Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 306407 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#306407, RRID:AB_2100664
- Product name
- PE anti-human CD178 (Fas-L)
- Antibody type
- Monoclonal
- Antigen
- L5178Y mouse T lymphoma cells expressing recombinant human FasL
- Description
- CD178 is a 38-42 kD type II glycoprotein also known as Fas ligand and CD95L. CD178 belongs to the TNF superfamily and is expressed on activated T lymphocytes, NK cells, monocytes, and granulocytes. CD178 is also expressed on parenchymal cells of the retina and cornea, retinal pigment epithelial cells, and testis. The extracellular region of FasL can be cleaved by matrix metalloproteinases (MMPs) to give rise to a 26 kD soluble protein. CD178 binds to CD95, a member of the TNFR superfamily, to induce apoptosis. CD95/CD95L interactions play an important role in the maintenance of peripheral tolerance and survival.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells.
Medina MA, Couturier J, Feske ML, Mahne AE, Turner M, Yu X, Kozinetz CA, Orozco AF, Hutchison AT, Savidge TC, Rodgers JR, Lewis DE
Journal of leukocyte biology 2012 May;91(5):759-71
Journal of leukocyte biology 2012 May;91(5):759-71
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human Fas Ligand transfected cells stained with NOK-1 PE
- Conjugate
- Yellow dye