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Learn26161-1-AP
antibody from Proteintech Group
Targeting: CCL2
GDCF-2, HC11, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [87]
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- Product number
- 26161-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- MCP1 antibody
- Antibody type
- Polyclonal
- Description
- Mcp1 antibody (Cat. #26161-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Berberine Ameliorates Diabetic Kidney Disease by Modulating Macrophage Polarization via Inhibiting IL-17A Signaling.
Multi-omics reveals that 4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acute liver injury by modulating the miR-30e-3p/Tfrc axis and a multi-dimensional network of ferroptosis, inflammation, metabolism, and gut microbiota.
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Exploring potential mechanism of Chuanzhi Qingyu recipe for vulnerable atherosclerosis plaques based on UPLC-Q-TOF-MS(E), systems biology strategy, and experimental validation.
Tenascin C(+) myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice.
7-dehydrocholesterol promotes CCL2-secretion from porcine skeletal muscle satellite cells, enhancing the migration of preadipocytes.
Characterizing Chemokine Signaling Pathways and Hub Genes in Calcium Oxalate-Induced Kidney Stone Formation: Insights from Rodent Models.
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction.
Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress.
C5aR1(+) microglia exacerbate neuroinflammation and cerebral edema in acute brain injury.
Tet2 deficiency-induced expansion of monocyte-derived macrophages promotes liver fibrosis.
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.
HMGA2 promotes hepatocellular carcinoma progression by regulating tumor-associated macrophage via Notch1/CCL2 signaling.
The multilayer coatings on polylactic acid implants spatiotemporally regulates the microenvironment to enhance antibacterial and osseointegration capacity.
Human induced pluripotent stem cell-derived chimeric antigen receptor-macrophages eradicate IL-13Rα2-positive solid tumors.
Kv1.3 regulates macrophage immune function through PI3K/AKT signaling pathway to alleviate metabolic dysfunction-associated steatohepatitis.
GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation.
Gut microbial metabolite, sphingosine-1-phosphate (S1P), drives mesangial cell phenotypic transformation and accelerates progression of IgA nephropathy via CCL2-MET-FAK pathway.
Extracts of Portulaca oleracea and Patrinia scabiosaefolia relieve ultraviolet B-induced skin injury in solar dermatitis mice via inhibiting IL-17/CCL2 pathway and oxidative stress.
Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and experimental verification.
Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling.
Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration.
Transcription factor RUNX2 participates in astrocyte-mediated neuropathic pain via transcriptional activation of Ccl2.
Nitrate-driven maintenance of lipid homeostasis by M2 macrophages alleviates atherosclerosis via downregulation of LOX1 expression and reduction of lipid deposition.
Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis.
Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway.
Phenolipid JE from Syzygium cumini attenuated obesity via modulating NF-κB/NLRP3 signaling pathway and gut microbiota-bile acid-FXR axis in high-fat diet-fed mice.
Exosomes derived from baicalin‑pretreated mesenchymal stem cells mitigate atherosclerosis by regulating the SIRT1/NF‑κB signaling pathway.
Role of bFGF on astrocytes to expression of protein molecules of blood-brain barrier via PI3K/mTOR signaling pathway after TBI.
Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies.
Aldosterone induces renal lymphangiogenesis through macrophage-lymphatic endothelial cell transformation and Inhibition by esaxerenone.
TRIM21 knockdown alleviates hemorrhage induced hepatic ischemia reperfusion injury by suppressing ferroptosis-induced NETs.
Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway.
Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing.
Evidence for imbalanced polarization of caruncle macrophages in retained placenta of dairy cows.
Downregulation of cardiac inflammation via the CaMKII δ/NF-κB pathway in heart failure by Lonicerae Japonicae Flos and Angelicae Sinensis Radix.
Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis.
Extracellular vesicles from L. paracasei improve neuroinflammation, GABA neurotransmission and motor incoordination in hyperammonemic rats.
Curcumin relieves CFA-induced inflammatory pain by inhibiting the AP-1/c-Jun-CCL2-CCR2 pathway in the spinal dorsal horn.
Sirtuin 2 exacerbates renal tubule injury and inflammation in diabetic mice via deacetylation of c-Jun/c-Fos.
Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis.
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
Delivering miR-23b-3p by small extracellular vesicles to promote cell senescence and aberrant lipid metabolism.
C1QBP Drives M2 Macrophage Polarization Via TRAF2-CCL2 to Promote Oral Squamous Cell Carcinoma Progression.
Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation.
Deciphering the Proteomic Landscape of Circulating Extracellular Vesicles in Human Abdominal Aortic Aneurysm.
