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antibody from Invitrogen Antibodies
Targeting: CCL2
GDCF-2, HC11, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF
Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations [0]
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- Product number
- 14-7099-85 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CCL2 (MCP-1) Monoclonal Antibody (5D3-F7), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The 5D3-F7 antibody reacts with human, cynomolgus, and rhesus monkey monocyte chemoattractant protein-1 (MCP-1), also known as monocyte chemotactic and activating factor (MCAF) and CCL2. MCP-1 is a CC chemokine which presents as a dimer. Derived from monocytes and vascular endothelial cells, it exerts chemoattractant activity on a variety of cell types, such as monocytes, basophils, T cells and NK cells via chemokine receptors such as CCR2, CCR5, and CCR10.
- Antibody clone number
- 5D3-F7
- Concentration
- 0.5 mg/mL
Submitted references Peripheral immunophenotyping of AITD subjects reveals alterations in immune cells in pediatric vs adult-onset AITD.
Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring.
Development and validation of an immunosensor for monocyte chemotactic protein 1 using a silicon photonic microring resonator biosensing platform.
Mucosal Administration of Collagen V Ameliorates the Atherosclerotic Plaque Burden by Inducing Interleukin 35-dependent Tolerance.
Mechanism and role of MCP-1 upregulation upon chikungunya virus infection in human peripheral blood mononuclear cells.
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.
Magnetically-actuated, bead-enhanced silicon photonic immunosensor.
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes.
Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration.
Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus.
The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation.
The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.
Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment.
Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis.
Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure.
Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels.
The -2518 promotor polymorphism in the MCP-1 gene is associated with systemic sclerosis.
Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation.
A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells.
Stensland ZC, Coleman BM, Rihanek M, Baxter RM, Gottlieb PA, Hsieh EWY, Sarapura VD, Simmons KM, Cambier JC, Smith MJ
iScience 2022 Jan 21;25(1):103626
iScience 2022 Jan 21;25(1):103626
Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring.
Algaba-Chueca F, Maymó-Masip E, Ejarque M, Ballesteros M, Llauradó G, López C, Guarque A, Serena C, Martínez-Guasch L, Gutiérrez C, Bosch R, Vendrell J, Megía A, Fernández-Veledo S
Stem cells translational medicine 2020 Mar;9(3):351-363
Stem cells translational medicine 2020 Mar;9(3):351-363
Development and validation of an immunosensor for monocyte chemotactic protein 1 using a silicon photonic microring resonator biosensing platform.
Valera E, Shia WW, Bailey RC
Clinical biochemistry 2016 Jan;49(1-2):121-6
Clinical biochemistry 2016 Jan;49(1-2):121-6
Mucosal Administration of Collagen V Ameliorates the Atherosclerotic Plaque Burden by Inducing Interleukin 35-dependent Tolerance.
Park AC, Huang G, Jankowska-Gan E, Massoudi D, Kernien JF, Vignali DA, Sullivan JA, Wilkes DS, Burlingham WJ, Greenspan DS
The Journal of biological chemistry 2016 Feb 12;291(7):3359-70
The Journal of biological chemistry 2016 Feb 12;291(7):3359-70
Mechanism and role of MCP-1 upregulation upon chikungunya virus infection in human peripheral blood mononuclear cells.
Ruiz Silva M, van der Ende-Metselaar H, Mulder HL, Smit JM, Rodenhuis-Zybert IA
Scientific reports 2016 Aug 25;6:32288
Scientific reports 2016 Aug 25;6:32288
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.
Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum JL, McNamara CA
Arteriosclerosis, thrombosis, and vascular biology 2016 Apr;36(4):682-91
Arteriosclerosis, thrombosis, and vascular biology 2016 Apr;36(4):682-91
Magnetically-actuated, bead-enhanced silicon photonic immunosensor.
