Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [131]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 22401-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ACSL4/FACL4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ACSL4/FACL4 antibody (Cat. #22401-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism.
Surufatinib combined with photodynamic therapy induces ferroptosis to inhibit cholangiocarcinoma in vitro and in tumor models.
FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.
Emerging perfluoroalkyl substances retard skeletal growth by accelerating osteoblasts senescence via ferroptosis.
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia.
Development and Application of the CRISPR-dcas13d-eIF4G Translational Regulatory System to Inhibit Ferroptosis in Calcium Oxalate Crystal-Induced Kidney Injury.
FTH1 overexpression using a dCasRx translation enhancement system protects the kidney from calcium oxalate crystal-induced injury.
Metabolomics analysis revealed the neuroprotective role of 2-phosphoglyceric acid in hypoxic-ischemic brain damage through GPX4/ACSL4 axis regulation.
Evaluating the efficacy and mechanisms of Hua-Zhuo-Ning-Fu-Decoction on psoriasis using integrated bioinformatics analysis and metabolomics.
Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose.
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Allogeneic platelet-rich plasma inhibits ferroptosis in promoting wound repair of type 2 diabetic ulcers.
Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity.
Enhanced glutathione production protects against zearalenone-induced oxidative stress and ferroptosis in female reproductive system.
DTTZ suppresses ferroptosis and reverses mitochondrial dysfunction in normal tissues affected by chemotherapy.
Ozone-mediated cerebral protection: Unraveling the mechanism through ferroptosis and the NRF2/SLC7A11/GPX4 signaling pathway.
NRF2 activation ameliorates blood-brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation.
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.
Manganese drives ferroptosis of cancer cells via YAP/TAZ phase separation activated ACSL4 in OSCC.
ACSL4 promotes malignant progression of Hepatocellular carcinoma by targeting PAK2 transcription.
Delivery of exogenous miR-19b by Wharton's Jelly Mesenchymal Stem Cells attenuates transplanted kidney ischemia/reperfusion injury by regulating cellular metabolism.
Lipoxin A(4) ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes.
TaoHe ChengQi decoction ameliorates sepsis-induced cardiac dysfunction through anti-ferroptosis via the Nrf2 pathway.
Ferroptosis: First evidence in premature duck ovary induced by polyvinyl chloride microplastics.
Cadmium Induces Kidney Iron Deficiency and Chronic Kidney Injury by Interfering with the Iron Metabolism in Rats.
Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury.
FGF10 protects against LPS-induced epithelial barrier injury and inflammation by inhibiting SIRT1-ferroptosis pathway in acute lung injury in mice.
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway.
Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway.
Transient receptor potential channel TRPM4 favors oxidized low-density lipoprotein-induced coronary endothelial cell dysfunction via a mechanism involving ferroptosis.
7-Dehydrocholesterol dictates ferroptosis sensitivity.
SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.
Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner.
Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism.
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis.
4-amino-2-trifluoromethyl-phenyl retinate alleviates lipopolysaccharide-induced acute myocardial injury through activation of the KLF4/p62 axis.
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest.
High expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma.
A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro.
Preventive effects of lactoferrin on acute alcohol-induced liver injury via iron chelation and regulation of iron metabolism.
Sodium octanoate alleviates cardiac and cerebral injury after traumatic cardiac arrest in a porcine model.
Magnolin alleviated DSS-induced colitis by inhibiting ALOX5-mediated ferroptosis.
GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway.
Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1.
ACSL4 accelerates osteosarcoma progression via modulating TGF-β/Smad2 signaling pathway.
Non-targeted metabolomics strategy reveals the role of Geng-Nian-Shu in regulating ferroptosis in perimenopausal syndrome.
Phosphatidylethanolamine aggravates Angiotensin II-induced atrial fibrosis by triggering ferroptosis in mice.
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis.
TRAP1 inhibits MARCH5-mediated MIC60 degradation to alleviate mitochondrial dysfunction and apoptosis of cardiomyocytes under diabetic conditions.
URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers.
STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.
Insight into the effect of a heavy metal mixture on neurological damage in rats through combined serum metabolomic and brain proteomic analyses.
Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis.
E3 ubiquitin ligase Siah1 aggravates NAFLD through Scp2 ubiquitination.
The BRD4-SRPK2-SRSF2 signal modulates the splicing efficiency of ACSL3 pre-mRNA and influences erastin-induced ferroptosis in osteosarcoma cells.
PDPN(+) CAFs facilitate the motility of OSCC cells by inhibiting ferroptosis via transferring exosomal lncRNA FTX.
