Inhibition of CCN5 Protects Against Apoptosis and Endoplasmic Reticulum Stress in Bisphenol A-Induced Sertoli Cells via p38/JNK MAPK Signaling Pathway.
ETS1 promotes cisplatin resistance of NSCLC cells by promoting GRP78 transcription.
Sagittaria sagittifolia polysaccharide extract regulates Nrf2 to improve endoplasmic reticulum stress-mediated apoptosis in rat cataracts and HLEB3 cells.
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
Phosphatidate phosphatase Lipin1 alters mitochondria-associated endoplasmic reticulum membranes (MAMs) homeostasis: effects which contribute to the development of diabetic encephalopathy.
Luteolin Modulate Endoplasmic Reticulum Stress by Targeting SIRT1 to Ameliorate DSS-Induced Ulcerative Colitis in Mice.
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.
ITGB1 Alleviates High Glucose-Induced Myocardial Cell Injury by Inhibiting Endoplasmic Reticulum Stress and Cell Apoptosis.
Comprehensive Analysis of CCAAT/Enhancer Binding Protein Family in Ovarian Cancer.
Knocking-down annexin A3 suppresses inflammation, oxidative stress, apoptosis, and endoplasmic reticulum stress to attenuate sepsis-induced acute kidney injury in HK2 cells.
Combination of TrxR1 inhibitor and lenvatinib triggers ROS-dependent cell death in human lung cancer cells.
MiR-204-5p regulates SIRT1 to promote the endoplasmic reticulum stress-induced apoptosis of inner ear cells in C57BL/6 mice with hearing loss.
SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo.
DDIT3 is associated with breast cancer prognosis and immune microenvironment: an integrative bioinformatic and immunohistochemical analysis.
Puerarin attenuates myocardial ischemic injury and endoplasmic reticulum stress by upregulating the Mzb1 signal pathway.
Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens.
ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
Irisflorentin improves functional recovery after spinal cord injury by protecting the blood-spinal cord barrier and promoting axonal growth.
UFL1 regulates cellular homeostasis by targeting endoplasmic reticulum and mitochondria in NEFA-stimulated bovine mammary epithelial cells via the IRE1α/XBP1 pathway.
GABAergic interneurons in the hippocampal CA1 mediate contextual fear generalization in PTSD rats.
The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis.
A 700 nm LED Light Activated Ru(II) Complex Destroys Tumor Cytoskeleton via Photosensitization and Photocatalysis.
Attenuation of PM2.5-Induced Lung Injury by 4-Phenylbutyric Acid: Maintenance of [Ca(2+)]i Stability between Endoplasmic Reticulum and Mitochondria.
Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects.
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice.
eIF2B localization and its regulation during the integrated stress response is cell-type specific.
The Delayed Turnover of Proteasome Processing of Myocilin upon Dexamethasone Stimulation Introduces the Profiling of Trabecular Meshwork Cells' Ubiquitylome.
Cepharanthine triggers ferroptosis through inhibition of NRF2 for robust ER stress against lung cancer.
TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice.
DMDD, isolated from Averrhoa carambola L., ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-autophagy crosstalk.
Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway.
Lowering an ER stress-regulated long noncoding RNA protects mice from diabetes and isolated pancreatic islets from cell death.
Neuronal ferroptosis and ferroptosis-mediated endoplasmic reticulum stress: Implications in cognitive dysfunction induced by chronic intermittent hypoxia in mice.
Roles of m(6)A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death.
Nimbolide protects against diabetic cardiomyopathy by regulating endoplasmic reticulum stress and mitochondrial function via the Akt/mTOR pathway.
Omentin-1 attenuates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal ligament stem cells and reduces M1 macrophages polarization through repressing endoplasmic reticulum stress.
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
Valproic Acid Inhibits Endoplasmic Reticulum Stress and Reduces Ferroptosis After Traumatic Brain Injury.
Quantitative proteomics reveals the mechanism of endoplasmic reticulum stress-mediated pulmonary fibrosis in mice.
ML385, an Nrf2 Inhibitor, Synergically Enhanced Celastrol Triggered Endoplasmic Reticulum Stress in Lung Cancer Cells.
Tribbles pseudokinase 3 promoted renal fibrosis by regulating the expression of DNA damage-inducible transcript 3 in diabetic nephropathy.
Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition.
Endoplasmic reticulum stress promotes oxidative stress, inflammation, and apoptosis: A novel mechanism of citrinin-induced renal injury and dysfunction.
Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier.
Implications of endoplasmic reticulum stress and beta-cell loss in immunodeficient diabetic NRG-Akita mice for understanding monogenic diabetes.
NUS1 Variants Cause Lennox-Gastaut Syndrome Related to Unfolded Protein Reaction Activation.
Proteasome inhibition induces apoptosis through simultaneous inactivation of MCL-1/BCL-XL by NOXA independent of CHOP and JNK pathways.
PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes.
Naringin Induces ROS-Stimulated G(1) Cell-Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma Cells.
OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.
Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.
HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis.
Mechanism of efficacy of trabectedin against myxoid liposarcoma entails detachment of the FUS-DDIT3 transcription factor from its DNA binding sites.
Urolithin A Protects Hepatocytes from Palmitic Acid-Induced ER Stress by Regulating Calcium Homeostasis in the MAM.
Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway.
Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway.
Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression.
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux.
Epigallocatechin gallate alleviated the in vivo toxicity of ZnO nanoparticles to mouse intestine.
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress.
Apelin‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress.
Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells.
Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells.
Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway.
AGR2-mediated unconventional secretion of 14-3-3ε and α-actinin-4, responsive to ER stress and autophagy, drives chemotaxis in canine mammary tumor cells.
Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.
(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation.
Esculin suppresses the PERK-eIF2α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model.
Inhibition of the endoplasmic reticulum stress-associated IRE-1 pathway alleviates preterm birth.
Remote ischemic postconditioning alleviates cerebral ischemic injury through SERCA2/endoplasmic reticulum stress-mediated apoptosis.
D-pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin-mediated endoplasmic reticulum stress and glycophagy signaling pathway.
LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling.
Prenatal inflammation exposure accelerates lung cancer tumorigenesis in offspring mouse: possible links to IRE1α/XBP1-mediated M2-like polarization of TAMs and PD-L1 up-expression.
Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway.
Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma.
Effects of gas signaling molecule SO(2) in cardiac functions of hyperthyroid rats.
DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response.
Excessive load promotes temporomandibular joint chondrocyte apoptosis via Piezo1/endoplasmic reticulum stress pathway.
Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens.
Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling.
Identification of osteoblastic autophagy-related genes for predicting diagnostic markers in osteoarthritis.
HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model.
CDK5RAP3 is a novel super-enhancer-driven gene activated by master TFs and regulates ER-Phagy in neuroblastoma.
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function.
Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1.
Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice.
LIM homeobox 1 (LHX1) induces endoplasmic reticulum stress and promotes preterm birth.
Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress.
Mitofusin2 Ameliorated Endoplasmic Reticulum Stress and Mitochondrial Reactive Oxygen Species Through Maintaining Mitochondria-Associated Endoplasmic Reticulum Membrane Integrity in Cisplatin-Induced Acute Kidney Injury.
Empagliflozin reduces endoplasmic reticulum stress associated TXNIP/NLRP3 activation in tunicamycin-stimulated aortic endothelial cells.
Suppression of endoplasmic reticulum stress by 4-PBA enhanced atherosclerotic plaque stability via up-regulating CLOCK expression.
A beneficial adaptive role for CHOP in driving cell fate selection during ER stress.
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury.
Dual targeting agent Thiotert inhibits the progression of glioblastoma by inducing ER stress-dependent autophagy.
Bioinformatics-driven discovery of silica nanoparticles induces apoptosis and renal damage via the unfolded protein response in NRK-52E cells and rat kidney.
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Inhibition of RXRA-mediated PLA2G2A improves delirium in COPD mice by regulating endoplasmic reticulum stress pathway and inhibiting cell apoptosis.
Buyang Huanwu decoction ameliorates bleomycin-induced pulmonary fibrosis in rats by attenuating the apoptosis of alveolar type II epithelial cells mediated by endoplasmic reticulum stress.
Cell surface GRP78: A potential therapeutic target for high glucose-induced endothelial injury.
Patulin induces ROS-dependent cardiac cell toxicity by inducing DNA damage and activating endoplasmic reticulum stress apoptotic pathway.
Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis.
Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia‒Reperfusion Injury.
Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis.
Identification of hypoxia- and immune-related biomarkers in patients with ischemic stroke.
Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression.
A novel bystander effect in tamoxifen treatment: PPIB derived from ER+ cells attenuates ER- cells via endoplasmic reticulum stress-induced apoptosis.
Repositioning of mifepristone as an integrated stress response activator to potentiate cisplatin efficacy in non-small cell lung cancer.
Qing Hua Chang Yin ameliorates chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and the NF-κB signalling pathway.
Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.
Selenium participates in the formation of kidney stones by alleviating endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells.
Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells.
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
20(R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2/HO-1 axis.
Cepharanthine-mediated endoplasmic reticulum stress inhibits Notch1 via binding GRP78 for suppressing hepatocellular carcinoma metastasis.
Corilagin alleviated intestinal ischemia-reperfusion injury by modulating endoplasmic reticulum stress via bonding with Bip.
Design, synthesis and biological evaluation of plant-derived miliusol derivatives achieve TNBC profound regression in vivo.
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway.
Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2.
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
Rutin Attenuates the Oxidative Damage Induced by Zearalenone in Piglet Endometrial Stromal Cells via the p53 Signaling Pathway.
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
Discovery and optimization of anthraquinone derivatives containing substituted bisbenzyloxy groups as a novel scaffold damaged endoplasmic reticulum and against hepatocellular carcinoma cells.
Puerarin Attenuates Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress and Suppresses Inflammation by Modulating the JNK and IKKβ/NF-κB Pathways in Epididymal White Adipose Tissue of Mice on a High-Fat Diet.
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.
MicroRNA-15b promotes cardiac ischemia injury by the inhibition of Mitofusin 2/PERK pathway.
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression.
Maltol Improves Peripheral Nerve Function by Inhibiting Schwann Cell Apoptosis via the PERK/eIF2α/CHOP Pathway and MME Upregulation in Diabetic Peripheral Neuropathy.
Mito-LND and (E)-Akt inhibitor-IV: novel compounds inducing endoplasmic reticulum stress and ROS accumulation against hepatocellular carcinoma.
Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells.
Phenylbutyric acid inhibits hypoxia-induced trophoblast apoptosis and autophagy in preeclampsia via the PERK/ATF-4/CHOP pathway.
Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin.
Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages.
Integrating Network Pharmacology and Experimental Validation to Reveal the Mechanism of Vine Grape Tea Polyphenols on Hyperuricemia-Induced Renal Injury in Mice.
An anti-tumor protein PFAP specifically interacts with cholesterol-enriched membrane domains of A549 cells and induces paraptosis and endoplasmic reticulum stress.
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration.
Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors.
CHOP regulated by METTL14-m6A affects cell cycle arrest and regorafenib sensitivity in HCC cells.
Triptolide induces apoptosis and cytoprotective autophagy by ROS accumulation via directly targeting peroxiredoxin 2 in gastric cancer cells.
The developmental regulator HAND1 inhibits gastric carcinogenesis through enhancing ER stress apoptosis via targeting CHOP and BAK which is augmented by cisplatin.
Exogenous Hydrogen Sulfide Induces A375 Melanoma Cell Apoptosis Through Overactivation of the Unfolded Protein Response.
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer.
Down-regulation of Hrd1 protects against myocardial ischemia-reperfusion injury by regulating PPARα to prevent oxidative stress, endoplasmic reticulum stress, and cellular apoptosis.
Exogenous spermidine alleviates diabetic cardiomyopathy via suppressing reactive oxygen species, endoplasmic reticulum stress, and Pannexin-1-mediated ferroptosis.
ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer.
The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice.
Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway.
Bavachin induces liver injury and cell apoptosis by targeting Wnt/β-catenin/DRP1 signaling pathway mediated mitochondrial dysfunction.
A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models.
Stress response mechanisms in protein misfolding diseases: Profiling a cellular model of Huntington's disease.
Diosmetin-7-O-β-D-glucopyranoside suppresses endothelial-mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis.
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae.
Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress.
Undesirable ER stress induced by bavachin contributed to follicular atresia in zebrafish ovary.
Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress-mitophagy.
A beneficial adaptive role for CHOP in driving cell fate selection during ER stress.
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.
IKVAV peptide-containing hydrogel decreases fibrous scar after spinal cord injury by inhibiting fibroblast migration and activation.
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota.
Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells.
Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response.
3-Acetyldeoxynivalenol induces apoptosis, barrier dysfunction and endoplasmic reticulum stress by inhibiting mTORC1-dependent autophagy in porcine enterocytes.
Role of SIRT2 in intestinal barrier under cold exposure.
Key Subdomains of Cerebral Dopamine Neurotrophic Factor Regulate Its Protective Function in 6-Hydroxydopamine-Lesioned PC12 Cells.
Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma.
Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway.
Systemic deuteration of SCID mice using the water-isotopologue deuterium oxide (D(2) O) inhibits tumor growth in an orthotopic bioluminescent model of human pancreatic ductal adenocarcinoma.
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice.
Vitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4.
Thioredoxin 1 overexpression attenuated diabetes-induced endoplasmic reticulum stress in Müller cells via apoptosis signal-regulating kinase 1.
JQ-1/bortezomib combination strongly impairs MM and PEL survival by inhibiting c-Myc and mTOR despite the activation of prosurvival mechanisms.
RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy.
Atorvastatin prevents endoplasmic reticulum stress-mediated apoptosis via the Nrf2/HO-1 signaling pathway in TBI mice.
Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation.
Scalp acupuncture alleviates cerebral ischemic stroke-induced motor dysfunction in rats via regulating endoplasmic reticulum stress and ER-phagy.
[Cordycepin, a metabolite of Cordyceps militaris, inhibits xenograft tumor growth of tongue squamous cell carcinoma in nude mice].
Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer.
Ginsenoside Rg1 regulates autophagy and endoplasmic reticulum stress via the AMPK/mTOR and PERK/ATF4/CHOP pathways to alleviate alcohol‑induced myocardial injury.
Bavachin protects against diet-induced hepatic steatosis and obesity in mice.
Betulinic acid mitigates zearalenone-induced liver injury by ERS/MAPK/Nrf2 signaling pathways in mice.
Coffee prevents IQ-induced liver damage by regulating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and the MAPK/NF-κB signaling pathway in zebrafish.
Xylanase improves the intestinal barrier function of Nile tilapia (Oreochromis niloticus) fed with soybean (Glycine max) meal.
Identification of EGF Receptor and Thrombospondin-1 as Endogenous Targets of ER-Associated Degradation Enhancer EDEM1 in HeLa Cells.
Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress.
Glutamine supplementation reverses manganese neurotoxicity by eliciting the mitochondrial unfolded protein response.
Glucotropaeolin Promotes Apoptosis by Calcium Dysregulation and Attenuates Cell Migration with FOXM1 Suppression in Pancreatic Cancer Cells.
Identification of genomic binding sites and direct target genes for the transcription factor DDIT3/CHOP.
Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress.
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage.
Non-Lethal Concentrations of CdCl(2) Cause Marked Alternations in Cellular Stress Responses within Exposed Sertoli Cell Line.
Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes.
Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds with Endoplasmic Reticulum Stress-Relieving Properties for Promoted Scarless Wound Healing.
Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice.
Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure.
NRF2 and Bip Interconnection Mediates Resistance to the Organometallic Ruthenium-Cymene Bisdemethoxycurcumin Complex Cytotoxicity in Colon Cancer Cells.
Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress.
Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer.
The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Lead and cadmium co-exposure modified PC12 viability and ER stress: study from a 3 × 3 factorial design.
Betaine ameliorates heat stress-induced apoptosis by affecting oxidative and endoplasmic reticulum stress in mouse Leydig cells.
Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma.
ER Stress-Perturbed Intracellular Protein O-GlcNAcylation Aggravates Podocyte Injury in Diabetes Nephropathy.
Glycyrrhetinic acid attenuates endoplasmic reticulum stress-induced hepatocyte apoptosis via CHOP/DR5/Caspase 8 pathway in cholestasis.
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells.
Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner.
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1.
VPS34-IN1 induces apoptosis of ER+ breast cancer cells via activating PERK/ATF4/CHOP pathway.
Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.
Zinc deficiency causes oxidative stress, endoplasmic reticulum stress, apoptosis and inflammation in hepatocytes in grass carp.
SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.
Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease.
cFLIP(L) Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Endoplasmic Reticulum Stress.
Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy.
Dihydroartemisinin elicits immunogenic death through ferroptosis-triggered ER stress and DNA damage for lung cancer immunotherapy.
Apurinic/apyrimidinic endonuclease 1 regulates palmitic acid-mediated apoptosis in cardiomyocytes via endoplasmic reticulum stress.
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo.
Citrinin Exposure Induced Testicular Damage and Spermatogenesis Disorder by Triggering Endoplasmic Reticulum Stress.
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Effects of folic acid on oxidative damage of kidney in lead-exposed rats.
Qingfei Tongluo Formula Mitigates Mycoplasma pneumoniae Infection via the PERK Signaling Pathway.
Bixin Prevents Colorectal Cancer Development through AMPK-Activated Endoplasmic Reticulum Stress.
Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.
Saikosaponin D Inducing Apoptosis and Autophagy through the Activation of Endoplasmic Reticulum Stress in Glioblastoma.
Upregulation of Glutaminyl Cyclase Contributes to ERS-Induced Apoptosis in PC12 Cells.
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.
Ursolic Acid Derivative UA232 Promotes Tumor Cell Apoptosis by Inducing Endoplasmic Reticulum Stress and Lysosomal Dysfunction.
Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction.
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Pitavastatin protects against neomycin-induced ototoxicity through inhibition of endoplasmic reticulum stress.
Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.
Cryptotanshinone alleviates myocardial ischemia and reperfusion injury in rats to mitigate ER stress-dependent apoptosis by modulating the JAK1/STAT3 axis.
TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease.
Melatonin promotes sirtuin 1 expression and inhibits IRE1α-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes.
Pinelliae rhizoma alleviated acute lung injury induced by lipopolysaccharide via suppressing endoplasmic reticulum stress-mediated NLRP3 inflammasome.
Ginsenoside Rb1 Ameliorated Bavachin-Induced Renal Fibrosis via Suppressing Bip/eIF2α/CHOP Signaling-Mediated EMT.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Fuzheng Nizeng Decoction regulated ferroptosis and endoplasmic reticulum stress in the treatment of gastric precancerous lesions: A mechanistic study based on metabolomics coupled with transcriptomics.
Oxaloacetate acid ameliorates paraquat-induced acute lung injury by alleviating oxidative stress and mitochondrial dysfunction.
FUS-DDIT3 Fusion Oncoprotein Expression Affects JAK-STAT Signaling in Myxoid Liposarcoma.
RRBP1 depletion of bone metastatic cancer cells contributes to enhanced expression of the osteoblastic phenotype.
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway.
Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis.
HSPA5 repressed ferroptosis to promote colorectal cancer development by maintaining GPX4 stability.
Identification of Ferroptotic Genes in Spinal Cord Injury at Different Time Points: Bioinformatics and Experimental Validation.
Role of Mydgf in the regulation of hypoxia/reoxygenation-induced apoptosis in cardiac microvascular endothelial cells.
Acacetin antagonized lipotoxicity in pancreatic β-cells via ameliorating oxidative stress and endoplasmic reticulum stress.
UFL1 alleviates ER stress and apoptosis stimulated by LPS via blocking the ferroptosis pathway in human granulosa-like cells.
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Role of hair follicles in the pathogenesis of arsenical-induced cutaneous damage.
Zearalenone Promotes LPS-Induced Oxidative Stress, Endoplasmic Reticulum Stress, and Accelerates Bovine Mammary Epithelial Cell Apoptosis.
Liproxstatin‑1 induces cell cycle arrest, apoptosis, and caspase‑3/GSDME‑dependent secondary pyroptosis in K562 cells.
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.
Exploring the molecular mechanisms underlie the endoplasmic reticulum stress-mediated methylmercury-induced neuronal developmental damage.
ER stress transforms random olfactory receptor choice into axon targeting precision.
A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.
Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy.
Ellagic acid attenuates muscle atrophy in STZ-induced diabetic mice.
Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis.
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Manganese Mitigates Heat Stress-Induced Apoptosis by Alleviating Endoplasmic Reticulum Stress and Activating the NRF2/SOD2 Pathway in Primary Chick Embryonic Myocardial Cells.
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma.
Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells.
diTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C(2)-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation.
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a.
Targeting c-Myc Unbalances UPR towards Cell Death and Impairs DDR in Lymphoma and Multiple Myeloma Cells.
Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction.
The Impact of NRF2 Inhibition on Drug-Induced Colon Cancer Cell Death and p53 Activity: A Pilot Study.
Protective Effects of Taraxasterol against Deoxynivalenol-Induced Damage to Bovine Mammary Epithelial Cells.
Hesperadin suppresses pancreatic cancer through ATF4/GADD45A axis at nanomolar concentrations.
FAdV-4 induce autophagy via the endoplasmic reticulum stress-related unfolded protein response.
Contribution of Endoplasmic Reticulum Stress to the Clinical Instability of Carotid Plaques in Human Carotid Stenosis.
Quinoa Reduces High-Fat Diet-Induced Obesity in Mice via Potential Microbiota-Gut-Brain-Liver Interaction Mechanisms.
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
Intravenously transplanted mesenchymal stromal cells: a new endocrine reservoir for cardioprotection.
Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer.
Podophyllotoxin-combined 5-aminolevulinic acid photodynamic therapy significantly promotes HR-HPV-infected cell death.
The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells.
GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis.
TRPV4 contributes to ER stress and inflammation: implications for Parkinson's disease.
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Nrf2 loss of function exacerbates endoplasmic reticulum stress-induced apoptosis in TBI mice.
Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation.
Nrf2 activation mediates the protection of mouse Sertoli Cells damage under acute heat stress conditions.
Inhibition of the miR-193b-3p protects against oxidized low-density lipoprotein-induced HUVECs injury by upregulating ALDH2.
Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpox(nct) mice.
Zinc Protects against Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells.
A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice.
Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma.
Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy.
Endoplasmic reticulum stress mediates parathyroid hormone-induced apoptosis in vascular smooth muscle cells.
The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators.
Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis.
Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway.
Knockdown of TMEM160 leads to an increase in reactive oxygen species generation and the induction of the mitochondrial unfolded protein response.
Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells.
Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease.
African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α Pathway.
Diverse injury responses of human oligodendrocyte to mediators implicated in multiple sclerosis.
Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function.
Role of Ero1α in cognitive impairment induced by chronic hypoxia.
The IRE1/JNK signaling pathway regulates inflammation cytokines and production of glomerular extracellular matrix in the acute kidney injury to chronic kidney disease transition.
Sodium selenite attenuates zearalenone-induced apoptosis through inhibition of endoplasmic reticulum stress in goat trophoblast cells.
Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells.
LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis.
Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells.
Azoramide ameliorated tachypacing-induced injury of atrial myocytes differentiated from human induced pluripotent stem cell by regulating endoplasmic reticulum stress.
Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma.
Citrinin-Induced Hepatotoxicity in Mice Is Regulated by the Ca(2+)/Endoplasmic Reticulum Stress Signaling Pathway.
RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway.
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Chlorogenic acid improves the intestinal barrier by relieving endoplasmic reticulum stress and inhibiting ROCK/MLCK signaling pathways.
Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress.
Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration.
Wenxin Granules Regulate Endoplasmic Reticulum Stress Unfolded Protein Response and Improve Ventricular Remodeling on Rats with Myocardial Infarction.
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress.
Magnesium-Assisted Cisplatin Inhibits Bladder Cancer Cell Survival by Modulating Wnt/β-Catenin Signaling Pathway.
Interventional Efects of the Topical of "Sanse Powder" Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis.
IL-6/STAT3 Induced Neuron Apoptosis in Hypoxia by Downregulating ATF6 Expression.
Extracts of Vine Tea Improve Diet-Induced Non-Alcoholic Steatohepatitis Through AMPK-LXRα Signaling.
Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor α-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway.
Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis.
Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.
Lamprey Immune Protein Mediates Apoptosis of Lung Cancer Cells Via the Endoplasmic Reticulum Stress Signaling Pathway.
Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine.
Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway.
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment.
Role of UPR Sensor Activation in Cell Death-Survival Decision of Colon Cancer Cells Stressed by DPE Treatment.
Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH.
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Expression liabilities in a four-chain bispecific molecule.
CK1δ stimulates ubiquitination-dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer.
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation.
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
2-Amino-3-Methylimidazo[4,5-f]quinoline Triggering Liver Damage by Inhibiting Autophagy and Inducing Endoplasmic Reticulum Stress in Zebrafish (Danio rerio).
TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement.
Suppression of alveolar bone resorption by salubrinal in a mouse model of periodontal disease.
Autophagy triggers endoplasmic reticulum stress and C/EBP homologous protein-mediated apoptosis in OGD/R-treated neurons in a caspase-12-independent manner.
The seed oil of Paeonia ludlowii ameliorates Aβ25-35-induced Alzheimer's disease in rats.
Near-infrared emission Cu, N-doped carbon dots for human umbilical vein endothelial cell labeling and their biocompatibility in vitro.
PGE2 Released by Pancreatic Cancer Cells Undergoing ER Stress Transfers the Stress to DCs Impairing Their Immune Function.
Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression.
Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice.
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.
4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation.
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Combination of Palmitic Acid and Methylseleninic Acid Induces Mitochondria-Dependent Apoptosis via Attenuation of the IRE1α Arm and Enhancement of CHOP in Hepatoma.
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.
Polybrominated diphenyl ethers quinone-induced intracellular protein oxidative damage triggers ubiquitin-proteasome and autophagy-lysosomal system activation in LO2 cells.
Comparison of multi-walled carbon nanotubes and halloysite nanotubes on lipid profiles in human umbilical vein endothelial cells.
Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung.
Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis.
Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells.
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing.
Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells.
Autophagy impairment as a key feature for acetaminophen-induced ototoxicity.
MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-κB pathway in LPS-challenged HUVECs and septic mice.
Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice.
Cytosolic PINK1 orchestrates protein translation during proteasomal stress by phosphorylating the translation elongation factor eEF1A1.
Boron Attenuates Heat Stress-Induced Apoptosis by Inhibiting Endoplasmic Reticulum Stress in Mouse Granulosa Cells.
Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin.
AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo.
Cigarette smoke extracts induce apoptosis in Raw264.7 cells via endoplasmic reticulum stress and the intracellular Ca(2+)/P38/STAT1 pathway.
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis.
Reticulocalbin 1 is required for proliferation and migration of non-small cell lung cancer cells regulated by osteoblast-conditioned medium.
Sinapic acid attenuates muscle atrophy in streptozotocin-induced diabetic mice.
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome.
Mannan-binding lectin deficiency augments hepatic endoplasmic reticulum stress through IP3R-controlled calcium release.
Long non-coding RNA RP5-821D11.7 promotes proliferation, migration, and epithelial-mesenchymal transition in glioma and glioma stem-like cells.
Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity.
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca(2+) Homeostasis, and Bcl2 Expression.
Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis.
Integration of Metabolomics and Transcriptomics Reveals Ketone Body and Lipid Metabolism Disturbance Related to ER Stress in the Liver.
KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats.
Estrogen Regulates Endoplasmic Reticulum Stress-Mediated Apoptosis by ERK-p65 Pathway to Promote Endometrial Angiogenesis.
ARFGAP1 binds to classical swine fever virus NS5A protein and enhances CSFV replication in PK-15 cells.
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Antrodia Cinnamomea Attenuates Non-Alcoholic Steatohepatitis by Suppressing NLRP3 Inflammasome Activation In Vitro and In Vivo.
Methane-Rich Saline Alleviates CA/CPR Brain Injury by Inhibiting Oxidative Stress, Microglial Activation-Induced Inflammatory Responses, and ER Stress-Mediated Apoptosis.
Topical Application of Fibroblast Growth Factor 10-PLGA Microsphere Accelerates Wound Healing via Inhibition of ER Stress.
Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation.
Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway.
Chlorin A-mediated photodynamic therapy induced apoptosis in human cholangiocarcinoma cells via impaired autophagy flux.
Role of Endoplasmic Reticulum Stress in Otitis Media.
Maimendong Decoction Improves Pulmonary Function in Rats With Idiopathic Pulmonary Fibrosis by Inhibiting Endoplasmic Reticulum Stress in AECIIs.
EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.
Apigetrin ameliorates streptozotocin-induced pancreatic β-cell damages via attenuating endoplasmic reticulum stress.
A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells.
Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy.
Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.
Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress.
Lycopene protects neuroblastoma cells against oxidative damage via depression of ER stress.
FABP4 inhibitor BMS309403 protects against hypoxia-induced H9c2 cardiomyocyte apoptosis through attenuating endoplasmic reticulum stress.
Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
T-type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation.
Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE(-/-) mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage.
Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.
Aging is associated with increased TRB3, ER stress, and hepatic glucose production in the liver of rats.
Knockdown of fatty acid binding protein 4 exacerbates Bacillus Calmette-Guerin infection-induced RAW264.7 cell apoptosis via the endoplasmic reticulum stress pathway.
TRPV4 contributes to ER stress: Relation to apoptosis in the MPP(+)-induced cell model of Parkinson's disease.
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy.
Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Pyruvate alleviates high glucose-induced endoplasmic reticulum stress and apoptosis in HK-2 cells.
Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling.
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
A novel splice site indel alteration in the EIF2AK3 gene is responsible for the first cases of Wolcott-Rallison syndrome in Hungary.
Astrocyte elevated gene 1 (AEG-1) promotes anoikis resistance and metastasis by inducing autophagy in hepatocellular carcinoma.
Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum.
Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation.
Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes.
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Circulating Exosomes From Lipopolysaccharide-Induced Ards Mice Trigger Endoplasmic Reticulum Stress in Lung Tissue.
4-Phenylbutyrate Prevents Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Heatstroke in the Intestines of Mice.
ALA protects against ERS-mediated apoptosis in a cochlear cell model with low citrate synthase expression.
TMEM216 Deletion Causes Mislocalization of Cone Opsin and Rhodopsin and Photoreceptor Degeneration in Zebrafish.
Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Minocycline induces apoptosis of photoreceptor cells by regulating ER stress.
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells.
MCP-1 mediates ischemia-reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR.
N-glycosylation of uterine endometrium determines its receptivity.
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Oxidative Stress and Endoplasmic Reticulum Stress Are Involved in the Protective Effect of Alpha Lipoic Acid Against Heat Damage in Chicken Testes.
Melatonin protects against Epirubicin-induced ovarian damage.
Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases.
Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress.
Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner.
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes.
Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21(Cip1) and p27(Kip1).
Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol.
IL13Rα1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes.
25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress.
Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats.
N6-(2-hydroxyethyl)-Adenosine Induces Apoptosis via ER Stress and Autophagy of Gastric Carcinoma Cells In Vitro and In Vivo.
Artemisinin and dihydroartemisinin promote β-cell apoptosis induced by palmitate via enhancing ER stress.
All-trans-retinal induces autophagic cell death via oxidative stress and the endoplasmic reticulum stress pathway in human retinal pigment epithelial cells.
Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo.
Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
Tandem Molecular Self-Assembly Selectively Inhibits Lung Cancer Cells by Inducing Endoplasmic Reticulum Stress.
Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells.
Multi-Walled Carbon Nanotubes (MWCNTs) Activate Apoptotic Pathway Through ER Stress: Does Surface Chemistry Matter?
Autophagy Activation Is Involved in Acidic Fibroblast Growth Factor Ameliorating Parkinson's Disease via Regulating Tribbles Homologue 3.
Vildagliptin Reduces Stenosis of Injured Carotid Artery in Diabetic Mouse Through Inhibiting Vascular Smooth Muscle Cell Proliferation via ER Stress/NF-κB Pathway.
Effect of endoplasmic reticulum calcium on paraquat‑induced apoptosis of human lung type II alveolar epithelial A549 cells.
Multi-walled carbon nanotubes (MWCNTs) promoted lipid accumulation in THP-1 macrophages through modulation of endoplasmic reticulum (ER) stress.
Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.
Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles.
Japanese Encephalitis Virus Induces Apoptosis and Encephalitis by Activating the PERK Pathway.
Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells.
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.
Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin-1 signaling.
Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway.
Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model.
Structure-toxicity relationships of saturated and unsaturated free fatty acids for elucidating the lipotoxic effects in human EndoC-βH1 beta-cells.
Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway.
FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.
FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma.
Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration.
Icariside II prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats.
A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.
Exosomes from Microglia Attenuate Photoreceptor Injury and Neovascularization in an Animal Model of Retinopathy of Prematurity.
Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability.
A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress.
Metformin induces TPC-1 cell apoptosis through endoplasmic reticulum stress-associated pathways in vitro and in vivo.
Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells.
Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na(+) and Ca(2+) handling.
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
Autophagy activation alleviates nonylphenol-induced apoptosis in cultured cortical neurons.
The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.
Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS.
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress.
Chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and nonalcoholic steatohepatitis via angiogenesis rather than endoplasmic reticulum stress.
Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress.
Signaling from mTOR to eIF2α mediates cell migration in response to the chemotherapeutic doxorubicin.
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress.
Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice.
20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway.
TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis.
Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture.
Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells.
MnTMPyP inhibits paraquat-induced pulmonary epithelial-like cell injury by inhibiting oxidative stress.
A comparative study of toxicity of TiO(2), ZnO, and Ag nanoparticles to human aortic smooth-muscle cells.
Apoptosis of bone marrow mesenchymal stromal/stem cells via the MAPK and endoplasmic reticulum stress signaling pathways.
Effects of knee loading on obesity-related non-alcoholic fatty liver disease in an ovariectomized mouse model with high-fat diet.
TMCO1 is essential for ovarian follicle development by regulating ER Ca(2+) store of granulosa cells.
Ticagrelor protects against AngII-induced endothelial dysfunction by alleviating endoplasmic reticulum stress.
Benefits of combination low-dose pioglitazone plus fish oil on aged type 2 diabetes mice.
