Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Immunohistochemistry [2]
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Validation data
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- Product number
- 20108-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20108-1-AP, RRID:AB_10666848
- Product name
- FAM96B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FAM96B antibody (Cat. #20108-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The cytosolic iron-sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors.
The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2.
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins.
The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Redwood AB, Zhang X, Seth SB, Ge Z, Bindeman WE, Zhou X, Sinha VC, Heffernan TP, Piwnica-Worms H
NPJ breast cancer 2021 Dec 2;7(1):152
NPJ breast cancer 2021 Dec 2;7(1):152
The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2.
Mariotti L, Wild S, Brunoldi G, Piceni A, Ceppi I, Kummer S, Lutz RE, Cejka P, Gari K
Communications biology 2020 Jun 23;3(1):322
Communications biology 2020 Jun 23;3(1):322
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
Naseri NN, Ergel B, Kharel P, Na Y, Huang Q, Huang R, Dolzhanskaya N, Burré J, Velinov MT, Sharma M
Nature structural & molecular biology 2020 Feb;27(2):192-201
Nature structural & molecular biology 2020 Feb;27(2):192-201
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA
Molecular cell 2019 Jul 25;75(2):382-393.e5
Molecular cell 2019 Jul 25;75(2):382-393.e5
The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins.
Odermatt DC, Gari K
Cell reports 2017 Feb 7;18(6):1434-1443
Cell reports 2017 Feb 7;18(6):1434-1443
The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
Vashisht AA, Yu CC, Sharma T, Ro K, Wohlschlegel JA
The Journal of biological chemistry 2015 May 29;290(22):14218-25
The Journal of biological chemistry 2015 May 29;290(22):14218-25
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Stehling O, Mascarenhas J, Vashisht AA, Sheftel AD, Niggemeyer B, Rösser R, Pierik AJ, Wohlschlegel JA, Lill R
Cell metabolism 2013 Aug 6;18(2):187-98
Cell metabolism 2013 Aug 6;18(2):187-98
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Stehling O, Vashisht AA, Mascarenhas J, Jonsson ZO, Sharma T, Netz DJ, Pierik AJ, Wohlschlegel JA, Lill R
Science (New York, N.Y.) 2012 Jul 13;337(6091):195-9
Science (New York, N.Y.) 2012 Jul 13;337(6091):195-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 20108-1-AP(FAM96B antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FAM96B antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FAM96B. This antibody recognizes human, mouse, rat antigen. The FAM96B antibody has been validated for the following applications: ELISA, IHC analysis.