Targeting CDK1 inhibits Golgi apparatus stress-mediated neuroinflammation and neuronal apoptosis after intracerebral hemorrhage by modulating GRASP55 phosphorylation.
Inhibition of Circadian Rhythm Gene per1 Promotes Macrophage Infiltration in e‑Cigarette Aerosol-Induced Pulmonary Fibrosis in Mice.
Identification of candidate immunity biomarkers associated with age-related variations in osteoclast activity in a mouse model of orthodontic tooth movement.
USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment.
The Role of Luteolin in Inhibiting Prostaglandin-Endoperoxide Synthase 2 to Relieve Neointimal Hyperplasia in Arteriovenous Fistula.
Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission.
Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion.
Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway.
From Organotypic Mouse Brain Slices to Human Alzheimer Plasma Biomarkers: A Focus on Microglia.
Extracellular Vesicles from Mesenchymal Stem Cells Reverse Neuroinflammation and Restore Motor Coordination in Hyperammonemic Rats.
A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats.
Deguelin inhibits the glioblastoma progression through suppressing CCL2/NFκB signaling pathway.
Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization.
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching.
Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway.
Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation.
Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy.
The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice.
X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
Shape-fixing hydrogel promotes scarless healing of wounds under tension.
PPAR gamma and PGC-1alpha activators protect against diabetic nephropathy by suppressing the inflammation and NF-kappaB activation.
Mechanism of Xue-Jie-San treating Crohn's disease complicated by atherosclerosis: Network pharmacology, molecular docking and experimental validation.
Jia Wei Qingxin Lotus Seed Drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C/SP1/ZEB1 signaling pathway.
Sphingosine-1-phosphate receptor 3 promotes neuronal apoptosis via the TNF-α/caspase-3 signaling pathway after acute intracerebral hemorrhage.
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
Macrophage NLRP3-dependent IL-1β production contributes to aortic fibrosis in heart failure with preserved ejection fraction.
Nppb contributes to Sepsis-Induced myocardial injury by regulating Senescence-Related genes.
-RAMP3 promotes hepatocellular carcinoma tumor cell-mediated CCL2 degradation by supporting membrane distribution of ACKR2.
Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy.
Protective effect of rubber seed oil on human endothelial cells.
PL-Relief(TM)plus Alleviates Atopic Dermatitis and Regulates Inflammatory Responses via Inhibiting NF-κB Signaling Pathway.
TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells.
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats.
Neutrophil infiltration associated genes on the prognosis and tumor immune microenvironment of lung adenocarcinoma.
rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice.
Cuyun Recipe ameliorates pregnancy loss by regulating macrophage polarization and hypercoagulable state during the peri-implantation period in an ovarian hyperstimulation mouse model.
Bacterial indole-3-lactic acid affects epithelium-macrophage crosstalk to regulate intestinal homeostasis.
Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats.
Targeted Therapy of Acute Liver Injury via Cryptotanshinone-Loaded Biomimetic Nanoparticles Derived from Mesenchymal Stromal Cells Driven by Homing.
Effects of Ischemia on the Migratory Capacity of Microglia Along Collagen Microcontact Prints on Organotypic Mouse Cortex Brain Slices.
Fan J, Liu Y, Zheng C, Liu J, Liu W, Geng R, Zhao A, Wang Y, Wang R, Qi Z
Journal of inflammation research 2026;19:580534
Journal of inflammation research 2026;19:580534
Multi-omics reveals that 4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acute liver injury by modulating the miR-30e-3p/Tfrc axis and a multi-dimensional network of ferroptosis, inflammation, metabolism, and gut microbiota.
Zhang T, Zou R, Chen Z, Li Y, Sun X, Sun X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158022
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158022
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Chen SX, Qi X, Zheng XT, Bi ZM, Zhang Y, Wang YM
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Wang D, Zhou Z, Zhao Z, Liu M, Li Y, Mu L, Zhou H, Li X, Zhang F, Tian S, Zhou X, Shi Y
Free radical biology & medicine 2026 Jun;249:246-259
Free radical biology & medicine 2026 Jun;249:246-259
Exploring potential mechanism of Chuanzhi Qingyu recipe for vulnerable atherosclerosis plaques based on UPLC-Q-TOF-MS(E), systems biology strategy, and experimental validation.
Weng J, Huan L, Zhang S, Cao W, Xu F, Zhang Y
Journal of pharmaceutical and biomedical analysis 2026 Jul 15;274:117404
Journal of pharmaceutical and biomedical analysis 2026 Jul 15;274:117404
Tenascin C(+) myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice.