Ambient particulate matter exposure plus chronic ethanol ingestion exacerbates hepatic fibrosis by triggering the mitochondrial ROS-ferroptosis signaling pathway in mice.
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy.
ACSL4 serves as a novel prognostic biomarker correlated with immune infiltration in Cholangiocarcinoma.
Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes.
ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma.
1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells.
Glycyrrhizic acid glycosides reduces extensive tripterygium glycosides-induced lipid deposition in hepatocytes.
Curcumin preconditioning enhances the neuroprotective effects of olfactory mucosa-derived mesenchymal stem cells on experimental intracerebral hemorrhage.
Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway.
SCP2 mediates the transport of lipid hydroperoxides to mitochondria in chondrocyte ferroptosis.
Long non-coding RNA PVT1 regulates atherosclerosis progression via the microRNA-106b-5p/ACSL4 axis.
A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2.
Protective effect of total flavonoids of Engelhardia roxburghiana Wall. leaves against radiation-induced intestinal injury in mice and its mechanism.
Protective effects of brain and muscle ARNT-like gene 1 on oxidized low-density lipoprotein-induced human brain microvascular endothelial cell injury by alleviating ferroptosis.
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation.
Xanthohumol attenuates renal ischemia/reperfusion injury by inhibiting ferroptosis.
Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer.
Characteristics and time points to inhibit ferroptosis in human osteoarthritis.
lnc-HC ameliorates steatosis by promoting miR-130b-3p biogenesis and the assembly of an RNA-induced silencing complex.
Sculponeatin A promotes the ETS1-SYVN1 interaction to induce SLC7A11/xCT-dependent ferroptosis in breast cancer.
PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis.
Pterostilbene ameliorates oxidative damage and ferroptosis in human ovarian granulosa cells by regulating the Nrf2/HO-1 pathway.
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer.
Cyclosporine A-loaded apoferritin alleviates myocardial ischemia-reperfusion injury by simultaneously blocking ferroptosis and apoptosis of cardiomyocytes.
The Effects of Alda-1 Treatment on Renal and Intestinal Injuries After Cardiopulmonary Resuscitation in Pigs.
Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage.
Atorvastatin Inhibits Ferroptosis of H9C2 Cells by regulatingSMAD7/Hepcidin Expression to Improve Ischemia-Reperfusion Injury.
Zinc Oxide Nanoparticle Inhibits Tumorigenesis of Renal Cell Carcinoma by Modulating Lipid Metabolism Targeting miR-454-3p to Repressing Metabolism Enzyme ACSL4.
Probiotic Saccharomyces boulardii attenuates cardiopulmonary bypass-induced acute lung injury by inhibiting ferroptosis.
Itraconazole Inhibits the Growth of Cutaneous Squamous Cell Carcinoma by Targeting HMGCS1/ACSL4 Axis.
NAT10: An RNA cytidine transferase regulates fatty acid metabolism in cancer cells.
Context-dependent regulation of ferroptosis sensitivity.
Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells.
α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease.
Amentoflavone promotes ferroptosis by regulating reactive oxygen species (ROS) /5'AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) to inhibit the malignant progression of endometrial carcinoma cells.
Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Puerarin Attenuates Oxidative Stress and Ferroptosis via AMPK/PGC1α/Nrf2 Pathway after Subarachnoid Hemorrhage in Rats.
IRF2-ferroptosis related gene is associated with prognosis and EMT in gliomas.
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming.
Ferroptosis is involved in PGPS-induced otitis media in C57BL/6 mice.
Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance.
Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling.
The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.
Oxalate Activates Autophagy to Induce Ferroptosis of Renal Tubular Epithelial Cells and Participates in the Formation of Kidney Stones.
Stearoyl-CoA Desaturase 1 Potentiates Hypoxic plus Nutrient-Deprived Pancreatic Cancer Cell Ferroptosis Resistance.
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Comprehensive Analysis of the Tumor Microenvironment and Ferroptosis-Related Genes Predict Prognosis with Ovarian Cancer.
Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway.
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
Ferrostatin-1 alleviated TNBS induced colitis via the inhibition of ferroptosis.
High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma.
Nuclear receptor coactivator 4-mediated ferritinophagy drives proliferation of dental pulp stem cells in hypoxia.
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p.
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis.
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Quantitative proteomics by SWATH-MS reveals sophisticated metabolic reprogramming in hepatocellular carcinoma tissues.
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer.
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells.
Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4.
