643602

antibody from BioLegend

Targeting: DDIT3 CHOP, CHOP10, GADD153

Western blot (Data presented on provider website)

Antibody Data

Product number

643602

Provider

BioLegend

Proper citation

BioLegend Cat#643602, RRID:AB_2245710

Product name

Purified anti-CHOP (GADD153)

Antibody type

Polyclonal

Antigen

Peptide

Description

CHOP (also known as growth arrest and DNA-damage-inducible protein GADD153) is a 27 kD member of the C/EBP transcription factor family containing a basic region involved in DNA binding and a leucine zipper domain. This nuclear protein functions as a dimer to inhibit the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA target sequences. CHOP (GADD153) is induced by endoplasmic-reticulum stress and nutrient deprivation. Phosphorylation by p38-MAP kinase enhances activity of this protein while CK2 phosphorylation decreases activity. CHOP (GADD153) has been shown to interact with c-jun, c-fos, C/EBP, and LAP. The Poly6436 antibody has been shown to be useful for Western blotting of the human CHOP protein.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 µl

Storage

Upon receipt, store frozen at -20°C.

References

Submitted references

Signaling through C/EBP homologous protein and death receptor 5 and calpain activation differentially regulate THP-1 cell maturation-dependent apoptosis induced by Shiga toxin type 1.

Lee MS, Cherla RP, Lentz EK, Leyva-Illades D, Tesh VL
Infection and immunity 2010 Aug;78(8):3378-91