Tong X, Shi G, Fang Z, Tang S, Zhou B, Meng Q, Zhang P, Li H, Cai X, Wang Z, Zheng X, Chen W, Jiang G, Wang H, Jiang D, Li Q
Nature communications 2026 Jan 30;17(1)
Nature communications 2026 Jan 30;17(1)
7-dehydrocholesterol promotes CCL2-secretion from porcine skeletal muscle satellite cells, enhancing the migration of preadipocytes.
Zhao Y, Yao Y, Wang X, Zhang L, Wei W, Chen J
Biochemical and biophysical research communications 2026 Jan 1;794:153070
Biochemical and biophysical research communications 2026 Jan 1;794:153070
Characterizing Chemokine Signaling Pathways and Hub Genes in Calcium Oxalate-Induced Kidney Stone Formation: Insights from Rodent Models.
Wang B, Tan Z, She W, Wang X, Guan X, Tao Z, Guo F, Xu H, Deng Y
Biochemical genetics 2026 Feb;64(1):430-445
Biochemical genetics 2026 Feb;64(1):430-445
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction.
Guo CH, Wang QQ, Li JQ, Ji W, Chen L, Chang ML, Ma LY, Liu XL, Ni M
Acta pharmacologica Sinica 2026 Feb;47(2):315-327
Acta pharmacologica Sinica 2026 Feb;47(2):315-327
Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress.
Cheng L, Cheng S, Zhu R, Xu G
Journal of diabetes and its complications 2026 Feb;40(2):109250
Journal of diabetes and its complications 2026 Feb;40(2):109250
C5aR1(+) microglia exacerbate neuroinflammation and cerebral edema in acute brain injury.
Zhou J, Ma S, Feng D, Tian Y, Li L, Guo H, Shi Y, Cui W, Dong J, Hao S, Guo C, Xu M, Han L, Bai H, He D, Cui X, Chen L, Wu X, Gao F, Hu Q, Zhang Z, Wang K, Zhou G, Feng T, Xue D, Lin Q, Wang L, Gao L, Heng L, Zhao T, Luo T, Tian B, Zhang X, Guo W, Li Z, Liu H, Ge S, Liu Q, Qu Y
Neuron 2026 Feb 4;114(3):444-462.e9
Neuron 2026 Feb 4;114(3):444-462.e9
Tet2 deficiency-induced expansion of monocyte-derived macrophages promotes liver fibrosis.
Feng J, Wu B, Li Y, Sun P, Liu Q, Xiao Q, Cai JB, Zheng Y, Chen H, Xu Y, Liu Y, Shi GM, Tan L, Shi YG
The Journal of experimental medicine 2026 Feb 2;223(2)
The Journal of experimental medicine 2026 Feb 2;223(2)
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.
Li Z, Tan D, Lin J, Zhang T, Liu B, Zhao B, Liang D, Li L, Wei X, Lv Z, Wang R, Hu M
Journal of advanced research 2026 Apr;82:845-862
Journal of advanced research 2026 Apr;82:845-862
HMGA2 promotes hepatocellular carcinoma progression by regulating tumor-associated macrophage via Notch1/CCL2 signaling.
Xing Z, Xun J, Deng L
Molecular and cellular biochemistry 2026 Apr;481(4):1677-1693
Molecular and cellular biochemistry 2026 Apr;481(4):1677-1693
The multilayer coatings on polylactic acid implants spatiotemporally regulates the microenvironment to enhance antibacterial and osseointegration capacity.
Lyu J, Jiang S, Ma T, Zhang Y, Yu J, Zhang Z, Teng Z, Helili M, Cao S, Geng X, Wang X, Jiang J, Qiu J, Sun X, Liu X, Ma X
Materials today. Bio 2026 Apr;37:102871
Materials today. Bio 2026 Apr;37:102871
Human induced pluripotent stem cell-derived chimeric antigen receptor-macrophages eradicate IL-13Rα2-positive solid tumors.
Yang Y, Wang L, Zhang Y, Lyu S, Ruan Q, Wang C, Dou F, Liang G, Yan G, Wang M, Fan H, Qi H, Kong W, Guo H, Liu Q, Wang W, Mao M, Huang Y, Zhou X, Duan J, Song W, Huang B, Cheng Y, Zhou L, Xu S, Shen J, Ping YF, Bian XW, He Z, Shi Y
The Journal of pathology 2026 Apr 15;
The Journal of pathology 2026 Apr 15;
Kv1.3 regulates macrophage immune function through PI3K/AKT signaling pathway to alleviate metabolic dysfunction-associated steatohepatitis.