ERp44 depletion exacerbates ER stress and aggravates diabetic nephropathy in db/db mice.
Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet-Induced Metabolic Dysfunction in Mice.
Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78.
Effects of sevoflurane pretreatment on the apoptosis of rat H9c2 cardiomyocytes and the expression of GRP78.
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma.
TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.
STF-083010, an inhibitor of XBP1 splicing, attenuates acute renal failure in rats by suppressing endoplasmic reticulum stress-induced apoptosis and inflammation.
Dihydroartemisinin inhibits ER stress-mediated mitochondrial pathway to attenuate hepatocyte lipoapoptosis via blocking the activation of the PI3K/Akt pathway.
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Endoplasmic Reticulum Stress in the Dorsal Root Ganglion Contributes to the Development of Pain Hypersensitivity after Nerve Injury.
Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.
CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage.
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Transthyretin Exerts Pro-Apoptotic Effects in Human Retinal Microvascular Endothelial Cells Through a GRP78-Dependent Pathway in Diabetic Retinopathy.
Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model.
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H(2)S system: Role of oxidative stress and endoplasmic reticulum stress.
Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG.
Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation.
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Identification of Novel SCIRR69-Interacting Proteins During ER Stress Using SILAC-Immunoprecipitation Quantitative Proteomics Approach.
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway.
Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation.
Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells.
TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-κB pathway.
The reproductive toxicology of male SD rats after PM(2.5) exposure mediated by the stimulation of endoplasmic reticulum stress.
Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.
Role of endoplasmic reticulum stress in disuse osteoporosis.
Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts.
Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice.
Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis.
4-Phenylbutyric Acid Induces Protection against Pulmonary Arterial Hypertension in Rats.
Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice.
Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway.
Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Japanese encephalitis virus induces apoptosis by the IRE1/JNK pathway of ER stress response in BHK-21 cells.
Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.
Protective effects of fish oil and pioglitazone on pancreatic tissue in obese KK mice with type 2 diabetes.
Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.
The protective effect of the earthworm active ingredients on hepatocellular injury induced by endoplasmic reticulum stress.
Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking.
Beclin-1-independent autophagy mediates programmed cancer cell death through interplays with endoplasmic reticulum and/or mitochondria in colbat chloride-induced hypoxia.
Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells.
Endoplasmic reticulum stress is involved in the lidocaine-induced apoptosis in SH-SY5Y neuroblastoma cells.
Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.
Role of Endoplasmic Reticulum Stress in Brain Damage After Cardiopulmonary Resuscitation in Rats.
Inhibition of c-Src/p38 MAPK pathway ameliorates renal tubular epithelial cells apoptosis in db/db mice.
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Normal and functional TP53 in genetically stable myxoid/round cell liposarcoma.
Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats.
Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants.
Protein degradation and quality control in cells from laforin and malin knockout mice.
Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway.
ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway.
Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy.
Arsenic trioxide alleviates airway hyperresponsiveness and promotes apoptosis of CD4+ T lymphocytes: evidence for involvement of the ER stress-CHOP pathway.
Selenium deficiency is associated with endoplasmic reticulum stress in a rat model of cardiac malfunction.
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.
Lei Y, Chen Y, Pan Y
Folia morphologica 2026;85:e01726044
Folia morphologica 2026;85:e01726044
After Traumatic Brain Injury, EPHA4 Enhances Endoplasmic Reticulum Stress to Promote M1 Microglial Polarization Through the MAPK Signaling Pathway.
Tan Y, Xia J, Liu M, Deng S, Wu H, Qian C
Mediators of inflammation 2026;2026:5595023
Mediators of inflammation 2026;2026:5595023
Meningeal lymphatic vessel dysfunction exacerbates brain injury in CVST mice via endoplasmic reticulum and oxidative stress pathways.
Ying J, Li J, Wu X, Chen X, Zhang H, Wei L, Jing J, Wang S
Frontiers in immunology 2026;17:1745066
Frontiers in immunology 2026;17:1745066
A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells.
Lin H, Wei J, Yao W, Zhang Q, Jin J
Frontiers in pharmacology 2026;17:1739226
Frontiers in pharmacology 2026;17:1739226
Electroacupuncture reduces calcium influx and inhibits endoplasmic reticulum stress by inhibiting the PKCδ-TRPA1 pathway to promote motor function recovery after spinal cord injury.
Zhang Y, Liang C, Huang Z, Hu Y, Mo Y, Ning S, Li Z, Wu Y, Zhang J, Li X, Wang Z
Burns & trauma 2026;14:tkaf066
Burns & trauma 2026;14:tkaf066
Nur77 attenuates Paneth cell necroptosis-induced intestinal inflammation through regulating endoplasmic reticulum homeostasis in sepsis.
Cui C, Huo Q, Ran S, Wang W, Wei H, Peng J
Journal of advanced research 2026 May;83:269-285
Journal of advanced research 2026 May;83:269-285
CYR61 promotes obesity-induced kidney injury by activating endoplasmic reticulum stress.
Li B, Lv H, Gong K, Gao Y, Zhen J, Hu Z
Molecular immunology 2026 May;193:91-102
Molecular immunology 2026 May;193:91-102
Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress response.
Garellick VA, Gul N, Horrieh P, Mustafa D, Patel AAH, Dankis M, Alvarez SW, Berndtson J, Mahdavi S, Schwarz M, Persson A, Zahirovic F, Wiel C, Sayin VI, Lindahl P
Redox biology 2026 Mar;90:103988
Redox biology 2026 Mar;90:103988
Inhibition of α-1,3-mannosyltransferase sensitizes head and neck squamous cell carcinomas to cetuximab via endoplasmic reticulum stress.
Hao Y, Deng G, Li B, Cheng L, Wang S, Yang Z
Cell stress & chaperones 2026 Mar;31(2):100153
Cell stress & chaperones 2026 Mar;31(2):100153
A novel MMP13 frameshift variant causes short stature via enhanced MMP13-HSPA5 interaction and activated endoplasmic reticulum stress.
Lu H, Feng X, Dai S, Zhu Y, Yuan K, Chen Y, Zhu J, Fang Y, Yan Q, Wang C
Clinical and translational medicine 2026 Mar;16(3):e70648
Clinical and translational medicine 2026 Mar;16(3):e70648
PERK-eIF2alpha-mediated translational inhibition of MCL-1 contributes to potential 2-deoxy-D-glucose and BAD mimetic combinatorial cancer therapy.
Sun M, Li L, Fu R, Yang Q, Chen W, Sun Y, Gao H, Gao H, Dong N
Cellular signalling 2026 Mar;139:112333
Cellular signalling 2026 Mar;139:112333
Endoplasmic reticulum stress-induced CHOP activation mediates NLRP3 inflammasome-dependent pyroptosis in BDE-47-induced cognitive dysfunction.
Yuan Q, Zhang R, Hu J, Lin S, Zhu Y, Geng J, Du G, Yang X, Zhao Y, Wang D, Wang B, Fan H
Neurotoxicology 2026 Mar;113:103409
Neurotoxicology 2026 Mar;113:103409
Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
Xia C, Dai Z, Wang Y, Yu J, Wang Z, Huang Z, Pan K, Yang K, Chen Y, Zhong P, Gu C, Fan S, Lin X, Chen P
Nature communications 2026 Mar 31;17(1)
Nature communications 2026 Mar 31;17(1)
Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction.
Zhao YY, Wang YH, Li ZH, Chang DY, Nie L, Zhao MH, Tang SCW, Chen M
Cell discovery 2026 Mar 31;12(1)
Cell discovery 2026 Mar 31;12(1)
Dissecting Complex Interactions Between Ferroptosis and the Proteasome.
Murray MB, Upadhyay R, Szylo K, Gautam A, Goncalves J, Forcina G, Vinayak A, Brandmann O, Dixon SJ
bioRxiv : the preprint server for biology 2026 Mar 30;
bioRxiv : the preprint server for biology 2026 Mar 30;
Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips.
Li J, Peng W, Kwok M, Ding H, Zhuo D, Gurung B, Lakhani IR, Yu H, Poon EN, Li RA, Yao X
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma.
Larion M, Muley H, Zaibaq F, Zhang M, Davis D, Kruhlak M, Mathur S, Lita A, Song H, Zhang W, Wong Z, Harmon T, Zhang L, Cam-El Makranz C, Li A, Karadimov G, Lang F, Herold-Mende C, Yang C, Dowdy T
Research square 2026 Mar 25;
Research square 2026 Mar 25;
MSMO1 promotes chemotherapy resistance through modulation of T-MAS metabolism via PERK/elF2α/ATF4/CHOP pathway.
Ren H, Wang X, Shao Z, Xiong M, Chi W, Sang Y, Zhang Q, Wang Z, Liu D, Zhang L, Chen M, Zhu H, Xue J, Xiu B, Chi Y, Wu J
iScience 2026 Mar 20;29(3):114790
iScience 2026 Mar 20;29(3):114790
ASCC3 promotes chemosensitivity in colorectal cancer cells.
Tu A, Martyn RDC, Cui S, Batenburg NL, Fayyazi R, Di Pastena F, Berthiaume L, Singh K, Saleem R, Scott GR, Berg T, Audet-Walsh É, Steinberg GR, Zhu XD
Scientific reports 2026 Mar 17;16(1)
Scientific reports 2026 Mar 17;16(1)
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Chen SX, Qi X, Zheng XT, Bi ZM, Zhang Y, Wang YM
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.
Abdollahi M, Malek V, Tanwar VS, Kato M, Lanting L, Rezaei A, Zhang L, Yang L, Pillai RK, Kebrom L, Nandi J, Huang W, Ma K, Natarajan R
Molecular therapy. Nucleic acids 2026 Mar 12;37(1):102792
Molecular therapy. Nucleic acids 2026 Mar 12;37(1):102792
African swine fever virus MGF_110-8L promotes host cell autophagy and suppresses interferon signaling by activating the unfolded protein response.
Hou YP, Yang JK, Wang Y, Xia T, Wu X
Veterinary microbiology 2026 Jun;317:111013
Veterinary microbiology 2026 Jun;317:111013
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
Zhao Q, Zhang HJ, Han MM, Abiti J, Dong YJ, Wang JN, Lu JT, Wang W, Zhang X, Geng SL, Qiu LL, Wang XY, Hua ZC, Wang TY, Jia YL
Synthetic and systems biotechnology 2026 Jun;12:197-208
Synthetic and systems biotechnology 2026 Jun;12:197-208
Tetramethylpyrazine mitigates ER-stress-driven ATF4/CHOP apoptosis to protect dopaminergic neurons in cellular and MPTP models of Parkinson's disease.
Zhan S, Wen S, Wu L, Zhang X, Liu J, Zhang G, Liu H
Neuropharmacology 2026 Jun 1;290:110899
Neuropharmacology 2026 Jun 1;290:110899
LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells.
Hou X, Wang Y, Chen Y, Zhong P, Wang G, Li B, Lu B, Jiang H, Ning S
Oncology reports 2026 Jan;55(1)
Oncology reports 2026 Jan;55(1)
SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma.
Liu B, Zhang X, Tian J, Huang X, Li X, Zhao J, Xu Z, Pu J
European journal of histochemistry : EJH 2026 Jan 26;70(1)
European journal of histochemistry : EJH 2026 Jan 26;70(1)
Differential Toxicity of Water-Soluble Versus Water-Insoluble Components of Cowshed PM2.5 on Ovarian Granulosa Cells and the Regulatory Role of Txnip in Overall Toxicity.
Ma Z, Zhang X, Du X, Zhao C, Jia Y, Wang Y, Li X, Yu X, Gao Y
Antioxidants (Basel, Switzerland) 2026 Jan 21;15(1)
Antioxidants (Basel, Switzerland) 2026 Jan 21;15(1)
Detection of factors related to ROS and ERS in the reproductive organs of hibernating Daurian ground squirrels (Spermophilus dauricus)†.
Wang MD, Dong JY, Chen L, Li LF, Xi YF, Wang JC, Hu LJ, Xu JH, Wang Z
Biology of reproduction 2026 Jan 11;114(1):310-324
Biology of reproduction 2026 Jan 11;114(1):310-324
Citicoline Triggers Proteome Remodeling and Proteostatic Adaptation: Evidence from Shotgun Proteomics.
Cavaterra D, Giammaria S, Pandino I, Zingale GA, Delli Paoli V, Fiore R, Michelessi M, Roberti G, Carnevale C, Tanga L, Cazzato D, Peroni E, Grasso G, Manni G, Bocedi A, Oddone F, Coletta M, Sbardella D, Tundo GR
Pharmaceutics 2026 Jan 1;18(1)
Pharmaceutics 2026 Jan 1;18(1)
Multi-omics-informed hydrogel design: modulating IL-6 to reduce endoplasmic reticulum stress in bone regeneration.
Zhou J, Dai J, Hu S, Qi C, Chen J, Zhang W, Alexander D, Li A, Xiao Y, Li P
Bioactive materials 2026 Feb;56:95-114
Bioactive materials 2026 Feb;56:95-114
Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress.
Qiu QQ, Zhang N, Xu YY, Qin JW, Yu GF, Song XR
Molecular medicine reports 2026 Feb;33(2)
Molecular medicine reports 2026 Feb;33(2)
DNA damage-inducible transcript 3-mediated endoplasmic reticulum stress drives manganese-induced apoptosis in bovine testicular Leydig cells.
Huang L, Cheng Y, Pan X, Li H, Liu J, Zhao G, Huang L, Wang L, Song C, Song P, Zhao L, Yu X, Xiong J, Li X, Rao Q, Wang X, Song R
Cell stress & chaperones 2026 Feb;31(1):100144
Cell stress & chaperones 2026 Feb;31(1):100144
Characterization of Novel Decenoic Acid Derivatives Exhibiting Cytotoxic Activity Against T98G Glioma Cells Under a Serum- and Glucose-deprived Condition.
Ito Y, Tada N, Muraki C, Kubota Y, Kandeel M, Kitade Y, Itoh A, Oh-Hashi K
Cell biochemistry and biophysics 2026 Feb 3;
Cell biochemistry and biophysics 2026 Feb 3;
Paris polyphylla Smith var. yunnanensis-derived saponins potentiate the antitumor activity of GPX4 inhibitors.
Liu YX, Song YS, Liu CK, Liu J, Yu FX, Jiang WS, Liu G, Xu TR, Sang J
Journal of ethnopharmacology 2026 Feb 28;357:120890
Journal of ethnopharmacology 2026 Feb 28;357:120890
Mazdutide Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Endoplasmic Reticulum Stress, Improving Lipid Metabolism and Alleviating Inflammation.
Gan L, Duan L, Zheng X
Pharmaceuticals (Basel, Switzerland) 2026 Feb 26;19(3)
Pharmaceuticals (Basel, Switzerland) 2026 Feb 26;19(3)
Integrative analysis of single-cell RNA sequencing, bulk RNA sequencing, and proteomic data identified NOTCH3 as a hub gene contributing to human intervertebral disc fibrosis.
Ding Q, Chen X, Zheng Q, Dou Q, Zuo C, Wang Q, Shen C
Scientific reports 2026 Feb 26;16(1)
Scientific reports 2026 Feb 26;16(1)
Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cells.
Gonnella R, Corrado V, Scaffidi GF, Benedetti R, Di Crosta M, Zarrella R, Gilardini Montani MS, Santarelli R, Cirone M
Cell death discovery 2026 Feb 26;12(1)
Cell death discovery 2026 Feb 26;12(1)
Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbates endoplasmic reticulum stress in lupus nephritis.
Wen M, Li J, Li Y, Hun M, Yang T, Meng Y, Liu L, Gong H, Yu Y, Zhang Z, Zhang Y, Dang X, Zhao M, He Q
Cell & bioscience 2026 Feb 22;16(1)
Cell & bioscience 2026 Feb 22;16(1)
SMG6's PIN (PilT N-Terminus) Domain Is Required for Nonsense-Mediated mRNA Decay (NMD) In Vivo.
Chai B, Tan X, Li Y, Chen C, Ma X, Li T
Cells 2026 Feb 2;15(3)
Cells 2026 Feb 2;15(3)
Hesperetin, Acting Through Inhibition of c-Jun Signaling, Mitigates Hypomyelinating Disease-Associated Stop-Loss Claudin-11-Induced Defective Morphogenesis in Oligodendroglial FBD-102b Cells.
Miyamoto Y, Omata T, Muraki Y, Yagi M, Yamamoto M, Nishi A, Yako H, Yamauchi J
International journal of molecular sciences 2026 Feb 18;27(4)
International journal of molecular sciences 2026 Feb 18;27(4)
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.
Fu C, Lan S, Lin Y, Chen D, Yang Z, Chen C, Chen Y, Yuan Y, Zhong W, Lin Q, Huang Z
Pharmaceutical biology 2026 Dec;64(1):278-294
Pharmaceutical biology 2026 Dec;64(1):278-294
Ageing promotes metastasis via activation of the integrated stress response.
Patel AAH, Dzanan JJ, Ali KX, Eklund EA, Alvarez SW, Raj D, Dankis M, Altinönder I, Schwarz M, Le Gal K, Bedel E, El Zowalaty AE, Jonasson E, Albatrok H, Gul N, Bossowski JP, Pillai R, Micke P, Botling J, Akyürek LM, Angeletti D, Sayin SI, Härtlova A, Papagiannakopoulos T, Olofsson Bagge R, Ståhlberg A, Hallqvist A, Wiel C, Sayin VI
Nature 2026 Apr;652(8112):1339-1348
Nature 2026 Apr;652(8112):1339-1348
Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.
Yang JK, Huang S, Hou YP, Yuan HF, Wang Y, Li M, Cao LB, Xia T, Shu HB, Wu X
The Journal of biological chemistry 2026 Apr;302(4):111333
The Journal of biological chemistry 2026 Apr;302(4):111333
Endoplasmic reticulum stress-mediated epithelial-mesenchymal transition contributes to cardiac biomarker-induced kidney injury.
Cheng M, Zhang X, Shi Y, Hu Z, Li J, Wei Y, Peng Y, Ding Y
Biochimica et biophysica acta. Molecular cell research 2026 Apr;1873(4):120134
Biochimica et biophysica acta. Molecular cell research 2026 Apr;1873(4):120134
Inhibition of N-Terminal Acetyltransferase C Mitigates Endoplasmic Reticulum Stress-Mediated Muscle Atrophy in Cancer Cachexia.
Kaneko Y, Hino T, Taminishi S, Matoba Y, Motooka D, Hoshino A, Matoba S
Journal of cachexia, sarcopenia and muscle 2026 Apr;17(2):e70249
Journal of cachexia, sarcopenia and muscle 2026 Apr;17(2):e70249
The Bufei Nashen Pill Alleviates COPD by Targeting Endoplasmic Reticulum Stress Through the PERK/eIF2α Signaling Pathway.
He T, Zhang A, Zhang C
Immunity, inflammation and disease 2026 Apr;14(4):e70418
Immunity, inflammation and disease 2026 Apr;14(4):e70418
Sortilin is Associated with PGRN-Mediated Endoplasmic Reticulum Stress and Activation of Microglia in a Rat Model of Degenerative Cervical Myelopathy.
Lei L, Wang X, Zhang J, Zhao J
Neuromolecular medicine 2026 Apr 25;28(1)
Neuromolecular medicine 2026 Apr 25;28(1)
Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple-Negative Breast Cancer by Disrupting the Hippo-YAP/TEAD4-PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation.
Shang Y, Si W, Zhang Y, Liu J, Zhang H, Li Y, Su H, Jiang W, Ding Z, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 2;:e19006
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 2;:e19006
Sunitinib induces immunogenic cell death through eIF2α phosphorylation to potentiate immunotherapy in HCC.
Gu Y, Mai H, Huang P, Yuan H, Sun M, Gao H, Shang C, Ou Y, Liu T, Huang X, Tan J
iScience 2026 Apr 17;29(4):115378
iScience 2026 Apr 17;29(4):115378
Cardiac and brain pathological alterations with potential biomarker screening in stress-related fatalities.
Cong J, Wang L, Wang Y, Ji X, Xin H, Cong L, Zhang G, Zhu W, Cong B, Shi W
Journal of forensic and legal medicine 2026 Apr 16;120:103132
Journal of forensic and legal medicine 2026 Apr 16;120:103132
Pathogenic mechanisms of amyotrophic lateral sclerosis-linked VAPB P56S mutation in the degeneration of corticospinal motor neurons.
Yang X, Zheng J, Wang X, Cai H, Yu J
Ageing and neurodegenerative diseases 2025;5(3)
Ageing and neurodegenerative diseases 2025;5(3)
Pentadecyl, an Active Component of Microalgae, Ameliorates Endoplasmic Reticulum Stress and Blue Light-Induced Cell Death in Mouse Retina-Derived 661W Cells.
Obayashi M, Otsu W, Yamazaki K, Nakamura S, Ishikawa H, Sakata Y, Tsuboi M, Tsusaki H, Shimazawa M
Biological & pharmaceutical bulletin 2025;48(6):791-800
Biological & pharmaceutical bulletin 2025;48(6):791-800
CB1 Receptor Agonist ACEA Resists ER Stress-Mediated Apoptosis via CB1R-Independent Mechanism.
Mori K, Togo A, Ohta K, Asahi T, Nozaki C, Kataoka K
Biological & pharmaceutical bulletin 2025;48(6):769-781
Biological & pharmaceutical bulletin 2025;48(6):769-781
Qizhi Kebitong Formula Ameliorates Sciatic Nerve Injury in Streptozocin-induced Diabetic Mice through PERK/ATF4/CHOP Endoplasmic Reticulum Stress Signaling Pathway.
Yu H, Yang C, Wang G, Lv J, Li X, Qi W, Wang X
Current pharmaceutical design 2025;31(29):2370-2384
Current pharmaceutical design 2025;31(29):2370-2384
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling.
Zhang Z, Cheng D, Dang J, Wang X, Fan H, Liu D
International journal of medical sciences 2025;22(15):3906-3923
International journal of medical sciences 2025;22(15):3906-3923
Leonurine Attenuates CCl(4)-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway.
Wang P, Bai J, Ye M, Huang Z, Chen J, Sun L, Zhong X, Zheng Y, Ma T, Fu W, Du Y
Drug design, development and therapy 2025;19:6553-6571
Drug design, development and therapy 2025;19:6553-6571
Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway.
Zhang Z, Yu X, Li J, Shen X, Fu W, Liu Y, Dong X, Wang Z
Drug design, development and therapy 2025;19:1067-1081
Drug design, development and therapy 2025;19:1067-1081
Huanglian Jiedu Decoction Alleviates Myocardial Ischemia-Reperfusion Injury via AKT-Mediated Regulation of Endoplasmic Reticulum Stress.
Gu M, Xu J, Liao Z, Lin J, Li R, Wu W, Qiu Y
Journal of inflammation research 2025;18:17025-17044
Journal of inflammation research 2025;18:17025-17044
Semaphorin 6D Alleviates Osteoarthritis by Inhibiting NLRP3 Inflammasome Activation and Endoplasmic Reticulum Stress.
Zhang W, Li C, Yao J, Xu Z, Huang Y, Lu Y, Lin X, Guo Z, Zhou X
Journal of inflammation research 2025;18:13909-13924
Journal of inflammation research 2025;18:13909-13924
Volatile Oil From Acorus Gramineus Rhizoma Synergizes with Crebanine to Alleviate Oxidative Stress and Endoplasmic Reticulum Stress in Myocardial Ischemia-Reperfusion Injury by Suppressing GRP78-PERK/ATF6-CHOP and MAPK-NF-κB-TNF-α Signaling Pathways.
Zha L, Cui L, Mei J, Pu J, Hao J, Fan X, Wang H, Fang H, Ma Y
Journal of inflammation research 2025;18:12929-12948
Journal of inflammation research 2025;18:12929-12948
Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk.
Liang L, Nie X, Zhao N, Li M, Li M, Li Z, Wu M, Wu X, Lee CL, Shu P, Zhong J
Frontiers in pharmacology 2025;16:1686234
Frontiers in pharmacology 2025;16:1686234
Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways.
Liu H, Yang Q, Wang S, Wang T, Pan L, Wang X, Chi Y, Jin Z
Frontiers in pharmacology 2025;16:1660599
Frontiers in pharmacology 2025;16:1660599
Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus.
Yang J, Wang Y, Xu Y, Jia X, Lu F
Frontiers in physiology 2025;16:1607873
Frontiers in physiology 2025;16:1607873
Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis.
Li J, Yang X, Lian X, Li B, Ma Q, Yang L, Gao G, Deng Y, Yang Z
Frontiers in pharmacology 2025;16:1557125
Frontiers in pharmacology 2025;16:1557125
Endoplasmic reticulum stress aggravates ferroptosis via PERK/ATF4/HSPA5 pathway in UUO-induced renal fibrosis.
Huang Z, Zhou L, Liu B, Li X, Sang Y
Frontiers in pharmacology 2025;16:1545972
Frontiers in pharmacology 2025;16:1545972
Polymethoxyflavones extracted from Bauhinia championii alleviate LPS-induced acute lung injury by ameliorating endoplasmic reticulum stress.
Li Y, Yang X, Ye W, Jing J, Chen R, Wu L, You Z, Zhang S, Shi J
Frontiers in pharmacology 2025;16:1544916
Frontiers in pharmacology 2025;16:1544916
Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway.
Zhang J, Liu T, Xue T, Jia Z
Frontiers in pharmacology 2025;16:1529343
Frontiers in pharmacology 2025;16:1529343
Bioinformatics-based identification of mirdametinib as a potential therapeutic target for idiopathic pulmonary fibrosis associated with endoplasmic reticulum stress.
Chen J, Du Y, Yu Q, Liu D, Zhang J, Luo T, Huang H, Cai S, Dong H
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12449-12471
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12449-12471
Quercetin diminishes scleral ER stress and protein misfolding: High throughput transcriptome analysis in form-deprivation myopia of Guinea pigs.
Lv L, Che D, Zhang Z, Zhang W, Zhou Q, Li F, Zhou J
Experimental eye research 2025 Sep;258:110485
Experimental eye research 2025 Sep;258:110485
Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation.
Li M, Xu J, Du K, Wang G, Feng Y, Liu P
Free radical biology & medicine 2025 Sep;237:585-599
Free radical biology & medicine 2025 Sep;237:585-599
Unveiling the HSP90 inhibitor mediated effects on endoplasmic reticulum stress and redox signaling:from a cancer inhibitor to retinal degeneration catalyst.
Liu Y, Li S, Wang K, Wang Y, Wang Y, Zhang C, Wu H, Wang G, Qin F, Song Z, Tao Y
Free radical biology & medicine 2025 Sep;237:176-194
Free radical biology & medicine 2025 Sep;237:176-194
Unraveling the molecular mechanisms of paraquat toxicity: The interplay of ATF4, ferroptosis, and endoplasmic reticulum stress.
Ke J, Cai Q, Ge X, Zhang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115602
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115602
PMAIP1 mediates endoplasmic reticulum stress in human dental pulp stem cells during pulpitis pathogenesis.
Zhou C, Zhang J, Chen L, Yu Y, Sun Y, Pan Y, Cai S, Zhong P
BMC oral health 2025 Sep 26;25(1):1472
BMC oral health 2025 Sep 26;25(1):1472
Short-term high-dose gemcitabine induces PERK-mediated immunogenic cell death and potentiates antitumor immunity in bladder cancer.
Xiong W, Liu Y, Yang H, Zhang B, Zhang X, Du Y, Wang H, Zhang X, Luo Y, Ha H, Fu Y, Zhang B, Zhang H, Lu J, Shang P, Yue Z
International immunopharmacology 2025 Sep 23;162:115057
International immunopharmacology 2025 Sep 23;162:115057
Excessive mitochondrial stress response triggers neuronal injury through the persistent eIF2α phosphorylation in mice exposed to manganese.
Jia Y, He B, Chen K, Liu K, Yu C, Sun B, Ma Z, Xu B
Journal of hazardous materials 2025 Sep 15;496:139407
Journal of hazardous materials 2025 Sep 15;496:139407
Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca(2 +) ]i stability.
Ma Z, Du X, Zhao C, Sun Y, Jia Y, Liang X, Yu X, Gao Y
Ecotoxicology and environmental safety 2025 Sep 1;302:118537
Ecotoxicology and environmental safety 2025 Sep 1;302:118537
PADI1 aggravates endoplasmic reticulum stress in trophoblast cells by inhibiting the FAK-ERK signaling pathway.
Ning J, Yang S, Gao F, Wang L, Lin Z, Cheng D, Fan K
Tissue & cell 2025 Oct;96:102976
Tissue & cell 2025 Oct;96:102976
RCN3 functions as a tumor promoter in colorectal cancer by modulating the GRP78-PI3K-AKT signaling pathway.
Huang M, Qin B, Xie Z, Zhou R, Lin Z, Zhou L, Han Z, Liu S, Zhuang K
Oncogene 2025 Oct;44(40):3850-3863
Oncogene 2025 Oct;44(40):3850-3863
Baicalin inhibits LPS-induced apoptosis and inflammation in WI- 38 cells by promoting FOXA2/TRIM27 Interaction: Implications for pediatric pneumonia mechanisms.
Gao L, Zeng X, Huang Y, Huang L
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):14131-14142
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):14131-14142
Maresin1 ameliorates osseointegration in type 2 diabetes mellitus by promoting FAM134B-mediated ER-phagy in osteoblasts.
Gui H, Wang X, Wu A, Li B, Zhang B, Diao J, Chen J, Zhang X, Wu D, He Q, Xu X, Zhang D
Biochemical pharmacology 2025 Oct;240:117099
Biochemical pharmacology 2025 Oct;240:117099
Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury.
Wang S, Wang Y, Shan W, Li G, Yan R, Wang Z, Zhao Y, Yao J, Zhang N
British journal of pharmacology 2025 Oct;182(20):5023-5037
British journal of pharmacology 2025 Oct;182(20):5023-5037
Usenamine A, an RGS2 inhibitor, exerts anti-NSCLC activity and enhances cytotoxicity of gemcitabine by inducing ER stress and Notch1-mediated autophagy.
Cheng L, Li H, Xie C, Kuang K, Wan B, Chen P, Sui H, Zhao Q, Cho N, Cui R
Bioorganic chemistry 2025 Oct;165:109010
Bioorganic chemistry 2025 Oct;165:109010
IL-6/KIAA1429 promotes ferroptosis resistance in endometrial cancer through m6A modification of DDIT3.
Shen X, Shu W, Zhang J, Zhou T, Dong K, Zhang J, Yao Y, Li H, Cheng S, Zhang T, Chen G, Yu S, Zhang Q, Wang H, Liu Y
Cellular signalling 2025 Oct;134:111906
Cellular signalling 2025 Oct;134:111906
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Zhu MY, Guo YJ, Zhu YQ, Wang HZ, Wang HD, Chen HY, Jiang YX, Li H, Hui H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Intestinal Epithelial-Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78-mediated Endoplasmic Reticulum Stress.
Qian C, Hu C, Xu Y, Xu W, Wang Z, Gan W, Tang W, Huang L, Samorodov AV, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e00741
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e00741
Legionella pneumophila Effector Protein LegU1 Mediates the Ubiquitination of Endoplasmic Reticulum Chaperone BiP.
Zhao B, He S, Huang M, Lu Y, Ge Z
Journal of microbiology and biotechnology 2025 Oct 28;35:e2507056
Journal of microbiology and biotechnology 2025 Oct 28;35:e2507056
Combination of B-AP15 and HSP90 inhibitor tanespimycin induces ROS-mediated cytotoxicity in human lung cancer cells.
Fu W, Lu H, Yan Y, Shu C, Xu C, Chen Y, Xia Y, Chen J, Chen Y, Zou P, Cui R, Ni D
BMC pharmacology & toxicology 2025 Oct 28;26(1):177
BMC pharmacology & toxicology 2025 Oct 28;26(1):177
Rab26-mediated lysosomal translocation of eEF1A alleviates myocardial hypertrophy and cardiac remodeling.
Tong Y, Li Y, Bi Y, Liu Y, Peng X, He B, Wang X
Life sciences 2025 Oct 1;378:123830
Life sciences 2025 Oct 1;378:123830
An endoplasmic reticulum-targeting photodynamic AMPK agonist activates breast cancer immunotherapy through promoting immunogenic cell death and downregulation of PD-L1.
Wu YY, Zhang KY, Huang JQ, Nie JM, Cheng H
Acta pharmacologica Sinica 2025 Nov;46(11):3022-3035
Acta pharmacologica Sinica 2025 Nov;46(11):3022-3035
Astragalin induces immunogenic cell death in liver cancer by targeting NQO2 to promote ROS-mediated endoplasmic reticulum stress pathway.
Zheng L, Zhao Z, Chen L, Yang W, Ercolani G, Qin P, Lin B, Han M, Weng Q, Zhang Y, Wu B, Chen M, Yao Z, Fang S, Ji J
Free radical biology & medicine 2025 Nov;239:317-335
Free radical biology & medicine 2025 Nov;239:317-335
Mechanistic and target study of anthraquinone modifier KA-4c triggering endoplasmic reticulum stress to inhibit triple-negative breast cancer cells.
Yang Y, Xu S, Chen Q, Zhao Y, Li X, Li J, Hou H, Li D
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):168020
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):168020
Identification and validation of BCL11A as a neural and immune vulnerability factor in pancreatic adenocarcinoma.
Chen A, Wang J, Yang J, Wang Y, Wu C, Yang H, Fan Y, Gao Q, Hu Y, Li X, Zou X
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167988
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167988
Hydrogen sulfide alleviates vascular smooth muscle cell senescence by inhibiting endoplasmic reticulum stress.
Jiao L, Yan Q, Yang J, Wu R, Wei Z, Ruan J, Yan G, Chen X, Li H
Cellular signalling 2025 Nov;135:112075
Cellular signalling 2025 Nov;135:112075
Novel Disulfiram-Loaded Metal-Organic Nanoparticles Inhibit Tumor Growth and Induce Immunogenic Cell Death of Triple-Negative Breast Cancer Cells.
Huang CH, Kang X, Zhou L, Wang J, Wu S, Sun P, Wang Q, Keeton AB, Chen P, Piazza GA
Pharmaceutics 2025 Nov 9;17(11)
Pharmaceutics 2025 Nov 9;17(11)
RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease.