Liu S, Han S, Wang C, Chen H, Xu Q, Feng S, Wang Y, Yao J, Zhou Q, Tang X, Lin L, Hu L, Davidson AJ, Yang B, Ye C, Yang F, Mao J, Tong C, Chen J, Jiang H
International journal of biological sciences 2024;20(2):569-584
International journal of biological sciences 2024;20(2):569-584
Surufatinib combined with photodynamic therapy induces ferroptosis to inhibit cholangiocarcinoma in vitro and in tumor models.
Huang YP, Wang YX, Zhou H, Liu ZT, Zhang ZJ, Xiong L, Zou H, Wen Y
Frontiers in pharmacology 2024;15:1288255
Frontiers in pharmacology 2024;15:1288255
FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.
Zeng H, Xu J, Wu R, Wang X, Jiang Y, Wang Q, Guo J, Xiao F
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307
Emerging perfluoroalkyl substances retard skeletal growth by accelerating osteoblasts senescence via ferroptosis.
Wang X, Wang K, Mao W, Fan Z, Liu T, Hong R, Chen H, Pan C
Environmental research 2024 Oct 1;258:119483
Environmental research 2024 Oct 1;258:119483
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia.
López-Molina L, Sancho-Balsells A, Al-Massadi O, Montalban E, Alberch J, Arranz B, Girault JA, Giralt A
Neurobiology of disease 2024 May;194:106487
Neurobiology of disease 2024 May;194:106487
Development and Application of the CRISPR-dcas13d-eIF4G Translational Regulatory System to Inhibit Ferroptosis in Calcium Oxalate Crystal-Induced Kidney Injury.
He Z, Song C, Li S, Dong C, Liao W, Xiong Y, Yang S, Liu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(17):e2309234
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(17):e2309234
FTH1 overexpression using a dCasRx translation enhancement system protects the kidney from calcium oxalate crystal-induced injury.
He Z, Dong C, Song T, Zhou J, Xu T, He R, Li S
Cellular & molecular biology letters 2024 May 7;29(1):65
Cellular & molecular biology letters 2024 May 7;29(1):65
Metabolomics analysis revealed the neuroprotective role of 2-phosphoglyceric acid in hypoxic-ischemic brain damage through GPX4/ACSL4 axis regulation.
Chen H, Wusiman Y, Zhao J, Zhang W, Liu W, Wang S, Qian G, Zhang G, Le M, Dong X
European journal of pharmacology 2024 May 15;971:176539
European journal of pharmacology 2024 May 15;971:176539
Evaluating the efficacy and mechanisms of Hua-Zhuo-Ning-Fu-Decoction on psoriasis using integrated bioinformatics analysis and metabolomics.
Man S, Ma W, Jiang H, Haider A, Shi S, Li X, Wu Z, Song Y
Journal of ethnopharmacology 2024 May 10;325:117856
Journal of ethnopharmacology 2024 May 10;325:117856
Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose.
Xie HB, Guo JH, Yang MM, Wang JT
In vitro cellular & developmental biology. Animal 2024 Mar;60(3):278-286
In vitro cellular & developmental biology. Animal 2024 Mar;60(3):278-286
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Yuan Q, Fang Y, Guo J, Zhang Z, Liao J, Kuang J
Toxicology and applied pharmacology 2024 Mar;484:116845
Toxicology and applied pharmacology 2024 Mar;484:116845
Allogeneic platelet-rich plasma inhibits ferroptosis in promoting wound repair of type 2 diabetic ulcers.
Zhou D, Liang Q, Ge X, Xu J
Free radical biology & medicine 2024 Mar;215:37-47
Free radical biology & medicine 2024 Mar;215:37-47
Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity.
Wei Y, Liu W, Wang R, Chen Y, Liu J, Guo X, Can C, Yang X, Wang D, Hu X, Ma D
Free radical biology & medicine 2024 Mar;213:36-51
Free radical biology & medicine 2024 Mar;213:36-51
Enhanced glutathione production protects against zearalenone-induced oxidative stress and ferroptosis in female reproductive system.
Fu W, Dai C, Ma Z, Li Q, Lan D, Sun C, Wu X, Li J, Wang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114462
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114462
DTTZ suppresses ferroptosis and reverses mitochondrial dysfunction in normal tissues affected by chemotherapy.
Yang Y, Chen Y, Tang H, Zhang Z, Zhou X, Xu W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116227
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116227
Ozone-mediated cerebral protection: Unraveling the mechanism through ferroptosis and the NRF2/SLC7A11/GPX4 signaling pathway.
Zhu F, Ding S, Liu Y, Wang X, Wu Z
Journal of chemical neuroanatomy 2024 Mar;136:102387
Journal of chemical neuroanatomy 2024 Mar;136:102387
NRF2 activation ameliorates blood-brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation.