Ke T, Zhen WJ, Chen XX, Wang H, Chen S, Tian YY, Wang YT, Zhang L, Wu BM
Journal of molecular medicine (Berlin, Germany) 2026 Apr 11;104(1)
Journal of molecular medicine (Berlin, Germany) 2026 Apr 11;104(1)
GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation.
Jiang R, Li L, Luo Y, Wang W, Zeng X, Qian C, Gong C, Sheng J
International immunopharmacology 2026 Apr 1;174:116394
International immunopharmacology 2026 Apr 1;174:116394
Gut microbial metabolite, sphingosine-1-phosphate (S1P), drives mesangial cell phenotypic transformation and accelerates progression of IgA nephropathy via CCL2-MET-FAK pathway.
Tang YY, Zhang DL, Huang LS, Hu P, Liu P, Wu JJ, Xie T, Sun WQ, Xu XD, Jin MP, He HD
Current research in microbial sciences 2025;9:100494
Current research in microbial sciences 2025;9:100494
Extracts of Portulaca oleracea and Patrinia scabiosaefolia relieve ultraviolet B-induced skin injury in solar dermatitis mice via inhibiting IL-17/CCL2 pathway and oxidative stress.
Li B, Yang J, Wang Z, He M, Chen X, Chen Y, Shen B, Chen J, Yang C, Li T, Lai C, Gao Y, Cai H
International journal of medical sciences 2025;22(4):856-872
International journal of medical sciences 2025;22(4):856-872
Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and experimental verification.
Liu X, Zhang C, Fu Y, Dai J, Lu J, Liu G, Yang X
Frontiers in pharmacology 2025;16:1625286
Frontiers in pharmacology 2025;16:1625286
Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling.
Hu L, Yang Z, Zhang Y, Du C, Yang Y, Chang Z, Li X, Shan Z
Frontiers in immunology 2025;16:1622094
Frontiers in immunology 2025;16:1622094
Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration.
Yang X, Zhu H, Li Z, Wang Q, Gao Y, Li Z, Tao L, Li L, Sun D, Zhang L, Shen W, Cheng H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157039
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157039
Transcription factor RUNX2 participates in astrocyte-mediated neuropathic pain via transcriptional activation of Ccl2.
Shen W, Song S, Zhao X, Li D, Liu J, Yue S
Biochemical and biophysical research communications 2025 Sep 1;777:152263
Biochemical and biophysical research communications 2025 Sep 1;777:152263
Nitrate-driven maintenance of lipid homeostasis by M2 macrophages alleviates atherosclerosis via downregulation of LOX1 expression and reduction of lipid deposition.
Si Y, Du H, Li S, Zhang C, Wang J, Wang S, Zhou J
Science China. Life sciences 2025 Oct;68(10):2995-3009
Science China. Life sciences 2025 Oct;68(10):2995-3009
Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis.
Zhan Y, Xu J, Zhang Z, Hu Y, Li Y, Qian J, Ling Y, Wu D, Deng H, Li G, Shen Z, Fang Y
Cancer communications (London, England) 2025 Oct;45(10):1203-1228
Cancer communications (London, England) 2025 Oct;45(10):1203-1228
Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway.
Liu W, Mei T, Jiang Y, Wang J, Li M, Wang L, Meng Z, Qin T, Huang D
Cancer biology & medicine 2025 Oct 23;22(12):1578-604
Cancer biology & medicine 2025 Oct 23;22(12):1578-604
Phenolipid JE from Syzygium cumini attenuated obesity via modulating NF-κB/NLRP3 signaling pathway and gut microbiota-bile acid-FXR axis in high-fat diet-fed mice.
Wang G, Sun X, Chen X, Zhang L, Fan S, Mu Y, Zheng D, Huang X, Xu J, Li L
Biochemical pharmacology 2025 Nov;241:117136
Biochemical pharmacology 2025 Nov;241:117136
Exosomes derived from baicalin‑pretreated mesenchymal stem cells mitigate atherosclerosis by regulating the SIRT1/NF‑κB signaling pathway.
Yang X, Wu W, Huang W, Fang J, Chen Y, Chen X, Lin X, He Y
Molecular medicine reports 2025 May;31(5)
Molecular medicine reports 2025 May;31(5)
Role of bFGF on astrocytes to expression of protein molecules of blood-brain barrier via PI3K/mTOR signaling pathway after TBI.
Long H, Chen F, Deng Y, Zhou W, Wang Y, Xiong W, Zhang Y, Chen P
International journal of biological macromolecules 2025 May;307(Pt 2):142077
International journal of biological macromolecules 2025 May;307(Pt 2):142077
Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies.
