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- Antibody Data
- Antigen structure
- References [10]
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- Validations
- Immunohistochemistry [2]
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- Product number
- 20108-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20108-1-AP, RRID:AB_10666848
- Product name
- FAM96B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FAM96B antibody (Cat. #20108-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references An iron-sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and -unwinding activities.
Iron-regulated assembly of the cytosolic iron-sulfur cluster biogenesis machinery.
The cytosolic iron-sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors.
The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2.
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins.
The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Maio N, Raza MK, Li Y, Zhang DL, Bollinger JM Jr, Krebs C, Rouault TA
Proceedings of the National Academy of Sciences of the United States of America 2023 Aug 15;120(33):e2303860120
Proceedings of the National Academy of Sciences of the United States of America 2023 Aug 15;120(33):e2303860120
Iron-regulated assembly of the cytosolic iron-sulfur cluster biogenesis machinery.
Fan X, Barshop WD, Vashisht AA, Pandey V, Leal S, Rayatpisheh S, Jami-Alahmadi Y, Sha J, Wohlschlegel JA
The Journal of biological chemistry 2022 Jul;298(7):102094
The Journal of biological chemistry 2022 Jul;298(7):102094
The cytosolic iron-sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors.
Redwood AB, Zhang X, Seth SB, Ge Z, Bindeman WE, Zhou X, Sinha VC, Heffernan TP, Piwnica-Worms H
NPJ breast cancer 2021 Dec 2;7(1):152
NPJ breast cancer 2021 Dec 2;7(1):152
The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2.
Mariotti L, Wild S, Brunoldi G, Piceni A, Ceppi I, Kummer S, Lutz RE, Cejka P, Gari K
Communications biology 2020 Jun 23;3(1):322
Communications biology 2020 Jun 23;3(1):322
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
Naseri NN, Ergel B, Kharel P, Na Y, Huang Q, Huang R, Dolzhanskaya N, Burré J, Velinov MT, Sharma M
Nature structural & molecular biology 2020 Feb;27(2):192-201
Nature structural & molecular biology 2020 Feb;27(2):192-201
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA
Molecular cell 2019 Jul 25;75(2):382-393.e5
Molecular cell 2019 Jul 25;75(2):382-393.e5
The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins.
Odermatt DC, Gari K
Cell reports 2017 Feb 7;18(6):1434-1443
Cell reports 2017 Feb 7;18(6):1434-1443
The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
Vashisht AA, Yu CC, Sharma T, Ro K, Wohlschlegel JA
The Journal of biological chemistry 2015 May 29;290(22):14218-25
The Journal of biological chemistry 2015 May 29;290(22):14218-25
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Stehling O, Mascarenhas J, Vashisht AA, Sheftel AD, Niggemeyer B, Rösser R, Pierik AJ, Wohlschlegel JA, Lill R
Cell metabolism 2013 Aug 6;18(2):187-98
Cell metabolism 2013 Aug 6;18(2):187-98
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Stehling O, Vashisht AA, Mascarenhas J, Jonsson ZO, Sharma T, Netz DJ, Pierik AJ, Wohlschlegel JA, Lill R
Science (New York, N.Y.) 2012 Jul 13;337(6091):195-9
Science (New York, N.Y.) 2012 Jul 13;337(6091):195-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 20108-1-AP(FAM96B antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FAM96B antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FAM96B. This antibody recognizes human, mouse, rat antigen. The FAM96B antibody has been validated for the following applications: ELISA, IHC analysis.