Fan W, Chen H, Li M, Fan X, Jiang F, Xu C, Wang Y, Wei W, Song J, Zhong D, Li G
Scientific reports 2024 Mar 4;14(1):5300
Scientific reports 2024 Mar 4;14(1):5300
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.
Xiang Z, Zhang P, Jia C, Xu R, Cao D, Xu Z, Lu T, Liu J, Wang X, Qiu C, Fu W, Li W, Cheng L, Yang Q, Feng S, Wang L, Zhao Y, Liu X
Bone research 2024 Mar 29;12(1):20
Bone research 2024 Mar 29;12(1):20
Manganese drives ferroptosis of cancer cells via YAP/TAZ phase separation activated ACSL4 in OSCC.
Chen H, Cui H, Liu W, Li BW, Tian Z, Zhao YY, Yu GT
Oral diseases 2024 Mar 10;
Oral diseases 2024 Mar 10;
ACSL4 promotes malignant progression of Hepatocellular carcinoma by targeting PAK2 transcription.
Wu D, Zuo Z, Sun X, Li X, Yin F, Yin W
Biochemical pharmacology 2024 Jun;224:116206
Biochemical pharmacology 2024 Jun;224:116206
Delivery of exogenous miR-19b by Wharton's Jelly Mesenchymal Stem Cells attenuates transplanted kidney ischemia/reperfusion injury by regulating cellular metabolism.
Wu X, Wu X, Wang Z, Tian X, Zhang C, Cao G, Gu Y, Yan T
Drug delivery and translational research 2024 Jun 25;
Drug delivery and translational research 2024 Jun 25;
Lipoxin A(4) ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes.
Hu Z, Chen L, Zhao J, Zhang W, Jin Z, Sun Y, Li Z, Chang B, Shen P, Yang Y
Redox biology 2024 Jul;73:103143
Redox biology 2024 Jul;73:103143
TaoHe ChengQi decoction ameliorates sepsis-induced cardiac dysfunction through anti-ferroptosis via the Nrf2 pathway.
Lu SM, Yang B, Tan ZB, Wang HJ, Xie JD, Xie MT, Jiang WH, Huang JZ, Li J, Zhang L, Tan YZ, Zhang JZ, Liu B, Wu WW, Zhang SW
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155597
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155597
Ferroptosis: First evidence in premature duck ovary induced by polyvinyl chloride microplastics.
Ali W, Chen Y, Shah MG, Buriro RS, Sun J, Liu Z, Zou H
The Science of the total environment 2024 Jul 10;933:173032
The Science of the total environment 2024 Jul 10;933:173032
Cadmium Induces Kidney Iron Deficiency and Chronic Kidney Injury by Interfering with the Iron Metabolism in Rats.
Zhang K, Long M, Dong W, Li J, Wang X, Liu W, Huang Q, Ping Y, Zou H, Song R, Liu G, Ran D, Liu Z
International journal of molecular sciences 2024 Jan 7;25(2)
International journal of molecular sciences 2024 Jan 7;25(2)
Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury.
Wang S, Li X, Li J, Wang A, Li F, Hu H, Long T, Pei X, Li H, Zhong F, Zhu F
Chemico-biological interactions 2024 Jan 5;387:110825
Chemico-biological interactions 2024 Jan 5;387:110825
FGF10 protects against LPS-induced epithelial barrier injury and inflammation by inhibiting SIRT1-ferroptosis pathway in acute lung injury in mice.
Lin L, Yang L, Wang N, Chen S, Du X, Chen R, Zhang H, Kong X
International immunopharmacology 2024 Jan 25;127:111426
International immunopharmacology 2024 Jan 25;127:111426
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Jia C, Xiang Z, Zhang P, Liu L, Zhu X, Yu R, Liu Z, Wang S, Liu K, Wang Z, Vasilev K, Zhou S, Geng Z, Liu X, Zhao Y, Gao Y, Cheng L, Li Y
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Yu S, Xiong W, Xu W, Chen Y
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway.
Peng C, Ai Q, Zhao F, Li H, Sun Y, Tang K, Yang Y, Chen N, Liu F
European journal of pharmacology 2024 Jan 15;963:176264
European journal of pharmacology 2024 Jan 15;963:176264
Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway.
Zou W, Wang X, Xia X, Zhang T, Nie M, Xiong J, Fang X
Biochemical and biophysical research communications 2024 Jan 15;692:149338
Biochemical and biophysical research communications 2024 Jan 15;692:149338
Transient receptor potential channel TRPM4 favors oxidized low-density lipoprotein-induced coronary endothelial cell dysfunction via a mechanism involving ferroptosis.