Chen B, Chen M, Chang M, Ge Y, Gunning W, Assaly R, Dworkin LD, Qiao YJ, Gong R
Kidney international 2025 May;107(5):835-851
Kidney international 2025 May;107(5):835-851
Aldosterone induces renal lymphangiogenesis through macrophage-lymphatic endothelial cell transformation and Inhibition by esaxerenone.
Guo H, Liu Z, Lv R, Zhang B, Qiang P, Wang X, Chang Y, Yang F, Shimosawa T, Xu Q, Xiong Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 May 24;74(1):85
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 May 24;74(1):85
TRIM21 knockdown alleviates hemorrhage induced hepatic ischemia reperfusion injury by suppressing ferroptosis-induced NETs.
Wang S, Li Z, Chang Y, He D, Dong K, Cheng X
Scientific reports 2025 May 14;15(1):16731
Scientific reports 2025 May 14;15(1):16731
Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway.
Wen L, Lin X, Hu D, Li J, Xie K, Li S, Su S, Duan X, Zhong G, Lin Y, Chen Y, Xu T, Zeng Q
Atherosclerosis 2025 Mar;402:119109
Atherosclerosis 2025 Mar;402:119109
Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing.
Luo Z, Zheng S, Hu Z, Li P, Zeng J, Lu Y, Ali M, Chen Z, Wang Q, Qi F
Free radical biology & medicine 2025 Jun;233:302-316
Free radical biology & medicine 2025 Jun;233:302-316
Evidence for imbalanced polarization of caruncle macrophages in retained placenta of dairy cows.
Zhang H, Li M, Zhao B, Chang R, Wang J, Yang Y, Huang Q, Aernouts B, Jiang Q, Loor JJ, Xu C
Journal of dairy science 2025 Jul;108(7):7437-7451
Journal of dairy science 2025 Jul;108(7):7437-7451
Downregulation of cardiac inflammation via the CaMKII δ/NF-κB pathway in heart failure by Lonicerae Japonicae Flos and Angelicae Sinensis Radix.
Tang J, Li X, Yu X, Wang D, Huang K, Pu H, Yu J, Li S, Wang W, Liu B, Guo S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156326
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156326
Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis.
Zhang H, Hu J, Zhao X, Zheng B, Han Y, Luo G, Dou D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156271
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156271
Extracellular vesicles from L. paracasei improve neuroinflammation, GABA neurotransmission and motor incoordination in hyperammonemic rats.
Arenas YM, Pérez-Martinez G, Montoliu C, Llansola M, Felipo V
Brain, behavior, and immunity 2025 Jan;123:556-570
Brain, behavior, and immunity 2025 Jan;123:556-570
Curcumin relieves CFA-induced inflammatory pain by inhibiting the AP-1/c-Jun-CCL2-CCR2 pathway in the spinal dorsal horn.
Zhu Y, Jiang Y, Lu X, Li S, Liu F, Xu Y, Tian Y, Gao L, Wei L
Molecular pain 2025 Jan-Dec;21:17448069251323668
Molecular pain 2025 Jan-Dec;21:17448069251323668
Sirtuin 2 exacerbates renal tubule injury and inflammation in diabetic mice via deacetylation of c-Jun/c-Fos.
Chen L, Li D, Zhan Z, Quan J, Peng J, Huang Z, Yi B
Cellular and molecular life sciences : CMLS 2025 Jan 21;82(1):45
Cellular and molecular life sciences : CMLS 2025 Jan 21;82(1):45
Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis.
Xia B, Lu YL, Peng J, Liang JW, Li FQ, Ding JY, Wan CW, Le CY, Dai JL, Jie-Wang, Guo B, Huang J
Scientific reports 2025 Jan 2;15(1):603
Scientific reports 2025 Jan 2;15(1):603
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
Xiang J, Lv M, Luo Y, Ke K, Zhang B, Wang M, Zhang K, Li H
Scientific reports 2025 Feb 24;15(1):6669
Scientific reports 2025 Feb 24;15(1):6669
Delivering miR-23b-3p by small extracellular vesicles to promote cell senescence and aberrant lipid metabolism.
Jin Y, Sun G, Chen B, Feng S, Tang M, Wang H, Zhang Y, Wang Y, An Y, Xiao Y, Liu Z, Liu P, Tian Z, Yin H, Zhang S, Luan X
BMC biology 2025 Feb 11;23(1):41
BMC biology 2025 Feb 11;23(1):41
C1QBP Drives M2 Macrophage Polarization Via TRAF2-CCL2 to Promote Oral Squamous Cell Carcinoma Progression.