Du J, Du Q, Zhang Y, Gao J, Wang C, Kou B, Jiang Y, Zhao D, Lin J
Cell & bioscience 2025 Nov 28;15(1):164
Cell & bioscience 2025 Nov 28;15(1):164
Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury.
Tu YJ, Liu YQ, Pan YY, Cai HY, Liu C
World journal of stem cells 2025 Nov 26;17(11):112393
World journal of stem cells 2025 Nov 26;17(11):112393
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Zhang C, Wang H, He Z, He J, Wang F, Yan S, Sheng Y, Yuan N, Chen Y, Xu X, Huang Y, Hu R, Wang M, Xiao W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Programmable initiation of mRNA translation by trans-RNA.
Jia L, Nguyen TT, Uematsu S, Gu Y, Shi S, Hashem Y, Qian SB
Nature biotechnology 2025 Nov 21;
Nature biotechnology 2025 Nov 21;
Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation.
Yang X, Zhong H, Yu C, Cheng J, Jiang H, Wang C, Song C, Yang H
Virology journal 2025 Nov 17;22(1):378
Virology journal 2025 Nov 17;22(1):378
Quercetin alleviated cadmium-induced oxidative stress, endoplasmic reticulum stress, and autophagy in chicken kidneys.
Shi Y, Yan B, Huang R, Yu W, Xu B, Mao J, Liu Z, Wang J
Environmental pollution (Barking, Essex : 1987) 2025 Nov 15;385:127058
Environmental pollution (Barking, Essex : 1987) 2025 Nov 15;385:127058
Overexpression of Heme Oxygenase 1 Enhances the Neuroprotective Effects of Exosomes in Subarachnoid Hemorrhage by Suppressing Oxidative Stress and Endoplasmic Reticulum Stress.
Gao Q, Su Z, Pang X, Chen J, Luo R, Li X, Zhang C, Zhao Y
Molecular neurobiology 2025 May;62(5):6088-6101
Molecular neurobiology 2025 May;62(5):6088-6101
SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound.
Hou W, Shang X, Hao X, Pan C, Zheng Z, Zhang Y, Deng X, Chi R, Liu J, Guo F, Sun K, Xu T
Journal of orthopaedic translation 2025 May;52:233-248
Journal of orthopaedic translation 2025 May;52:233-248
Apolipoprotein B100 acts as a tumor suppressor in ovarian cancer via lipid/ER stress axis-induced blockade of autophagy.
Yin ZY, He SM, Zhang XY, Yu XC, Sheng KX, Fu T, Jiang YX, Xu L, Hu BX, Zhang JB, Li YY, Wang Q, Zhang BB, Qi YM, Adu-Amankwaah J, Zhou XY, Qi Q, Zhang B, Li CL
Acta pharmacologica Sinica 2025 May;46(5):1445-1461
Acta pharmacologica Sinica 2025 May;46(5):1445-1461
Simulated microgravity activates autophagy expression in the rat retina.
Liu M, Wang Y, Ren F, Zhang W, Zheng H, Zhang R, Gao C, Luo L, Nie C, Gu J
Life sciences in space research 2025 May;45:107-116
Life sciences in space research 2025 May;45:107-116
Loss of ADAMTS5 promotes vascular calcification via versican/integrin β1/FAK signal.
Zhu Z, Liu H, Feng L, Lu L, Zhu J, Liang Q, Lan Z, Ye Y, Wang S, Chen A, Yan J
Atherosclerosis 2025 May;404:119190
Atherosclerosis 2025 May;404:119190
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Al-Maamari A, Sultan M, Wu S, Zhang T, Wang C, Han B, Duan Y, Ding SS, Chen N, Zhang H, Sun F, Chen X, Yu D, Su S
International journal of biological macromolecules 2025 May;310(Pt 4):143549
International journal of biological macromolecules 2025 May;310(Pt 4):143549
FAM134B-mediated ER-phagy alleviates alcohol-related liver fibrosis by reducing endoplasmic reticulum stress.
Wang T, Li X, Xia G, Gong M, Lv X
International journal of biological macromolecules 2025 May;308(Pt 2):142395
International journal of biological macromolecules 2025 May;308(Pt 2):142395
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production.
Otsuka Y, Yano M
FEBS open bio 2025 May;15(5):738-753
FEBS open bio 2025 May;15(5):738-753
HDAC4 regulates apoptosis in Acan-Cre(ERT2);HDAC4(d) (/d) mice with osteoarthritis by downregulating ATF4.
Huang J, Xu Y, Li Y, Pang Y, Ding X, Zhou R, Liang D, Che X, Zhang Y, Wang C, Li W, Li P
FEBS open bio 2025 May;15(5):726-737
FEBS open bio 2025 May;15(5):726-737
GRP78 Nanobody-Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy.
Wang H, Zhou R, Xu C, Dai L, Hou R, Zheng L, Fu C, Shi G, Wang J, Li Y, Cen J, Xu X, Yu L, Li Y, Wang J, Du Q, Li Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2408086
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2408086
Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury.
Qi J, Wang Y, Chen H, Wu K, Zhou P, Dou Y, Xiong B, Zhou W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2407802
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2407802
TRAF3IP3 Induces ER Stress-Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation.
Zhao G, Qi J, Li F, Ma H, Wang R, Yu X, Wang Y, Qin S, Wu J, Huang C, Ren H, Zhang B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2411020
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2411020
Dihydrotanshinone I potentiates the anti-tumor activity of cisplatin by activating ROS-mediated ER stress through targeting HSPD1 in lung cancer cells.
Lin H, Sui H, Yu Y, Xie C, Shen Y, Cheng L, Wang J, Yu Y, Xie C, Cui R
European journal of pharmacology 2025 May 5;994:177378
European journal of pharmacology 2025 May 5;994:177378
HNF4A Regulated APEH Deficiency Promotes UPR Activation in Diabetic Kidney Disease.
Wang F, Peng Y, Liang L, Ruan Y, Yu S, Mo X, Tan W, Xu X, Jia J, Peng J, Yu X, Chen Y, Long C, Li M, Shi M, Zhang F, Xiao Y, Liu L, Zhou Y, Zhang T, Guo B, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70649
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70649
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson's Disease.
Wen Y, Han Z, Wang B, Feng C, Ding X, Li Y, Lv Y, Wang X, Gao L
Cellular and molecular neurobiology 2025 May 29;45(1):53
Cellular and molecular neurobiology 2025 May 29;45(1):53
Potential mechanisms by which Jiawei Lianpu Yin inhibits Helicobacter pylori colonization and alleviates gastric mucosal inflammation and damage: Integrated transcriptomics, network pharmacology, and experimental validation.
Zhang X, Wang L, Huang L, Cao G, Huang C, Duan Y, Lyu W
Journal of ethnopharmacology 2025 May 28;348:119793
Journal of ethnopharmacology 2025 May 28;348:119793
NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors.
Gao Y, Zuo L, Zheng Y, Sun K, Gao Y, Xu X, Li Z, Zuo D
Breast cancer research : BCR 2025 May 26;27(1):92
Breast cancer research : BCR 2025 May 26;27(1):92
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
Ning Q, Liu J, Liu S, Zou Q, Li K, Li Z
International immunopharmacology 2025 May 16;155:114610
International immunopharmacology 2025 May 16;155:114610
Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants.
Pindwarawala M, Abid FA, Lee J, Miller ML, Noppers JS, Rideout AP, Agosto MA
Life science alliance 2025 Mar;8(3)
Life science alliance 2025 Mar;8(3)
5-Azacytidine inhibits endoplasmic reticulum stress and apoptosis of nucleus pulposus cells by preserving PPARγ via promoter demethylation.
Cheng P, Li H, Chen HW, Wang ZQ, Li PW, Zhang HH
In vitro cellular & developmental biology. Animal 2025 Mar;61(3):288-297
In vitro cellular & developmental biology. Animal 2025 Mar;61(3):288-297
Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice.
Zhang X, Wang G, Chen S
Biological trace element research 2025 Mar;203(3):1494-1501
Biological trace element research 2025 Mar;203(3):1494-1501
Cryoshocked Adipocytes Mediated Dual-Modal Strategy Combining Photodynamic Therapy and Triptolide Palmitate for Pulmonary Metastatic Melanoma Treatment.
Li A, Qi F, Zeng Y, Liu R, Cai H, He M, Li D, Gu Y, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(9):e2414307
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(9):e2414307
Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway.
He J, Huang Z, Zou R
Cell biology and toxicology 2025 Mar 7;41(1):56
Cell biology and toxicology 2025 Mar 7;41(1):56
Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor.
Pu S, Pan Y, Wang Z, Liu H, Zhang J, Zhang Q, Wang M
Molecules (Basel, Switzerland) 2025 Mar 6;30(5)
Molecules (Basel, Switzerland) 2025 Mar 6;30(5)
Clemastine fumarate alleviates endoplasmic reticulum stress through the Nur77/GFPT2/CHOP pathway after ischemia/reperfusion in rat hearts.
He Y, Sun F, Song C, Liu Y, Wang R, Wang Y, Sun X, Juan Z, Wang Y
International immunopharmacology 2025 Mar 6;149:114242
International immunopharmacology 2025 Mar 6;149:114242
Androgen receptor alleviates doxorubicin-induced endoplasmic reticulum stress and myocardial injury by interacting with SERCA2a.
Ning S, Li J, He M, Yu Y, Guo Z
Free radical biology & medicine 2025 Mar 16;230:127-137
Free radical biology & medicine 2025 Mar 16;230:127-137
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Li XJ, Zhang MC, Li X, Guan LL, Liang YR, Hao EJ, Wang Y, Guo HM
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Citrinin-Induced Intestinal Onset of Pyroptosis via the IP3R1-GRP75-VDAC1 Complex-Mediated Mitochondrial Oxidative Stress.
Li Y, Zhang Q, Liu X, Wang Y, Yang C, Wu Y, Xiao B, Feng Y, Wu A, Yi J, Wu J, Liang Z, Yuan Z
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5803-5815
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5803-5815
Triclosan Caused Oocyte Meiotic Arrest by Modulating Oxidative Stress, Organelle Dysfunctions, Autophagy, and Apoptosis in Pigs.
Zhao N, Xu A, Yang J, Zhao J, Xie J, Li B, Duan J, Cao G
Animals : an open access journal from MDPI 2025 Mar 12;15(6)
Animals : an open access journal from MDPI 2025 Mar 12;15(6)
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Fu X, Zhang Q, Chen Y, Li Y, Wang H
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation Underlie Silver Nanoparticles-Induced Neurologic Deficits in Adult Mice.
Zhang W, Zhai M, Wu M, Yuan Y, Su X, Yang M, Ba Y, Deng Q, Zhang Y, Han L, Gao L, Huang H
Journal of biochemical and molecular toxicology 2025 Jun;39(6):e70289
Journal of biochemical and molecular toxicology 2025 Jun;39(6):e70289
Polygonatum cyrtonema polysaccharide alleviates dopaminergic neuron apoptosis in Parkinson's disease mouse model via inhibiting oxidative stress and endoplasmic reticulum stress.
Li QM, Xu H, Zha XQ, Zhang FY, Luo JP
International journal of biological macromolecules 2025 Jun;311(Pt 3):143986
International journal of biological macromolecules 2025 Jun;311(Pt 3):143986
Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress-regulated neuronal apoptosis in APP/PS1 transgenic mice.
Zhang N, Zhao Z, Chen X, Yao H, Zhu M, Ma S, Wang H, Yin X, Zhou Y, Zheng C, Li J, Pan J, Wang K, Yang B, Wang Y, Fan J, Gong Y, Liu R, Zeng J, Fan X, Shentu Y
Neuroprotection (Chichester, England) 2025 Jun;3(2):183-201
Neuroprotection (Chichester, England) 2025 Jun;3(2):183-201
Alterations of retinal autophagy after a blast simulated microgravity in rats.
Liu M, Wang Y, Ren F, Zhang W, Zheng H, Shi Q, Zhang R, Gao C, Luo L, Gu J, Nie C
Experimental eye research 2025 Jun;255:110366
Experimental eye research 2025 Jun;255:110366
Unfolded protein response-activated NLRP3 inflammasome contributes to pyroptotic and apoptotic podocyte injury in diabetic kidney disease via the CHOP-TXNIP axis.
Cao Y, Hu L, Chen R, Chen Y, Liu H, Wei J
Cellular signalling 2025 Jun;130:111702
Cellular signalling 2025 Jun;130:111702
Nimbolide Targeting SIRT1 Protects Against Acetaminophen-Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.
Ba J, Lin Y, Zhang J, Wang Y, Wu B
Pharmacology research & perspectives 2025 Jun;13(3):e70120
Pharmacology research & perspectives 2025 Jun;13(3):e70120
Transcriptional regulation of solute carrier family 6 member 9 gene.
Kirii M, Yoshida Y, Takashima S, Uchio-Yamada K, Oh-Hashi K
Molecular biology reports 2025 Jun 3;52(1):540
Molecular biology reports 2025 Jun 3;52(1):540
Endoplasmic reticulum stress induces trophoblast pyroptosis via regulating CYLD during labor initiation.
Zhang X, Yang M, Lv D, Zhang Y, Xie Y, He M, Fan Y, Li X, Jallow F, Li F, Deng D
Placenta 2025 Jun 26;167:204-215
Placenta 2025 Jun 26;167:204-215
Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice.
Zhao W, Eid S, Sackmann C, Williams D, Wang X, Ouyang Y, Zerbes T, Schmitt-Ulms G
Acta neuropathologica 2025 Jun 23;149(1):68
Acta neuropathologica 2025 Jun 23;149(1):68
SREBF1 mediates immunoparalysis of dendritic cells in sepsis by regulating lipid metabolism and endoplasmic reticulum stress.
Zhang Y, Wu F, Li Y, Liu J, Zhu L, Zhang M, Lu Z
Cell communication and signaling : CCS 2025 Jun 16;23(1):286
Cell communication and signaling : CCS 2025 Jun 16;23(1):286
Eeyarestatin I (ESI)-induced ERAD inhibition exhibits anti-cancer activity through multiple mechanisms in human colorectal cancer cells.
Peng J, Wei CI, Lee SH
European journal of pharmacology 2025 Jun 15;997:177623
European journal of pharmacology 2025 Jun 15;997:177623
Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress.
Wang C, Zha YL, Wang H, Sun B, Qiang WG, Yuan Y, Shi HB, Hu WW
Translational oncology 2025 Jul;57:102393
Translational oncology 2025 Jul;57:102393
SERP1 Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting ER Stress-Mediated Apoptosis.
Yin L, Wang D, Zhang X, Wang X, Jiao H, Liu X, Zheng J
Cell biology international 2025 Jul;49(7):878-894
Cell biology international 2025 Jul;49(7):878-894
Ubiquitination of ALOX15 regulates endoplasmic reticulum stress in Schwann cells and experimental autoimmune neuritis (EAN) models.
Song J, Han B, Du X, Chen H, Li M, Tang Z, Xu C, Wei W, Jia F, Wang X, Sun S, Zhong D
Free radical biology & medicine 2025 Jul;234:141-150
Free radical biology & medicine 2025 Jul;234:141-150
Calcium Fructoborate Improves Knee Osteoarthritis in Rats by Activating Hedgehog Signaling Through DDIT3.
Yan T, Wang P, Cao Z
Biological trace element research 2025 Jul;203(7):3803-3819
Biological trace element research 2025 Jul;203(7):3803-3819
Constitutive Hepatic mTORC1 Activation Aggravates Alcohol-Induced Liver Injury via Endoplasmic Reticulum Stress-Mediated Ferroptosis.
Xu L, Zhao Y, Yang Y, Qi E, Liu B, Zhuang P, Song S, Chang T, Chen Z, Kang X, Xiong X
The American journal of pathology 2025 Jul;195(7):1209-1222
The American journal of pathology 2025 Jul;195(7):1209-1222
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
Li XJ, Huang KX, Wang KX, Liu R, Wang DC, Liang YR, Hao EJ, Wang Y, Guo HM
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
Koumine mediates the generation of mtROS through the IP3R1-GRP75-VDAC1 complex to improve Citrinin induced intestinal inflammation.
Li Y, Liu X, Zhang Q, Jiang Z, Zhang W, Yang C, Ni J, Deng S, Yi J, Wu J, Sun Z, Liang Z, Yuan Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156803
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156803
PERK inhibition with GSK2606414 in zebrafish evokes developmental defects consistent with Wolcott-Rallison syndrome phenotypes.
Almeida LM, Lima LP, Oliveira NAS, Silva RFO, Sousa B, Bessa J, Pinho BR, Oliveira JMA
bioRxiv : the preprint server for biology 2025 Jul 29;
bioRxiv : the preprint server for biology 2025 Jul 29;
Zika virus non-structural protein NS2A mediated endoplasmic reticulum stress through interacting with Sarco/endoplasmic reticulum Ca(2+)-ATPase 2.
Wang S, Tang S, Zhou Y, An Q, Du M, Yang X, Zou P, Tang L, Yu Y
Journal of virology 2025 Jul 22;99(7):e0040525
Journal of virology 2025 Jul 22;99(7):e0040525
Reactive oxygen species regulate adipose-osteogenic lineage commitment of human mesenchymal stem cells by modulating gene expression of C/EBP homology protein and aldo-keto reductase family 1 member A1.
Chiang CH, Kao YC, Lin YH, Ma YS, Wu YT, Jian BY, Wei YH, Chen CM, Liou YM
Cell & bioscience 2025 Jul 18;15(1):104
Cell & bioscience 2025 Jul 18;15(1):104
DDX3X promotes endoplasmic reticulum protein reprogramming via interaction with ERN1 to amplify cerebral ischemia/reperfusion injury.
Du Q, Liu Y, Guo J
European journal of medical research 2025 Jul 1;30(1):538
European journal of medical research 2025 Jul 1;30(1):538
Glycosylation of ceramide synthase 6 is required for its activity.
Straus AJ, Mavodza G, Senkal CE
Journal of lipid research 2025 Jan;66(1):100715
Journal of lipid research 2025 Jan;66(1):100715
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells.
Huang Y, Zhang Y, Liu Y, Jin Y, Yang H
The Journal of biological chemistry 2025 Jan;301(1):108111
The Journal of biological chemistry 2025 Jan;301(1):108111
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
Zhai X, Yang R, Chu Q, Guo Z, Hou P, Li X, Bai C, Lu Z, Qiao L, Fu Y, Niu J, Li B
Nature cell biology 2025 Jan;27(1):141-153
Nature cell biology 2025 Jan;27(1):141-153
Best1 mitigates ER stress induced by the increased cellular microenvironment stiffness in epilepsy.
Wu H, Dong Y, Meng Q, Jiang J, Gao B, Ren Y, Liu Y, Li H, Wang C, Zhang H
Neurobiology of disease 2025 Jan;204:106767
Neurobiology of disease 2025 Jan;204:106767
Anti-lung cancer synergy of low-dose doxorubicin and PD-L1 blocker co-delivered via mild photothermia-responsive black phosphorus.
Xu HZ, Chen FX, Li K, Zhang Q, Han N, Li TF, Xu YH, Chen Y, Chen X
Drug delivery and translational research 2025 Jan;15(1):269-290
Drug delivery and translational research 2025 Jan;15(1):269-290
Toosendanin alleviates acute lung injury by reducing pulmonary vascular barrier dysfunction mediated by endoplasmic reticulum stress through mTOR.
Mao X, Wang C, Tang H, Liu X, Wei C, Yin F, Fu T, Fang Y, Yu K, Zhang Z, Wu C, Liu H, Le A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156277
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156277
Caveolin 1 in bovine liver is associated with fatty acid-induced lipid accumulation and the endoplasmic reticulum unfolded protein response: Role in fatty liver development.
Li M, Zhao B, Wang J, Zhang H, Yang Y, Song S, Psifidi A, Wu W, Loor JJ, Xu C
Journal of dairy science 2025 Jan;108(1):1007-1021
Journal of dairy science 2025 Jan;108(1):1007-1021
IL-17A exacerbates synovial inflammation in osteoarthritis via activation of endoplasmic reticulum stress.
Sun W, Li X, Zhang L, Zhang Y, Shi Y, Tao H, Zhou J, Hao Y, Chen G, Gu C, Yang X
International immunopharmacology 2025 Jan 3;145:113733
International immunopharmacology 2025 Jan 3;145:113733
PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response.
Cheng L, Meliala I, Kong Y, Chen J, Proud CG, Björklund M
eLife 2025 Jan 29;13
eLife 2025 Jan 29;13
LINC00626 drives tamoxifen resistance in breast cancer cells by interaction with UPF1.
Yuan H, Zhou L, Hu W, Yang M
Scientific reports 2025 Jan 23;15(1):2997
Scientific reports 2025 Jan 23;15(1):2997
CUMS induces depressive-like behaviors and cognition impairment by activating the ERS-NLRP3 signaling pathway in mice.
Hao R, Gao X, Lu Q, Zhao T, Lu X, Zhang F, Pei Y, Lang J, Liu H, Song J, Zhang Z
Journal of affective disorders 2025 Jan 15;369:547-558
Journal of affective disorders 2025 Jan 15;369:547-558
More than just DNA damage: Pt(ΙΙ)-NHC complexes derived from 4,5-diarylimidazoles augment immunogenic cell death.
Tang L, Chang X, Shi J, Wen Z, Bi C, Liu W
European journal of medicinal chemistry 2025 Jan 15;282:117014
European journal of medicinal chemistry 2025 Jan 15;282:117014
Piperine inhibits the proliferation of colorectal adenocarcinoma by regulating ARL3-mediated endoplasmic reticulum stress.
Wu C, Qian Y, Jiang J, Li D, Feng L
Biomolecules & biomedicine 2025 Jan 14;25(2):391-405
Biomolecules & biomedicine 2025 Jan 14;25(2):391-405
Daphnetin ameliorates diabetic cardiomyopathy by regulating inflammation and endoplasmic reticulum stress-induced apoptosis.
Zhao X, Shang L, Shen C
Experimental animals 2025 Jan 10;74(1):49-57
Experimental animals 2025 Jan 10;74(1):49-57
PRDM16 in thermogenic adipocytes mediates an inter-organ protective signaling against alcohol-associated liver disease.
Liu S, Zhu K, Huang Y, Ye W, Wu J
Molecular and cellular endocrinology 2025 Jan 1;595:112407
Molecular and cellular endocrinology 2025 Jan 1;595:112407
MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis.
Gu B, Yu W, Huang Z, Bai J, Liu S, Ren B, Wang P, Sun L, Wen J, Zheng Y, Tan P, Fu W
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):149-166
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):149-166
Role of MFN2 in bovine embryonic development and the mitigation of ER stress.
Shi SM, Hu B, Chi ZC, Qu LY, Liu LY, He YY, Jia GL, Li JH, Kong I, Jin YX, Yu XF
Animal reproduction science 2025 Feb;273:107664
Animal reproduction science 2025 Feb;273:107664
Targeting ceramide transfer protein sensitizes AML to FLT3 inhibitors via a GRP78-ATF6-CHOP axis.
Sun X, Li Y, Du J, Liu F, Wu C, Xiao W, Yu G, Chen X, Gale RP, Zeng H
Nature communications 2025 Feb 4;16(1):1358
Nature communications 2025 Feb 4;16(1):1358
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Zhang R, Zhang Z, Xie L, Yu Z, Gao R, Zhang ZR, Zhang Y, Wei X, Chen Y, Jiao S, Gao Y, Guo JP
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
Sephin1 suppresses ER stress-induced cell death by inhibiting the formation of PP2A holoenzyme.
Gojo S, Kami D, Sano A, Teruyama F, Ogata T, Matoba S
Cell death & disease 2025 Feb 19;16(1):117
Cell death & disease 2025 Feb 19;16(1):117
Sulfonated albumin from hepatocytes accelerates liver fibrosis in nonalcoholic fatty liver disease through endoplasmic reticulum stress.
Liu T, Sui M, Tian M, Wu N, Zhao S, Wang Y, Yang Y, Ma S, Jiao D, Wang L, Feng Y, Zhang Y, Qin C, Liu C, Qi J, Zhu Q
Free radical biology & medicine 2025 Feb 16;228:150-162
Free radical biology & medicine 2025 Feb 16;228:150-162
Yinchen-Gancao decoction ameliorated NASH in mice by reducing hepatic lipid accumulation, inhibiting hepatic inflammatory and endoplasmic reticulum stress.
Zhao J, Jin J, Li Y, Zhang S, Li F, Cui J, Wang Z, Yan D, Qiu F
Journal of ethnopharmacology 2025 Feb 11;341:119318
Journal of ethnopharmacology 2025 Feb 11;341:119318
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis.
Shi J, Chen L, Wang X, Ma X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 10;74(1):35
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 10;74(1):35
6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling.
Qi X, Niu C, Zhang ZZ, Chen MR, Wang FZ, Fei HR
Cell biochemistry and biophysics 2025 Dec;83(4):5307-5319
Cell biochemistry and biophysics 2025 Dec;83(4):5307-5319
WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of TMEM176A.
Lin W, Qiu Y, Tan C, Liu Z, Yang Y, He Y, Zhao J, Cheng J, Wang Z, Li M, Wang L, Wang M, Zhang M
Inflammation 2025 Dec;48(6):4274-4288
Inflammation 2025 Dec;48(6):4274-4288
Study on the effect of HMGB1 on immune cells isolated from SLE mice.
Qin X, Gao J, Liu X, Chen J, Song X
Biochemistry and biophysics reports 2025 Dec;44:102262
Biochemistry and biophysics reports 2025 Dec;44:102262
Unlocking the potential of atractylenolide II: Mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay.
Gu M, Chen Z, Chen Y, Li Y, Wang H, Feng YR, Zheng P, Huang C
Journal of pharmaceutical analysis 2025 Dec;15(12):101318
Journal of pharmaceutical analysis 2025 Dec;15(12):101318
Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells.
Yang Y, Li M, Wang J, Zhang H, Chang R, Zhao B, Aernouts B, Huang Q, Xu C
Journal of dairy science 2025 Dec;108(12):13919-13937
Journal of dairy science 2025 Dec;108(12):13919-13937
Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca(2+) Imbalance.
Zhang Z, Zhang J, Li L, Zong L
Molecular neurobiology 2025 Dec 5;63(1):256
Molecular neurobiology 2025 Dec 5;63(1):256
An Enhanced Cancer Immunogenic Cell Death Strategy: Fibrate-Oxaliplatin(IV) Conjugates with Modulating Tumor Immune Microenvironment.
Liang XJ, Guo X, Zhu PH, Zhao ZH, You Z, Yang K, Song Y, Li L, Song XQ
Journal of medicinal chemistry 2025 Dec 25;68(24):26328-26347
Journal of medicinal chemistry 2025 Dec 25;68(24):26328-26347
Effects of psychosocial stress on myocardial injury by modulating endoplasmic reticulum stress-induced autophagy and inflammation.
Gao X, Huang G, Hao R, Wang L, Ma A, Zhang Z, Zhao T
iScience 2025 Dec 19;28(12):114022
iScience 2025 Dec 19;28(12):114022
Cochlear endoplasmic reticulum stress causes connexin 26 degradation is involved in age-related hearing loss.
Bai X, Liao B, Hu WH, Wang MQ, Sun Y, Chen XB, Xu K
iScience 2025 Dec 19;28(12):113891
iScience 2025 Dec 19;28(12):113891
Knockdown of FXYD2 inhibits mepivacaine-induced cardiomyocyte injury by activating the PI3K/AKT signaling pathway.
Cheng L, Wang B, Chen J, Qiao X, Jiang J, Sun Y
European journal of medical research 2025 Dec 18;31(1):121
European journal of medical research 2025 Dec 18;31(1):121
A combination of ethanol and arachidonic acid promotes steatosis and endoplasmic reticulum stress and impairs mitochondrial respiration in H9c2 cardiomyoblasts.
Ai W, New E, Casey CA, Saraswathi V
Lipids in health and disease 2025 Dec 16;24(1):385
Lipids in health and disease 2025 Dec 16;24(1):385
A study on the mechanism by which BCAT1 influences the formation of intracranial aneurysms by regulating autophagy through endoplasmic reticulum stress.
Liu S, Guan H, Wang F
International immunopharmacology 2025 Dec 10;167:115667
International immunopharmacology 2025 Dec 10;167:115667
E7386 Enhances Lenvatinib's Antitumor Activity in Preclinical Models and Human Hepatocellular Carcinoma.
Mesropian A, Gris-Oliver A, Balaseviciute U, Potdar AA, Kimura T, Shen J, Torres-Marcén M, Abril-Fornaguera J, Piqué-Gili M, Camell-Raventos D, Peix J, Fernández-Martínez E, Huguet-Pradell J, Hernández de Sande A, Keraite I, Esteban-Fabró R, Bárcena-Varela M, Lindblad KE, Lujambio A, Guccione E, Thung S, Ikeda M, Kudo M, Sia D, Pinyol R, Llovet JM
Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Dec 1;31(23):5037-5050
Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Dec 1;31(23):5037-5050
Carboxypeptidase D deficiency causes hearing loss amenable to treatment.
Ramzan M, Ortiz-Vega N, Zafeer MF, Lobato AG, Atik T, Abad C, Vadgama N, Duman D, Bozan N, Avcı Durmuşalioǧlu E, Greene S, Guo S, Tokgöz-Yılmaz S, Yekedüz MK, Eminoğlu FT, Aydın M, Seyhan S, Karakikes I, Camarena V, Robayo MC, Canic T, Bademci G, Wang G, Farooq A, Joiner ML, Walz K, Eberl DF, Nasir J, Zhai RG, Tekin M
The Journal of clinical investigation 2025 Dec 1;135(23)
The Journal of clinical investigation 2025 Dec 1;135(23)
Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU Through Smoothing Endoplasmic Reticulum Stress-Mediated Autophagic Flux.
Xu J, Hu M, Li Y, Gong H, Zhang X, He Z, Xiao C, Yang C, Zeng J
Cell biology international 2025 Aug;49(8):1042-1055
Cell biology international 2025 Aug;49(8):1042-1055
Yinchenhao Decoction Combined with Praziquantel Ameliorates Inflammation and Hepatic Fibrosis in Schistosoma japonicum-Infected Mice.
Liu JH, Peng M, Chen F, Song QY, Zhang LC, Liao Y, Song LG, Wu ZD
Current medical science 2025 Aug;45(4):944-956
Current medical science 2025 Aug;45(4):944-956
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
Li J, Zhang G, Sun Z, Jiang M, Jia G, Liu H, Liu N, Shi L, Zhang L, Nie L, Zhang Y, Fu Y
Biomaterials 2025 Aug;319:123201
Biomaterials 2025 Aug;319:123201
The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response.
Wang H, Suh F, Fischietti M, Wray B, Filip SK, Faull PA, Hu L, Huang W, Liu B, Platanias LC, Eklund EA
The Journal of biological chemistry 2025 Aug;301(8):110484
The Journal of biological chemistry 2025 Aug;301(8):110484
The structural characteristics of cellular phospholipid acyl chains required for ABCA1-mediated HDL formation.
Nagao K, Matsuo M, Hori Y, Namba N, Saito H
The Journal of biological chemistry 2025 Aug;301(8):110457
The Journal of biological chemistry 2025 Aug;301(8):110457
Protective effect of β-carotene against lipopolysaccharide-induced meiotic maturation defects in porcine cumulus-oocytes complexes.
Chen M, Li J, He Y, Wang W, Ju S, Li Q
Animal reproduction science 2025 Aug;279:107947
Animal reproduction science 2025 Aug;279:107947
Cadmium induces autophagy via IRE1 signaling pathway activated by Ca(2 +) in GC-2spd cells.
Han Y, Dai J, Cheng J, He Y, Zhao C, Li R, Zhang Y, Zhang L, Zhou T, Shi Y
Reproductive toxicology (Elmsford, N.Y.) 2025 Aug;135:108950
Reproductive toxicology (Elmsford, N.Y.) 2025 Aug;135:108950
Cardiopulmonary Bypass-Induced IL-17A Aggravates Caspase-12-Dependent Neuronal Apoptosis Through the Act1-IRE1-JNK1 Pathway.
Zhao R, Ma Y, Li S, Li J
Biomolecules 2025 Aug 6;15(8)
Biomolecules 2025 Aug 6;15(8)
Isolation and Characterization of a Novel Porcine Teschovirus 2 Strain: Incomplete PERK-Mediated Unfolded Protein Response Supports Viral Replication.
Feng X, Du Y, Lv Y, Wei X, Cui C, Qin Y, Lu B, Chen Z, Ouyang K, Chen Y, Wei Z, Huang W, He Y, Qin Y
Viruses 2025 Aug 31;17(9)
Viruses 2025 Aug 31;17(9)
In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma.
Kwong K, Pan Y, Morales J, Watson M, Allegakoen DV, Lee AG, Bivona TG, Wipf P, Guerriero CJ, Brodsky JL, Sabnis AJ
Oncotarget 2025 Aug 29;16:681-696
Oncotarget 2025 Aug 29;16:681-696
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
Xie X, Tong W, Xie Y, Jiang H, Jiang A, Huang J, Liu Z, Yu J
Cell death & disease 2025 Aug 28;16(1):655
Cell death & disease 2025 Aug 28;16(1):655
The endoplasmic reticulum stress-ferroptosis reciprocal signaling orchestrates anti-tumor effect of anlotinib in anaplastic thyroid cancer.
Guo Y, Liang J, Ding L, Wu J, Teng W, Wang J, Jiang L, Tan Z
Cancer cell international 2025 Aug 21;25(1):310
Cancer cell international 2025 Aug 21;25(1):310
Pyrotinib targeted EGFR/GRP78 mediated cell apoptosis in high EGFR gene copy number gastric cancer.
Bao L, Wang X, Liao X, Li D, Li C, Dai N, Dai X, Yang J, Hu N, Tong X, He Z, Zhao Y, Liu Z, Hu Y, Shan J, Wang D, Li M, Chen Q
Journal of experimental & clinical cancer research : CR 2025 Aug 19;44(1):245
Journal of experimental & clinical cancer research : CR 2025 Aug 19;44(1):245
Glia maturation factor-β in hepatocytes enhances liver regeneration and mitigates steatosis and ballooning in zebrafish.