Ye F, Liu D, Zhang J
Tissue & cell 2024 Feb;86:102290
Tissue & cell 2024 Feb;86:102290
7-Dehydrocholesterol dictates ferroptosis sensitivity.
Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P
Nature 2024 Feb;626(7998):411-418
Nature 2024 Feb;626(7998):411-418
SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.
Xu X, Mao Y, Feng Z, Dai F, Gu T, Zheng J
Oncology reports 2024 Feb;51(2)
Oncology reports 2024 Feb;51(2)
Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner.
Fei Y, Li T, Wu R, Xu X, Hu S, Yang Y, Jin C, Tang W, Zhang X, Du Q, Liu C
Psychopharmacology 2024 Feb;241(2):379-399
Psychopharmacology 2024 Feb;241(2):379-399
Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism.
Maio G, Smith M, Bhawal R, Zhang S, Baskin JM, Li J, Lin H
Molecular & cellular proteomics : MCP 2024 Feb;23(2):100709
Molecular & cellular proteomics : MCP 2024 Feb;23(2):100709
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis.
Li Z, Wu B, Chen J, Ye N, Ma R, Song C, Sun Y, Zhang X, Sun G
Journal of translational internal medicine 2024 Feb;12(1):35-50
Journal of translational internal medicine 2024 Feb;12(1):35-50
4-amino-2-trifluoromethyl-phenyl retinate alleviates lipopolysaccharide-induced acute myocardial injury through activation of the KLF4/p62 axis.
Dan Z, Shi X, Shu C, Zhu R, Wang Y, Zhu H
Cellular signalling 2024 Feb;114:111001
Cellular signalling 2024 Feb;114:111001
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest.
Rodencal J, Kim N, He A, Li VL, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Long JZ, Sage J, Dixon SJ
Cell chemical biology 2024 Feb 15;31(2):234-248.e13
Cell chemical biology 2024 Feb 15;31(2):234-248.e13
High expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma.
Tao S, Cui D, Cheng H, Liu X, Jiang Z, Chen H, Gao Y
BMC cancer 2024 Feb 12;24(1):194
BMC cancer 2024 Feb 12;24(1):194
A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro.
Wu X, Wu J
Cancer chemotherapy and pharmacology 2024 Aug;94(2):183-195
Cancer chemotherapy and pharmacology 2024 Aug;94(2):183-195
Preventive effects of lactoferrin on acute alcohol-induced liver injury via iron chelation and regulation of iron metabolism.
Guan S, Zhang S, Liu M, Guo J, Chen Y, Shen X, Deng X, Lu J
Journal of dairy science 2024 Aug;107(8):5316-5329
Journal of dairy science 2024 Aug;107(8):5316-5329
Sodium octanoate alleviates cardiac and cerebral injury after traumatic cardiac arrest in a porcine model.
Lin Y, Chen Q, Zhang G, Xie L, Yang X, Zhong H, Xu J, Zhang M
The American journal of emergency medicine 2024 Apr;78:48-56
The American journal of emergency medicine 2024 Apr;78:48-56
Magnolin alleviated DSS-induced colitis by inhibiting ALOX5-mediated ferroptosis.
Yao T, Yao YY, Wang JZ, Jiang SM, Li LJ
The Kaohsiung journal of medical sciences 2024 Apr;40(4):360-373
The Kaohsiung journal of medical sciences 2024 Apr;40(4):360-373
GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway.
Mengjia W, Jun J, Xin Z, Jiahao Z, Jie G
Journal of cellular and molecular medicine 2024 Apr;28(7):e18231
Journal of cellular and molecular medicine 2024 Apr;28(7):e18231
Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1.
Wright T, Turnis ME, Grace CR, Li X, Brakefield LA, Wang YD, Xu H, Kaminska E, Climer LK, Mukiza TO, Chang CL, Moldoveanu T, Opferman JT
Molecular cell 2024 Apr 4;84(7):1338-1353.e8
Molecular cell 2024 Apr 4;84(7):1338-1353.e8
ACSL4 accelerates osteosarcoma progression via modulating TGF-β/Smad2 signaling pathway.
Li X, Chen Q, Zhao D, Tan J, Liao R, Gu Y, Zhu J, Zhang H, Xie J, Chen L
Molecular and cellular biochemistry 2024 Apr 2;
Molecular and cellular biochemistry 2024 Apr 2;
Non-targeted metabolomics strategy reveals the role of Geng-Nian-Shu in regulating ferroptosis in perimenopausal syndrome.