Qin X, Kang K, Zhu B, Shi Y, Bu S
International dental journal 2025 Dec;75(6):103938
International dental journal 2025 Dec;75(6):103938
Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation.
Xu J, Pu J, Chen H, Sun L, Fei S, Han Z, Tao J, Ju X, Wang Z, Tan R, Gu M
Renal failure 2025 Dec;47(1):2458749
Renal failure 2025 Dec;47(1):2458749
Deciphering the Proteomic Landscape of Circulating Extracellular Vesicles in Human Abdominal Aortic Aneurysm.
Yu C, Zhang G, Pei S, Zhang Y, Yuan P, Miao R, Kadier K, Zhang P, Gu T, Wu R, Zhang H, Zhang S, Yang B, Wu H, Xu Y, Hu K, Xu Q, Chen Y, Wang J, Cai Z, Tang J, Li T, Song Y
Journal of cellular and molecular medicine 2025 Aug;29(15):e70725
Journal of cellular and molecular medicine 2025 Aug;29(15):e70725
Targeting CDK1 inhibits Golgi apparatus stress-mediated neuroinflammation and neuronal apoptosis after intracerebral hemorrhage by modulating GRASP55 phosphorylation.
Zhang X, Yang M, Jiang F, Wang Y, Zhou Z, Wu Z
Cellular signalling 2025 Aug;132:111835
Cellular signalling 2025 Aug;132:111835
Inhibition of Circadian Rhythm Gene per1 Promotes Macrophage Infiltration in e‑Cigarette Aerosol-Induced Pulmonary Fibrosis in Mice.
Dong C, Li B, Liu C, Cui J, Li Y, Liang L, Song Y, Li X
Environment & health (Washington, D.C.) 2025 Aug 15;3(8):866-877
Environment & health (Washington, D.C.) 2025 Aug 15;3(8):866-877
Identification of candidate immunity biomarkers associated with age-related variations in osteoclast activity in a mouse model of orthodontic tooth movement.
Zhang R, Yang K, He L, Chen Z, Li Y, Huang S
BMC oral health 2025 Aug 12;25(1):1318
BMC oral health 2025 Aug 12;25(1):1318
USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment.
Han S, Cui L, Wang B, Ruan Y, Shi M, Hong C, Guan X, Chen Z, Li Y, Liao Y, Ma M, Lu X, Wang H, Zhang Y, Liu C
Cancer immunology research 2025 Aug 1;13(8):1226-1245
Cancer immunology research 2025 Aug 1;13(8):1226-1245
The Role of Luteolin in Inhibiting Prostaglandin-Endoperoxide Synthase 2 to Relieve Neointimal Hyperplasia in Arteriovenous Fistula.
Zhang R, Li W, Yang J, Fan X, Fan H, Li W
Advanced biology 2025 Apr;9(4):e2400437
Advanced biology 2025 Apr;9(4):e2400437
Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission.
Lin L, Wei J, Xue J, Fan G, Zhu W, Zhu Y, Wu R
Journal of cardiovascular translational research 2025 Apr;18(2):237-246
Journal of cardiovascular translational research 2025 Apr;18(2):237-246
Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion.
Shen S, Zhang M, Wang X, Liu Q, Su H, Sun B, Guo Z, Tian B, Gan H, Gong C, Ma L
Theranostics 2024;14(3):1241-1259
Theranostics 2024;14(3):1241-1259
Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway.
Li YX, Liu J, Li F
Cell biochemistry and biophysics 2024 Sep;82(3):2747-2757
Cell biochemistry and biophysics 2024 Sep;82(3):2747-2757
From Organotypic Mouse Brain Slices to Human Alzheimer Plasma Biomarkers: A Focus on Microglia.
Steiner K, Yilmaz SN, Gern A, Marksteiner J, Faserl K, Villunger M, Sarg B, Humpel C
Biomolecules 2024 Sep 3;14(9)
Biomolecules 2024 Sep 3;14(9)
Extracellular Vesicles from Mesenchymal Stem Cells Reverse Neuroinflammation and Restore Motor Coordination in Hyperammonemic Rats.
Izquierdo-Altarejos P, Martínez-García M, Atienza-Pérez I, Hernández A, Moreno-Manzano V, Llansola M, Felipo V
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2024 Oct 9;19(1):52
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2024 Oct 9;19(1):52
A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats.
Arenas YM, Montoliu C, Llansola M, Felipo V
Journal of neuroinflammation 2024 Nov 30;21(1):314
Journal of neuroinflammation 2024 Nov 30;21(1):314
Deguelin inhibits the glioblastoma progression through suppressing CCL2/NFκB signaling pathway.
