11381-1-AP

antibody from Proteintech Group

Targeting: CTTN EMS1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

11381-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#11381-1-AP, RRID:AB_2088125

Product name

Cortactin antibody

Antibody type

Polyclonal

Description

Cortactin antibody (Cat. #11381-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

PTTG1IP Orchestrates Epithelial-Mesenchymal Transition and DNA Damage Response in Thyroid Cancer Progression.

Zhang H, Zhou L, Wang S, Yao D, Ma J, Hu X, Zhang W, Tao M, Wang M, Lu W
Frontiers in bioscience (Landmark edition) 2025 Sep 23;30(9):44789

---

FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation.

Xiao D, Ran H, Chen L, Li Y, Cai Y, Zhang S, Qi Q, Wu H, Zhang C, Cao S, Mi L, Huang H, Qi J, Han Q, Tu H, Li H, Zhou T, Li F, Li A, Man J
Science China. Life sciences 2025 Mar;68(3):673-688

---

Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma.

Yu H, Du Y, He Y, Sun Y, Li J, Jia B, Chen J, Peng X, An T, Li J, Chi Y, Wang M, Cao L, Tai Y, Zhai X, Nuersulitan R, Li S, Wu N, Wang J, Xiong H, Wan S, Liu J, Yang X, Hu X, Lin D, Sun W, Wang Y, An G, Ji X, Kong L, Ding L, Ma Y, Tian Z, Dong B, Bi Y, Wu J, Wang Z
Cell host & microbe 2025 Jul 9;33(7):1089-1105.e7

---

Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells.

Hu M, Weldy A, Lovalvo I, Akins E, Jain S, Chang A, Sati A, Lad M, Lui A, Rajidi A, Kothekar A, Ding E, Kumar S, Aghi MK
bioRxiv : the preprint server for biology 2025 Jan 24;

---

CMAP prediction and experimental validation of Forskolin as a podocyte protective and anti-proteinuric drug for nephrotoxic serum-treated mice.

Huang W, Yu P, Zhao X, Shi J, Jin X, Jin R, Dong S, Xia W, Zhu X, Wang J, Zhang H, Ren L, Shi S
Biochemical pharmacology 2025 Feb;232:116727

---

Sulforaphane suppresses bladder cancer metastasis via blocking actin nucleation-mediated pseudopodia formation.

Huang L, Wang J, Wang X, Zheng S, Liang K, Kang YE, Chang JW, Koo BS, Liu L, Gal A, Shan Y
Cancer letters 2024 Oct 1;601:217145

---

HIF-1α activation impairs dendrites formation and elongation in osteocytogenesis.

Li X, Zhao J, Chen L, Zhou X, Qiu M, Deng L, Yang K, Xu Y
Heliyon 2024 Jun 30;10(12):e32889

---

Identification of a prognostic gene signature in patients with cisplatin resistant squamous cell lung cancer.

Mu Y, Dong Y, Zheng M, Barr MP, Roviello G, Hu Z, Liu J
Journal of thoracic disease 2024 Jul 30;16(7):4567-4583

---

Alternative splicing and intron retention: Their profiles and roles in cutaneous fibrosis of systemic sclerosis.

Xie S, Bao D, Xiao Y, Li H, Guo M, Dai B, Liu S, Huang J, Li M, Ding L, Meng Q, Lv CL, Distler JHW, Luo H, Zhu H
Journal of autoimmunity 2024 Dec;149:103306

---

RBM47 promotes cell proliferation and immune evasion by upregulating PDIA6: a novel mechanism of pancreatic cancer progression.

Ma Y, Liu E, Fan H, Li C, Huang P, Cui M, Wang Z, Zhou J, Chen K
Journal of translational medicine 2024 Dec 31;22(1):1164

---

ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7.

Zhang M, Cai F, Guo J, Liu S, Ma G, Cai M, Zhang R, Deng J
Cell death & disease 2024 Apr 26;15(4):297

---

Effects of Cortactin Expression on Prognosis in Patients with Breast Cancer.

Son H, Jee S, Cha H, Song K, Bang S, Kim H, Paik S, Park H, Myung J
Diagnostics (Basel, Switzerland) 2023 Sep 7;13(18)

---

Fiber Microarchitecture in Interpenetrating Collagen-Alginate Hydrogel with Tunable Mechanical Plasticity Regulates Tumor Cell Migration.