Lv X, Bi A, Zhang Z, Li J, Wei Y, Wan M, Wang J, Yan T, Jia Y
Journal of pharmaceutical and biomedical analysis 2024 Apr 15;241:115980
Journal of pharmaceutical and biomedical analysis 2024 Apr 15;241:115980
Phosphatidylethanolamine aggravates Angiotensin II-induced atrial fibrosis by triggering ferroptosis in mice.
Huang F, Liu X, Liu J, Xie Y, Zhao L, Liu D, Zeng Z, Liu X, Zheng S, Xiao Z
Frontiers in pharmacology 2023;14:1148410
Frontiers in pharmacology 2023;14:1148410
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
Xiong L, Huang J, Wu C, Yuan Q, Wang S, Zhu L, Li Z, Sun Z, Fang Y, Li W, Hu G
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis.
Xiao Y, Yu Y, Hu L, Yang Y, Yuan Y, Zhang W, Luo J, Yu L
Inflammation 2023 Oct;46(5):1684-1696
Inflammation 2023 Oct;46(5):1684-1696
TRAP1 inhibits MARCH5-mediated MIC60 degradation to alleviate mitochondrial dysfunction and apoptosis of cardiomyocytes under diabetic conditions.
Zhang L, Luo Y, Lv L, Chen S, Liu G, Zhao T
Cell death and differentiation 2023 Oct;30(10):2336-2350
Cell death and differentiation 2023 Oct;30(10):2336-2350
URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers.
Ding Z, Pan Y, Shang T, Jiang T, Lin Y, Yang C, Pang S, Cui X, Wang Y, Feng XF, Xu M, Pei M, Chen Y, Li X, Ding J, Tan Y, Wang H, Dong L, Wang L
Nature communications 2023 Oct 7;14(1):6269
Nature communications 2023 Oct 7;14(1):6269
STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.
Gao L, Zhang J, Yang T, Jiang L, Liu X, Wang S, Wang X, Huang Y, Wang H, Zhang M, Gong T, Ma L, Li C, He C, Meng XM, Wu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Oct 4;31(10):3084-3103
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Oct 4;31(10):3084-3103
Insight into the effect of a heavy metal mixture on neurological damage in rats through combined serum metabolomic and brain proteomic analyses.
Xie J, Zhou F, Ouyang L, Li Q, Rao S, Su R, Yang S, Li J, Wan X, Yan L, Liu P, Cheng H, Li L, Du G, Feng C, Fan G
The Science of the total environment 2023 Oct 15;895:165009
The Science of the total environment 2023 Oct 15;895:165009
Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
Wu Q, Liang Z, Jiang J, Feng X, Liu J, Zhang Z, Wang H, Wang N, Gou Y, Li Z, Cao Y
Cell death & disease 2023 Oct 11;14(10):668
Cell death & disease 2023 Oct 11;14(10):668
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis.
Xiao Y, Yuan Y, Yang Y, Liu B, Ding Z, Luo J, Chen S, Yu L
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Nov;72(10-11):1941-1955
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Nov;72(10-11):1941-1955
E3 ubiquitin ligase Siah1 aggravates NAFLD through Scp2 ubiquitination.
Zhu Z, Hu X, Liu K, Li J, Fan K, Wang H, Wang L, He L, Ma Y, Guan R, Wang Z
International immunopharmacology 2023 Nov;124(Pt A):110897
International immunopharmacology 2023 Nov;124(Pt A):110897
The BRD4-SRPK2-SRSF2 signal modulates the splicing efficiency of ACSL3 pre-mRNA and influences erastin-induced ferroptosis in osteosarcoma cells.
Luo SH, Tian JM, Chu Y, Zhu HY, Ni JD, Huang J
Cell death & disease 2023 Nov 23;14(11):760
Cell death & disease 2023 Nov 23;14(11):760
PDPN(+) CAFs facilitate the motility of OSCC cells by inhibiting ferroptosis via transferring exosomal lncRNA FTX.
Li Y, Ma Z, Li W, Xu X, Shen P, Zhang SE, Cheng B, Xia J
Cell death & disease 2023 Nov 22;14(11):759
Cell death & disease 2023 Nov 22;14(11):759
Ambient particulate matter exposure plus chronic ethanol ingestion exacerbates hepatic fibrosis by triggering the mitochondrial ROS-ferroptosis signaling pathway in mice.
Ding S, Jiang J, Zhang G, Yu M, Zheng Y
Ecotoxicology and environmental safety 2023 May;256:114897
Ecotoxicology and environmental safety 2023 May;256:114897
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy.