Li HY, Zeng WL, Ye YW, Chen X, Zhang MM, Chen YS, Liu CT, Zhong ZQ, Li J, Wang Y
American journal of physiology. Gastrointestinal and liver physiology 2025 Aug 1;329(2):G291-G306
American journal of physiology. Gastrointestinal and liver physiology 2025 Aug 1;329(2):G291-G306
Mitochondrial damage and ER stress in CB1 receptor antagonist-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Mori K, Togo A, Yamashita K, Sakuragi S, Bannai H, Umezawa T, Ohta K, Asahi T, Nozaki C, Kataoka K
Neuropharmacology 2025 Aug 1;273:110440
Neuropharmacology 2025 Aug 1;273:110440
NOD2 promotes sepsis-induced neuroinflammation by increasing brain endoplasmic reticulum stress mediated by LACC1.
Yi L, Chen Z, Zhou Q, Liu N, Li Q, Wu X, Zeng Y, Lin Y, Lin S, Luo L, Jiang S, Huang P, Wang H, Deng Y
Free radical biology & medicine 2025 Aug 1;235:280-293
Free radical biology & medicine 2025 Aug 1;235:280-293
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
Wang C, Liu Z, Xie X, Li Y, Sun L
Tissue & cell 2025 Apr;93:102646
Tissue & cell 2025 Apr;93:102646
Inhibition of CCN5 Protects Against Apoptosis and Endoplasmic Reticulum Stress in Bisphenol A-Induced Sertoli Cells via p38/JNK MAPK Signaling Pathway.
Zhao L, Wu X, Li Q, Shen Y, Zeng S, Wang J, Liu Q
DNA and cell biology 2025 Apr;44(4):174-185
DNA and cell biology 2025 Apr;44(4):174-185
ETS1 promotes cisplatin resistance of NSCLC cells by promoting GRP78 transcription.
Liu C, Jiang J, Luo J, Zhang Y, Yang C, Shi J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4633-4643
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4633-4643
Sagittaria sagittifolia polysaccharide extract regulates Nrf2 to improve endoplasmic reticulum stress-mediated apoptosis in rat cataracts and HLEB3 cells.
Zhou MY, Liu BQ, Gao X, Zhang SJ, Jiang Y, Yang T, Sun JB, Zhang X, Liao Y
International journal of biological macromolecules 2025 Apr;300:140270
International journal of biological macromolecules 2025 Apr;300:140270
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
Yu H, Chen K, Li X, Liang J, Jin Y, Bao Y, Chen H, Gou Y, Lu K, Wu L, Lin Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
Phosphatidate phosphatase Lipin1 alters mitochondria-associated endoplasmic reticulum membranes (MAMs) homeostasis: effects which contribute to the development of diabetic encephalopathy.
Huang S, Hua M, Liu W, Zhuang Z, Han X, Zhang X, Liang Z, Liu X, Lou N, Yu S, Chen S, Zhuang X
Journal of neuroinflammation 2025 Apr 18;22(1):111
Journal of neuroinflammation 2025 Apr 18;22(1):111
Luteolin Modulate Endoplasmic Reticulum Stress by Targeting SIRT1 to Ameliorate DSS-Induced Ulcerative Colitis in Mice.
Guo HX, Ji ZH, Wang BB, Xiao Y, Hu JP, Zheng Y, Gao W, Yuan B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70529
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70529
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.
Benedetti R, Di Crosta M, Gilardini Montani MS, D'Orazi G, Cirone M
Cell death discovery 2025 Apr 10;11(1):162
Cell death discovery 2025 Apr 10;11(1):162
ITGB1 Alleviates High Glucose-Induced Myocardial Cell Injury by Inhibiting Endoplasmic Reticulum Stress and Cell Apoptosis.
Cheng C, Li J, Zhang D, Xu D, Yu W
International heart journal 2024;65(6):1137-1143
International heart journal 2024;65(6):1137-1143
Comprehensive Analysis of CCAAT/Enhancer Binding Protein Family in Ovarian Cancer.
Tan J, Wang D, Dong W, Nian L, Zhang F, Zhao H, Zhang J, Feng Y
Cancer informatics 2024;23:11769351241275877
Cancer informatics 2024;23:11769351241275877
Knocking-down annexin A3 suppresses inflammation, oxidative stress, apoptosis, and endoplasmic reticulum stress to attenuate sepsis-induced acute kidney injury in HK2 cells.
Su J, Wang L, Guan X, Li N, Sun L
CytoJournal 2024;21:75
CytoJournal 2024;21:75
Combination of TrxR1 inhibitor and lenvatinib triggers ROS-dependent cell death in human lung cancer cells.
Zheng P, Xia Y, Shen X, Lu H, Chen Y, Xu C, Qiu C, Zhang Y, Zou P, Cui R, Huang X
International journal of biological sciences 2024;20(1):249-264
International journal of biological sciences 2024;20(1):249-264
MiR-204-5p regulates SIRT1 to promote the endoplasmic reticulum stress-induced apoptosis of inner ear cells in C57BL/6 mice with hearing loss.
Hu Y, Luo X, Chen H, Ke J, Feng M, Yuan W
PloS one 2024;19(11):e0309892
PloS one 2024;19(11):e0309892
SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo.
Cui H, Sun D, Meng S, Ma TJ, Ye Z, Li ZH
International journal of ophthalmology 2024;17(7):1205-1216
International journal of ophthalmology 2024;17(7):1205-1216
DDIT3 is associated with breast cancer prognosis and immune microenvironment: an integrative bioinformatic and immunohistochemical analysis.
Yu X, Li W, Sun S, Li J
Journal of Cancer 2024;15(12):3873-3889
Journal of Cancer 2024;15(12):3873-3889
Puerarin attenuates myocardial ischemic injury and endoplasmic reticulum stress by upregulating the Mzb1 signal pathway.
Xue J, Ren H, Zhang Q, Gu J, Xu Q, Sun J, Zhang L, Zhou MS
Frontiers in pharmacology 2024;15:1442831
Frontiers in pharmacology 2024;15:1442831
Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens.
Shi Y, Gao Z, Xu B, Mao J, Wang Y, Liu Z, Wang J
Frontiers in pharmacology 2024;15:1440877
Frontiers in pharmacology 2024;15:1440877
ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
Li C, Cai Y, Chen Y, Tong J, Li Y, Liu D, Wang Y, Li Z, Wang Y, Li Q
Redox biology 2024 Sep;75:103262
Redox biology 2024 Sep;75:103262
Irisflorentin improves functional recovery after spinal cord injury by protecting the blood-spinal cord barrier and promoting axonal growth.
Hu Z, Tan H, Zhang Y, Qi T, Li Y, Li N, Zhou Z, Wang Y, Wang H, Zhang H, Wang Q
Experimental neurology 2024 Sep;379:114886
Experimental neurology 2024 Sep;379:114886
UFL1 regulates cellular homeostasis by targeting endoplasmic reticulum and mitochondria in NEFA-stimulated bovine mammary epithelial cells via the IRE1α/XBP1 pathway.
Yan Y, Huang J, Chen X, Li Y, Zhao W, Li C
Free radical biology & medicine 2024 Sep;222:16-26
Free radical biology & medicine 2024 Sep;222:16-26
GABAergic interneurons in the hippocampal CA1 mediate contextual fear generalization in PTSD rats.
Gong X, Fan Z, Xu H, Qu Y, Li B, Li L, Yan Y, Wu L, Yan C
Journal of neurochemistry 2024 Sep;168(9):2587-2600
Journal of neurochemistry 2024 Sep;168(9):2587-2600
The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis.
Wu X, Liu R, Zhang Z, Yang J, Liu X, Jiang L, Fang M, Wang S, Lai L, Song Y, Li Z
EMBO molecular medicine 2024 Sep;16(9):2002-2023
EMBO molecular medicine 2024 Sep;16(9):2002-2023
A 700 nm LED Light Activated Ru(II) Complex Destroys Tumor Cytoskeleton via Photosensitization and Photocatalysis.
Dao A, Chen S, Pan L, Ren Q, Wang X, Wu H, Gong Q, Chen Z, Ji S, Ru J, Zhu H, Liang C, Zhang P, Xia H, Huang H
Advanced healthcare materials 2024 Sep;13(23):e2400956
Advanced healthcare materials 2024 Sep;13(23):e2400956
Attenuation of PM2.5-Induced Lung Injury by 4-Phenylbutyric Acid: Maintenance of [Ca(2+)]i Stability between Endoplasmic Reticulum and Mitochondria.
Ma Z, Du X, Sun Y, Jia Y, Liang X, Gao Y
Biomolecules 2024 Sep 8;14(9)
Biomolecules 2024 Sep 8;14(9)
Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects.
Lu Y, Liang Z, Liu L, Zhou Y, Liu C, Zhao Z, Zheng T, Du Q, Liu W
European journal of medicinal chemistry 2024 Sep 5;275:116534
European journal of medicinal chemistry 2024 Sep 5;275:116534
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice.
Tan Y, Huang Z, Jin Y, Wang J, Fan H, Liu Y, Zhang L, Wu Y, Liu P, Li T, Ran J, Tian H, Lam SM, Liu M, Zhou J, Yang Y
Nature communications 2024 Sep 27;15(1):8273
Nature communications 2024 Sep 27;15(1):8273
eIF2B localization and its regulation during the integrated stress response is cell-type specific.
Hanson FM, Ribeiro de Oliveira MI, Cross AK, Allen KE, Campbell SG
iScience 2024 Sep 20;27(9):110851
iScience 2024 Sep 20;27(9):110851
The Delayed Turnover of Proteasome Processing of Myocilin upon Dexamethasone Stimulation Introduces the Profiling of Trabecular Meshwork Cells' Ubiquitylome.
Tundo GR, Cavaterra D, Pandino I, Zingale GA, Giammaria S, Boccaccini A, Michelessi M, Roberti G, Tanga L, Carnevale C, Figus M, Grasso G, Coletta M, Bocedi A, Oddone F, Sbardella D
International journal of molecular sciences 2024 Sep 17;25(18)
International journal of molecular sciences 2024 Sep 17;25(18)
Cepharanthine triggers ferroptosis through inhibition of NRF2 for robust ER stress against lung cancer.
Bai XF, Hu J, Wang MF, Li LG, Han N, Wang H, Chen NN, Gao YJ, You H, Wang X, Xu X, Yu TT, Li TF, Ren T
European journal of pharmacology 2024 Sep 15;979:176839
European journal of pharmacology 2024 Sep 15;979:176839
TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice.
Wang J, Yin Y, Yang L, Qin J, Wang Z, Qiu C, Gao Y, Lu G, Gao F, Chen ZJ, Zhang X, Liu H, Liu Z
eLife 2024 Sep 13;13
eLife 2024 Sep 13;13
DMDD, isolated from Averrhoa carambola L., ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-autophagy crosstalk.
Shi J, Wang Y, Liang T, Wang X, Xie J, Huang R, Xu X, Wei X
Chinese medicine 2024 Sep 12;19(1):125
Chinese medicine 2024 Sep 12;19(1):125
Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway.
Besser E, Gelfand A, Procaccia S, Berman P, Meiri D
eLife 2024 Sep 11;12
eLife 2024 Sep 11;12
Lowering an ER stress-regulated long noncoding RNA protects mice from diabetes and isolated pancreatic islets from cell death.
Kato M, Abdollahi M, Omori K, Malek V, Lanting L, Kandeel F, Rawson J, Tsark W, Zhang L, Wang M, Tunduguru R, Natarajan R
Molecular therapy. Nucleic acids 2024 Sep 10;35(3):102252
Molecular therapy. Nucleic acids 2024 Sep 10;35(3):102252
Neuronal ferroptosis and ferroptosis-mediated endoplasmic reticulum stress: Implications in cognitive dysfunction induced by chronic intermittent hypoxia in mice.
Zhong P, Li L, Feng X, Teng C, Cai W, Zheng W, Wei J, Li X, He Y, Chen B, An X, Cai X
International immunopharmacology 2024 Sep 10;138:112579
International immunopharmacology 2024 Sep 10;138:112579
Roles of m(6)A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death.
Sun Y, Li R, Li W, Zhang N, Liu G, Zhao B, Mei Z, Gu S, He Z
Ecotoxicology and environmental safety 2024 Sep 1;282:116672
Ecotoxicology and environmental safety 2024 Sep 1;282:116672
Nimbolide protects against diabetic cardiomyopathy by regulating endoplasmic reticulum stress and mitochondrial function via the Akt/mTOR pathway.
Zhang H, Zhao X, Wei W, Shen C
Tissue & cell 2024 Oct;90:102478
Tissue & cell 2024 Oct;90:102478
Omentin-1 attenuates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal ligament stem cells and reduces M1 macrophages polarization through repressing endoplasmic reticulum stress.
Yang Y, Chen L
Prostaglandins & other lipid mediators 2024 Oct;174:106882
Prostaglandins & other lipid mediators 2024 Oct;174:106882
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
Ji Y, Li C, Wan S, Dong Z, Liu C, Guo L, Shi S, Ci M, Xu M, Li Q, Hu H, Cui H, Liu Y
Journal of pharmaceutical analysis 2024 Oct;14(10):101036
Journal of pharmaceutical analysis 2024 Oct;14(10):101036
Valproic Acid Inhibits Endoplasmic Reticulum Stress and Reduces Ferroptosis After Traumatic Brain Injury.
Chen J, Li L, Huang L, Zhao C, Ruan Z
Dose-response : a publication of International Hormesis Society 2024 Oct-Dec;22(4):15593258241303646
Dose-response : a publication of International Hormesis Society 2024 Oct-Dec;22(4):15593258241303646
Quantitative proteomics reveals the mechanism of endoplasmic reticulum stress-mediated pulmonary fibrosis in mice.
Li H, Wang J, Li Z, Wu Z, Zhang Y, Kong L, Yang Q, Wang D, Shi H, Shen G, Zou S, Zhu W, Fan K, Xu Z
Heliyon 2024 Oct 30;10(20):e39150
Heliyon 2024 Oct 30;10(20):e39150
ML385, an Nrf2 Inhibitor, Synergically Enhanced Celastrol Triggered Endoplasmic Reticulum Stress in Lung Cancer Cells.
Xu C, Chen Y, Zhou Z, Yan Y, Fu W, Zou P, Ni D
ACS omega 2024 Oct 29;9(43):43697-43705
ACS omega 2024 Oct 29;9(43):43697-43705
Tribbles pseudokinase 3 promoted renal fibrosis by regulating the expression of DNA damage-inducible transcript 3 in diabetic nephropathy.
Kong L, Kong L, Li P, Gao L, Ma H, Shi B
Biomolecules & biomedicine 2024 Oct 17;24(6):1559-1570
Biomolecules & biomedicine 2024 Oct 17;24(6):1559-1570
Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition.
Chang Y, Wang X, Yang J, Tien JC, Mannan R, Cruz G, Zhang Y, Vo JN, Magnuson B, Mahapatra S, Cho H, Dhanasekaran SM, Wang C, Wang Z, Zhou L, Zhou K, Zhou Y, Zhang P, Huang W, Xiao L, Liu WR, Hamadeh R, Su F, Wang R, Miner SJ, Cao X, Cheng Y, Mehra R, Ding K, Chinnaiyan AM
Cell reports. Medicine 2024 Oct 15;5(10):101752
Cell reports. Medicine 2024 Oct 15;5(10):101752
Endoplasmic reticulum stress promotes oxidative stress, inflammation, and apoptosis: A novel mechanism of citrinin-induced renal injury and dysfunction.
Wang Y, Li Y, Wu Y, Wu A, Xiao B, Liu X, Zhang Q, Feng Y, Yuan Z, Yi J, Wu J, Yang C
Ecotoxicology and environmental safety 2024 Oct 1;284:116946
Ecotoxicology and environmental safety 2024 Oct 1;284:116946
Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier.
Li Y, Wang Y, Jiang Z, Yang C, Wu Y, Wu A, Zhang Q, Liu X, Xiao B, Feng Y, Wu J, Liang Z, Yuan Z
Ecotoxicology and environmental safety 2024 Oct 1;284:116877
Ecotoxicology and environmental safety 2024 Oct 1;284:116877
Implications of endoplasmic reticulum stress and beta-cell loss in immunodeficient diabetic NRG-Akita mice for understanding monogenic diabetes.
Rashwan AM, Abumandour MMA, Kandyel R, Choudhary OP, Soliman RM, El Sharaby A, Nomir AG
International journal of surgery (London, England) 2024 Oct 1;110(10):6231-6242
International journal of surgery (London, England) 2024 Oct 1;110(10):6231-6242
NUS1 Variants Cause Lennox-Gastaut Syndrome Related to Unfolded Protein Reaction Activation.
Shen NX, Qu XC, Yu J, Fan CX, Min FL, Li LY, Zhang MR, Li BM, Wang J, He N, Liao WP, Shi YW, Li WB
Molecular neurobiology 2024 Nov;61(11):8518-8530
Molecular neurobiology 2024 Nov;61(11):8518-8530
Proteasome inhibition induces apoptosis through simultaneous inactivation of MCL-1/BCL-XL by NOXA independent of CHOP and JNK pathways.
Chen W, Sun M, Sun Y, Yang Q, Gao H, Li L, Fu R, Dong N
Toxicology 2024 Nov;508:153906
Toxicology 2024 Nov;508:153906
PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes.
Liu Y, Wei Y, Jin X, Cai H, Chen Q, Zhang X
Diabetes & metabolism journal 2024 Nov;48(6):1058-1072
Diabetes & metabolism journal 2024 Nov;48(6):1058-1072
Naringin Induces ROS-Stimulated G(1) Cell-Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma Cells.
Chen CH, Tien N, Yao CH, Chen SJ, Bau DT, Pandey S, Yang HL, Hseu YC, Chen SS, Lin ML
Environmental toxicology 2024 Nov;39(11):5059-5073
Environmental toxicology 2024 Nov;39(11):5059-5073
OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.
Shen R, Zhou J, Xin L, Zhou HB, Huang J
The Journal of steroid biochemistry and molecular biology 2024 Nov;244:106599
The Journal of steroid biochemistry and molecular biology 2024 Nov;244:106599
Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.
Dai Y, Chen J, Fang J, Liang S, Zhang H, Li H, Chen W
Biochemical pharmacology 2024 Nov;229:116518
Biochemical pharmacology 2024 Nov;229:116518
HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis.
Zou HM, Yu J, Ruan YY, Xie Y, An XM, Chen PL, Luo YQ, Shi MJ, Liu M, Xu LF, Liu J, Guo B, Zhang F
Lupus science & medicine 2024 Nov 27;11(2)
Lupus science & medicine 2024 Nov 27;11(2)
Mechanism of efficacy of trabectedin against myxoid liposarcoma entails detachment of the FUS-DDIT3 transcription factor from its DNA binding sites.
Craparotta I, Mannarino L, Zadro R, Ballabio S, Marchini S, Pavesi G, Russo M, Renne SL, Meroni M, Ponzo M, Bello E, Sanfilippo R, Casali PG, D'Incalci M, Frapolli R
Journal of experimental & clinical cancer research : CR 2024 Nov 26;43(1):309
Journal of experimental & clinical cancer research : CR 2024 Nov 26;43(1):309
Urolithin A Protects Hepatocytes from Palmitic Acid-Induced ER Stress by Regulating Calcium Homeostasis in the MAM.
Ryu G, Ko M, Lee S, Park SI, Choi JW, Lee JY, Kim JY, Kwon HJ
Biomolecules 2024 Nov 26;14(12)
Biomolecules 2024 Nov 26;14(12)
Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway.
Liu H, Chai Z, Gao Y, Wang Y, Lu M
Acta biochimica et biophysica Sinica 2024 Nov 22;57(6):995-1005
Acta biochimica et biophysica Sinica 2024 Nov 22;57(6):995-1005
Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway.
Xue XC, Zhou YY, Xu LY, Wei LY, Hu YJ, Yang J, Zhang XQ, Wang MY, Han YL, Chen JJ
BMC complementary medicine and therapies 2024 Nov 16;24(1):400
BMC complementary medicine and therapies 2024 Nov 16;24(1):400
Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression.
Pan Y, Zhou Y, Shen Y, Xu L, Liu H, Zhang N, Huang T, Meng K, Liu Y, Wang L, Bai G, Chen Q, Zhu Y, Zou X, Wang S, Wang Z, Wang L
Cancer research 2024 Nov 15;84(22):3803-3817
Cancer research 2024 Nov 15;84(22):3803-3817
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux.
Tian X, Ou Y, Shi S, Zhou Q, Long S, Xiang Y, Zhao W, Long D
Toxics 2024 Nov 11;12(11)
Toxics 2024 Nov 11;12(11)
Epigallocatechin gallate alleviated the in vivo toxicity of ZnO nanoparticles to mouse intestine.
Wang C, Huang C, Cao Y
Journal of applied toxicology : JAT 2024 May;44(5):686-698
Journal of applied toxicology : JAT 2024 May;44(5):686-698
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Teng C, Wu J, Zhang Z, Wang J, Yang Y, Dong C, Wu L, Lin Z, Hu Y, Wang J, Zhang X, Lin Z
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress.
Ji XD, Yang D, Cui XY, Lou LX, Nie B, Zhao JL, Zhao MJ, Wu AM
Chinese journal of integrative medicine 2024 May;30(5):398-407
Chinese journal of integrative medicine 2024 May;30(5):398-407
Apelin‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress.
Huo Z, Gu J, He T
Experimental and therapeutic medicine 2024 May;27(5):226
Experimental and therapeutic medicine 2024 May;27(5):226
Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells.
Sang J, Liu CK, Liu J, Luo GC, Zheng WJ, Bai Y, Jiang DY, Pu JN, An S, Xu TR
Biochemical pharmacology 2024 May;223:116194
Biochemical pharmacology 2024 May;223:116194
Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells.
Shen X, Xia Y, Lu H, Zheng P, Wang J, Chen Y, Xu C, Qiu C, Zhang Y, Xiao Z, Zou P, Cui R, Ni D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116507
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116507
Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway.
Chen X, Chen K, Hu J, Dong Y, Zheng M, Jiang J, Hu Q, Zhang W
Communications biology 2024 May 7;7(1):539
Communications biology 2024 May 7;7(1):539
AGR2-mediated unconventional secretion of 14-3-3ε and α-actinin-4, responsive to ER stress and autophagy, drives chemotaxis in canine mammary tumor cells.
Yuan SH, Wu CC, Wang YC, Chan XY, Chu HW, Yang Y, Liu HP
Cellular & molecular biology letters 2024 May 31;29(1):84
Cellular & molecular biology letters 2024 May 31;29(1):84
Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.
Kang H, Hu Q, Yang Y, Huang G, Li J, Zhao X, Zhu L, Su H, Tang W, Wan M
ACS nano 2024 May 28;18(21):13885-13898
ACS nano 2024 May 28;18(21):13885-13898
(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation.
Zhang X, Huo Z, Jia X, Xiong Y, Li B, Zhang L, Li X, Li X, Fang Y, Dong X, Chen G
Food & function 2024 May 20;15(10):5450-5465
Food & function 2024 May 20;15(10):5450-5465
Esculin suppresses the PERK-eIF2α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model.
Cheng Z, Liu Z, Liu C, Yang A, Miao H, Bai X
International immunopharmacology 2024 May 10;132:112061
International immunopharmacology 2024 May 10;132:112061
Inhibition of the endoplasmic reticulum stress-associated IRE-1 pathway alleviates preterm birth.
Qiu L, Liu H, Chen S, Wu Y, Yan J
American journal of reproductive immunology (New York, N.Y. : 1989) 2024 Mar;91(3):e13826
American journal of reproductive immunology (New York, N.Y. : 1989) 2024 Mar;91(3):e13826
Remote ischemic postconditioning alleviates cerebral ischemic injury through SERCA2/endoplasmic reticulum stress-mediated apoptosis.
Chen W, Li M, Lei X, Cheng Y, Wu X, Sun X, Wu Y, Li Z, Luo G, Wei M
Microscopy research and technique 2024 Mar;87(3):424-433
Microscopy research and technique 2024 Mar;87(3):424-433
D-pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin-mediated endoplasmic reticulum stress and glycophagy signaling pathway.
Li X, Yu X, Yu F, Fu C, Zhao W, Liu X, Dai C, Gao H, Cheng M, Li B
Phytotherapy research : PTR 2024 Mar;38(3):1681-1694
Phytotherapy research : PTR 2024 Mar;38(3):1681-1694
LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling.
Gu M, Chen YJ, Feng YR, Tang ZP
Chinese medicine 2024 Mar 4;19(1):41
Chinese medicine 2024 Mar 4;19(1):41
Prenatal inflammation exposure accelerates lung cancer tumorigenesis in offspring mouse: possible links to IRE1α/XBP1-mediated M2-like polarization of TAMs and PD-L1 up-expression.
Ma J, Tan J, Zhang W, Bai M, Liu K
Cancer immunology, immunotherapy : CII 2024 Mar 30;73(5):88
Cancer immunology, immunotherapy : CII 2024 Mar 30;73(5):88
Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway.
Xie W, Deng L, Qian R, Huang X, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2024 Mar 29;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 29;13(4)
Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma.
Patil SV, Kaipa BR, Ranshing S, Sundaresan Y, Millar JC, Nagarajan B, Kiehlbauch C, Zhang Q, Jain A, Searby CC, Scheetz TE, Clark AF, Sheffield VC, Zode GS
Scientific reports 2024 Mar 23;14(1):6958
Scientific reports 2024 Mar 23;14(1):6958
Effects of gas signaling molecule SO(2) in cardiac functions of hyperthyroid rats.
Yang Q, Yang T, Liu X, Liu S, Liu W, Nie L, Chu C, Yang J
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2024 Mar 1;28(2):129-143
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2024 Mar 1;28(2):129-143
DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response.
Li M, Wu X, Chen M, Hao S, Yu Y, Li X, Zhao E, Xu M, Yu Z, Wang Z, Xu N, Jin C, Yin Y
Haematologica 2024 Mar 1;109(3):751-764
Haematologica 2024 Mar 1;109(3):751-764
Excessive load promotes temporomandibular joint chondrocyte apoptosis via Piezo1/endoplasmic reticulum stress pathway.
Wang X, Tao J, Zhou J, Shu Y, Xu J
Journal of cellular and molecular medicine 2024 Jun;28(11):e18472
Journal of cellular and molecular medicine 2024 Jun;28(11):e18472
Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens.
Hao EY, Liu XL, Chen XY, Xue H, Su BF, Chen YF, Wang DH, Shi L, Bai K, Hou F, Hou JK, Bao HL, Chen H
Poultry science 2024 Jun;103(6):103656
Poultry science 2024 Jun;103(6):103656
Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling.
Shi C, Wang Y, Guo J, Zhang D, Zhang Y, Gong Z
Cell death discovery 2024 Jun 8;10(1):275
Cell death discovery 2024 Jun 8;10(1):275
Identification of osteoblastic autophagy-related genes for predicting diagnostic markers in osteoarthritis.
Cai R, Jiang Q, Chen D, Feng Q, Liang X, Ouyang Z, Liao W, Zhang R, Fang H
iScience 2024 Jun 21;27(6):110130
iScience 2024 Jun 21;27(6):110130
HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model.
Gu X, Li F, Che X, Wei X, Li P
BMC musculoskeletal disorders 2024 Jun 15;25(1):467
BMC musculoskeletal disorders 2024 Jun 15;25(1):467
CDK5RAP3 is a novel super-enhancer-driven gene activated by master TFs and regulates ER-Phagy in neuroblastoma.
Zhuo R, Zhang Z, Chen Y, Li G, Du S, Guo X, Yang R, Tao Y, Li X, Fang F, Xie Y, Wu D, Yang Y, Yang C, Yin H, Qian G, Wang H, Yu J, Jia S, Zhu F, Feng C, Wang J, Xu Y, Li Z, Shi L, Wang X, Pan J, Wang J
Cancer letters 2024 Jun 1;591:216882
Cancer letters 2024 Jun 1;591:216882
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function.
Cheng W, Wei B, Liu W, Jin L, Guo S, Ding M, Liu Y, Fan H, Li R, Zhang X, He X, Li X, Duan C
Experimental neurology 2024 Jul;377:114778
Experimental neurology 2024 Jul;377:114778
Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1.
Hirano J, Hayashi T, Kitamura K, Nishimura Y, Shimizu H, Okamoto T, Okada K, Uemura K, Yeh MT, Ono C, Taguwa S, Muramatsu M, Matsuura Y
Journal of virology 2024 Jul 23;98(7):e0081324
Journal of virology 2024 Jul 23;98(7):e0081324
Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice.
Liu L, Wu J, Zhang C, Cao T, Lu Y, He Z, Li Z
Brain research 2024 Jul 15;1835:148930
Brain research 2024 Jul 15;1835:148930
LIM homeobox 1 (LHX1) induces endoplasmic reticulum stress and promotes preterm birth.
Qiu L, Liu Z, Chen S, Wu Y, Yan J
Heliyon 2024 Jul 15;10(13):e32457
Heliyon 2024 Jul 15;10(13):e32457
Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress.
Li M, Tang S, Velkov T, Shen J, Dai C
Environmental pollution (Barking, Essex : 1987) 2024 Jul 1;352:124145
Environmental pollution (Barking, Essex : 1987) 2024 Jul 1;352:124145
Mitofusin2 Ameliorated Endoplasmic Reticulum Stress and Mitochondrial Reactive Oxygen Species Through Maintaining Mitochondria-Associated Endoplasmic Reticulum Membrane Integrity in Cisplatin-Induced Acute Kidney Injury.
Liu YT, Zhang H, Duan SB, Wang JW, Chen H, Zhan M, Zhang W, Li AM, Liu Y, Yang Y, Yang S
Antioxidants & redox signaling 2024 Jan;40(1-3):16-39
Antioxidants & redox signaling 2024 Jan;40(1-3):16-39
Empagliflozin reduces endoplasmic reticulum stress associated TXNIP/NLRP3 activation in tunicamycin-stimulated aortic endothelial cells.
Campeau MA, Leask RL
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jan;397(1):267-279
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jan;397(1):267-279
Suppression of endoplasmic reticulum stress by 4-PBA enhanced atherosclerotic plaque stability via up-regulating CLOCK expression.
Zhu G, Gao H, Li Y, Li X, Yang X, Wang C, Guo Z, Fan H, Fan L
Pathology, research and practice 2024 Jan;253:154969
Pathology, research and practice 2024 Jan;253:154969
A beneficial adaptive role for CHOP in driving cell fate selection during ER stress.
Liu K, Zhao C, Adajar RC, DeZwaan-McCabe D, Rutkowski DT
EMBO reports 2024 Jan;25(1):228-253
EMBO reports 2024 Jan;25(1):228-253
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
Wang R, Feng W, Wang Y, Jiang Y, Lin Y, Chen X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury.
Huang M, Wang J, Zhai M, Liu J, Zhu Y, Zhang Y, Zhao J, Wang H, Sun J, Yu H, Liu C
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166885
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166885
Dual targeting agent Thiotert inhibits the progression of glioblastoma by inducing ER stress-dependent autophagy.
Dong J, Qian Y, Zhang W, Wang Q, Jia M, Yue J, Fan Z, Jiang Y, Wang L, Wang Y, Huang Z, Yu L, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115867
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115867
Bioinformatics-driven discovery of silica nanoparticles induces apoptosis and renal damage via the unfolded protein response in NRK-52E cells and rat kidney.
Liu N, Li M, Pang H, Tiantian T, Li X, Su Y, Jin M, Wu H, Qian C, Sun M
Computers in biology and medicine 2024 Jan;168:107816
Computers in biology and medicine 2024 Jan;168:107816
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Wang Y, She S, Li W, Zhu J, Li X, Yang F, Dai K
Molecular immunology 2024 Jan;165:42-54
Molecular immunology 2024 Jan;165:42-54
Inhibition of RXRA-mediated PLA2G2A improves delirium in COPD mice by regulating endoplasmic reticulum stress pathway and inhibiting cell apoptosis.
Zhang T, Wang G
Cellular and molecular biology (Noisy-le-Grand, France) 2024 Jan 31;70(1):226-232
Cellular and molecular biology (Noisy-le-Grand, France) 2024 Jan 31;70(1):226-232
Buyang Huanwu decoction ameliorates bleomycin-induced pulmonary fibrosis in rats by attenuating the apoptosis of alveolar type II epithelial cells mediated by endoplasmic reticulum stress.
Zhou P, Wu X, Chen K, Du J, Wang F
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117300
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117300
Cell surface GRP78: A potential therapeutic target for high glucose-induced endothelial injury.
Wang B, He X, Zhang J, Zhang Y
Biochemical and biophysical research communications 2024 Jan 15;692:149347
Biochemical and biophysical research communications 2024 Jan 15;692:149347
Patulin induces ROS-dependent cardiac cell toxicity by inducing DNA damage and activating endoplasmic reticulum stress apoptotic pathway.
Zhang B, Huang C, Xu D, Huang K, Li Y, Jiao L, Fu B, Li S, Li Y
Ecotoxicology and environmental safety 2024 Jan 1;269:115784
Ecotoxicology and environmental safety 2024 Jan 1;269:115784
Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis.
Zhang P, Zhou C, Ren X, Jing Q, Gao Y, Yang C, Shen Y, Zhou Y, Hu W, Jin F, Xu H, Yu L, Liu Y, Tong X, Li Y, Wang Y, Du J
Redox biology 2024 Feb;69:103007
Redox biology 2024 Feb;69:103007
Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia‒Reperfusion Injury.
Li Z, Wang B, Tian L, Zheng B, Zhao X, Liu R
Inflammation 2024 Feb;47(1):376-389
Inflammation 2024 Feb;47(1):376-389
Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis.
Guo X, Asthana P, Zhai L, Cheng KW, Gurung S, Huang J, Wu J, Zhang Y, Mahato AK, Saarma M, Ustav M, Kwan HY, Lyu A, Chan KM, Xu P, Bian ZX, Wong HLX
Nature communications 2024 Feb 3;15(1):1034
Nature communications 2024 Feb 3;15(1):1034
Identification of hypoxia- and immune-related biomarkers in patients with ischemic stroke.