Qian Y, Dong J, Zhang W, Xue X, Xiong Z, Zeng W, Wang Q, Fan Z, Zuo Z, Huang Z, Jiang Y
Neuropharmacology 2024 Nov 15;259:110109
Neuropharmacology 2024 Nov 15;259:110109
Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization.
Lu S, Jin H, Nong T, Li D, Long K, Chen Y, Li Y, Xing H, Pan T, He S, Jiang K, Zhong F
Free radical biology & medicine 2024 Nov 1;224:506-520
Free radical biology & medicine 2024 Nov 1;224:506-520
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching.
Shen SC, Xu J, Cheng C, Xiang XJ, Hong BY, Zhang M, Gong C, Ma LK
Acta pharmacologica Sinica 2024 May;45(5):959-974
Acta pharmacologica Sinica 2024 May;45(5):959-974
Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway.
Wang JB, Du MW, Zheng Y
World journal of stem cells 2024 May 26;16(5):591-603
World journal of stem cells 2024 May 26;16(5):591-603
Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation.
Song G, Zhao F, Ni R, Deng B, Chen S, Hu R, Zheng J, Peng Y, Liu H, Luo Y, Zhou Z, Huang G, Shen W
Journal of nanobiotechnology 2024 May 10;22(1):236
Journal of nanobiotechnology 2024 May 10;22(1):236
Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy.
Ma J, Chen S, Liu J, Liao Y, Li L, Wang CC, Song S, Feng R, Hu H, Quan S
Free radical biology & medicine 2024 May 1;217:1-14
Free radical biology & medicine 2024 May 1;217:1-14
The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice.
Li B, Zhang Y, Zheng Y, Cai H
iScience 2024 Mar 15;27(3):109134
iScience 2024 Mar 15;27(3):109134
X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
Mou J, Ning XL, Wang XY, Hou SY, Meng FB, Zhou C, Wu JW, Li C, Jia T, Wu X, Wu Y, Chen Y, Li GB
Journal of medicinal chemistry 2024 Jun 13;67(11):8730-8756
Journal of medicinal chemistry 2024 Jun 13;67(11):8730-8756
Shape-fixing hydrogel promotes scarless healing of wounds under tension.
Fu D, Huang J, Wu X, Li Y, Zhang Y, Chen L, Liu Z, He Y, Zhou Y, Yang L, Hu Z, Miao Y
Acta biomaterialia 2024 Jul 15;183:173-190
Acta biomaterialia 2024 Jul 15;183:173-190
PPAR gamma and PGC-1alpha activators protect against diabetic nephropathy by suppressing the inflammation and NF-kappaB activation.
Huang S, Jin Y, Zhang L, Zhou Y, Chen N, Wang W
Nephrology (Carlton, Vic.) 2024 Dec;29(12):858-872
Nephrology (Carlton, Vic.) 2024 Dec;29(12):858-872
Mechanism of Xue-Jie-San treating Crohn's disease complicated by atherosclerosis: Network pharmacology, molecular docking and experimental validation.
Wu D, Lin Q, Wang Z, Huang H, Song X, Gao Y, Yang X, Wen K, Sun X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156169
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156169
Jia Wei Qingxin Lotus Seed Drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C/SP1/ZEB1 signaling pathway.
Xie J, Lin H, Jin F, Luo Y, Yang P, Song J, Yao W, Lin W, Yuan D, Zuo A, Sun J, Wang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156142
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156142
Sphingosine-1-phosphate receptor 3 promotes neuronal apoptosis via the TNF-α/caspase-3 signaling pathway after acute intracerebral hemorrhage.
Song D, Li M, Zhang L, Zhang K, An Y, Feng M, Wang F, Yeh CT, Wang J, Guo F
Molecular and cellular neurosciences 2024 Dec;131:103979
Molecular and cellular neurosciences 2024 Dec;131:103979
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
Li J, Tian Z, Zhang T, Jin J, Zhang X, Xie P, Lin H, Gu J, Wu Y, Wang X, Zhang S, Yan X, Guo D, Wang Z, Zhang Q
Cellular & molecular biology letters 2024 Dec 3;29(1):148
Cellular & molecular biology letters 2024 Dec 3;29(1):148
Macrophage NLRP3-dependent IL-1β production contributes to aortic fibrosis in heart failure with preserved ejection fraction.
Chen S, Lu Z
Acta biochimica et biophysica Sinica 2024 Dec 26;57(7):1175-1183
Acta biochimica et biophysica Sinica 2024 Dec 26;57(7):1175-1183
Nppb contributes to Sepsis-Induced myocardial injury by regulating Senescence-Related genes.
