10-4064-25

antibody from ABEOMICS Inc.
Targeting: CD33 FLJ00391, p67, SIGLEC-3, SIGLEC3
Provider product page for 10-4064-25

Antibody data

Product number
10-4064-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-CD33Antibody
Antibody type
Monoclonal
Description
CD33 is a member of the SIGLEC (Sialic Acid-Binding Ig-Like Lectin) family of receptors, and the gene comprises seven coding exons. Exon 2 encodes the canonical IgV domain, exon 4 encodes the IgC structural domain, and exons 6 and 7 encode cytosolic ITIMs (Immunotyrosine Inhibitory Motifs). CD33 acts as a cell surface antigen which is expressed on normal myeloid cells and CD34+ blasts in AML (Acute Myeloid Leukemia). The antigen serves as a target of GO (Gemtuzumab/Ozogamicin), which exerts anti-leukemic effects in refractory AML.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant CD33 p
rotein (amino acids 28-320) was use
d as the immunogen for this antibod
y.
Isotype
IgG
Antibody clone number
ABM29D3
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
CD33 protein structure - 10-4064-25 shown in red.