ABIN362958

antibody from antibodies-online

Targeting: CTTN EMS1

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN362958

Provider

antibodies-online

Product name

anti-Cortactin (CTTN) (AA 419-423) antibody

Antibody type

Polyclonal

Antigen

Peptide sequence around AA 419-423 (P-I-Y-E-D) derived from Human CORTACTIN. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reactivity

Human, Mouse

Host

Rabbit

Epitope

AA 419-423

Isotype

IgG

Vial size

100 μL

Concentration

1 mg/mL

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

References

Submitted references

CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis.

Luo C, Pan H, Mines M, Watson K, Zhang J, Fan GH
The Journal of biological chemistry 2006 Oct 6;281(40):30081-93

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Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC
Proceedings of the National Academy of Sciences of the United States of America 2003 Jan 21;100(2):443-8

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Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.

Head JA, Jiang D, Li M, Zorn LJ, Schaefer EM, Parsons JT, Weed SA
Molecular biology of the cell 2003 Aug;14(8):3216-29

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The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells.

Huang C, Liu J, Haudenschild CC, Zhan X
The Journal of biological chemistry 1998 Oct 2;273(40):25770-6