Wang Y, He X, Xue M, Sun W, He Q, Jin J
Free radical research 2023 May-Jun;57(6-12):413-429
Free radical research 2023 May-Jun;57(6-12):413-429
ACSL4 serves as a novel prognostic biomarker correlated with immune infiltration in Cholangiocarcinoma.
Liu S, Fan S, Wang Y, Chen R, Wang Z, Zhang Y, Jiang W, Chen Y, Xu X, Yu Y, Li C, Li X
BMC cancer 2023 May 16;23(1):444
BMC cancer 2023 May 16;23(1):444
Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes.
Li J, Hui Y, Xu Z, Tan J, Yin K, Kuang L, Tang Y, Wei J, Zhong Q, Zheng T
iScience 2023 Mar 17;26(3):106271
iScience 2023 Mar 17;26(3):106271
ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma.
Yang H, Sun W, Bi T, Sun J, Lu Z, Li J, Wei H
DNA and cell biology 2023 Jun;42(6):336-347
DNA and cell biology 2023 Jun;42(6):336-347
1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells.
Jiang Y, Yang J, Du K, Luo K, Yuan X, Hua F
Hormones (Athens, Greece) 2023 Jun;22(2):273-280
Hormones (Athens, Greece) 2023 Jun;22(2):273-280
Glycyrrhizic acid glycosides reduces extensive tripterygium glycosides-induced lipid deposition in hepatocytes.
Yang Y, Fu X, Xia B, Zhou L, Zhang H, Li C, Ye X, Liu T
Heliyon 2023 Jul;9(7):e17891
Heliyon 2023 Jul;9(7):e17891
Curcumin preconditioning enhances the neuroprotective effects of olfactory mucosa-derived mesenchymal stem cells on experimental intracerebral hemorrhage.
Huang Y, Liu J, He J, Tan F, Lu M, Yuan F, Zhu X, Kong L
Heliyon 2023 Jul;9(7):e17874
Heliyon 2023 Jul;9(7):e17874
Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway.
Li D, Lu X, Xu G, Liu S, Gong Z, Lu F, Xia X, Jiang J, Wang H, Zou F, Ma X
CNS neuroscience & therapeutics 2023 Jul;29(7):1923-1939
CNS neuroscience & therapeutics 2023 Jul;29(7):1923-1939
SCP2 mediates the transport of lipid hydroperoxides to mitochondria in chondrocyte ferroptosis.
Dai T, Xue X, Huang J, Yang Z, Xu P, Wang M, Xu W, Feng Z, Zhu W, Xu Y, Chen J, Li S, Meng Q
Cell death discovery 2023 Jul 8;9(1):234
Cell death discovery 2023 Jul 8;9(1):234
Long non-coding RNA PVT1 regulates atherosclerosis progression via the microRNA-106b-5p/ACSL4 axis.
Zhang M, Yu Z, Zhao L, Luo H
Biochemical and biophysical research communications 2023 Jul 30;667:170-179
Biochemical and biophysical research communications 2023 Jul 30;667:170-179
A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2.
Rodencal J, Kim N, Li VL, He A, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Sage J, Long JZ, Dixon SJ
bioRxiv : the preprint server for biology 2023 Jul 19;
bioRxiv : the preprint server for biology 2023 Jul 19;
Protective effect of total flavonoids of Engelhardia roxburghiana Wall. leaves against radiation-induced intestinal injury in mice and its mechanism.
Wu S, Tian C, Tu Z, Guo J, Xu F, Qin W, Chang H, Wang Z, Hu T, Sun X, Ning H, Li Y, Gou W, Hou W
Journal of ethnopharmacology 2023 Jul 15;311:116428
Journal of ethnopharmacology 2023 Jul 15;311:116428
Protective effects of brain and muscle ARNT-like gene 1 on oxidized low-density lipoprotein-induced human brain microvascular endothelial cell injury by alleviating ferroptosis.
Yu S, Zeng Y, Ruan C, Bai L, Liang Z
Human & experimental toxicology 2023 Jan-Dec;42:9603271231184630
Human & experimental toxicology 2023 Jan-Dec;42:9603271231184630
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74
Cell death & disease 2023 Jan 31;14(1):74
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638
Nature communications 2023 Feb 6;14(1):638
3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation.
Usukhbayar N, Takano Y, Uesugi S, Muroi M, Osada H, Kimura KI
Free radical research 2023 Dec;57(3):208-222
Free radical research 2023 Dec;57(3):208-222
Xanthohumol attenuates renal ischemia/reperfusion injury by inhibiting ferroptosis.