Zhang H, Sun J, Zou P, Huang Y, Yang Q, Zhang Z, Luo P, Jiang X
Heliyon 2024 Feb 29;10(4):e25866
Heliyon 2024 Feb 29;10(4):e25866
Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression.
Yang M, Chen Y, Huang X, Shen F, Meng Y
Experimental cell research 2024 Feb 15;435(2):113945
Experimental cell research 2024 Feb 15;435(2):113945
A novel bystander effect in tamoxifen treatment: PPIB derived from ER+ cells attenuates ER- cells via endoplasmic reticulum stress-induced apoptosis.
Yang T, Li W, Zhou J, Xu M, Huang Z, Ming J, Huang T
Cell death & disease 2024 Feb 15;15(2):147
Cell death & disease 2024 Feb 15;15(2):147
Repositioning of mifepristone as an integrated stress response activator to potentiate cisplatin efficacy in non-small cell lung cancer.
Namkaew J, Zhang J, Yamakawa N, Hamada Y, Tsugawa K, Oyadomari M, Miyake M, Katagiri T, Oyadomari S
Cancer letters 2024 Feb 1;582:216509
Cancer letters 2024 Feb 1;582:216509
Qing Hua Chang Yin ameliorates chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and the NF-κB signalling pathway.
Liu L, Chen Y, Han Y, Zhang X, Wu Y, Lin J, Cao L, Wu M, Zheng H, Fang Y, Wei L, Sferra TJ, Jafri A, Ke X, Peng J, Shen A
Pharmaceutical biology 2024 Dec;62(1):607-620
Pharmaceutical biology 2024 Dec;62(1):607-620
Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.
Li L, Jin RJ, Ji L
Environmental toxicology 2024 Dec;39(12):5382-5390
Environmental toxicology 2024 Dec;39(12):5382-5390
Selenium participates in the formation of kidney stones by alleviating endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells.
Su X, Chen H, Xiang H, Ke H, Dong C, Song Q, Zhou J, Jiang Q, Wang Y, Chen L, Yang S
Redox report : communications in free radical research 2024 Dec;29(1):2416825
Redox report : communications in free radical research 2024 Dec;29(1):2416825
Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells.
Ke H, Su X, Dong C, He Z, Song Q, Song C, Zhou J, Liao W, Wang C, Yang S, Xiong Y
Redox report : communications in free radical research 2024 Dec;29(1):2391139
Redox report : communications in free radical research 2024 Dec;29(1):2391139
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Yu B, Yuan C, Chen J, Zhou Z, Zhang Y, Su M, Wei D, Wu P
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
20(R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2/HO-1 axis.
Li WL, Li K, Chang WG, Shi H, Zhang WX, Wang Z, Li W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156202
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156202
Cepharanthine-mediated endoplasmic reticulum stress inhibits Notch1 via binding GRP78 for suppressing hepatocellular carcinoma metastasis.
Hu J, Chen NN, Li LG, Yu TT, Qin Y, Peng XC, Li HT, Li XY, Ma TQ, Lu YH, Han N, Xu Z, Hui YJ, Li TF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156162
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156162
Corilagin alleviated intestinal ischemia-reperfusion injury by modulating endoplasmic reticulum stress via bonding with Bip.
Wang Y, Liu G, Qiu F, Li X, Diao Y, Yang M, Yang S, Li B, Han Q, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156011
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156011
Design, synthesis and biological evaluation of plant-derived miliusol derivatives achieve TNBC profound regression in vivo.
Zhao X, Cheng X, Liu Z, Chen W, Hao W, Ma S, Zhang J, Huang W, Yao D
European journal of medicinal chemistry 2024 Dec 5;279:116882
European journal of medicinal chemistry 2024 Dec 5;279:116882
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Yu H, Liang J, Bao Y, Chen K, Jin Y, Li X, Chen H, Gou Y, Lu K, Lin Z
International immunopharmacology 2024 Dec 5;142(Pt B):113116
International immunopharmacology 2024 Dec 5;142(Pt B):113116
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway.
Geng Q, Wu W, Yang M, Gu F, Cai W, Qin Y, Wei L, Wang H, Li N
Heliyon 2024 Dec 30;10(24):e39987
Heliyon 2024 Dec 30;10(24):e39987
Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2.
Chen C, Wang C, Jiang H, Wang M, Rahman SU, Chen C, Ding H, Zhao C, Huang W, Wang X
Toxins 2024 Dec 26;17(1)
Toxins 2024 Dec 26;17(1)
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
Yuan C, Yu B, Li L, Chen J, Qin W, Zhou Z, Su M, Wang D, Zhang Y, Wu Q, He C, Wei D
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
Rutin Attenuates the Oxidative Damage Induced by Zearalenone in Piglet Endometrial Stromal Cells via the p53 Signaling Pathway.
Wang C, Wang M, Yang Y, Chen C, Rahman SU, Yang Z, Ding H, Huang W, Wang X
Journal of agricultural and food chemistry 2024 Dec 18;72(50):28138-28147
Journal of agricultural and food chemistry 2024 Dec 18;72(50):28138-28147
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
Nong WJ, Tong XY, Ouyang JM
Cells 2024 Dec 15;13(24)
Cells 2024 Dec 15;13(24)
Discovery and optimization of anthraquinone derivatives containing substituted bisbenzyloxy groups as a novel scaffold damaged endoplasmic reticulum and against hepatocellular carcinoma cells.
Shen X, Zhai H, Tian W, Lai L, Ma T, Chen X, Wang C, Hou H
Bioorganic & medicinal chemistry 2024 Dec 1;115:117969
Bioorganic & medicinal chemistry 2024 Dec 1;115:117969
Puerarin Attenuates Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress and Suppresses Inflammation by Modulating the JNK and IKKβ/NF-κB Pathways in Epididymal White Adipose Tissue of Mice on a High-Fat Diet.
Sun J, Liu Y, Zhang J, Shi H, Jiang R, Guo M, Liu Y, Liu B, Wang N, Ma R, Zhang D, Zhang F, Wang S, Wu Y
Molecular nutrition & food research 2024 Aug;68(16):e2400003
Molecular nutrition & food research 2024 Aug;68(16):e2400003
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.
Yao H, Zhao H, Du Y, Zhang Y, Li Y, Zhu H
Translational research : the journal of laboratory and clinical medicine 2024 Aug;270:1-12
Translational research : the journal of laboratory and clinical medicine 2024 Aug;270:1-12
MicroRNA-15b promotes cardiac ischemia injury by the inhibition of Mitofusin 2/PERK pathway.
Zhang W, Zhang M, Ma J, Yao Y, Jiang Y, Huo Q, Jin S, Ji D, Zhao Y, Liu X, Sun H, Xu C, Zhang R
Biochemical pharmacology 2024 Aug;226:116372
Biochemical pharmacology 2024 Aug;226:116372
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression.
Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, D'Orazi G, Cirone M
Autophagy 2024 Aug;20(8):1854-1867
Autophagy 2024 Aug;20(8):1854-1867
Maltol Improves Peripheral Nerve Function by Inhibiting Schwann Cell Apoptosis via the PERK/eIF2α/CHOP Pathway and MME Upregulation in Diabetic Peripheral Neuropathy.
Li J, Liu Q, Liu S, Xin H, Zhang X, Guo N
Pharmaceuticals (Basel, Switzerland) 2024 Aug 29;17(9)
Pharmaceuticals (Basel, Switzerland) 2024 Aug 29;17(9)
Mito-LND and (E)-Akt inhibitor-IV: novel compounds inducing endoplasmic reticulum stress and ROS accumulation against hepatocellular carcinoma.
Liao S, Wang Q, Chen S, Huang Q, Zhou L, Liu H, He S, Zhou Z
Journal of translational medicine 2024 Aug 28;22(1):792
Journal of translational medicine 2024 Aug 28;22(1):792
Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells.
Fukushima N, Miyamoto Y, Yamauchi J
Pathophysiology : the official journal of the International Society for Pathophysiology 2024 Aug 26;31(3):420-435
Pathophysiology : the official journal of the International Society for Pathophysiology 2024 Aug 26;31(3):420-435
Phenylbutyric acid inhibits hypoxia-induced trophoblast apoptosis and autophagy in preeclampsia via the PERK/ATF-4/CHOP pathway.
Li Y, Guo Y, Wu D, Ai L, Wu R, Ping Z, Zhu K
Molecular reproduction and development 2024 Apr;91(4):e23742
Molecular reproduction and development 2024 Apr;91(4):e23742
Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin.
Lin H, Guo X, Liu J, Tang Y, Chen L, Chen H, Zhao Y, Wang L, Li H, Yu J, Yao P
Molecular nutrition & food research 2024 Apr;68(7):e2300343
Molecular nutrition & food research 2024 Apr;68(7):e2300343
Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages.
Wu Y, Gong X, Shen J, Zhu K
Journal of advanced research 2024 Apr;58:117-128
Journal of advanced research 2024 Apr;58:117-128
Integrating Network Pharmacology and Experimental Validation to Reveal the Mechanism of Vine Grape Tea Polyphenols on Hyperuricemia-Induced Renal Injury in Mice.
Li X, Li B, Meng X, Yu F, Yu X, Zhao W, Wang Y, Gao H, Cheng M, Zhong L
Journal of medicinal food 2024 Apr;27(4):312-329
Journal of medicinal food 2024 Apr;27(4):312-329
An anti-tumor protein PFAP specifically interacts with cholesterol-enriched membrane domains of A549 cells and induces paraptosis and endoplasmic reticulum stress.
Liu MH, Liu ZK, Liu F
International journal of biological macromolecules 2024 Apr;264(Pt 2):130690
International journal of biological macromolecules 2024 Apr;264(Pt 2):130690
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
Dai Y, Xu R, Chen J, Fang J, Zhang H, Li H, Chen W
British journal of pharmacology 2024 Apr;181(7):967-986
British journal of pharmacology 2024 Apr;181(7):967-986
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
Wang TB, He Y, Li RC, Yu YX, Liu Y, Qi ZQ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration.
Liu H, Zheng Y, Kan S, Hao M, Jiang H, Li S, Li R, Wang Y, Wang D, Liu W
Heliyon 2024 Apr 30;10(8):e29291
Heliyon 2024 Apr 30;10(8):e29291
Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors.
Muley H, Dowdy T, Zaibaq F, Karadimov G, Li A, Song H, Zhang M, Zhang W, Wong Z, Zhang L, Lita A, Larion M
bioRxiv : the preprint server for biology 2024 Apr 29;
bioRxiv : the preprint server for biology 2024 Apr 29;
CHOP regulated by METTL14-m6A affects cell cycle arrest and regorafenib sensitivity in HCC cells.
Pan Y, You B, Zhao X, Zhang S, Li W
BMC cancer 2024 Apr 25;24(1):525
BMC cancer 2024 Apr 25;24(1):525
Triptolide induces apoptosis and cytoprotective autophagy by ROS accumulation via directly targeting peroxiredoxin 2 in gastric cancer cells.
Chen P, Zhong X, Song Y, Zhong W, Wang S, Wang J, Huang P, Niu Y, Yang W, Ding Z, Luo Q, Yang C, Wang J, Zhang W
Cancer letters 2024 Apr 10;587:216622
Cancer letters 2024 Apr 10;587:216622
The developmental regulator HAND1 inhibits gastric carcinogenesis through enhancing ER stress apoptosis via targeting CHOP and BAK which is augmented by cisplatin.
Kuang Y, He Z, Li L, Wang C, Cheng X, Shi Q, Fu G, Ying J, Tao Q, Hu X
International journal of biological sciences 2023;19(1):120-136
International journal of biological sciences 2023;19(1):120-136
Exogenous Hydrogen Sulfide Induces A375 Melanoma Cell Apoptosis Through Overactivation of the Unfolded Protein Response.
Ma W, Zhang X, Zhuang L
Clinical, cosmetic and investigational dermatology 2023;16:1641-1651
Clinical, cosmetic and investigational dermatology 2023;16:1641-1651
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer.
Zhang X, Chen X, Qian F, Zhu Y, He G, Yang J, Wu X, Zhang H, Yu X, Liu X
Clinical and translational medicine 2023 Sep;13(9):e1398
Clinical and translational medicine 2023 Sep;13(9):e1398
Down-regulation of Hrd1 protects against myocardial ischemia-reperfusion injury by regulating PPARα to prevent oxidative stress, endoplasmic reticulum stress, and cellular apoptosis.
Xia B, Li Q, Zheng K, Wu J, Huang C, Liu K, You Q, Yuan X
European journal of pharmacology 2023 Sep 5;954:175864
European journal of pharmacology 2023 Sep 5;954:175864
Exogenous spermidine alleviates diabetic cardiomyopathy via suppressing reactive oxygen species, endoplasmic reticulum stress, and Pannexin-1-mediated ferroptosis.
Sun J, Xu J, Liu Y, Lin Y, Wang F, Han Y, Zhang S, Gao X, Xu C, Yuan H
Biomolecules & biomedicine 2023 Sep 4;23(5):825-837
Biomolecules & biomedicine 2023 Sep 4;23(5):825-837
ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer.
Farmaki E, Nath A, Emond R, Karimi KL, Grolmusz VK, Cosgrove PA, Bild AH
eLife 2023 Sep 29;12
eLife 2023 Sep 29;12
The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice.
Chang L, Fujii W, Yogo K
Biochemical and biophysical research communications 2023 Sep 24;674:102-108
Biochemical and biophysical research communications 2023 Sep 24;674:102-108
Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway.
Sheng B, Wang W, Xia D, Qu X
BMC pharmacology & toxicology 2023 Sep 22;24(1):45
BMC pharmacology & toxicology 2023 Sep 22;24(1):45
Bavachin induces liver injury and cell apoptosis by targeting Wnt/β-catenin/DRP1 signaling pathway mediated mitochondrial dysfunction.
Yang Y, Zhou W, Wang Y, Ge Y, Fan Z, Liu Q, Gao Y
Toxicology letters 2023 Sep 15;387:1-13
Toxicology letters 2023 Sep 15;387:1-13
A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models.
Kim DY, Shin JY, Lee JE, Kim HN, Chung SJ, Yoo HS, Kim SJ, Cho HJ, Lee EJ, Nam SJ, Kim SH, Jang J, Lee SE, Lee PH
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 12;120(37):e2221929120
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 12;120(37):e2221929120
Stress response mechanisms in protein misfolding diseases: Profiling a cellular model of Huntington's disease.
Almeida LM, Oliveira Â, Oliveira JMA, Pinho BR
Archives of biochemistry and biophysics 2023 Sep 1;745:109711
Archives of biochemistry and biophysics 2023 Sep 1;745:109711
Diosmetin-7-O-β-D-glucopyranoside suppresses endothelial-mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis.
Wang H, Zhang X, Liu Y, Zhang Y, Wang Y, Peng Y, Ding Y
Clinical and experimental pharmacology & physiology 2023 Oct;50(10):789-805
Clinical and experimental pharmacology & physiology 2023 Oct;50(10):789-805
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Fan R, Wang S, Wu Y, Feng Y, Gao M, Cao Y, Ma X, Xie S, Wang C, Gao L, Wang Y, Dai F
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae.
Park KH, Makki HMM, Kim SH, Chung HJ, Jung J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115350
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115350
Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress.
Chiang YF, Lin IC, Huang KC, Chen HY, Ali M, Huang YJ, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115327
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115327
Undesirable ER stress induced by bavachin contributed to follicular atresia in zebrafish ovary.
Huang CS, Deng HF, Zhou L, Shen P, Ni YH, Wang NN, Li GF, Yue LX, Zhou YQ, Zhou W, Gao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115322
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115322
Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress-mitophagy.
Yan M, Wang J, Wang H, Zhou J, Qi H, Naji Y, Zhao L, Tang Y, Dai Y
Journal of translational medicine 2023 Oct 8;21(1):701
Journal of translational medicine 2023 Oct 8;21(1):701
A beneficial adaptive role for CHOP in driving cell fate selection during ER stress.
Liu K, Zhao C, Adajar RC, DeZwaan-McCabe D, Rutkowski DT
bioRxiv : the preprint server for biology 2023 Oct 23;
bioRxiv : the preprint server for biology 2023 Oct 23;
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.
Fu Y, Sacco O, DeBitetto E, Kanshin E, Ueberheide B, Sfeir A
Molecular cell 2023 Oct 19;83(20):3740-3753.e9
Molecular cell 2023 Oct 19;83(20):3740-3753.e9
IKVAV peptide-containing hydrogel decreases fibrous scar after spinal cord injury by inhibiting fibroblast migration and activation.
Jiang T, Li S, Xu B, Liu K, Qiu T, Dai H
Behavioural brain research 2023 Oct 18;455:114683
Behavioural brain research 2023 Oct 18;455:114683
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota.
Li K, Wu J, Xu S, Li X, Zhang Y, Gao X-j
Microbiology spectrum 2023 Oct 17;11(5):e0191423
Microbiology spectrum 2023 Oct 17;11(5):e0191423
Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells.
Qiu C, Shen X, Lu H, Chen Y, Xu C, Zheng P, Xia Y, Wang J, Zhang Y, Li S, Zou P, Cui R, Chen J
Cell death discovery 2023 Oct 13;9(1):375
Cell death discovery 2023 Oct 13;9(1):375
Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response.
Li Y, Zhang Q, Yang J, He W, Jiang Y, Chen Y, Wang Y
Biochemical and biophysical research communications 2023 Oct 1;675:146-154
Biochemical and biophysical research communications 2023 Oct 1;675:146-154
3-Acetyldeoxynivalenol induces apoptosis, barrier dysfunction and endoplasmic reticulum stress by inhibiting mTORC1-dependent autophagy in porcine enterocytes.
Zhang T, Bai J, Chen G, Chen Z, Zeng S, Yang Y, Wu Z
Chemico-biological interactions 2023 Oct 1;384:110695
Chemico-biological interactions 2023 Oct 1;384:110695
Role of SIRT2 in intestinal barrier under cold exposure.
Guo J, Xu J, Chen L, Chen Z, Hu H, Nie J, Yuan J, Ma L, Lu J, Ji H, Xu B
Life sciences 2023 Oct 1;330:121949
Life sciences 2023 Oct 1;330:121949
Key Subdomains of Cerebral Dopamine Neurotrophic Factor Regulate Its Protective Function in 6-Hydroxydopamine-Lesioned PC12 Cells.
Liu H, Dong H, Wang C, Jia W, Wang G, Wang H, Zhong L, Gong L
DNA and cell biology 2023 Nov;42(11):680-688
DNA and cell biology 2023 Nov;42(11):680-688
Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma.
Huang Y, Yan H, Zhang B, Zhu G, Yu J, Xiao X, He W, Chen Y, Gao X, She Z, Li M, Yuan J
Marine drugs 2023 Nov 21;21(12)
Marine drugs 2023 Nov 21;21(12)
Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway.
Jin N, Wang B, Liu X, Yin C, Li X, Wang Z, Chen X, Liu Y, Bu W, Sun H
Journal of nanobiotechnology 2023 Nov 15;21(1):426
Journal of nanobiotechnology 2023 Nov 15;21(1):426
Systemic deuteration of SCID mice using the water-isotopologue deuterium oxide (D(2) O) inhibits tumor growth in an orthotopic bioluminescent model of human pancreatic ductal adenocarcinoma.
Jandova J, Galons JP, Dettman DL, Wondrak GT
Molecular carcinogenesis 2023 May;62(5):598-612
Molecular carcinogenesis 2023 May;62(5):598-612
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
Hou XX, Li YW, Song JL, Zhang W, Liu R, Yuan H, Feng TT, Jiang ZY, Li WT, Zhu CL
World journal of gastroenterology 2023 May 7;29(17):2616-2627
World journal of gastroenterology 2023 May 7;29(17):2616-2627
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
Wu J, Subbaiah KCV, Hedaya O, Chen S, Munger J, Tang WHW, Yan C, Yao P
bioRxiv : the preprint server for biology 2023 May 22;
bioRxiv : the preprint server for biology 2023 May 22;
Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice.
Zhang ZH, Zhou XM, Zhang X
Brain sciences 2023 May 18;13(5)
Brain sciences 2023 May 18;13(5)
Vitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4.
Tang S, Wu X, Dai Q, Li Z, Yang S, Liu Y, Yi B, Wang J, Liao Q, Zhang W, Zhang H
Cell death discovery 2023 May 12;9(1):158
Cell death discovery 2023 May 12;9(1):158
Thioredoxin 1 overexpression attenuated diabetes-induced endoplasmic reticulum stress in Müller cells via apoptosis signal-regulating kinase 1.
Yu X, Teng Q, Bao K, Chudhary M, Qi H, Zhou W, Che H, Liu J, Ren X, Kong L
Journal of cellular biochemistry 2023 Mar;124(3):421-433
Journal of cellular biochemistry 2023 Mar;124(3):421-433
JQ-1/bortezomib combination strongly impairs MM and PEL survival by inhibiting c-Myc and mTOR despite the activation of prosurvival mechanisms.
Arena A, Romeo MA, Benedetti R, Gilardini Montani MS, Cirone M
Experimental hematology 2023 Mar-Apr;119-120:28-41
Experimental hematology 2023 Mar-Apr;119-120:28-41
RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy.
Chen J, Lei C, Zhang H, Huang X, Yang Y, Liu J, Jia Y, Shi H, Zhang Y, Zhang J, Du J
BMC molecular and cell biology 2023 Mar 3;24(1):7
BMC molecular and cell biology 2023 Mar 3;24(1):7
Atorvastatin prevents endoplasmic reticulum stress-mediated apoptosis via the Nrf2/HO-1 signaling pathway in TBI mice.
Feng Y, Lang J, Sun B, Yan Z, Zhao Z, Sun G
Neurological research 2023 Jun;45(6):590-602
Neurological research 2023 Jun;45(6):590-602
Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation.
Chen G, Tang Q, Yu S, Shen Y, Sun J, Peng J, Yin Y, Feng G, Lu X, Mei G, Zhang Y, Wan Q, Zhang L, Chen L
Cell death and differentiation 2023 Jun;30(6):1503-1516
Cell death and differentiation 2023 Jun;30(6):1503-1516
Scalp acupuncture alleviates cerebral ischemic stroke-induced motor dysfunction in rats via regulating endoplasmic reticulum stress and ER-phagy.
Zhang Y, Lou H, Lu J, Tang X, Pang T, Lei S, Cong D, Wang Y, Sun L
Scientific reports 2023 Jun 21;13(1):10119
Scientific reports 2023 Jun 21;13(1):10119
[Cordycepin, a metabolite of Cordyceps militaris, inhibits xenograft tumor growth of tongue squamous cell carcinoma in nude mice].
Zheng Q, Shao Y, Zheng W, Zou Y
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Jun 20;43(6):873-878
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Jun 20;43(6):873-878
Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer.
Zhou F, Gao H, Shang L, Li J, Zhang M, Wang S, Li R, Ye L, Yang S
Journal of experimental & clinical cancer research : CR 2023 Jun 19;42(1):150
Journal of experimental & clinical cancer research : CR 2023 Jun 19;42(1):150
Ginsenoside Rg1 regulates autophagy and endoplasmic reticulum stress via the AMPK/mTOR and PERK/ATF4/CHOP pathways to alleviate alcohol‑induced myocardial injury.
Tian G, Li J, Zhou L
International journal of molecular medicine 2023 Jul;52(1)
International journal of molecular medicine 2023 Jul;52(1)
Bavachin protects against diet-induced hepatic steatosis and obesity in mice.
Wei X, Lin L, Yuan QQ, Wang XY, Zhang Q, Zhang XM, Tang KC, Guo MY, Dong TY, Han W, Huang DK, Qi YL, Zhang M, Zhang HB
Acta pharmacologica Sinica 2023 Jul;44(7):1416-1428
Acta pharmacologica Sinica 2023 Jul;44(7):1416-1428
Betulinic acid mitigates zearalenone-induced liver injury by ERS/MAPK/Nrf2 signaling pathways in mice.
Wu J, Li J, Wu Y, Yang M, Chen Y, Wang N, Wang J, Yuan Z, Yi J, Yang C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113811
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113811
Coffee prevents IQ-induced liver damage by regulating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and the MAPK/NF-κB signaling pathway in zebrafish.
Li D, Li Z, Dong L, Zhang Y, Lu Y, Wang J, Sun H, Wang S
Food research international (Ottawa, Ont.) 2023 Jul;169:112946
Food research international (Ottawa, Ont.) 2023 Jul;169:112946
Xylanase improves the intestinal barrier function of Nile tilapia (Oreochromis niloticus) fed with soybean (Glycine max) meal.
Wang T, Zhou N, He J, Hao Z, Zhou C, Du Y, Du Z, Su X, Zhang M
Journal of animal science and biotechnology 2023 Jul 7;14(1):86
Journal of animal science and biotechnology 2023 Jul 7;14(1):86
Identification of EGF Receptor and Thrombospondin-1 as Endogenous Targets of ER-Associated Degradation Enhancer EDEM1 in HeLa Cells.
Miura K, Katsuki R, Yoshida S, Ohta R, Tamura T
International journal of molecular sciences 2023 Jul 29;24(15)
International journal of molecular sciences 2023 Jul 29;24(15)
Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress.
Chen M, Zhang R, Chen Y, Chen X, Li Y, Shen J, Yuan M, Chen Y, Wu J, Sun Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154902
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154902
Glutamine supplementation reverses manganese neurotoxicity by eliciting the mitochondrial unfolded protein response.
Zhang S, Zhang J, Wu L, Chen L, Niu P, Li J
iScience 2023 Jul 21;26(7):107136
iScience 2023 Jul 21;26(7):107136
Glucotropaeolin Promotes Apoptosis by Calcium Dysregulation and Attenuates Cell Migration with FOXM1 Suppression in Pancreatic Cancer Cells.
Lee W, Song G, Bae H
Antioxidants (Basel, Switzerland) 2023 Jan 23;12(2)
Antioxidants (Basel, Switzerland) 2023 Jan 23;12(2)
Identification of genomic binding sites and direct target genes for the transcription factor DDIT3/CHOP.
Osman A, Lindén M, Österlund T, Vannas C, Andersson L, Escobar M, Ståhlberg A, Åman P
Experimental cell research 2023 Jan 1;422(1):113418
Experimental cell research 2023 Jan 1;422(1):113418
Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress.
Abulikemu A, Zhao X, Xu H, Li Y, Ma R, Yao Q, Wang J, Sun Z, Li Y, Guo C
Redox biology 2023 Feb;59:102569
Redox biology 2023 Feb;59:102569
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Li Y, She W, Guo T, Huang T, Liu Y, Liu P, Xu X, Wang X, Wang M, Yu C, Liu Y, Wei Y
Biochemical pharmacology 2023 Feb;208:115404
Biochemical pharmacology 2023 Feb;208:115404
Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage.
Yu TT, Hu J, Li QR, Peng XC, Xu HZ, Han N, Li LG, Yang XX, Xu X, Yang ZY, Chen H, Chen X, Wang MF, Li TF
International immunopharmacology 2023 Feb;115:109661
International immunopharmacology 2023 Feb;115:109661
Non-Lethal Concentrations of CdCl(2) Cause Marked Alternations in Cellular Stress Responses within Exposed Sertoli Cell Line.
Man Y, Liu Y, Xiong C, Zhang Y, Zhang L
Toxics 2023 Feb 9;11(2)
Toxics 2023 Feb 9;11(2)
Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes.
Shah A, Huck I, Duncan K, Gansemer ER, Apte U, Stamnes MA, Rutkowski DT
bioRxiv : the preprint server for biology 2023 Feb 9;
bioRxiv : the preprint server for biology 2023 Feb 9;
Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds with Endoplasmic Reticulum Stress-Relieving Properties for Promoted Scarless Wound Healing.
Dou Z, Li B, Wu L, Qiu T, Wang X, Zhang X, Shen Y, Lu M, Yang Y
ACS applied materials & interfaces 2023 Feb 8;15(5):6297-6311
ACS applied materials & interfaces 2023 Feb 8;15(5):6297-6311
Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice.
Liu H, Ju A, Dong X, Luo Z, Tang J, Ma B, Fu Y, Luo Y
Journal of translational medicine 2023 Feb 6;21(1):89
Journal of translational medicine 2023 Feb 6;21(1):89
Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure.
Li WY, Yang F, Li X, Wang LW, Wang Y
World journal of gastroenterology 2023 Feb 28;29(8):1315-1329
World journal of gastroenterology 2023 Feb 28;29(8):1315-1329
NRF2 and Bip Interconnection Mediates Resistance to the Organometallic Ruthenium-Cymene Bisdemethoxycurcumin Complex Cytotoxicity in Colon Cancer Cells.
Garufi A, Pettinari R, Marchetti F, Cirone M, D'Orazi G
Biomedicines 2023 Feb 16;11(2)
Biomedicines 2023 Feb 16;11(2)
Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress.
Liu Q, Duan SB, Wang L, Luo XQ, Wang HS, Deng YH, Wu X, Wu T, Yan And P, Kang YX
Renal failure 2023 Dec;45(1):2179852
Renal failure 2023 Dec;45(1):2179852
Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer.
Wu H, Zhang Y, Liang J, Wu J, Zhang Y, Su H, Zhang Q, Shen Y, Shen S, Wang L, Zou X, Hang C, Zhang S, Lv Y
Translational oncology 2023 Dec;38:101792
Translational oncology 2023 Dec;38:101792
The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.
Luo G, Aldridge K, Chen T, Aslot V, Kim BG, Han EH, Singh N, Li S, Xiao TS, Sporn MB, Letterio JJ
Molecular oncology 2023 Dec;17(12):2526-2545
Molecular oncology 2023 Dec;17(12):2526-2545
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Lu D, Liu Y, Huang H, Hu M, Li T, Wang S, Shen S, Wu R, Cai W, Lu T, Lu Z
Translational stroke research 2023 Dec;14(6):910-928
Translational stroke research 2023 Dec;14(6):910-928
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Zhang S, Wang M, Li H, Li Q, Liu N, Dong S, Zhao Y, Pang K, Huang J, Ren C, Wang Y, Tian Z, Lu F, Zhang W
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Lead and cadmium co-exposure modified PC12 viability and ER stress: study from a 3 × 3 factorial design.
Su X, Wang R, Wu Y, Yang M, Ba Y, Huang H
Toxicology research 2023 Dec;12(6):1135-1142
Toxicology research 2023 Dec;12(6):1135-1142
Betaine ameliorates heat stress-induced apoptosis by affecting oxidative and endoplasmic reticulum stress in mouse Leydig cells.
Xiong Y, Li B, Wang K, Li J, He S
Bioscience, biotechnology, and biochemistry 2023 Dec 19;88(1):53-62
Bioscience, biotechnology, and biochemistry 2023 Dec 19;88(1):53-62
Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma.
Patil SV, Kaipa BR, Ranshing S, Sundaresan Y, Millar JC, Nagarajan B, Kiehlbauch C, Zhang Q, Jain A, Searby CC, Scheetz TE, Clark AF, Sheffield VC, Zode GS
Research square 2023 Dec 19;
Research square 2023 Dec 19;
ER Stress-Perturbed Intracellular Protein O-GlcNAcylation Aggravates Podocyte Injury in Diabetes Nephropathy.
Song S, Hu T, Shi X, Jin Y, Liu S, Li X, Zou W, Wang C
International journal of molecular sciences 2023 Dec 18;24(24)
International journal of molecular sciences 2023 Dec 18;24(24)
Glycyrrhetinic acid attenuates endoplasmic reticulum stress-induced hepatocyte apoptosis via CHOP/DR5/Caspase 8 pathway in cholestasis.
Zou B, Zhang S, Zhao J, Song G, Weng F, Xu X, Li F, Jin J, Yan D, Huang K, Liu C, Li Y, Qiu F
European journal of pharmacology 2023 Dec 15;961:176193
European journal of pharmacology 2023 Dec 15;961:176193
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
Xie F, Qu J, Lin D, Feng K, Tan M, Liao H, Zeng L, Xiong Q, Huang J, Chen W
Molecular biology reports 2023 Dec 12;51(1):10
Molecular biology reports 2023 Dec 12;51(1):10
XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells.
Cui Z, Qin R, Feng J, Liu Y, Zhou X, Qin X, Li Y, Zhang Z, He X
Tissue & cell 2023 Aug;83:102139
Tissue & cell 2023 Aug;83:102139
Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner.
Huang S, Zhang NQ, Xu CJ, Huang WQ, Li DX, Li J, Yao LL, Sundquist K, Sundquist J, Jiang SH, Xing X, Hu LP, Zhang ZG, Ji J, Zhang XL
Cellular oncology (Dordrecht, Netherlands) 2023 Aug;46(4):953-967
Cellular oncology (Dordrecht, Netherlands) 2023 Aug;46(4):953-967
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1.
Wu S, Lu D, Gajendran B, Hu Q, Zhang J, Wang S, Han M, Xu Y, Shen X
Phytotherapy research : PTR 2023 Aug;37(8):3543-3558
Phytotherapy research : PTR 2023 Aug;37(8):3543-3558
VPS34-IN1 induces apoptosis of ER+ breast cancer cells via activating PERK/ATF4/CHOP pathway.
Wu Q, Zhou D, Shen Z, Chen B, Wang G, Wu L, Zhang L, Li X, Yuan L, Wu Y, Qu N, Zhou W
Biochemical pharmacology 2023 Aug;214:115634
Biochemical pharmacology 2023 Aug;214:115634
Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.
Liu Z, Nan P, Gong Y, Tian L, Zheng Y, Wu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114897
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114897
Zinc deficiency causes oxidative stress, endoplasmic reticulum stress, apoptosis and inflammation in hepatocytes in grass carp.
Cui J, Xu T, Lv H, Guo MY
Fish & shellfish immunology 2023 Aug;139:108905
Fish & shellfish immunology 2023 Aug;139:108905
SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.
Xu R, Song J, Ruze R, Chen Y, Yin X, Wang C, Zhao Y
Cell death & disease 2023 Aug 4;14(8):497
Cell death & disease 2023 Aug 4;14(8):497
Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease.
Shi J, Wang W, Sun S, Xu X, Fei J, Zhou Q, Qin C, Ou S, Wu F, Wu FT, Xu T, Bai L, Xie F
iScience 2023 Aug 18;26(8):107312
iScience 2023 Aug 18;26(8):107312
cFLIP(L) Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Endoplasmic Reticulum Stress.