Yang H, Jiang Z, Feng L, Wang C, Xu H, Wu X, Lin C, Zeng K
International immunopharmacology 2024 Dec 25;143(Pt 2):113461
International immunopharmacology 2024 Dec 25;143(Pt 2):113461
-RAMP3 promotes hepatocellular carcinoma tumor cell-mediated CCL2 degradation by supporting membrane distribution of ACKR2.
Yang L, Fang A, Zhou S, Liu H
International immunopharmacology 2024 Dec 25;143(Pt 2):113419
International immunopharmacology 2024 Dec 25;143(Pt 2):113419
Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy.
Shi M, Yang Y, Huang N, Zeng D, Mo Z, Wang J, Zhang X, Liu R, Wang C, Rong X, Wu Z, Huang Q, Shang H, Tang J, Wang Z, Cai J, Huang G, Guan Y, Guo J, Mu Q, Wang J, Liao W
Cell reports. Medicine 2024 Dec 17;5(12):101838
Cell reports. Medicine 2024 Dec 17;5(12):101838
Protective effect of rubber seed oil on human endothelial cells.
Zhang Y, Huang F, Wu Y, Jiao L, Wang Y, Ding T
Journal of molecular histology 2024 Aug;55(4):589-598
Journal of molecular histology 2024 Aug;55(4):589-598
PL-Relief(TM)plus Alleviates Atopic Dermatitis and Regulates Inflammatory Responses via Inhibiting NF-κB Signaling Pathway.
Zhang X, Shen Z, Zhu W, Lin L, Fan Y, Cheng X, Yu M, Yu S, Zhao B
Chemistry & biodiversity 2024 Aug;21(8):e202400349
Chemistry & biodiversity 2024 Aug;21(8):e202400349
TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells.
Li X, An T, Yang Y, Xu Z, Chen S, Yi Z, Deng C, Zhou F, Man Y, Hu C
Cell death & disease 2024 Aug 17;15(8):598
Cell death & disease 2024 Aug 17;15(8):598
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats.
Arenas YM, López-Gramaje A, Montoliu C, Llansola M, Felipo V
Biological research 2024 Apr 27;57(1):18
Biological research 2024 Apr 27;57(1):18
Neutrophil infiltration associated genes on the prognosis and tumor immune microenvironment of lung adenocarcinoma.
Liu R, Zhu G, Sun Y, Li M, Hu Z, Cao P, Li X, Song Z, Chen J
Frontiers in immunology 2023;14:1304529
Frontiers in immunology 2023;14:1304529
rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice.
Li L, Wang H, Pang S, Wang L, Fan Z, Ma C, Yang S, Banda J, Hui Q, Lv F, Fan H, Huang T, Zhang X, Wang X
The Journal of biological chemistry 2023 Sep;299(9):105127
The Journal of biological chemistry 2023 Sep;299(9):105127
Cuyun Recipe ameliorates pregnancy loss by regulating macrophage polarization and hypercoagulable state during the peri-implantation period in an ovarian hyperstimulation mouse model.
Zhu W, Xu M, Zhu M, Song Y, Zhang J, Zheng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154974
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154974
Bacterial indole-3-lactic acid affects epithelium-macrophage crosstalk to regulate intestinal homeostasis.
Yu K, Li Q, Sun X, Peng X, Tang Q, Chu H, Zhou L, Wang B, Zhou Z, Deng X, Yang J, Lv J, Liu R, Miao C, Zhao W, Yao Z, Wang Q
Proceedings of the National Academy of Sciences of the United States of America 2023 Nov 7;120(45):e2309032120
Proceedings of the National Academy of Sciences of the United States of America 2023 Nov 7;120(45):e2309032120
Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats.
Sancho-Alonso M, Arenas YM, Izquierdo-Altarejos P, Martinez-Garcia M, Llansola M, Felipo V
International journal of molecular sciences 2023 Dec 8;24(24)
International journal of molecular sciences 2023 Dec 8;24(24)
Targeted Therapy of Acute Liver Injury via Cryptotanshinone-Loaded Biomimetic Nanoparticles Derived from Mesenchymal Stromal Cells Driven by Homing.
Zhang X, Yi Y, Jiang Y, Liao J, Yang R, Deng X, Zhang L
Pharmaceutics 2023 Dec 12;15(12)
Pharmaceutics 2023 Dec 12;15(12)
Effects of Ischemia on the Migratory Capacity of Microglia Along Collagen Microcontact Prints on Organotypic Mouse Cortex Brain Slices.
Steiner K, Humpel C
Frontiers in cellular neuroscience 2022;16:858802
Frontiers in cellular neuroscience 2022;16:858802
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