Wei Z, Liu J, Jia Y, Lei M, Zhang S, Xi P, Ma Y, Zhang M, Ma J, Wang L, Guo H, Xu F
Advanced healthcare materials 2023 Nov;12(29):e2301586

---

Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein.

Norris ML, Mendell JT
Genes & development 2023 Mar 1;37(5-6):191-203

---

Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma.

Wang J, Huang TJ, Mei Y, Luo FF, Xie DH, Peng LX, Liu BQ, Fan ML, Zhang JB, Zheng ST, Qian CN, Huang BJ
Cancer gene therapy 2023 Feb;30(2):375-387

---

ERRα Up-Regulates Invadopodia Formation by Targeting HMGCS1 to Promote Endometrial Cancer Invasion and Metastasis.

Tang S, Ma J, Su P, Lei H, Tong Y, Cai L, Xu S, Mao X, Sun P
International journal of molecular sciences 2023 Feb 16;24(4)

---

CTTN Overexpression Confers Cancer Stem Cell-like Properties and Trastuzumab Resistance via DKK-1/WNT Signaling in HER2 Positive Breast Cancer.

Moon SJ, Choi HJ, Kye YH, Jeong GY, Kim HY, Myung JK, Kong G
Cancers 2023 Feb 11;15(4)

---

Gab1 regulates invadopodia and autocrine VEGF through SHP2/ERK1/2 in hilar cholangiocarcinoma cells.

Li T, Tian Y, Ren W, Chen P, Luo M, Sang H
American journal of translational research 2022;14(12):8934-8946

---

A four oxidative stress gene prognostic model and integrated immunity-analysis in pancreatic adenocarcinoma.

Wang H, Tian RF, Liang X, Fan J, Duan ZC, Fan XY, Zhang JJ, Yao DS, Chen ZN, Li L
Frontiers in oncology 2022;12:1015042

---

TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis.

Huang Q, Wu D, Zhao J, Yan Z, Chen L, Guo S, Wang D, Yuan C, Wang Y, Liu X, Xing J
The EMBO journal 2022 Jun 1;41(11):e110324

---

Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC.

Huang C, Ou R, Chen X, Zhang Y, Li J, Liang Y, Zhu X, Liu L, Li M, Lin D, Qiu J, Liu G, Zhang L, Wu Y, Tang H, Liu Y, Liang L, Ding Y, Liao W
Journal of experimental & clinical cancer research : CR 2021 Sep 28;40(1):304

---

Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).

Zhao Y, Lei Y, He SW, Li YQ, Wang YQ, Hong XH, Liang YL, Li JY, Chen Y, Luo WJ, Zhang PP, Yang XJ, He QM, Ma J, Liu N, Tang LL
Cells 2020 Feb 27;9(3)

---

WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis.

Zhao K, Wang D, Zhao X, Wang C, Gao Y, Liu K, Wang F, Wu X, Wang X, Sun L, Zang J, Mei Y
EMBO reports 2020 Apr 3;21(4):e49269

---

High Expression of lncRNA AFAP1-AS1 Promotes the Progression of Colon Cancer and Predicts Poor Prognosis.

Bo H, Fan L, Li J, Liu Z, Zhang S, Shi L, Guo C, Li X, Liao Q, Zhang W, Zhou M, Xiang B, Li X, Li G, Xiong W, Zeng Z, Xiong F, Gong Z
Journal of Cancer 2018;9(24):4677-4683

---

Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.

Ma D, Zheng B, Suzuki T, Zhang R, Jiang C, Bai D, Yin W, Yang Z, Zhang X, Hou L, Zhan H, Wen JK
Circulation research 2017 Mar 3;120(5):799-815

---

Decreased expression of cortactin in the schizophrenia brain.

Bhambhvani HP, Simmons M, Haroutunian V, Meador-Woodruff JH
Neuroreport 2016 Feb 10;27(3):145-50

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HeLa cells were subjected to SDS PAGE followed by western blot with 11381-1-AP(CTTN antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using CTTN antibody 11381-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human pancreas cancer using 11381-1-AP(CTTN antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Cortactin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Cortactin. This antibody recognizes human,mouse,rat antigen. The Cortactin antibody has been validated for the following applications: ELISA, WB, IHC, IF, FC analysis.

Appendix

11381-1-AP.pdf

Show more