Li YZ, Wu H, Liu D, Yang J, Yang J, Ding JW, Zhou G, Zhang J, Zhang D
Cardiovascular drugs and therapy 2023 Apr;37(2):225-238
Cardiovascular drugs and therapy 2023 Apr;37(2):225-238
Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy.
Peng S, Wang M, Zhang S, Liu N, Li Q, Kang J, Chen L, Li M, Pang K, Huang J, Lu F, Zhao D, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114200
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114200
Dihydroartemisinin elicits immunogenic death through ferroptosis-triggered ER stress and DNA damage for lung cancer immunotherapy.
Han N, Yang ZY, Xie ZX, Xu HZ, Yu TT, Li QR, Li LG, Peng XC, Yang XX, Hu J, Xu X, Chen X, Wang MF, Li TF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154682
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154682
Apurinic/apyrimidinic endonuclease 1 regulates palmitic acid-mediated apoptosis in cardiomyocytes via endoplasmic reticulum stress.
Fan J, Liu M, Li X, Gao S, Wang Y, Li A, Chen L, Zhou D, Chen H, Xu Z, Wu Z, Wu K
Biochemical and biophysical research communications 2023 Apr 2;650:123-131
Biochemical and biophysical research communications 2023 Apr 2;650:123-131
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo.
Benvenuto M, Angiolini V, Focaccetti C, Nardozi D, Palumbo C, Carrano R, Rufini A, Bei R, Miele MT, Mancini P, Barillari G, Cirone M, Ferretti E, Tundo GR, Mutti L, Masuelli L, Bei R
Biology direct 2023 Apr 17;18(1):17
Biology direct 2023 Apr 17;18(1):17
Citrinin Exposure Induced Testicular Damage and Spermatogenesis Disorder by Triggering Endoplasmic Reticulum Stress.
Wu J, Wu Y, Fan H, Yang C, Yang M, Kong X, Ning C, Wang S, Xiao W, Wang N, Yi J, Yuan Z
Foods (Basel, Switzerland) 2023 Apr 11;12(8)
Foods (Basel, Switzerland) 2023 Apr 11;12(8)
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Li J, Bai J, Si X, Jia H, Wu Z
Chemico-biological interactions 2023 Apr 1;374:110386
Chemico-biological interactions 2023 Apr 1;374:110386
Effects of folic acid on oxidative damage of kidney in lead-exposed rats.
Li N, Wen L, Yu Z, Li T, Wang T, Qiao M, Song L, Huang X
Frontiers in nutrition 2022;9:1035162
Frontiers in nutrition 2022;9:1035162
Qingfei Tongluo Formula Mitigates Mycoplasma pneumoniae Infection via the PERK Signaling Pathway.
Liu X, Wang M, Kan Q, Lin Y, Jiang Z
Disease markers 2022;2022:9340353
Disease markers 2022;2022:9340353
Bixin Prevents Colorectal Cancer Development through AMPK-Activated Endoplasmic Reticulum Stress.
Qiu Y, Li C, Zhang B
BioMed research international 2022;2022:9329151
BioMed research international 2022;2022:9329151
Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.
Zhang B, Wan S, Liu H, Qiu Q, Chen H, Chen Z, Wang L, Liu X
Oxidative medicine and cellular longevity 2022;2022:5992436
Oxidative medicine and cellular longevity 2022;2022:5992436
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.
Feng S, Wan S, Liu S, Wang W, Tang M, Bai L, Zhu Y
Oxidative medicine and cellular longevity 2022;2022:5501346
Oxidative medicine and cellular longevity 2022;2022:5501346
Saikosaponin D Inducing Apoptosis and Autophagy through the Activation of Endoplasmic Reticulum Stress in Glioblastoma.
Liu G, Guan Y, Liu Y, Wang Y, Zhang J, Liu Y, Liu X
BioMed research international 2022;2022:5489553
BioMed research international 2022;2022:5489553
Upregulation of Glutaminyl Cyclase Contributes to ERS-Induced Apoptosis in PC12 Cells.
Shang Q, Yu X, Ouyang N, Xu P, Chen X, Wang Y, Li C, Wang X, Lu X, Xu C, Wu H
BioMed research international 2022;2022:4154697
BioMed research international 2022;2022:4154697
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y
Journal of immunology research 2022;2022:2291877
Journal of immunology research 2022;2022:2291877
Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.
Qi S, Yan Q, Wang Z, Liu D, Zhan M, Du J, Chen L
PPAR research 2022;2022:2212996
PPAR research 2022;2022:2212996
Ursolic Acid Derivative UA232 Promotes Tumor Cell Apoptosis by Inducing Endoplasmic Reticulum Stress and Lysosomal Dysfunction.
Gou W, Luo N, Yu B, Wu H, Wu S, Tian C, Guo J, Ning H, Bi C, Wei H, Hou W, Li Y
International journal of biological sciences 2022;18(6):2639-2651
International journal of biological sciences 2022;18(6):2639-2651
Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction.
Jiang L, Dong R, Xu M, Liu Y, Xu J, Ma Z, Xia T, Gu X
Frontiers in cellular neuroscience 2022;16:992869
Frontiers in cellular neuroscience 2022;16:992869
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug design, development and therapy 2022;16:1713-1729
Drug design, development and therapy 2022;16:1713-1729
Pitavastatin protects against neomycin-induced ototoxicity through inhibition of endoplasmic reticulum stress.
Wu Y, Meng W, Guan M, Zhao X, Zhang C, Fang Q, Zhang Y, Sun Z, Cai M, Huang D, Yang X, Yu Y, Cui Y, He S, Chai R
Frontiers in molecular neuroscience 2022;15:963083
Frontiers in molecular neuroscience 2022;15:963083
Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.
Liu X, Zhang L, Zhang H, Liang X, Zhang B, Tu J, Zhao Y
Frontiers in molecular neuroscience 2022;15:919718
Frontiers in molecular neuroscience 2022;15:919718
Cryptotanshinone alleviates myocardial ischemia and reperfusion injury in rats to mitigate ER stress-dependent apoptosis by modulating the JAK1/STAT3 axis.
Wang S, Sun L, Zhu Z, Liu J, Ge W, Li B, Wang B
American journal of translational research 2022;14(7):5024-5039
American journal of translational research 2022;14(7):5024-5039
TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease.
Xie M, Mak JWY, Yu H, Cheng CTY, Chan HCH, Chan TT, Lau LHS, Wong MTL, Ko WH, Jiang L, Yao X
Cellular and molecular gastroenterology and hepatology 2022;14(2):245-270
Cellular and molecular gastroenterology and hepatology 2022;14(2):245-270
Melatonin promotes sirtuin 1 expression and inhibits IRE1α-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes.
Qin K, Tang H, Ren Y, Yang D, Li Y, Huang W, Wu Y, Yin Z
Frontiers in pharmacology 2022;13:940629
Frontiers in pharmacology 2022;13:940629
Pinelliae rhizoma alleviated acute lung injury induced by lipopolysaccharide via suppressing endoplasmic reticulum stress-mediated NLRP3 inflammasome.
Wang NN, Zhang XX, Shen P, Huang CS, Deng HF, Zhou L, Yue LX, Shen BY, Zhou W, Gao Y
Frontiers in pharmacology 2022;13:883865
Frontiers in pharmacology 2022;13:883865
Ginsenoside Rb1 Ameliorated Bavachin-Induced Renal Fibrosis via Suppressing Bip/eIF2α/CHOP Signaling-Mediated EMT.
Ni YH, Deng HF, Zhou L, Huang CS, Wang NN, Yue LX, Li GF, Yu HJ, Zhou W, Gao Y
Frontiers in pharmacology 2022;13:872474
Frontiers in pharmacology 2022;13:872474
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Fuzheng Nizeng Decoction regulated ferroptosis and endoplasmic reticulum stress in the treatment of gastric precancerous lesions: A mechanistic study based on metabolomics coupled with transcriptomics.
Chu YM, Wang TX, Jia XF, Yang Y, Shi ZM, Cui GH, Huang QY, Ye H, Zhang XZ
Frontiers in pharmacology 2022;13:1066244
Frontiers in pharmacology 2022;13:1066244
Oxaloacetate acid ameliorates paraquat-induced acute lung injury by alleviating oxidative stress and mitochondrial dysfunction.
Li W, Li M, Chen K, Tang Y, Yin R, Lan L, Hong G
Frontiers in pharmacology 2022;13:1029775
Frontiers in pharmacology 2022;13:1029775
FUS-DDIT3 Fusion Oncoprotein Expression Affects JAK-STAT Signaling in Myxoid Liposarcoma.
Dolatabadi S, Jonasson E, Andersson L, Luna Santamaría M, Lindén M, Österlund T, Åman P, Ståhlberg A
Frontiers in oncology 2022;12:816894
Frontiers in oncology 2022;12:816894
RRBP1 depletion of bone metastatic cancer cells contributes to enhanced expression of the osteoblastic phenotype.
Chen R, Wang Y, Xu Y, He Y, Li Q, Xia C, Zhang B
Frontiers in oncology 2022;12:1005152
Frontiers in oncology 2022;12:1005152
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway.
Zhang L, Li C, Fu L, Yu Z, Xu G, Zhou J, Shen M, Feng Z, Zhu H, Xie T, Zhou L, Zhou X
PeerJ 2022;10:e12759
PeerJ 2022;10:e12759
Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis.
Sun S, Han Y, Zhang C, Liu H, Wang B, Cao S, Yuan Q, Wei S, Chen Y
Frontiers in cell and developmental biology 2022;10:827714
Frontiers in cell and developmental biology 2022;10:827714
HSPA5 repressed ferroptosis to promote colorectal cancer development by maintaining GPX4 stability.
Wang R, Hua L, Ma P, Song Y, Min J, Guo Y, Yang C, Li J, Su H
Neoplasma 2022 Sep;69(5):1054-1069
Neoplasma 2022 Sep;69(5):1054-1069
Identification of Ferroptotic Genes in Spinal Cord Injury at Different Time Points: Bioinformatics and Experimental Validation.
Kang Y, Li Q, Zhu R, Li S, Xu X, Shi X, Yin Z
Molecular neurobiology 2022 Sep;59(9):5766-5784
Molecular neurobiology 2022 Sep;59(9):5766-5784
Role of Mydgf in the regulation of hypoxia/reoxygenation-induced apoptosis in cardiac microvascular endothelial cells.
Wang Y, Zhang Y, Li J, Zhao R, Long X, Li C, Liu W, Chen W, Shi B
In vitro cellular & developmental biology. Animal 2022 Sep;58(8):669-678
In vitro cellular & developmental biology. Animal 2022 Sep;58(8):669-678
Acacetin antagonized lipotoxicity in pancreatic β-cells via ameliorating oxidative stress and endoplasmic reticulum stress.
Wang N, Gao Q, Shi J, Yulan C, Ji W, Sheng X, Zhang R
Molecular biology reports 2022 Sep;49(9):8727-8740
Molecular biology reports 2022 Sep;49(9):8727-8740
UFL1 alleviates ER stress and apoptosis stimulated by LPS via blocking the ferroptosis pathway in human granulosa-like cells.
Li J, Tang X, Tu X, Jin Z, Dong H, Yang Q, Yao T, Pan Z
Cell stress & chaperones 2022 Sep;27(5):485-497
Cell stress & chaperones 2022 Sep;27(5):485-497
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Wang L, Yang Z, Wang S, Que Y, Shu X, Wu F, Liu G, Li S, Hu P, Chen H, Shi J, Tong X
British journal of pharmacology 2022 Sep;179(17):4423-4439
British journal of pharmacology 2022 Sep;179(17):4423-4439
Role of hair follicles in the pathogenesis of arsenical-induced cutaneous damage.
Srivastava RK, Wang Y, Khan J, Muzaffar S, Lee MB, Weng Z, Croutch C, Agarwal A, Deshane J, Athar M
Annals of the New York Academy of Sciences 2022 Sep;1515(1):168-183
Annals of the New York Academy of Sciences 2022 Sep;1515(1):168-183
Zearalenone Promotes LPS-Induced Oxidative Stress, Endoplasmic Reticulum Stress, and Accelerates Bovine Mammary Epithelial Cell Apoptosis.
Fu Y, Jin Y, Tian Y, Yu H, Wang R, Qi H, Feng B, Zhang J
International journal of molecular sciences 2022 Sep 18;23(18)
International journal of molecular sciences 2022 Sep 18;23(18)
Liproxstatin‑1 induces cell cycle arrest, apoptosis, and caspase‑3/GSDME‑dependent secondary pyroptosis in K562 cells.
Dong HQ, Liang SJ, Xu YL, Dai Y, Sun N, Deng DH, Cheng P
International journal of oncology 2022 Oct;61(4)
International journal of oncology 2022 Oct;61(4)
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Su H, Mei Y, Luo S, Wu H, He Y, Shiraishi Y, Hu P, Cohen RA, Tong X
British journal of pharmacology 2022 Oct;179(20):4778-4791
British journal of pharmacology 2022 Oct;179(20):4778-4791
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L
International journal of molecular sciences 2022 Oct 4;23(19)
International journal of molecular sciences 2022 Oct 4;23(19)
Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.
Chen Y, Zhang H, Li Y, Ji S, Jia P, Wang T
Journal of agricultural and food chemistry 2022 Oct 26;70(42):13661-13675
Journal of agricultural and food chemistry 2022 Oct 26;70(42):13661-13675
Exploring the molecular mechanisms underlie the endoplasmic reticulum stress-mediated methylmercury-induced neuronal developmental damage.
Pan J, Li X, Liu H, Wang C, Xu S, Xu B, Deng Y, Yang T, Liu W
Ecotoxicology and environmental safety 2022 Oct 15;245:114099
Ecotoxicology and environmental safety 2022 Oct 15;245:114099
ER stress transforms random olfactory receptor choice into axon targeting precision.
Shayya HJ, Kahiapo JK, Duffié R, Lehmann KS, Bashkirova L, Monahan K, Dalton RP, Gao J, Jiao S, Schieren I, Belluscio L, Lomvardas S
Cell 2022 Oct 13;185(21):3896-3912.e22
Cell 2022 Oct 13;185(21):3896-3912.e22
A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.
Márton M, Bánhegyi G, Gyöngyösi N, Kálmán EÉ, Pettkó-Szandtner A, Káldi K, Kapuy O
FEBS open bio 2022 Nov;12(11):2065-2082
FEBS open bio 2022 Nov;12(11):2065-2082
Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy.
Chen Y, Zhang H, Li Y, Ji S, Jia P, Wang T
Journal of animal science and biotechnology 2022 Nov 4;13(1):125
Journal of animal science and biotechnology 2022 Nov 4;13(1):125
Ellagic acid attenuates muscle atrophy in STZ-induced diabetic mice.
Liu X, Cheng C, Deng B, Liu M
Physiological research 2022 Nov 28;71(5):631-641
Physiological research 2022 Nov 28;71(5):631-641
Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis.
Kong K, Chang Y, Qiao H, Zhao C, Chen X, Rong K, Zhang P, Jin M, Zhang J, Li H, Zhai Z
Journal of translational medicine 2022 Nov 26;20(1):549
Journal of translational medicine 2022 Nov 26;20(1):549
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Peng S, Zhao D, Li Q, Wang M, Zhang S, Pang K, Huang J, Lu F, Chen H, Zhang W
Cells 2022 Nov 2;11(21)
Cells 2022 Nov 2;11(21)
Manganese Mitigates Heat Stress-Induced Apoptosis by Alleviating Endoplasmic Reticulum Stress and Activating the NRF2/SOD2 Pathway in Primary Chick Embryonic Myocardial Cells.
Qin S, Wang R, Tang D, Qin S, Guo Y, Shi Z
Biological trace element research 2022 May;200(5):2312-2320
Biological trace element research 2022 May;200(5):2312-2320
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Chen S, Acosta D, Li L, Liang J, Chang Y, Wang C, Fitzgerald J, Morrison C, Goulbourne CN, Nakano Y, Villegas NCH, Venkataraman L, Brown C, Serrano GE, Bell E, Wemlinger T, Wu M, Kokiko-Cochran ON, Popovich P, Flowers XE, Honig LS, Vonsattel JP, Scharre DW, Beach TG, Ma Q, Kuret J, Kõks S, Urano F, Duff KE, Fu H
Acta neuropathologica 2022 May;143(5):547-569
Acta neuropathologica 2022 May;143(5):547-569
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Li T, Chen Y, Tan P, Shi H, Huang Z, Cai T, Cheng Y, Du Y, Fu W
Bioorganic chemistry 2022 May;122:105737
Bioorganic chemistry 2022 May;122:105737
The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma.
Zullow HJ, Sankar A, Ingram DR, Samé Guerra DD, D'Avino AR, Collings CK, Lazcano R, Wang WL, Liang Y, Qi J, Lazar AJ, Kadoch C
Molecular cell 2022 May 5;82(9):1737-1750.e8
Molecular cell 2022 May 5;82(9):1737-1750.e8
Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells.
Tang X, Dong H, Fang Z, Li J, Yang Q, Yao T, Pan Z
Reproductive biology and endocrinology : RB&E 2022 May 24;20(1):84
Reproductive biology and endocrinology : RB&E 2022 May 24;20(1):84
diTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C(2)-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation.
Chiu CC, Chen YC, Bow YD, Chen JY, Liu W, Huang JL, Shu ED, Teng YN, Wu CY, Chang WT
Cancers 2022 May 20;14(10)
Cancers 2022 May 20;14(10)
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6
Molecular cell 2022 May 19;82(10):1821-1835.e6
sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
Zhu L, Li B, Chen D, Chen N, Xu L, Li Q, Chen X
Life sciences 2022 May 1;296:120438
Life sciences 2022 May 1;296:120438
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Chang L, Liu X, Chen J, Liu H, Wang G, Wang G, Liao X, Shen X
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).
Zhang Y, Ge L, Song G, Zhang R, Li S, Shi H, Zhang H, Li Y, Pan J, Wang L, Han J
British journal of pharmacology 2022 Mar;179(6):1201-1219
British journal of pharmacology 2022 Mar;179(6):1201-1219
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a.
Chen J, Liu Y, Pan D, Xu T, Luo Y, Wu W, Wu P, Zhu H, Li D
Cell communication and signaling : CCS 2022 Mar 24;20(1):38
Cell communication and signaling : CCS 2022 Mar 24;20(1):38
Targeting c-Myc Unbalances UPR towards Cell Death and Impairs DDR in Lymphoma and Multiple Myeloma Cells.
Arena A, Romeo MA, Benedetti R, Gilardini Montani MS, Cirone M
Biomedicines 2022 Mar 22;10(4)
Biomedicines 2022 Mar 22;10(4)
Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction.
Chen C, Zhang B, Xue J, Li Z, Dou S, Chen H, Wang Q, Qu M, Wang H, Zhang Y, Wan L, Zhou Q, Xie L
Investigative ophthalmology & visual science 2022 Mar 2;63(3):4
Investigative ophthalmology & visual science 2022 Mar 2;63(3):4
The Impact of NRF2 Inhibition on Drug-Induced Colon Cancer Cell Death and p53 Activity: A Pilot Study.
Garufi A, Pistritto G, D'Orazi V, Cirone M, D'Orazi G
Biomolecules 2022 Mar 17;12(3)
Biomolecules 2022 Mar 17;12(3)
Protective Effects of Taraxasterol against Deoxynivalenol-Induced Damage to Bovine Mammary Epithelial Cells.
Wang J, Zheng K, Jin Y, Fu Y, Wang R, Zhang J
Toxins 2022 Mar 15;14(3)
Toxins 2022 Mar 15;14(3)
Hesperadin suppresses pancreatic cancer through ATF4/GADD45A axis at nanomolar concentrations.
Zhang Y, Wu J, Fu Y, Yu R, Su H, Zheng Q, Wu H, Zhou S, Wang K, Zhao J, Shen S, Xu G, Wang L, Yan C, Zou X, Lv Y, Zhang S
Oncogene 2022 Jun;41(25):3394-3408
Oncogene 2022 Jun;41(25):3394-3408
FAdV-4 induce autophagy via the endoplasmic reticulum stress-related unfolded protein response.
Ma H, Ding Y, Du K, Chang K, Niu Y
Veterinary microbiology 2022 Jun;269:109388
Veterinary microbiology 2022 Jun;269:109388
Contribution of Endoplasmic Reticulum Stress to the Clinical Instability of Carotid Plaques in Human Carotid Stenosis.
Hosoda K, Imahori T, Tanaka K, Uno T, Nakai T, Kohta M, Fujita A, Sasayama T
Translational stroke research 2022 Jun;13(3):420-431
Translational stroke research 2022 Jun;13(3):420-431
Quinoa Reduces High-Fat Diet-Induced Obesity in Mice via Potential Microbiota-Gut-Brain-Liver Interaction Mechanisms.
Wang TY, Tao SY, Wu YX, An T, Lv BH, Liu JX, Liu YT, Jiang GJ
Microbiology spectrum 2022 Jun 29;10(3):e0032922
Microbiology spectrum 2022 Jun 29;10(3):e0032922
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, Di Renzo L, D'Orazi G, Cirone M
Cell death discovery 2022 Jun 25;8(1):295
Cell death discovery 2022 Jun 25;8(1):295
Intravenously transplanted mesenchymal stromal cells: a new endocrine reservoir for cardioprotection.
Huang A, Liu Y, Qi X, Chen S, Huang H, Zhang J, Han Z, Han ZC, Li Z
Stem cell research & therapy 2022 Jun 17;13(1):253
Stem cell research & therapy 2022 Jun 17;13(1):253
Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer.
Xiao R, You L, Zhang L, Guo X, Guo E, Zhao F, Yang B, Li X, Fu Y, Lu F, Wang Z, Liu C, Peng W, Li W, Yang X, Dou Y, Liu J, Wang W, Qin T, Cui Y, Zhang X, Li F, Jin Y, Zeng Q, Wang B, Mills GB, Chen G, Sheng X, Sun C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jul;9(21):e2105469
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jul;9(21):e2105469
Podophyllotoxin-combined 5-aminolevulinic acid photodynamic therapy significantly promotes HR-HPV-infected cell death.
Wang J, Wang Q, Chen P, Li Q, Li Z, Xu M, Zeng K, Li C
Photodermatology, photoimmunology & photomedicine 2022 Jul;38(4):343-353
Photodermatology, photoimmunology & photomedicine 2022 Jul;38(4):343-353
The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells.
Arena A, Romeo MA, Benedetti R, Gilardini Montani MS, Cirone M
Biochemical and biophysical research communications 2022 Jul 12;613:19-25
Biochemical and biophysical research communications 2022 Jul 12;613:19-25
GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis.
Ding K, Li X, Ren X, Ding N, Tao L, Dong X, Chen Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22119
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22119
TRPV4 contributes to ER stress and inflammation: implications for Parkinson's disease.
Liu N, Bai L, Lu Z, Gu R, Zhao D, Yan F, Bai J
Journal of neuroinflammation 2022 Jan 29;19(1):26
Journal of neuroinflammation 2022 Jan 29;19(1):26
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Cheng M, Yu H, Kong Q, Wang B, Shen L, Dong D, Sun L
International journal of molecular sciences 2022 Jan 25;23(3)
International journal of molecular sciences 2022 Jan 25;23(3)
Nrf2 loss of function exacerbates endoplasmic reticulum stress-induced apoptosis in TBI mice.
Sun G, Zhao Z, Lang J, Sun B, Zhao Q
Neuroscience letters 2022 Jan 23;770:136400
Neuroscience letters 2022 Jan 23;770:136400
Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation.
Gonnella R, Guttieri L, Gilardini Montani MS, Santarelli R, Bassetti E, D'Orazi G, Cirone M
Biology 2022 Jan 13;11(1)
Biology 2022 Jan 13;11(1)
Nrf2 activation mediates the protection of mouse Sertoli Cells damage under acute heat stress conditions.
He C, Sun J, Yang D, He W, Wang J, Qin D, Zhang H, Cai H, Liu Y, Li N, Hua J, Peng S
Theriogenology 2022 Jan 1;177:183-194
Theriogenology 2022 Jan 1;177:183-194
Inhibition of the miR-193b-3p protects against oxidized low-density lipoprotein-induced HUVECs injury by upregulating ALDH2.
Bai Y, Wang M, Yang Y, Liu X, Chen Q, Guo Z
Cell biology international 2022 Feb;46(2):192-202
Cell biology international 2022 Feb;46(2):192-202
Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpox(nct) mice.
Liu C, Miyahara H, Dai J, Cui X, Li Y, Kang X, Higuchi K, Mori M
Experimental eye research 2022 Feb;215:108905
Experimental eye research 2022 Feb;215:108905
Zinc Protects against Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells.
Xiong Y, Li J, He S
Biological trace element research 2022 Feb;200(2):728-739
Biological trace element research 2022 Feb;200(2):728-739
A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation.
Yin J, Wang J, Zhang X, Liao Y, Luo W, Wang S, Ding J, Huang J, Chen M, Wang W, Fang S, Chao J
Cell & bioscience 2022 Feb 25;12(1):21
Cell & bioscience 2022 Feb 25;12(1):21
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice.
Yang S, Hou Y, Zhang H, Hao Y, Zhang Y, Zhao Z, Ruan W, Duan X
Archives of biochemistry and biophysics 2022 Feb 15;716:109116
Archives of biochemistry and biophysics 2022 Feb 15;716:109116
Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma.
Bian M, Fan R, Yang Z, Chen Y, Xu Z, Lu Y, Liu W
Journal of medicinal chemistry 2022 Feb 10;65(3):1848-1866
Journal of medicinal chemistry 2022 Feb 10;65(3):1848-1866
Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy.
Sang J, Gan L, Zou MF, Lin ZJ, Fan RZ, Huang JL, Li W, Tang GH, Yin S
Cancer letters 2022 Feb 1;526:352-362
Cancer letters 2022 Feb 1;526:352-362
Endoplasmic reticulum stress mediates parathyroid hormone-induced apoptosis in vascular smooth muscle cells.
Duan S, Chen X, Liu Y, Guo W, Liu W
Renal failure 2022 Dec;44(1):126-136
Renal failure 2022 Dec;44(1):126-136
The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators.
Kaokhum N, Pinto-Fernández A, Wilkinson M, Kessler BM, Ismail HM
Molecular & cellular proteomics : MCP 2022 Dec;21(12):100419
Molecular & cellular proteomics : MCP 2022 Dec;21(12):100419
Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis.
Wang Y, Fan A, Lu L, Pan Z, Ma M, Luo S, Liu Z, Yang L, Cai J, Yin F
Biochemical pharmacology 2022 Dec;206:115343
Biochemical pharmacology 2022 Dec;206:115343
Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway.
Liu H, He S, Li C, Wang J, Zou Q, Liao Y, Chen R
Brain and behavior 2022 Dec;12(12):e2786
Brain and behavior 2022 Dec;12(12):e2786
Knockdown of TMEM160 leads to an increase in reactive oxygen species generation and the induction of the mitochondrial unfolded protein response.
Yamashita K, Haraguchi M, Yano M
FEBS open bio 2022 Dec;12(12):2179-2190
FEBS open bio 2022 Dec;12(12):2179-2190
Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells.
Zhou H, Zhuang W, Huang H, Ma N, Lei J, Jin G, Wu S, Zhou S, Zhao X, Lan L, Xia H, Shangguan F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154428
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154428
Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease.
Sun ZJ, Chang DY, Chen M, Zhao MH
JCI insight 2022 Dec 22;7(24)
JCI insight 2022 Dec 22;7(24)
African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α Pathway.
Zhong H, Fan S, Du Y, Zhang Y, Zhang A, Jiang D, Han S, Wan B, Zhang G
Microbiology spectrum 2022 Dec 21;10(6):e0328222
Microbiology spectrum 2022 Dec 21;10(6):e0328222
Diverse injury responses of human oligodendrocyte to mediators implicated in multiple sclerosis.
Pernin F, Luo JXX, Cui QL, Blain M, Fernandes MGF, Yaqubi M, Srour M, Hall J, Dudley R, Jamann H, Larochelle C, Zandee SEJ, Prat A, Stratton JA, Kennedy TE, Antel JP
Brain : a journal of neurology 2022 Dec 19;145(12):4320-4333
Brain : a journal of neurology 2022 Dec 19;145(12):4320-4333
Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function.
Jang W, Puchkov D, Samsó P, Liang Y, Nadler-Holly M, Sigrist SJ, Kintscher U, Liu F, Mamchaoui K, Mouly V, Haucke V
Science (New York, N.Y.) 2022 Dec 16;378(6625):eabq5209
Science (New York, N.Y.) 2022 Dec 16;378(6625):eabq5209
Role of Ero1α in cognitive impairment induced by chronic hypoxia.
Zhang N, Shentu Y, Zhu M, Wang H, Yin X, Du C, Xue F, Fan J, Gong Y, Fan X
Brain research 2022 Dec 15;1797:148117
Brain research 2022 Dec 15;1797:148117
The IRE1/JNK signaling pathway regulates inflammation cytokines and production of glomerular extracellular matrix in the acute kidney injury to chronic kidney disease transition.
Liang Y, Qu L, Liu Z, Liang L, Wang Y, Quan S, Wang Y, Tang L
Molecular biology reports 2022 Aug;49(8):7709-7718
Molecular biology reports 2022 Aug;49(8):7709-7718
Sodium selenite attenuates zearalenone-induced apoptosis through inhibition of endoplasmic reticulum stress in goat trophoblast cells.
Xiong Y, Li B, Li J, Jin E, He S
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2022 Aug;35(4):699-710
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2022 Aug;35(4):699-710
Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells.
Wei W, Li Y, Wang C, Gao S, Zhao Y, Yang Z, Wang H, Gao Z, Jiang Y, He Y, Zhao L, Gao H, Yao X, Hu Y
Pharmacological research 2022 Aug;182:106285
Pharmacological research 2022 Aug;182:106285
LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis.
Wang S, Duan J, Liao J, Wang Y, Xiao X, Li L, Liu Y, Gu H, Yang P, Fu D, Du J, Li X, Shao M
Aging 2022 Aug 30;14(16):6809-6828
Aging 2022 Aug 30;14(16):6809-6828
Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells.
Yan Y, Huang J, Huan C, Li L, Li C
Metabolites 2022 Aug 27;12(9)
Metabolites 2022 Aug 27;12(9)
Azoramide ameliorated tachypacing-induced injury of atrial myocytes differentiated from human induced pluripotent stem cell by regulating endoplasmic reticulum stress.
Miao W, Shi J, Huang J, Lin Y, Cui C, Zhu Y, Zheng B, Li M, Jiang Q, Chen M
Stem cell research 2022 Apr;60:102686
Stem cell research 2022 Apr;60:102686
Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma.
Li B, Huang J, Liu J, He F, Wen F, Yang C, Wang W, Wu T, Zhao T, Yao J, Liu S, Qiu Y, Fang M, Zeng J, Wu Z
Bioorganic chemistry 2022 Apr;121:105651
Bioorganic chemistry 2022 Apr;121:105651
Citrinin-Induced Hepatotoxicity in Mice Is Regulated by the Ca(2+)/Endoplasmic Reticulum Stress Signaling Pathway.
Wu D, Yang C, Yang M, Wu Y, Mao Y, Zhou X, Wang J, Yuan Z, Wu J
Toxins 2022 Apr 6;14(4)
Toxins 2022 Apr 6;14(4)
RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway.
Luo R, Liang H, Zhang W, Li G, Zhao K, Hua W, Song Y, Yang C
Acta biochimica et biophysica Sinica 2022 Apr 25;54(4):524-536
Acta biochimica et biophysica Sinica 2022 Apr 25;54(4):524-536
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Cheng F, Dun Y, Cheng J, Ripley-Gonzalez JW, Jiang W, You B, Liu S
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Chlorogenic acid improves the intestinal barrier by relieving endoplasmic reticulum stress and inhibiting ROCK/MLCK signaling pathways.
Song L, Wu T, Zhang L, Wan J, Ruan Z
Food & function 2022 Apr 20;13(8):4562-4575
Food & function 2022 Apr 20;13(8):4562-4575
Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress.
Zeng HF, Xu J, Wang XL, Li SJ, Han ZY
Ecotoxicology and environmental safety 2022 Apr 15;235:113441
Ecotoxicology and environmental safety 2022 Apr 15;235:113441
Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.
Liu Z, Yan M, Lei W, Jiang R, Dai W, Chen J, Wang C, Li L, Wu M, Nian X, Li D, Sun D, Lv X, Wang C, Xie C, Yao L, Wu C, Hu J, Xiao N, Mo W, Wang Z, Zhang L
The Journal of clinical investigation 2022 Apr 1;132(7)
The Journal of clinical investigation 2022 Apr 1;132(7)
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Zhang XM, Gu YH, Deng H, Xu ZQ, Zhong ZY, Lyu XJ, Jin HM, Yang XH
Frontiers in cardiovascular medicine 2021;8:691336
Frontiers in cardiovascular medicine 2021;8:691336
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration.
Wang B, Ke W, Wang K, Li G, Ma L, Lu S, Xiang Q, Liao Z, Luo R, Song Y, Hua W, Wu X, Zhang Y, Zeng X, Yang C
Oxidative medicine and cellular longevity 2021;2021:8884922
Oxidative medicine and cellular longevity 2021;2021:8884922
Wenxin Granules Regulate Endoplasmic Reticulum Stress Unfolded Protein Response and Improve Ventricular Remodeling on Rats with Myocardial Infarction.
Liu K, Lv M, Ji X, Lou L, Nie B, Zhao J, Wu A, Zhao M
Evidence-based complementary and alternative medicine : eCAM 2021;2021:7375549
Evidence-based complementary and alternative medicine : eCAM 2021;2021:7375549
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Du Y, Zhong F, Cheng H, Li T, Chen Y, Tan P, Huang M, Liang T, Liu Y, Xia X, Fu W
Oxidative medicine and cellular longevity 2021;2021:4628050
Oxidative medicine and cellular longevity 2021;2021:4628050
Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress.
Liu Z, Fei B, Xie L, Liu J, Chen X, Zhu W, Lv L, Ma W, Gao Z, Hou J, She W
Open life sciences 2021;16(1):695-702
Open life sciences 2021;16(1):695-702
Magnesium-Assisted Cisplatin Inhibits Bladder Cancer Cell Survival by Modulating Wnt/β-Catenin Signaling Pathway.