Valera E, McClellan MS, Bailey RC
Analytical methods : advancing methods and applications 2015 Oct 21;7(20):8539-8544
Analytical methods : advancing methods and applications 2015 Oct 21;7(20):8539-8544
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
Moyon S, Dubessy AL, Aigrot MS, Trotter M, Huang JK, Dauphinot L, Potier MC, Kerninon C, Melik Parsadaniantz S, Franklin RJ, Lubetzki C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jan 7;35(1):4-20
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jan 7;35(1):4-20
Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes.
Bekkering S, Quintin J, Joosten LA, van der Meer JW, Netea MG, Riksen NP
Arteriosclerosis, thrombosis, and vascular biology 2014 Aug;34(8):1731-8
Arteriosclerosis, thrombosis, and vascular biology 2014 Aug;34(8):1731-8
Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration.
Arana L, Ordoñez M, Ouro A, Rivera IG, Gangoiti P, Trueba M, Gomez-Muñoz A
American journal of physiology. Endocrinology and metabolism 2013 Jun 1;304(11):E1213-26
American journal of physiology. Endocrinology and metabolism 2013 Jun 1;304(11):E1213-26
Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus.
Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, Shum AK, Anderson MS, Cheng MH, Robinson WH, Browne SK, Holland SM, Baechler EC, Utz PJ
The Journal of clinical investigation 2013 Dec;123(12):5135-45
The Journal of clinical investigation 2013 Dec;123(12):5135-45
The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation.
Gellatly SL, Needham B, Madera L, Trent MS, Hancock RE
Infection and immunity 2012 Sep;80(9):3122-31
Infection and immunity 2012 Sep;80(9):3122-31
The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.
Nijnik A, Pistolic J, Cho P, Filewod NC, Falsafi R, Ramin A, Harder KW, Hancock RE
Journal of leukocyte biology 2012 Apr;91(4):599-607
Journal of leukocyte biology 2012 Apr;91(4):599-607
Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment.
Nijnik A, Madera L, Ma S, Waldbrook M, Elliott MR, Easton DM, Mayer ML, Mullaly SC, Kindrachuk J, Jenssen H, Hancock RE
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 1;184(5):2539-50
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 1;184(5):2539-50
Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis.
Hu H, Sun L, Guo C, Liu Q, Zhou Z, Peng L, Pan J, Yu L, Lou J, Yang Z, Zhao P, Ran Y
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Sep 1;15(17):5485-93
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Sep 1;15(17):5485-93
Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure.
Robey RW, Shukla S, Steadman K, Obrzut T, Finley EM, Ambudkar SV, Bates SE
Molecular cancer therapeutics 2007 Jun;6(6):1877-85
Molecular cancer therapeutics 2007 Jun;6(6):1877-85
Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels.
Zhou S, Zong Y, Ney PA, Nair G, Stewart CF, Sorrentino BP
Blood 2005 Mar 15;105(6):2571-6
Blood 2005 Mar 15;105(6):2571-6
The -2518 promotor polymorphism in the MCP-1 gene is associated with systemic sclerosis.
Karrer S, Bosserhoff AK, Weiderer P, Distler O, Landthaler M, Szeimies RM, Müller-Ladner U, Schölmerich J, Hellerbrand C
The Journal of investigative dermatology 2005 Jan;124(1):92-8
The Journal of investigative dermatology 2005 Jan;124(1):92-8
Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation.
Piemonti L, Leone BE, Nano R, Saccani A, Monti P, Maffi P, Bianchi G, Sica A, Peri G, Melzi R, Aldrighetti L, Secchi A, Di Carlo V, Allavena P, Bertuzzi F
Diabetes 2002 Jan;51(1):55-65
Diabetes 2002 Jan;51(1):55-65
A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells.
Peri G, Milanese C, Matteucci C, Ruco L, Zhou D, Sozzani S, Coletta I, Mantovani A
Journal of immunological methods 1994 Sep 14;174(1-2):249-57
Journal of immunological methods 1994 Sep 14;174(1-2):249-57
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