10840-1-AP

antibody from Proteintech Group

Targeting: RAP1B DKFZp586H0723, K-REV, RAL1B

Provider product page for 10840-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [25]
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Validations
Western blot [1]

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Product number: 10840-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10840-1-AP, RRID:AB_2253539
Product name: RAP1B antibody
Antibody type: Polyclonal
Description: RAP1B antibody (Cat. #10840-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RAP1B protein structure - 10840-1-AP shown in red.

Submitted references Levels of Talin1 in Platelet-Derived Microvesicles Affect Platelet Activation in Patients with Nonvalvular Atrial Fibrillation.

Liu Z, Yang J, Chen H, Zhang L
Biochemical genetics 2026 Feb;64(1):847-864

Mechanistic study of the role of emodin in targeting and inhibiting the Rap1 signaling pathway to regulate epithelial-mesenchymal transition and reverse cisplatin resistance in hepatocellular carcinoma.

Zhang R, Jiao Y, Wang S, Wang L, Leng Y, Xiong Z, Yang M
Translational cancer research 2026 Feb 28;15(2):93

Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation.

Zhang S, Yan M, Liang P, Zhang Y, Liu J, Huang H, Li G, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2247-2265

Overexpression of Rap1B alleviate central precocious puberty and neurodevelopmental damage.

Liu X, Zeng L
Cellular signalling 2025 Oct;134:111941

Exosomal Proteome from Hepatocellular Carcinoma Patient-Derived Xenograft Mice Serves as Identity of Liver Cancer.

Zuo T, Chen P, Zhang Z, Mao M, Li Y, Li Z, Feng X, Wang Y, Sun Z, Jiao F, Gao F, Zhang T, Li Y, Zhang Y, Liu F, Zhang Y, Ruan Y, Chang L, Hu L, Zhang Y, Xu P
Journal of proteome research 2025 Oct 3;24(10):4977-4987

Targeting METTL16 attenuates mesangial cell viability and fibrosis in a high-glucose state by suppressing m6A modification and the expression of RAP1B.

Wang W, Luo Y
BMC molecular and cell biology 2025 Oct 28;26(1):32

FAK regulates trophoblast functions of invasion and proliferation through Rap1 pathway in early-onset preeclampsia.

Wang T, Tong H, Chen R, Jiang Y, Zhang C, Qi H, Zhang X
Biochemical and biophysical research communications 2025 May 12;763:151788

miR-28-5p targeted Rap1b attenuates splenic inflammation infiltration in immune thrombocytopenia.

Yu R, Cen L, Wu X, Liu H, Zhai X, Bin Q
Platelets 2025 Dec;36(1):2487756

Exosomal circPVT1 promotes angiogenesis in laryngeal cancer by activating the Rap1b-VEGFR2 signaling pathway.

Lyu K, Tang B, Huang B, Xu Z, Liu T, Fang R, Li Y, Chen Y, Chen L, Zhang M, Chen L, Lei W
Carcinogenesis 2024 Sep 11;45(9):642-657

LncRNA AC100826.1 regulated PLCB1 to promote progression in non-small cell lung cancer.

Dai S, Wang Q, Lyu Y, Chen Z, Liu X, Zhao G, Zhang H
Thoracic cancer 2024 Jul;15(19):1477-1489

Somatic RAP1B gain-of-function variant underlies isolated thrombocytopenia and immunodeficiency.

Benavides-Nieto M, Adam F, Martin E, Boussard C, Lagresle-Peyrou C, Callebaut I, Kauskot A, Repérant C, Feng M, Bordet JC, Castelle M, Morelle G, Brouzes C, Zarhrate M, Panikulam P, Lambert N, Picard C, Bodet D, Rouger-Gaudichon J, Revy P, de Villartay JP, Moshous D
The Journal of clinical investigation 2024 Jul 11;134(17)

Extracellular vesicles derived from stored red blood cell suspensions enhance invasion and migration of lung cancer cells by miR1246 and miR150-3p.

Cheng Z, Kong Y, Xu H, Xiao L, Tian L, Liu Z
Vox sanguinis 2024 Aug;119(8):809-820

Circ_0000231 promotes paclitaxel resistance in ovarian cancer by regulating miR-140/RAP1B.

Liu J, Wang H, Xiao S, Zhang S, Qi Y, Wang M
American journal of cancer research 2023;13(3):872-885

Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells.

Zhang H, Tao Y, Ding X, Wang Y, Wang X
Acta biochimica et biophysica Sinica 2023 Mar 25;55(3):382-393

ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.

Zhang B, Ding J, Ma Z
Viruses 2023 Jun 27;15(7)

SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP.

Chen S, Li QH, Chen X, Bao HJ, Wu W, Shen F, Lu BF, Jiang RQ, Zong ZH, Zhao Y
Journal of cellular and molecular medicine 2022 Oct;26(20):5150-5164

Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.

Zhang B, Fan M, Fan J, Luo Y, Wang J, Wang Y, Liu B, Sun Y, Zhao Q, Hiscox JA, Nan Y, Zhou EM
Microbiology spectrum 2022 Feb 23;10(1):e0226521

33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways.

Guo C, Li N, Dong C, Wang L, Li Z, Liu Q, Ma Q, Greenaway FT, Tian Y, Hao L, Liu S, Sun MZ
Journal of advanced research 2021 May;30:85-102

Molecular and Pharmacological Characterization of the Interaction between Human Geranylgeranyltransferase Type I and Ras-Related Protein Rap1B.

Hinz S, Jung D, Hauert D, Bachmann HS
International journal of molecular sciences 2021 Mar 2;22(5)

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis.

Zhang Y, Yu G, Chu H, Wang X, Xiong L, Cai G, Liu R, Gao H, Tao B, Li W, Li G, Liang J, Yang W
Molecular cell 2018 Jul 19;71(2):201-215.e7

LncRNA AFAP1-AS Functions as a Competing Endogenous RNA to Regulate RAP1B Expression by sponging miR-181a in the HSCR.

Chen G, Peng L, Zhu Z, Du C, Shen Z, Zang R, Su Y, Xia Y, Tang W
International journal of medical sciences 2017;14(10):1022-1030

LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.

Liu L, Yue H, Liu Q, Yuan J, Li J, Wei G, Chen X, Lu Y, Guo M, Luo J, Chen R
Oncotarget 2016 Mar 29;7(13):15787-800

MicroRNA-100 regulates SW620 colorectal cancer cell proliferation and invasion by targeting RAP1B.

Peng H, Luo J, Hao H, Hu J, Xie SK, Ren D, Rao B
Oncology reports 2014 May;31(5):2055-62

Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.

Sheng Y, Ding S, Chen K, Chen J, Wang S, Zou C, Zhang J, Cao Y, Huang A, Tang H
Biochemistry and cell biology = Biochimie et biologie cellulaire 2014 Apr;92(2):152-62

Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation.

Guo H, Hu X, Ge S, Qian G, Zhang J
The international journal of biochemistry & cell biology 2012 Sep;44(9):1465-72

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The RAP1B-Specific antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RAP1B-Specific. This antibody recognizes human,mouse,rat antigen. The RAP1B-Specific antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 10840-1-AP.pdf

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