Li T, Tang Z, Li C, Liu X, Cheng L, Yang Z, Zhu X, Liu W, Huang Y
Frontiers in pharmacology 2021;12:804615
Frontiers in pharmacology 2021;12:804615
Interventional Efects of the Topical of "Sanse Powder" Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis.
Liu Z, Liao T, Yang N, Ding L, Li X, Wu P, Wang P
Frontiers in pharmacology 2021;12:739644
Frontiers in pharmacology 2021;12:739644
IL-6/STAT3 Induced Neuron Apoptosis in Hypoxia by Downregulating ATF6 Expression.
Zhou S, Zhong Z, Huang P, Xiang B, Li X, Dong H, Zhang G, Wu Y, Li P
Frontiers in physiology 2021;12:729925
Frontiers in physiology 2021;12:729925
Extracts of Vine Tea Improve Diet-Induced Non-Alcoholic Steatohepatitis Through AMPK-LXRα Signaling.
Chen YJ, Song HY, Zhang ZW, Chen Q, Tang ZP, Gu M
Frontiers in pharmacology 2021;12:711763
Frontiers in pharmacology 2021;12:711763
Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor α-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway.
Xiang H, Shao M, Lu Y, Wang J, Wu T, Ji G
Frontiers in pharmacology 2021;12:690736
Frontiers in pharmacology 2021;12:690736
Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis.
Xu J, Tang Z, He Y, Cai S, Wang B, Zhang S, Wu M, Qian K, Zhang K, Chai B, Chen G, Xu K, Ji H, Xiao J, Wu Y
Frontiers in pharmacology 2021;12:628950
Frontiers in pharmacology 2021;12:628950
Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.
Zhao L, Li H, Gao Q, Xu J, Zhu Y, Zhai M, Zhang P, Shen N, Di Y, Wang J, Chen T, Huang M, Sun J, Liu C
Frontiers in pharmacology 2021;12:609693
Frontiers in pharmacology 2021;12:609693
Lamprey Immune Protein Mediates Apoptosis of Lung Cancer Cells Via the Endoplasmic Reticulum Stress Signaling Pathway.
Song X, Xu X, Lu J, Chi X, Pang Y, Li Q
Frontiers in oncology 2021;11:663600
Frontiers in oncology 2021;11:663600
Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine.
Zheng Y, Zhang B, Guan H, Jiao X, Yang J, Cai J, Liu Q, Zhang Z
BioFactors (Oxford, England) 2021 Sep;47(5):788-800
BioFactors (Oxford, England) 2021 Sep;47(5):788-800
Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway.
Dong JY, Xia KJ, Liang W, Liu LL, Yang F, Fang XS, Xiong YJ, Wang L, Zhou ZJ, Li CY, Zhang WD, Wang JY, Chen DP
Acta pharmacologica Sinica 2021 Sep;42(9):1461-1471
Acta pharmacologica Sinica 2021 Sep;42(9):1461-1471
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment.
Ren X, Lv J, Fu Y, Zhang N, Zhang C, Dong Z, Chudhary M, Zhong S, Kong L, Kong H
Diabetes research and clinical practice 2021 Sep;179:109025
Diabetes research and clinical practice 2021 Sep;179:109025
Role of UPR Sensor Activation in Cell Death-Survival Decision of Colon Cancer Cells Stressed by DPE Treatment.
Benedetti R, Gilardini Montani MS, Romeo MA, Arena A, Santarelli R, D'Orazi G, Cirone M
Biomedicines 2021 Sep 18;9(9)
Biomedicines 2021 Sep 18;9(9)
Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH.
Zeng H, Chen H, Li M, Zhuang J, Peng Y, Zhou H, Xu C, Yu Q, Fu X, Cao S, Cai J, Yan F, Chen G
Journal of neuroinflammation 2021 Sep 16;18(1):210
Journal of neuroinflammation 2021 Sep 16;18(1):210
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Sun Y, Zhang L, Lu B, Wen J, Wang M, Zhang S, Li Q, Shu F, Lu F, Liu N, Peng S, Zhao Y, Dong S, Lu F, Zhang W, Wang Y
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Expression liabilities in a four-chain bispecific molecule.
Guo C, Chen F, Xiao Q, Catterall HB, Robinson JH, Wang Z, Mock M, Hubert R
Biotechnology and bioengineering 2021 Oct;118(10):3744-3759
Biotechnology and bioengineering 2021 Oct;118(10):3744-3759
CK1δ stimulates ubiquitination-dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer.
Feng L, Li M, Hu X, Li Y, Zhu L, Chen M, Wei Q, Xu W, Zhou Q, Wang W, Chen D, Wang X, Jin H
Clinical and translational medicine 2021 Oct;11(10):e587
Clinical and translational medicine 2021 Oct;11(10):e587
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation.
Feng T, Wang J, Cheng K, Lu Q, Zhao R, Wang S, Zhang Q, Ge L, Pan J, Song G, Wang L
Cancer biology & medicine 2021 Oct 18;19(7):1008-28
Cancer biology & medicine 2021 Oct 18;19(7):1008-28
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Tan X, Cai D, Chen N, Du S, Qiao D, Yue X, Wang T, Li J, Xie W, Wang H
Toxicology letters 2021 Oct 10;350:98-110
Toxicology letters 2021 Oct 10;350:98-110
2-Amino-3-Methylimidazo[4,5-f]quinoline Triggering Liver Damage by Inhibiting Autophagy and Inducing Endoplasmic Reticulum Stress in Zebrafish (Danio rerio).
Li D, Li Z, Zhang T, Peng B, Zhang Y, Sun H, Wang S
Toxins 2021 Nov 22;13(11)
Toxins 2021 Nov 22;13(11)
TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement.
de Vicente LG, Muñoz VR, Pinto AP, Rovina RL, da Rocha AL, Marafon BB, Tavares MEA, Teixeira GR, Ferrari GD, Alberici LC, Frantz FG, Simabuco FM, Ropelle ER, de Moura LP, Cintra DE, Pauli JR, da Silva ASR
Life sciences 2021 Nov 15;285:119988
Life sciences 2021 Nov 15;285:119988
Suppression of alveolar bone resorption by salubrinal in a mouse model of periodontal disease.
Kimura F, Miyazawa K, Hamamura K, Tabuchi M, Sato T, Asano Y, Kako S, Aoki Y, Sugita Y, Maeda H, Togari A, Goto S
Life sciences 2021 Nov 1;284:119938
Life sciences 2021 Nov 1;284:119938
Autophagy triggers endoplasmic reticulum stress and C/EBP homologous protein-mediated apoptosis in OGD/R-treated neurons in a caspase-12-independent manner.
Tian Y, Wang L, Qiu Z, Xu Y, Hua R
Journal of neurophysiology 2021 Nov 1;126(5):1740-1750
Journal of neurophysiology 2021 Nov 1;126(5):1740-1750
The seed oil of Paeonia ludlowii ameliorates Aβ25-35-induced Alzheimer's disease in rats.
Lu YZ, Zhang CQ, Yu BX, Zhang EH, Quan H, Yin X, Cai H, Yuan F, Li LQ, Xu YJ, Su YJ, Xing YJ, Liao ZH, Lan XZ
Food science & nutrition 2021 May;9(5):2402-2413
Food science & nutrition 2021 May;9(5):2402-2413
Near-infrared emission Cu, N-doped carbon dots for human umbilical vein endothelial cell labeling and their biocompatibility in vitro.
Zhu P, Zhang T, Li J, Ma J, Ouyang X, Zhao X, Xu M, Wang D, Xu Q
Journal of applied toxicology : JAT 2021 May;41(5):789-798
Journal of applied toxicology : JAT 2021 May;41(5):789-798
PGE2 Released by Pancreatic Cancer Cells Undergoing ER Stress Transfers the Stress to DCs Impairing Their Immune Function.
Gilardini Montani MS, Benedetti R, Piconese S, Pulcinelli FM, Timperio AM, Romeo MA, Masuelli L, Mattei M, Bei R, D'Orazi G, Cirone M
Molecular cancer therapeutics 2021 May;20(5):934-945
Molecular cancer therapeutics 2021 May;20(5):934-945
Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression.
Pethő D, Hendrik Z, Nagy A, Beke L, Patsalos A, Nagy L, Póliska S, Méhes G, Tóth C, Potor L, Eaton JW, Jacob HS, Balla G, Balla J, Gáll T
Scientific reports 2021 May 17;11(1):10435
Scientific reports 2021 May 17;11(1):10435
Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice.
Xin Y, Xu L, Zhang X, Yang C, Wang Q, Xiong X
Biochemical and biophysical research communications 2021 Mar 12;544:44-51
Biochemical and biophysical research communications 2021 Mar 12;544:44-51
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.
Liu X, Chen A, Liang Q, Yang X, Dong Q, Fu M, Wang S, Li Y, Ye Y, Lan Z, Chen Y, Ou JS, Yang P, Lu L, Yan J
Aging cell 2021 Jun;20(6):e13377
Aging cell 2021 Jun;20(6):e13377
4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation.
Yen IC, Tu QW, Chang TC, Lin PH, Li YF, Lee SY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111504
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111504
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Zhu Q, Liu Z, Wang Y, Song E, Song Y
Journal of hazardous materials 2021 Jun 5;411:124958
Journal of hazardous materials 2021 Jun 5;411:124958
Combination of Palmitic Acid and Methylseleninic Acid Induces Mitochondria-Dependent Apoptosis via Attenuation of the IRE1α Arm and Enhancement of CHOP in Hepatoma.
Zhang H, Zheng Y, Han D, Lu J, Yin S, Hu H, Zhao C
ACS omega 2021 Jun 22;6(24):15708-15715
ACS omega 2021 Jun 22;6(24):15708-15715
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.
Sun S, Duan Z, Wang X, Chu C, Yang C, Chen F, Wang D, Wang C, Li Q, Ding W
Cell death & disease 2021 Jun 11;12(6):606
Cell death & disease 2021 Jun 11;12(6):606
Polybrominated diphenyl ethers quinone-induced intracellular protein oxidative damage triggers ubiquitin-proteasome and autophagy-lysosomal system activation in LO2 cells.
Wang Y, Xu L, Peng L, Fang C, Qin Q, Lv X, Liu Z, Yang B, Song E, Song Y
Chemosphere 2021 Jul;275:130034
Chemosphere 2021 Jul;275:130034
Comparison of multi-walled carbon nanotubes and halloysite nanotubes on lipid profiles in human umbilical vein endothelial cells.
Liu Y, Hu Q, Huang C, Cao Y
NanoImpact 2021 Jul;23:100333
NanoImpact 2021 Jul;23:100333
Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung.
Wang Z, Ma P, Wang Y, Hou B, Zhou C, Tian H, Li B, Shui G, Yang X, Qiang G, Yin C, Du G
Scientific reports 2021 Jul 19;11(1):14680
Scientific reports 2021 Jul 19;11(1):14680
Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis.
Al-Yacoub N, Colak D, Mahmoud SA, Hammonds M, Muhammed K, Al-Harazi O, Assiri AM, Al-Buraiki J, Al-Habeeb W, Poizat C
Communications biology 2021 Jul 16;4(1):884
Communications biology 2021 Jul 16;4(1):884
Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells.
Sang J, Li W, Diao HJ, Fan RZ, Huang JL, Gan L, Zou MF, Tang GH, Yin S
Cancer letters 2021 Jul 1;509:13-25
Cancer letters 2021 Jul 1;509:13-25
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
Arioka Y, Shishido E, Kushima I, Suzuki T, Saito R, Aiba A, Mori D, Ozaki N
EBioMedicine 2021 Jan;63:103138
EBioMedicine 2021 Jan;63:103138
Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing.
Lai YH, Lee PY, Lu CY, Liu YR, Wang SC, Liu CC, Chang YC, Chen YH, Su CC, Li CY, Liu PL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21200
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21200
Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells.
Hong X, Li ZX, Hou J, Zhang HY, Zhang CY, Zhang J, Sun H, Pang LH, Wang T, Deng ZH
BMC cancer 2021 Jan 7;21(1):33
BMC cancer 2021 Jan 7;21(1):33
Autophagy impairment as a key feature for acetaminophen-induced ototoxicity.
Zhao T, Zheng T, Yu H, Hu BH, Hu B, Ma P, Yang Y, Yang N, Hu J, Cao T, Chen G, Yan B, Peshoff M, Hatzoglou M, Geng R, Li B, Zheng QY
Cell death & disease 2021 Jan 4;12(1):3
Cell death & disease 2021 Jan 4;12(1):3
MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-κB pathway in LPS-challenged HUVECs and septic mice.
Liu L, Yan LN, Sui Z
Life sciences 2021 Jan 15;265:118744
Life sciences 2021 Jan 15;265:118744
Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice.
Jin H, Hou J, Meng X, Ma T, Wang B, Liu Z, Sha X, Ding J, Han X
Ecotoxicology and environmental safety 2021 Jan 15;208:111748
Ecotoxicology and environmental safety 2021 Jan 15;208:111748
Cytosolic PINK1 orchestrates protein translation during proteasomal stress by phosphorylating the translation elongation factor eEF1A1.
Qin S, Ye L, Zheng Y, Gao J
FEBS letters 2021 Feb;595(4):507-520
FEBS letters 2021 Feb;595(4):507-520
Boron Attenuates Heat Stress-Induced Apoptosis by Inhibiting Endoplasmic Reticulum Stress in Mouse Granulosa Cells.
Xiong Y, Jin E, Yin Q, Che C, He S
Biological trace element research 2021 Feb;199(2):611-621
Biological trace element research 2021 Feb;199(2):611-621
Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin.
Xu Y, Yu J, Ma C, Gong Z, Wu X, Deng G
Molecular immunology 2021 Feb;130:85-95
Molecular immunology 2021 Feb;130:85-95
AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo.
Ribas VT, Vahsen BF, Tatenhorst L, Estrada V, Dambeck V, Almeida RA, Bähr M, Michel U, Koch JC, Müller HW, Lingor P
Cell death & disease 2021 Feb 26;12(2):213
Cell death & disease 2021 Feb 26;12(2):213
Cigarette smoke extracts induce apoptosis in Raw264.7 cells via endoplasmic reticulum stress and the intracellular Ca(2+)/P38/STAT1 pathway.
Feng H, Li M, Altawil A, Yin Y, Zheng R, Kang J
Toxicology in vitro : an international journal published in association with BIBRA 2021 Dec;77:105249
Toxicology in vitro : an international journal published in association with BIBRA 2021 Dec;77:105249
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis.
Liu YN, Mu YD, Wang H, Zhang M, Shi YW, Mi G, Peng LX, Chen JH
Toxicology 2021 Dec;464:152989
Toxicology 2021 Dec;464:152989
Reticulocalbin 1 is required for proliferation and migration of non-small cell lung cancer cells regulated by osteoblast-conditioned medium.
Fu H, Chen R, Wang Y, Xu Y, Xia C, Zhang B
Journal of cellular and molecular medicine 2021 Dec;25(24):11198-11211
Journal of cellular and molecular medicine 2021 Dec;25(24):11198-11211
Sinapic acid attenuates muscle atrophy in streptozotocin-induced diabetic mice.
Xianchu L, Ming L, Changhao C, Beiwang D, Jingtao X
Iranian journal of basic medical sciences 2021 Dec;24(12):1695-1701
Iranian journal of basic medical sciences 2021 Dec;24(12):1695-1701
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome.
Huang L, Liu Q, Zhou T, Zhang J, Tian Q, Zhang Q, Wei W, Wu H
International immunopharmacology 2021 Dec;101(Pt A):108281
International immunopharmacology 2021 Dec;101(Pt A):108281
Mannan-binding lectin deficiency augments hepatic endoplasmic reticulum stress through IP3R-controlled calcium release.
Chen Y, Hu M, Deng F, Wang P, Lin J, Zheng Z, Liu Y, Dong L, Lu X, Chen Z, Zhou J, Zuo D
Cell calcium 2021 Dec;100:102477
Cell calcium 2021 Dec;100:102477
Long non-coding RNA RP5-821D11.7 promotes proliferation, migration, and epithelial-mesenchymal transition in glioma and glioma stem-like cells.
Younis M, Shaikh S, Shahzad KA
Progress in biophysics and molecular biology 2021 Dec 21;
Progress in biophysics and molecular biology 2021 Dec 21;
Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity.
Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, Oyadomari M, Kiyonari H, Oyadomari S
iScience 2021 Dec 17;24(12):103448
iScience 2021 Dec 17;24(12):103448
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca(2+) Homeostasis, and Bcl2 Expression.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Zhang Y, Peng X
Molecular nutrition & food research 2021 Aug;65(15):e2001202
Molecular nutrition & food research 2021 Aug;65(15):e2001202
Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis.
Chen M, Huang L, Lv Y, Li L, Dong Q
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Integration of Metabolomics and Transcriptomics Reveals Ketone Body and Lipid Metabolism Disturbance Related to ER Stress in the Liver.
Ma P, Wang Z, Wang Y, Hou B, Sun J, Tian H, Li B, Shui G, Yang X, Yang X, Qiang G, Liew CW, Du G
Journal of proteome research 2021 Aug 6;20(8):3875-3888
Journal of proteome research 2021 Aug 6;20(8):3875-3888
KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats.
Iwai S, Ikeda HO, Mera H, Nishitani K, Saito M, Tsujikawa A, Kakizuka A
Scientific reports 2021 Aug 2;11(1):15651
Scientific reports 2021 Aug 2;11(1):15651
Estrogen Regulates Endoplasmic Reticulum Stress-Mediated Apoptosis by ERK-p65 Pathway to Promote Endometrial Angiogenesis.
Zhang Y, Cao C, Du S, Fan L, Zhang D, Wang X, He M
Reproductive sciences (Thousand Oaks, Calif.) 2021 Apr;28(4):1216-1226
Reproductive sciences (Thousand Oaks, Calif.) 2021 Apr;28(4):1216-1226
ARFGAP1 binds to classical swine fever virus NS5A protein and enhances CSFV replication in PK-15 cells.
Zhang L, Jin M, Song M, Liu S, Wang T, Guo K, Zhang Y
Veterinary microbiology 2021 Apr;255:109034
Veterinary microbiology 2021 Apr;255:109034
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Fu N, Li D, Li W, Zhao W, Zhang S, Liu L, Zhao S, Du J, Kong L, Wang R, Zhang Y, Nan Y
Frontiers in molecular biosciences 2020;7:199
Frontiers in molecular biosciences 2020;7:199
Antrodia Cinnamomea Attenuates Non-Alcoholic Steatohepatitis by Suppressing NLRP3 Inflammasome Activation In Vitro and In Vivo.
Yen IC, Lin JC, Chen Y, Tu QW, Lee SY
The American journal of Chinese medicine 2020;48(8):1859-1874
The American journal of Chinese medicine 2020;48(8):1859-1874
Methane-Rich Saline Alleviates CA/CPR Brain Injury by Inhibiting Oxidative Stress, Microglial Activation-Induced Inflammatory Responses, and ER Stress-Mediated Apoptosis.
Cui R, Liu S, Wang C, Liu T, Ren J, Jia Y, Tong Y, Liu C, Zhang J
Oxidative medicine and cellular longevity 2020;2020:8829328
Oxidative medicine and cellular longevity 2020;2020:8829328
Topical Application of Fibroblast Growth Factor 10-PLGA Microsphere Accelerates Wound Healing via Inhibition of ER Stress.
Xu K, Chai B, Zhang K, Xiong J, Zhu Y, Xu J, An N, Xia W, Ji H, Wu Y, Li H, Xiao J, Feng Z, Zhang H
Oxidative medicine and cellular longevity 2020;2020:8586314
Oxidative medicine and cellular longevity 2020;2020:8586314
Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation.
Hamada Y, Furumoto Y, Izutani A, Taniuchi S, Miyake M, Oyadomari M, Teranishi K, Shimomura N, Oyadomari S
PloS one 2020;15(3):e0229948
PloS one 2020;15(3):e0229948
Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway.
Li L, Peng X, Guo L, Zhao Y, Cheng Q
International journal of clinical and experimental pathology 2020;13(5):964-971
International journal of clinical and experimental pathology 2020;13(5):964-971
Chlorin A-mediated photodynamic therapy induced apoptosis in human cholangiocarcinoma cells via impaired autophagy flux.
He C, Xia J, Gao Y, Chen Z, Wan X
American journal of translational research 2020;12(9):5080-5094
American journal of translational research 2020;12(9):5080-5094
Role of Endoplasmic Reticulum Stress in Otitis Media.
Zhao H, Wang Y, Li B, Zheng T, Liu X, Hu BH, Che J, Zhao T, Chen J, Hatzoglou M, Zhang X, Fan Z, Zheng Q
Frontiers in genetics 2020;11:495
Frontiers in genetics 2020;11:495
Maimendong Decoction Improves Pulmonary Function in Rats With Idiopathic Pulmonary Fibrosis by Inhibiting Endoplasmic Reticulum Stress in AECIIs.
Shen M, Nan Y, Zhang L, Di L, He S, Li Y, Li Y
Frontiers in pharmacology 2020;11:1262
Frontiers in pharmacology 2020;11:1262
EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.
Chen T, Xu J, Fu W
Frontiers in oncology 2020;10:1688
Frontiers in oncology 2020;10:1688
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.
Yang Z, Huang R, Wei X, Yu W, Min Z, Ye M
Frontiers in oncology 2020;10:1265
Frontiers in oncology 2020;10:1265
Apigetrin ameliorates streptozotocin-induced pancreatic β-cell damages via attenuating endoplasmic reticulum stress.
Zhang R, Shi J, Wang T, Qiu X, Liu R, Li Y, Gao Q, Wang N
In vitro cellular & developmental biology. Animal 2020 Sep;56(8):622-634
In vitro cellular & developmental biology. Animal 2020 Sep;56(8):622-634
A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells.
Jain Goyal M, Zhao X, Bozhinova M, Andrade-López K, de Heus C, Schulze-Dramac S, Müller-McNicoll M, Klumperman J, Béthune J
Life science alliance 2020 Sep;3(9)
Life science alliance 2020 Sep;3(9)
Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Liu Y, Wen D, Gao J, Xie B, Yu H, Shen Q, Zhang J, Jing W, Cong B, Ma C
Brain research bulletin 2020 Sep;162:73-83
Brain research bulletin 2020 Sep;162:73-83
Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy.
Pang X, Qiao Q, Vonglorkham S, Feng Z, Pang L, Chen S, Wang D, Lao L, Lin X, Wei J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110375
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110375
Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.
Yang L, Zhou X, Sun J, Lei Q, Wang Q, Pan D, Ding M, Ding Y
Cell death & disease 2020 Sep 17;11(9):766
Cell death & disease 2020 Sep 17;11(9):766
Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress.
Yao X, Li K, Liang C, Zhou Z, Wang J, Wang S, Liu L, Yu CL, Song ZB, Bao YL, Zheng LH, Sun Y, Wang G, Huang Y, Yi J, Sun L, Li Y
The Journal of biological chemistry 2020 Sep 11;295(37):12975-12992
The Journal of biological chemistry 2020 Sep 11;295(37):12975-12992
Lycopene protects neuroblastoma cells against oxidative damage via depression of ER stress.
Ou S, Fang Y, Tang H, Wu T, Chen L, Jiang M, Zhou L, Xu J, Guo K
Journal of food science 2020 Oct;85(10):3552-3561
Journal of food science 2020 Oct;85(10):3552-3561
FABP4 inhibitor BMS309403 protects against hypoxia-induced H9c2 cardiomyocyte apoptosis through attenuating endoplasmic reticulum stress.
Sun F, Du J, Li H, Hao S, Zhao G, Lu F
Journal of cellular and molecular medicine 2020 Oct;24(19):11188-11197
Journal of cellular and molecular medicine 2020 Oct;24(19):11188-11197
Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.
Song Q, He Z, Li B, Liu J, Liu L, Liao W, Xiong Y, Song C, Yang S, Liu Y
Cell cycle (Georgetown, Tex.) 2020 Oct;19(20):2600-2610
Cell cycle (Georgetown, Tex.) 2020 Oct;19(20):2600-2610
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
Xiong Y, Xin DQ, Hu Q, Wang LX, Qiu J, Yuan HT, Chu XL, Liu DX, Li G, Wang Z
Neural regeneration research 2020 Oct;15(10):1920-1930
Neural regeneration research 2020 Oct;15(10):1920-1930
T-type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation.
Chen M, Li S, Hao M, Chen J, Zhao Z, Hong S, Min J, Tang J, Hu M, Hong L
FEBS open bio 2020 Oct;10(10):2122-2136
FEBS open bio 2020 Oct;10(10):2122-2136
Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE(-/-) mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage.
Ma R, Qi Y, Zhao X, Li X, Sun X, Niu P, Li Y, Guo C, Chen R, Sun Z
Particle and fibre toxicology 2020 Oct 2;17(1):50
Particle and fibre toxicology 2020 Oct 2;17(1):50
Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.
Li B, Yao J, Guo K, He F, Chen K, Lin Z, Liu S, Huang J, Wu Q, Fang M, Zeng J, Wu Z
European journal of medicinal chemistry 2020 Oct 15;204:112608
European journal of medicinal chemistry 2020 Oct 15;204:112608
Aging is associated with increased TRB3, ER stress, and hepatic glucose production in the liver of rats.
Gaspar RC, Muñoz VR, Nakandakari SCBR, Vieira RFL, da Conceição LR, de Oliveira F, Crisol BM, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Zaghloul I, Mekary RA, Pauli JR
Experimental gerontology 2020 Oct 1;139:111021
Experimental gerontology 2020 Oct 1;139:111021
Knockdown of fatty acid binding protein 4 exacerbates Bacillus Calmette-Guerin infection-induced RAW264.7 cell apoptosis via the endoplasmic reticulum stress pathway.
Yu J, Ma C, Xu Y, Han L, Wu X, Wang Y, Deng G
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2020 Nov;85:104552
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2020 Nov;85:104552
TRPV4 contributes to ER stress: Relation to apoptosis in the MPP(+)-induced cell model of Parkinson's disease.
Liu N, Liu J, Wen X, Bai L, Shao R, Bai J
Life sciences 2020 Nov 15;261:118461
Life sciences 2020 Nov 15;261:118461
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy.
Wu J, Wu Y, Lian X
Biology open 2020 Nov 12;9(11)
Biology open 2020 Nov 12;9(11)
Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis.
Sun X, Liu H, Sun Z, Zhang B, Wang X, Liu T, Pan T, Gao Y, Jiang X, Li H
Molecular medicine (Cambridge, Mass.) 2020 Nov 10;26(1):105
Molecular medicine (Cambridge, Mass.) 2020 Nov 10;26(1):105
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Pyruvate alleviates high glucose-induced endoplasmic reticulum stress and apoptosis in HK-2 cells.
Zhang XM, Wang YZ, Tong JD, Ning XC, Zhou FQ, Yang XH, Jin HM
FEBS open bio 2020 May;10(5):827-834
FEBS open bio 2020 May;10(5):827-834
Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling.
Yao Y
Molecular medicine reports 2020 Mar;21(3):1059-1070
Molecular medicine reports 2020 Mar;21(3):1059-1070
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
Wang F, Liu L, Tong Y, Li L, Liu Y, Gao WQ
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):541-550
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):541-550
A novel splice site indel alteration in the EIF2AK3 gene is responsible for the first cases of Wolcott-Rallison syndrome in Hungary.
Sümegi A, Hendrik Z, Gáll T, Felszeghy E, Szakszon K, Antal-Szalmás P, Beke L, Papp Á, Méhes G, Balla J, Balla G
BMC medical genetics 2020 Mar 27;21(1):61
BMC medical genetics 2020 Mar 27;21(1):61
Astrocyte elevated gene 1 (AEG-1) promotes anoikis resistance and metastasis by inducing autophagy in hepatocellular carcinoma.
Zhu HD, Liu L, Deng H, Li ZB, Sheng JQ, He XX, Tian DA, Li PY
Journal of cellular physiology 2020 Jun;235(6):5084-5095
Journal of cellular physiology 2020 Jun;235(6):5084-5095
Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum.
Tang L, Ren X, Han Y, Chen L, Meng X, Zhang C, Chu H, Kong L, Ma H
Neurochemistry international 2020 Jun;136:104728
Neurochemistry international 2020 Jun;136:104728
Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation.
Yuan F, Jiang H, Yin H, Jiang X, Jiao F, Chen S, Ying H, Chen Y, Zhai Q, Guo F
Nature communications 2020 Jun 5;11(1):2847
Nature communications 2020 Jun 5;11(1):2847
Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes.
Chen KY, Chen YJ, Cheng CJ, Jhan KY, Wang LC
Parasites & vectors 2020 Jun 18;13(1):317
Parasites & vectors 2020 Jun 18;13(1):317
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Wang Y, Li C, Li J, Wang G, Li L
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Circulating Exosomes From Lipopolysaccharide-Induced Ards Mice Trigger Endoplasmic Reticulum Stress in Lung Tissue.
Tang X, Yu Q, Wen X, Qi D, Peng J, He J, Deng W, Zhu T, Zhao Y, Wang D
Shock (Augusta, Ga.) 2020 Jul;54(1):110-118
Shock (Augusta, Ga.) 2020 Jul;54(1):110-118
4-Phenylbutyrate Prevents Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Heatstroke in the Intestines of Mice.
Cao Y, Liu Z, Xiao W, Gu Z, Xiao G, Yuan F, Chen F, Pei Y, Li H, Su L
Shock (Augusta, Ga.) 2020 Jul;54(1):102-109
Shock (Augusta, Ga.) 2020 Jul;54(1):102-109
ALA protects against ERS-mediated apoptosis in a cochlear cell model with low citrate synthase expression.
Xu A, Shang W, Wang Y, Sun X, Zhou B, Xie Y, Xu X, Liu T, Han F
Archives of biochemistry and biophysics 2020 Jul 30;688:108402
Archives of biochemistry and biophysics 2020 Jul 30;688:108402
TMEM216 Deletion Causes Mislocalization of Cone Opsin and Rhodopsin and Photoreceptor Degeneration in Zebrafish.
Liu Y, Cao S, Yu M, Hu H
Investigative ophthalmology & visual science 2020 Jul 1;61(8):24
Investigative ophthalmology & visual science 2020 Jul 1;61(8):24
Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover.
Fu J, Nchambi KM, Wu H, Luo X, An X, Liu D
Life sciences 2020 Jul 1;252:117648
Life sciences 2020 Jul 1;252:117648
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
Minocycline induces apoptosis of photoreceptor cells by regulating ER stress.
Xu W, Tao M, Hu Z, Chang T, Wang Y
Experimental eye research 2020 Jan;190:107887
Experimental eye research 2020 Jan;190:107887
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Dong Y, Xing Y, Sun J, Sun W, Xu Y, Quan C
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells.
Xiong Y, Yin Q, Jin E, Chen H, He S
Molecules (Basel, Switzerland) 2020 Jan 28;25(3)
Molecules (Basel, Switzerland) 2020 Jan 28;25(3)
MCP-1 mediates ischemia-reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR.
Zhang W, Zhu T, Chen L, Luo W, Chao J
American journal of physiology. Heart and circulatory physiology 2020 Jan 1;318(1):H59-H71
American journal of physiology. Heart and circulatory physiology 2020 Jan 1;318(1):H59-H71
N-glycosylation of uterine endometrium determines its receptivity.
Yu M, Qin H, Wang H, Liu J, Liu S, Yan Q
Journal of cellular physiology 2020 Feb;235(2):1076-1089
Journal of cellular physiology 2020 Feb;235(2):1076-1089
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, Sun Y, Du H, Wang B, Chen J, Dong S, Lu F, Zhang W
British journal of pharmacology 2020 Feb;177(4):836-856
British journal of pharmacology 2020 Feb;177(4):836-856
Oxidative Stress and Endoplasmic Reticulum Stress Are Involved in the Protective Effect of Alpha Lipoic Acid Against Heat Damage in Chicken Testes.
Xiong Y, Yin Q, Li J, He S
Animals : an open access journal from MDPI 2020 Feb 27;10(3)
Animals : an open access journal from MDPI 2020 Feb 27;10(3)
Melatonin protects against Epirubicin-induced ovarian damage.
Wang N, Li H, Zhu Y, Li N, Chen ZJ, Zhang C
The Journal of reproduction and development 2020 Feb 14;66(1):19-27
The Journal of reproduction and development 2020 Feb 14;66(1):19-27
Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases.
Wang Y, Su NX, Pan SG, Ge XP, Dai XP
Pharmaceutical biology 2020 Dec;58(1):878-885
Pharmaceutical biology 2020 Dec;58(1):878-885
Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress.
Gou W, Luo N, Wei H, Wu H, Yu X, Duan Y, Bi C, Ning H, Hou W, Li Y
Pharmaceutical biology 2020 Dec;58(1):707-715
Pharmaceutical biology 2020 Dec;58(1):707-715
Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.
You H, Jin Y, Kang J, Mao Y, Su J, Sun L, Wang L, Meng H
Bioengineered 2020 Dec;11(1):1058-1070
Bioengineered 2020 Dec;11(1):1058-1070
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Aras S, Purandare N, Gladyck S, Somayajulu-Nitu M, Zhang K, Wallace DC, Grossman LI
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner.
Li J, Li X, Liu D, Zhang S, Tan N, Yokota H, Zhang P
Cell death & disease 2020 Dec 14;11(12):1069
Cell death & disease 2020 Dec 14;11(12):1069
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, Wang J, Sun L
IUBMB life 2020 Aug;72(8):1659-1679
IUBMB life 2020 Aug;72(8):1659-1679
The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes.
Wang J, Zheng B, Yang S, Tang X, Wang J, Wei D
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Aug;69(8):779-787
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Aug;69(8):779-787
Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21(Cip1) and p27(Kip1).
Zhang D, Fan R, Lei L, Lei L, Wang Y, Lv N, Chen P, Williamson RA, Wang B, Hu J
Journal of cellular and molecular medicine 2020 Aug;24(16):9428-9438
Journal of cellular and molecular medicine 2020 Aug;24(16):9428-9438
Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol.
