ABIN358600

antibody from antibodies-online

Targeting: BACE2 AEPLC, ALP56, CEAP1, DRAP

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN358600

Provider

antibodies-online

Product name

anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (Middle Region) antibody

Antibody type

Polyclonal

Description

Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Reactivity

Human

Host

Rabbit

Epitope

Middle Region

Vial size

0.4 mL

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A
Genome research 2003 Oct;13(10):2265-70

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BACE-2 is overexpressed in Down's syndrome.

Barbiero L, Benussi L, Ghidoni R, Alberici A, Russo C, Schettini G, Pagano SF, Parati EA, Mazzoli F, Nicosia F, Signorini S, Feudatari E, Binetti G
Experimental neurology 2003 Aug;182(2):335-45

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Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells.

Basi G, Frigon N, Barbour R, Doan T, Gordon G, McConlogue L, Sinha S, Zeller M
The Journal of biological chemistry 2003 Aug 22;278(34):31512-20