Wang TE, Lai YH, Yang KC, Lin SJ, Chen CL, Tsai PS
Antioxidants (Basel, Switzerland) 2020 Aug 9;9(8)
Antioxidants (Basel, Switzerland) 2020 Aug 9;9(8)
IL13Rα1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes.
Yang X, Guo Q, Feng T, Lu Q, Ge L, Pan J, Bi K, Qiao L, Tian L, Xie T, Yao C, Song G, Wang L
Arthritis research & therapy 2020 Aug 8;22(1):184
Arthritis research & therapy 2020 Aug 8;22(1):184
25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress.
Dong Q, Chen Y, Liu W, Liu X, Chen A, Yang X, Li Y, Wang S, Fu M, Ou JS, Lu L, Yan J
European journal of pharmacology 2020 Aug 5;880:173165
European journal of pharmacology 2020 Aug 5;880:173165
Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats.
Song L, Piao Z, Yao L, Zhang L, Lu Y
Experimental animals 2020 Aug 5;69(3):363-373
Experimental animals 2020 Aug 5;69(3):363-373
N6-(2-hydroxyethyl)-Adenosine Induces Apoptosis via ER Stress and Autophagy of Gastric Carcinoma Cells In Vitro and In Vivo.
Xie H, Li X, Yang W, Yu L, Jiang X, Chen Y, Shen Z, Li C, Gu M, Shi L
International journal of molecular sciences 2020 Aug 13;21(16)
International journal of molecular sciences 2020 Aug 13;21(16)
Artemisinin and dihydroartemisinin promote β-cell apoptosis induced by palmitate via enhancing ER stress.
Chen K, Hua H, Zhu Z, Wu T, Jia Z, Liu Q
Apoptosis : an international journal on programmed cell death 2020 Apr;25(3-4):192-204
Apoptosis : an international journal on programmed cell death 2020 Apr;25(3-4):192-204
All-trans-retinal induces autophagic cell death via oxidative stress and the endoplasmic reticulum stress pathway in human retinal pigment epithelial cells.
Zhang L, Zhou Y, Xia Q, Chen Y, Li J
Toxicology letters 2020 Apr 1;322:77-86
Toxicology letters 2020 Apr 1;322:77-86
Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo.
Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K, Hua W, Zhang Y, Wu X, Yang C
Theranostics 2019;9(14):4084-4100
Theranostics 2019;9(14):4084-4100
Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
Zheng Y, Liu P, Wang N, Wang S, Yang B, Li M, Chen J, Situ H, Xie M, Lin Y, Wang Z
Oxidative medicine and cellular longevity 2019;2019:8781690
Oxidative medicine and cellular longevity 2019;2019:8781690
Tandem Molecular Self-Assembly Selectively Inhibits Lung Cancer Cells by Inducing Endoplasmic Reticulum Stress.
Zheng D, Chen Y, Ai S, Zhang R, Gao Z, Liang C, Cao L, Chen Y, Hong Z, Shi Y, Wang L, Li X, Yang Z
Research (Washington, D.C.) 2019;2019:4803624
Research (Washington, D.C.) 2019;2019:4803624
Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells.
Huang W, Liang Y, Ma X
Cancer cell international 2019;19:151
Cancer cell international 2019;19:151
Multi-Walled Carbon Nanotubes (MWCNTs) Activate Apoptotic Pathway Through ER Stress: Does Surface Chemistry Matter?
Sun Y, Gong J, Cao Y
International journal of nanomedicine 2019;14:9285-9294
International journal of nanomedicine 2019;14:9285-9294
Autophagy Activation Is Involved in Acidic Fibroblast Growth Factor Ameliorating Parkinson's Disease via Regulating Tribbles Homologue 3.
Zhong X, Wang B, Zhang G, Yuan Y, Hu X, Xiong J, Zheng P, Liu Y, Xu K, Xiao J, Wu Y, Ye J
Frontiers in pharmacology 2019;10:1428
Frontiers in pharmacology 2019;10:1428
Vildagliptin Reduces Stenosis of Injured Carotid Artery in Diabetic Mouse Through Inhibiting Vascular Smooth Muscle Cell Proliferation via ER Stress/NF-κB Pathway.
Ji Y, Ge Y, Xu X, Ye S, Fan Y, Zhang J, Mei L, Zhang X, Ying L, Yang T, Li C
Frontiers in pharmacology 2019;10:142
Frontiers in pharmacology 2019;10:142
Effect of endoplasmic reticulum calcium on paraquat‑induced apoptosis of human lung type II alveolar epithelial A549 cells.
Song CQ, Sun DZ, Xu YM, Yang C, Cai Q, Dong XS
Molecular medicine reports 2019 Sep;20(3):2419-2425
Molecular medicine reports 2019 Sep;20(3):2419-2425
Multi-walled carbon nanotubes (MWCNTs) promoted lipid accumulation in THP-1 macrophages through modulation of endoplasmic reticulum (ER) stress.
Long J, Ma W, Yu Z, Liu H, Cao Y
Nanotoxicology 2019 Sep;13(7):938-951
Nanotoxicology 2019 Sep;13(7):938-951
Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.
Xin XL, Zhang R, Yuan XM, Liu L
Medical science monitor : international medical journal of experimental and clinical research 2019 Sep 22;25:7100-7114
Medical science monitor : international medical journal of experimental and clinical research 2019 Sep 22;25:7100-7114
Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles.
Liu X, Tu B, Jiang X, Xu G, Bai L, Zhang L, Meng P, Qin X, Chen C, Zou Z
Life sciences 2019 Sep 15;233:116741
Life sciences 2019 Sep 15;233:116741
Japanese Encephalitis Virus Induces Apoptosis and Encephalitis by Activating the PERK Pathway.
Wang Q, Xin X, Wang T, Wan J, Ou Y, Yang Z, Yu Q, Zhu L, Guo Y, Wu Y, Ding Z, Zhang Y, Pan Z, Tang Y, Li S, Kong L
Journal of virology 2019 Sep 1;93(17)
Journal of virology 2019 Sep 1;93(17)
Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells.
Zhang L, Xia Q, Zhou Y, Li J
Toxicology letters 2019 Sep 1;311:105-113
Toxicology letters 2019 Sep 1;311:105-113
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
Li CF, Pan YK, Gao Y, Shi F, Wang YC, Sun XQ
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Xie YK, Zhou X, Yuan HT, Qiu J, Xin DQ, Chu XL, Wang DC, Wang Z
Neural regeneration research 2019 Oct;14(10):1734-1742
Neural regeneration research 2019 Oct;14(10):1734-1742
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.
Li F, Zhang Y, Lu X, Shi J, Gong Q
Life sciences 2019 Oct 1;234:116739
Life sciences 2019 Oct 1;234:116739
Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin-1 signaling.
Chen X, Bian M, Jin H, Lian N, Shao J, Zhang F, Zheng S
IUBMB life 2019 Nov;71(11):1740-1750
IUBMB life 2019 Nov;71(11):1740-1750
Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway.
Tang S, Wang J, Liu J, Huang Y, Zhou Y, Yang S, Zhang W, Yang M, Zhang H
Renal failure 2019 Nov;41(1):455-466
Renal failure 2019 Nov;41(1):455-466
Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model.
Doycheva D, Xu N, Kaur H, Malaguit J, McBride DW, Tang J, Zhang JH
Disease models & mechanisms 2019 Nov 22;12(11)
Disease models & mechanisms 2019 Nov 22;12(11)
Structure-toxicity relationships of saturated and unsaturated free fatty acids for elucidating the lipotoxic effects in human EndoC-βH1 beta-cells.
Plötz T, von Hanstein AS, Krümmel B, Laporte A, Mehmeti I, Lenzen S
Biochimica et biophysica acta. Molecular basis of disease 2019 Nov 1;1865(11):165525
Biochimica et biophysica acta. Molecular basis of disease 2019 Nov 1;1865(11):165525
Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway.
Yin M, Shen Z, Yang L, Zheng W, Song H
International journal of molecular medicine 2019 May;43(5):2086-2102
International journal of molecular medicine 2019 May;43(5):2086-2102
FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.
Lindén M, Thomsen C, Grundevik P, Jonasson E, Andersson D, Runnberg R, Dolatabadi S, Vannas C, Luna Santamarίa M, Fagman H, Ståhlberg A, Åman P
EMBO reports 2019 May;20(5)
EMBO reports 2019 May;20(5)
FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma.
Zhao Y, Yu Y, Li H, Zhang Z, Guo S, Zhu S, Guo Q, Li P, Min L, Zhang S
Molecular oncology 2019 May;13(5):1150-1165
Molecular oncology 2019 May;13(5):1150-1165
Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration.
Stein MN, Malhotra J, Tarapore RS, Malhotra U, Silk AW, Chan N, Rodriguez L, Aisner J, Aiken RD, Mayer T, Haffty BG, Newman JH, Aspromonte SM, Bommareddy PK, Estupinian R, Chesson CB, Sadimin ET, Li S, Medina DJ, Saunders T, Frankel M, Kareddula A, Damare S, Wesolowsky E, Gabel C, El-Deiry WS, Prabhu VV, Allen JE, Stogniew M, Oster W, Bertino JR, Libutti SK, Mehnert JM, Zloza A
Journal for immunotherapy of cancer 2019 May 22;7(1):136
Journal for immunotherapy of cancer 2019 May 22;7(1):136
Icariside II prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats.
Wu Y, Yue Y, Fu S, Li Y, Wu D, Lv J, Yang D
The Journal of pharmacy and pharmacology 2019 Mar;71(3):400-407
The Journal of pharmacy and pharmacology 2019 Mar;71(3):400-407
A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.
Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S
Cell host & microbe 2019 Mar 13;25(3):454-462.e6
Cell host & microbe 2019 Mar 13;25(3):454-462.e6
Exosomes from Microglia Attenuate Photoreceptor Injury and Neovascularization in an Animal Model of Retinopathy of Prematurity.
Xu W, Wu Y, Hu Z, Sun L, Dou G, Zhang Z, Wang H, Guo C, Wang Y
Molecular therapy. Nucleic acids 2019 Jun 7;16:778-790
Molecular therapy. Nucleic acids 2019 Jun 7;16:778-790
Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability.
Fu Z, Liu F, Liu C, Jin B, Jiang Y, Tang M, Qi X, Guo X
Biochimica et biophysica acta. Molecular basis of disease 2019 Jun 1;1865(6):1428-1435
Biochimica et biophysica acta. Molecular basis of disease 2019 Jun 1;1865(6):1428-1435
A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress.
Huang C, Yao R, Zhu Z, Pang D, Cao X, Feng B, Paulsen BS, Li L, Yin Z, Chen X, Jia R, Song X, Ye G, Luo Q, Chen Z, Zou Y
International journal of biological macromolecules 2019 Jun 1;130:508-514
International journal of biological macromolecules 2019 Jun 1;130:508-514
Metformin induces TPC-1 cell apoptosis through endoplasmic reticulum stress-associated pathways in vitro and in vivo.
Ye J, Qi L, Chen K, Li R, Song S, Zhou C, Zhai W
International journal of oncology 2019 Jul;55(1):331-339
International journal of oncology 2019 Jul;55(1):331-339
Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells.
Zhu Y, Xie M, Meng Z, Leung LK, Chan FL, Hu X, Chi K, Liu C, Yao X
Oncogene 2019 Jul;38(29):5778-5791
Oncogene 2019 Jul;38(29):5778-5791
Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na(+) and Ca(2+) handling.
Nie J, Duan Q, He M, Li X, Wang B, Zhou C, Wu L, Wen Z, Chen C, Wang DW, Alsina KM, Wehrens XHT, Wang DW, Ni L
Journal of cellular physiology 2019 Jul;234(7):11587-11601
Journal of cellular physiology 2019 Jul;234(7):11587-11601
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
Yang H, Li J, Yang C, Liu H, Cao Y
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
Autophagy activation alleviates nonylphenol-induced apoptosis in cultured cortical neurons.
Li S, Jiang Z, Chai W, Xu Y, Wang Y
Neurochemistry international 2019 Jan;122:73-84
Neurochemistry international 2019 Jan;122:73-84
The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.
Hong J, Hu Z, Wu Q, Tang C, Hu J, Chen R, Li B, Wang Z
Bioscience reports 2019 Jan 31;39(1)
Bioscience reports 2019 Jan 31;39(1)
Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS.
Azhary JMK, Harada M, Takahashi N, Nose E, Kunitomi C, Koike H, Hirata T, Hirota Y, Koga K, Wada-Hiraike O, Fujii T, Osuga Y
Endocrinology 2019 Jan 1;160(1):119-132
Endocrinology 2019 Jan 1;160(1):119-132
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Jin HZ, Fang YY, Jin QG, Fang N
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X, Sun H
Inflammation 2019 Feb;42(1):64-80
Inflammation 2019 Feb;42(1):64-80
Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress.
Xu S, Di Z, He Y, Wang R, Ma Y, Sun R, Li J, Wang T, Shen Y, Fang S, Feng L, Shen Y
Journal of neuroinflammation 2019 Feb 13;16(1):35
Journal of neuroinflammation 2019 Feb 13;16(1):35
Chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and nonalcoholic steatohepatitis via angiogenesis rather than endoplasmic reticulum stress.
Wu W, Li W, Wei J, Wang C, Yao Y, Zhu W, He W, Zhou W, Liu J
Acta biochimica et biophysica Sinica 2019 Feb 1;51(2):159-167
Acta biochimica et biophysica Sinica 2019 Feb 1;51(2):159-167
Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress.
Hu J, Wu Q, Wang Z, Hong J, Chen R, Li B, Hu Z, Hu X, Zhang M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109475
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109475
Signaling from mTOR to eIF2α mediates cell migration in response to the chemotherapeutic doxorubicin.
Harvey RF, Pöyry TAA, Stoneley M, Willis AE
Science signaling 2019 Dec 17;12(612)
Science signaling 2019 Dec 17;12(612)
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
Zhao Y, Yan J, Li AP, Zhang ZL, Li ZR, Guo KJ, Zhao KC, Ruan Q, Guo L
Toxicology letters 2019 Aug;310:31-38
Toxicology letters 2019 Aug;310:31-38
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
Li SS, Jiang WL, Xiao WQ, Li K, Zhang YF, Guo XY, Dai YQ, Zhao QY, Jiang MJ, Lu ZJ, Wan R
World journal of gastrointestinal oncology 2019 Aug 15;11(8):599-621
World journal of gastrointestinal oncology 2019 Aug 15;11(8):599-621
Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress.
Ouyang M, Luo Z, Zhang W, Zhu D, Lu Y, Wu J, Yao X
International journal of oncology 2019 Apr;54(4):1376-1386
International journal of oncology 2019 Apr;54(4):1376-1386
Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice.
Gu M, Zhao P, Zhang S, Fan S, Yang L, Tong Q, Ji G, Huang C
British journal of pharmacology 2019 Apr;176(7):847-863
British journal of pharmacology 2019 Apr;176(7):847-863
20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway.
Wang X, Xia HY, Qin HY, Kang XP, Hu HY, Zheng J, Jiang JY, Yao LA, Xu YW, Zhang T, Zhang XL
Journal of cellular biochemistry 2019 Apr;120(4):5085-5096
Journal of cellular biochemistry 2019 Apr;120(4):5085-5096
TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis.
Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, Yang M, Zhang L, Zhu X
Journal of cell science 2019 Apr 3;132(7)
Journal of cell science 2019 Apr 3;132(7)
Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture.
Duan YM, Jin Y, Guo ML, Duan LX, Wang JG
Journal of Cancer 2018;9(15):2723-2733
Journal of Cancer 2018;9(15):2723-2733
Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells.
Gáll T, Pethő D, Nagy A, Hendrik Z, Méhes G, Potor L, Gram M, Åkerström B, Smith A, Nagy P, Balla G, Balla J
Frontiers in physiology 2018;9:1595
Frontiers in physiology 2018;9:1595
MnTMPyP inhibits paraquat-induced pulmonary epithelial-like cell injury by inhibiting oxidative stress.
Xu Y, Sun D, Song C, Wang R, Dong X
The Journal of toxicological sciences 2018;43(9):545-555
The Journal of toxicological sciences 2018;43(9):545-555
A comparative study of toxicity of TiO(2), ZnO, and Ag nanoparticles to human aortic smooth-muscle cells.
Wang M, Yang Q, Long J, Ding Y, Zou X, Liao G, Cao Y
International journal of nanomedicine 2018;13:8037-8049
International journal of nanomedicine 2018;13:8037-8049
Apoptosis of bone marrow mesenchymal stromal/stem cells via the MAPK and endoplasmic reticulum stress signaling pathways.
Chen T, Zhu H, Wang Y, Zhao P, Chen J, Sun J, Zhang X, Zhu G
American journal of translational research 2018;10(8):2555-2566
American journal of translational research 2018;10(8):2555-2566
Effects of knee loading on obesity-related non-alcoholic fatty liver disease in an ovariectomized mouse model with high-fat diet.
Tan N, Li X, Zhai L, Liu D, Li J, Yokota H, Zhang P
Hepatology research : the official journal of the Japan Society of Hepatology 2018 Sep;48(10):839-849
Hepatology research : the official journal of the Japan Society of Hepatology 2018 Sep;48(10):839-849
TMCO1 is essential for ovarian follicle development by regulating ER Ca(2+) store of granulosa cells.
Sun Z, Zhang H, Wang X, Wang QC, Zhang C, Wang JQ, Wang YH, An CQ, Yang KY, Wang Y, Gao F, Guo C, Tang TS
Cell death and differentiation 2018 Sep;25(9):1686-1701
Cell death and differentiation 2018 Sep;25(9):1686-1701
Ticagrelor protects against AngII-induced endothelial dysfunction by alleviating endoplasmic reticulum stress.
Wang X, Han X, Li M, Han Y, Zhang Y, Zhao S, Li Y
Microvascular research 2018 Sep;119:98-104
Microvascular research 2018 Sep;119:98-104
Benefits of combination low-dose pioglitazone plus fish oil on aged type 2 diabetes mice.
Iizuka Y, Kim H, Hirako S, Chiba K, Wada M, Matsumoto A
Journal of food and drug analysis 2018 Oct;26(4):1265-1274
Journal of food and drug analysis 2018 Oct;26(4):1265-1274
ERp44 depletion exacerbates ER stress and aggravates diabetic nephropathy in db/db mice.
Pang X, Zhang Y, Shi X, Li D, Han J
Biochemical and biophysical research communications 2018 Oct 12;504(4):921-926
Biochemical and biophysical research communications 2018 Oct 12;504(4):921-926
Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet-Induced Metabolic Dysfunction in Mice.
Chan JKW, Bittner S, Bittner A, Atwal S, Shen WJ, Inayathullah M, Rajada J, Nicolls MR, Kraemer FB, Azhar S
The Journal of pharmacology and experimental therapeutics 2018 May;365(2):281-290
The Journal of pharmacology and experimental therapeutics 2018 May;365(2):281-290
Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78.
Cai Y, Zheng Y, Gu J, Wang S, Wang N, Yang B, Zhang F, Wang D, Fu W, Wang Z
Cell death & disease 2018 May 25;9(6):636
Cell death & disease 2018 May 25;9(6):636
Effects of sevoflurane pretreatment on the apoptosis of rat H9c2 cardiomyocytes and the expression of GRP78.
Wang Z, Cui R, Wang K
Experimental and therapeutic medicine 2018 Mar;15(3):2818-2823
Experimental and therapeutic medicine 2018 Mar;15(3):2818-2823
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Tsai TC, Lai KH, Su JH, Wu YJ, Sheu JH
Marine drugs 2018 Mar 26;16(4)
Marine drugs 2018 Mar 26;16(4)
18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma.
Chen J, Zhang ZQ, Song J, Liu QM, Wang C, Huang Z, Chu L, Liang HF, Zhang BX, Chen XP
Scientific reports 2018 Jun 19;8(1):9365
Scientific reports 2018 Jun 19;8(1):9365
TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.
Li Z, Meng Z, Lu J, Chen FM, Wong WT, Tse G, Zheng C, Keung W, Tse K, Li RA, Jiang L, Yao X
Journal of molecular and cellular cardiology 2018 Jul;120:1-11
Journal of molecular and cellular cardiology 2018 Jul;120:1-11
STF-083010, an inhibitor of XBP1 splicing, attenuates acute renal failure in rats by suppressing endoplasmic reticulum stress-induced apoptosis and inflammation.
Liu L, Xu L, Zhang S, Wang D, Dong G, Chen H, Li X, Shu C, Wang R
Experimental animals 2018 Jul 30;67(3):373-382
Experimental animals 2018 Jul 30;67(3):373-382
Dihydroartemisinin inhibits ER stress-mediated mitochondrial pathway to attenuate hepatocyte lipoapoptosis via blocking the activation of the PI3K/Akt pathway.
Chen X, Bian M, Zhang C, Kai J, Yao Z, Jin H, Lu C, Shao J, Chen A, Zhang F, Zheng S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:975-984
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:975-984
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, Bai F, Sun X, Lin X, Wei J
International immunopharmacology 2018 Dec;65:256-267
International immunopharmacology 2018 Dec;65:256-267
Endoplasmic Reticulum Stress in the Dorsal Root Ganglion Contributes to the Development of Pain Hypersensitivity after Nerve Injury.
Yamaguchi Y, Oh-Hashi K, Matsuoka Y, Takemura H, Yamakita S, Matsuda M, Sawa T, Amaya F
Neuroscience 2018 Dec 1;394:288-299
Neuroscience 2018 Dec 1;394:288-299
Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.
Geng W, Qin F, Ren J, Xiao S, Wang A
Experimental cell research 2018 Aug 15;369(2):243-250
Experimental cell research 2018 Aug 15;369(2):243-250
CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage.
Zhao J, Xiang X, Zhang H, Jiang D, Liang Y, Qing W, Liu L, Zhao Q, He Z
Experimental neurology 2018 Apr;302:22-33
Experimental neurology 2018 Apr;302:22-33
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Sun W, Yang J, Zhang Y, Xi Y, Wen X, Yuan D, Wang Y, Wei C, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2017;7:67
Cell & bioscience 2017;7:67
Transthyretin Exerts Pro-Apoptotic Effects in Human Retinal Microvascular Endothelial Cells Through a GRP78-Dependent Pathway in Diabetic Retinopathy.
Shao J, Yin Y, Yin X, Ji L, Xin Y, Zou J, Yao Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(2):788-800
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(2):788-800
Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model.
Zong S, Liu T, Wan F, Chen P, Luo P, Xiao H
Audiology & neuro-otology 2017;22(3):160-168
Audiology & neuro-otology 2017;22(3):160-168
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H(2)S system: Role of oxidative stress and endoplasmic reticulum stress.
Liu S, Xin D, Wang L, Zhang T, Bai X, Li T, Xie Y, Xue H, Bo S, Liu D, Wang Z
Redox biology 2017 Oct;13:528-540
Redox biology 2017 Oct;13:528-540
Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG.
Huang R, Zhang Y, Han B, Bai Y, Zhou R, Gan G, Chao J, Hu G, Yao H
Autophagy 2017 Oct 3;13(10):1722-1741
Autophagy 2017 Oct 3;13(10):1722-1741
Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation.
Wang J, Wang L, Ho CT, Zhang K, Liu Q, Zhao H
Journal of agricultural and food chemistry 2017 May 10;65(18):3675-3683
Journal of agricultural and food chemistry 2017 May 10;65(18):3675-3683
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Dai C, Lei L, Li B, Lin Y, Xiao X, Tang S
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Identification of Novel SCIRR69-Interacting Proteins During ER Stress Using SILAC-Immunoprecipitation Quantitative Proteomics Approach.
Chen Y, Liu Y, Lin S, Yang S, Que H, Liu S
Neuromolecular medicine 2017 Mar;19(1):81-93
Neuromolecular medicine 2017 Mar;19(1):81-93
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Yang F, Yu X, Li T, Wu J, Zhao Y, Liu J, Sun A, Dong S, Wu J, Zhong X, Xu C, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway.
Huang YF, Zhu DJ, Chen XW, Chen QK, Luo ZT, Liu CC, Wang GX, Zhang WJ, Liao NZ
Oncotarget 2017 Jun 20;8(25):40264-40275
Oncotarget 2017 Jun 20;8(25):40264-40275
Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation.
Zhou B, Zhou DL, Wei XH, Zhong RY, Xu J, Sun L
Acta pharmacologica Sinica 2017 Jul;38(7):998-1008
Acta pharmacologica Sinica 2017 Jul;38(7):998-1008
Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells.
Liu J, Li M, Gong J, Han P, Wang Y, Li D, Tian D, Liao J
Biology open 2017 Jan 15;6(1):29-34
Biology open 2017 Jan 15;6(1):29-34
TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-κB pathway.
Jiang Y, Chen X, Fan M, Li H, Zhu W, Chen X, Cao C, Xu R, Wang Y, Ma Y
Molecular immunology 2017 Feb;82:123-136
Molecular immunology 2017 Feb;82:123-136
The reproductive toxicology of male SD rats after PM(2.5) exposure mediated by the stimulation of endoplasmic reticulum stress.
Liu X, Jin X, Su R, Li Z
Chemosphere 2017 Dec;189:547-555
Chemosphere 2017 Dec;189:547-555
Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.
Liu M, Liu S, Tan W, Tang F, Long J, Li Z, Liang B, Chu C, Yang J
Molecular medicine reports 2017 Dec;16(6):8953-8963
Molecular medicine reports 2017 Dec;16(6):8953-8963
Role of endoplasmic reticulum stress in disuse osteoporosis.
Li J, Yang S, Li X, Liu D, Wang Z, Guo J, Tan N, Gao Z, Zhao X, Zhang J, Gou F, Yokota H, Zhang P
Bone 2017 Apr;97:2-14
Bone 2017 Apr;97:2-14
Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts.
Colvin BN, Longtine MS, Chen B, Costa ML, Nelson DM
Reproduction (Cambridge, England) 2017 Apr;153(4):369-380
Reproduction (Cambridge, England) 2017 Apr;153(4):369-380
Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice.
Li T, Feng R, Zhao C, Wang Y, Wang J, Liu S, Cao J, Wang H, Wang T, Guo Y, Lu Z
Antioxidants & redox signaling 2017 Apr 10;26(11):598-609
Antioxidants & redox signaling 2017 Apr 10;26(11):598-609
Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis.
Cai Q, Zhao M, Liu X, Wang X, Nie Y, Li P, Liu T, Ge R, Han F
Biochemical and biophysical research communications 2017 Apr 1;485(2):388-394
Biochemical and biophysical research communications 2017 Apr 1;485(2):388-394
4-Phenylbutyric Acid Induces Protection against Pulmonary Arterial Hypertension in Rats.
Wu Y, Adi D, Long M, Wang J, Liu F, Gai MT, Aierken A, Li MY, Li Q, Wu LQ, Ma YT, Hujiaaihemaiti M
PloS one 2016;11(6):e0157538
PloS one 2016;11(6):e0157538
Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice.
Bai X, Liu S, Yuan L, Xie Y, Li T, Wang L, Wang X, Zhang T, Qin S, Song G, Ge L, Wang Z
Brain research 2016 Sep 1;1646:410-417
Brain research 2016 Sep 1;1646:410-417
Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway.
Zhang W, Chen L, Shen Y, Xu J
Toxicology in vitro : an international journal published in association with BIBRA 2016 Oct;36:186-196
Toxicology in vitro : an international journal published in association with BIBRA 2016 Oct;36:186-196
Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.
Sidoli M, Musner N, Silvestri N, Ungaro D, D'Antonio M, Cavener DR, Feltri ML, Wrabetz L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Nov 2;36(44):11350-11361
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Nov 2;36(44):11350-11361
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu K, Sun H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Japanese encephalitis virus induces apoptosis by the IRE1/JNK pathway of ER stress response in BHK-21 cells.
Huang M, Xu A, Wu X, Zhang Y, Guo Y, Guo F, Pan Z, Kong L
Archives of virology 2016 Mar;161(3):699-703
Archives of virology 2016 Mar;161(3):699-703
Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.
Lei X, Cui K, Liu Q, Zhang H, Li Z, Huang B, Shi D
Reproduction in domestic animals = Zuchthygiene 2016 Feb;51(1):75-84
Reproduction in domestic animals = Zuchthygiene 2016 Feb;51(1):75-84
Protective effects of fish oil and pioglitazone on pancreatic tissue in obese KK mice with type 2 diabetes.
Iizuka Y, Kim H, Izawa T, Sakurai K, Hirako S, Wada M, Matsumoto A
Prostaglandins, leukotrienes, and essential fatty acids 2016 Dec;115:53-59
Prostaglandins, leukotrienes, and essential fatty acids 2016 Dec;115:53-59
Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.
Wu H, Wang Y, Wu C, Yang P, Li H, Li Z
Journal of agricultural and food chemistry 2016 Dec 14;64(49):9356-9367
Journal of agricultural and food chemistry 2016 Dec 14;64(49):9356-9367
The protective effect of the earthworm active ingredients on hepatocellular injury induced by endoplasmic reticulum stress.
Wang Q, Duan LX, Xu ZS, Wang JG, Xi SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Aug;82:304-11
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Aug;82:304-11
Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking.
Zhou Y, Zhang S, Dai C, Tang S, Yang X, Li D, Zhao K, Xiao X
Cell biology and toxicology 2016 Apr;32(2):141-52
Cell biology and toxicology 2016 Apr;32(2):141-52
Beclin-1-independent autophagy mediates programmed cancer cell death through interplays with endoplasmic reticulum and/or mitochondria in colbat chloride-induced hypoxia.
Sun L, Liu N, Liu SS, Xia WY, Liu MY, Li LF, Gao JX
American journal of cancer research 2015;5(9):2626-42
American journal of cancer research 2015;5(9):2626-42
Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells.
Koubkova L, Vyzula R, Karban J, Pinkas J, Ondrouskova E, Vojtesek B, Hrstka R
Investigational new drugs 2015 Oct;33(5):1123-32
Investigational new drugs 2015 Oct;33(5):1123-32
Endoplasmic reticulum stress is involved in the lidocaine-induced apoptosis in SH-SY5Y neuroblastoma cells.
Li K, Han X
Journal of molecular neuroscience : MN 2015 May;56(1):122-30
Journal of molecular neuroscience : MN 2015 May;56(1):122-30
Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.
Xu D, Su C, Song X, Shi Q, Fu J, Hu L, Xia X, Song E, Song Y
Chemical research in toxicology 2015 Jun 15;28(6):1326-37
Chemical research in toxicology 2015 Jun 15;28(6):1326-37
Role of Endoplasmic Reticulum Stress in Brain Damage After Cardiopulmonary Resuscitation in Rats.
Zhang J, Xie X, Pan H, Wu Z, Lu W, Yang G
Shock (Augusta, Ga.) 2015 Jul;44(1):65-71
Shock (Augusta, Ga.) 2015 Jul;44(1):65-71
Inhibition of c-Src/p38 MAPK pathway ameliorates renal tubular epithelial cells apoptosis in db/db mice.
Wu H, Shi Y, Deng X, Su Y, Du C, Wei J, Ren Y, Wu M, Hou Y, Duan H
Molecular and cellular endocrinology 2015 Dec 5;417:27-35
Molecular and cellular endocrinology 2015 Dec 5;417:27-35
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Liao H, Bao X, Zhu J, Qu J, Sun Y, Ma X, Wang E, Guo X, Kang Q, Zhen Y
Chemico-biological interactions 2015 Dec 5;242:91-8
Chemico-biological interactions 2015 Dec 5;242:91-8
Normal and functional TP53 in genetically stable myxoid/round cell liposarcoma.
Ståhlberg A, Kåbjörn Gustafsson C, Engtröm K, Thomsen C, Dolatabadi S, Jonasson E, Li CY, Ruff D, Chen SM, Åman P
PloS one 2014;9(11):e113110
PloS one 2014;9(11):e113110
Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats.
Chen Y, Gui D, Chen J, He D, Luo Y, Wang N
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(6):1975-87
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(6):1975-87
Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants.
Zhang P, Gao K, Tang Y, Jin X, An J, Yu H, Wang H, Zhang Y, Wang D, Huang H, Yu L, Wang C
Human mutation 2014 Sep;35(9):1142-51
Human mutation 2014 Sep;35(9):1142-51
Protein degradation and quality control in cells from laforin and malin knockout mice.
Garyali P, Segvich DM, DePaoli-Roach AA, Roach PJ
The Journal of biological chemistry 2014 Jul 25;289(30):20606-14
The Journal of biological chemistry 2014 Jul 25;289(30):20606-14
Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway.
Hao J, Chen C, Huang K, Huang J, Li J, Liu P, Huang H
European journal of pharmacology 2014 Dec 15;745:152-65
European journal of pharmacology 2014 Dec 15;745:152-65
ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway.
Xue J, Wei J, Dong X, Zhu C, Li Y, Song A, Liu Z
The journal of physiological sciences : JPS 2013 Nov;63(6):435-44
The journal of physiological sciences : JPS 2013 Nov;63(6):435-44
Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy.
Liu ZW, Zhu HT, Chen KL, Dong X, Wei J, Qiu C, Xue JH
Cardiovascular diabetology 2013 Nov 2;12:158
Cardiovascular diabetology 2013 Nov 2;12:158
Arsenic trioxide alleviates airway hyperresponsiveness and promotes apoptosis of CD4+ T lymphocytes: evidence for involvement of the ER stress-CHOP pathway.
Li K, Zhang L, Xiang X, Gong S, Ma L, Xu L, Wang G, Liu Y, Ji X, Liu S, Chen P, Zeng H, Li J
Irish journal of medical science 2013 Dec;182(4):573-83
Irish journal of medical science 2013 Dec;182(4):573-83
Selenium deficiency is associated with endoplasmic reticulum stress in a rat model of cardiac malfunction.
Wang SQ, Niu XL, Liu ZW, Zhu YH, Gao DF
Biological trace element research 2013 Dec;156(1-3):196-201
Biological trace element research 2013 Dec;156(1-3):196-201
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.
Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, Yuan Z
Nature immunology 2013 Aug;14(8):793-803
Nature immunology 2013 Aug;14(8):793-803
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15204-1-AP(CHOP; GADD153 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 15204-1-AP(CHOP; GADD153 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CHOP antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CHOP. This antibody recognizes human,mouse,rat antigen. The CHOP antibody has been validated for the following applications: ELISA, WB, IHC analysis.