Tang Z, Feng Y, Nie W, Li C
Experimental and therapeutic medicine 2023 Dec;26(6):571
Experimental and therapeutic medicine 2023 Dec;26(6):571
Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer.
Feng S, Rao Z, Zhang J, She X, Chen Y, Wan K, Li H, Zhao C, Feng Y, Wang G, Hu J, Luo X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2303484
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2303484
Characteristics and time points to inhibit ferroptosis in human osteoarthritis.
Xu Y, Yang Z, Dai T, Xue X, Xia D, Feng Z, Huang J, Chen X, Sun S, Zhou J, Dai Y, Zong J, Li S, Meng Q
Scientific reports 2023 Dec 7;13(1):21592
Scientific reports 2023 Dec 7;13(1):21592
lnc-HC ameliorates steatosis by promoting miR-130b-3p biogenesis and the assembly of an RNA-induced silencing complex.
Lan X, Ren J, Du X, Zhang L, Wang S, Yang X, Lu S
Molecular and cellular endocrinology 2023 Dec 1;578:112061
Molecular and cellular endocrinology 2023 Dec 1;578:112061
Sculponeatin A promotes the ETS1-SYVN1 interaction to induce SLC7A11/xCT-dependent ferroptosis in breast cancer.
Peng P, Ren Y, Wan F, Tan M, Wu H, Shen J, Qian C, Liu X, Xiang Y, Yu Q, Zhang L, Si Y, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154921
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154921
PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis.
Xue X, Dai T, Chen J, Xu Y, Yang Z, Huang J, Xu W, Li S, Meng Q
Journal of orthopaedic surgery and research 2023 Aug 24;18(1):620
Journal of orthopaedic surgery and research 2023 Aug 24;18(1):620
Pterostilbene ameliorates oxidative damage and ferroptosis in human ovarian granulosa cells by regulating the Nrf2/HO-1 pathway.
Chen X, Song QL, Li ZH, Ji R, Wang JY, Cao ML, Mu XF, Zhang Y, Guo DY, Yang J
Archives of biochemistry and biophysics 2023 Apr;738:109561
Archives of biochemistry and biophysics 2023 Apr;738:109561
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311
Cell research 2023 Apr;33(4):299-311
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Dong C, Song C, He Z, Song Q, Song T, Liu J, Xiong Y, Su X, Zhou J, Yang S, Liao W
International immunopharmacology 2023 Apr;117:110042
International immunopharmacology 2023 Apr;117:110042
CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer.
Chen C, Yang Y, Guo Y, He J, Chen Z, Qiu S, Zhang Y, Ding H, Pan J, Pan Y
Cell death & disease 2023 Apr 14;14(4):271
Cell death & disease 2023 Apr 14;14(4):271
Cyclosporine A-loaded apoferritin alleviates myocardial ischemia-reperfusion injury by simultaneously blocking ferroptosis and apoptosis of cardiomyocytes.
Qian W, Liu D, Han Y, Liu M, Liu B, Ji Q, Zhang B, Mei Q, Zhou S, Cheng Y
Acta biomaterialia 2023 Apr 1;160:265-280
Acta biomaterialia 2023 Apr 1;160:265-280
The Effects of Alda-1 Treatment on Renal and Intestinal Injuries After Cardiopulmonary Resuscitation in Pigs.
Yu Q, Gao J, Shao X, Lu W, Chen L, Jin L
Frontiers in medicine 2022;9:892472
Frontiers in medicine 2022;9:892472
Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage.
Yuan B, Zhao XD, Shen JD, Chen SJ, Huang HY, Zhou XM, Han YL, Zhou LJ, Lu XJ, Wu Q
Oxidative medicine and cellular longevity 2022;2022:9069825
Oxidative medicine and cellular longevity 2022;2022:9069825
Atorvastatin Inhibits Ferroptosis of H9C2 Cells by regulatingSMAD7/Hepcidin Expression to Improve Ischemia-Reperfusion Injury.
Peng Y, Liao B, Zhou Y, Zeng W, Zeng ZY
Cardiology research and practice 2022;2022:3972829
Cardiology research and practice 2022;2022:3972829
Zinc Oxide Nanoparticle Inhibits Tumorigenesis of Renal Cell Carcinoma by Modulating Lipid Metabolism Targeting miR-454-3p to Repressing Metabolism Enzyme ACSL4.
Zhou X, Cao T
Journal of oncology 2022;2022:2883404
Journal of oncology 2022;2022:2883404
Probiotic Saccharomyces boulardii attenuates cardiopulmonary bypass-induced acute lung injury by inhibiting ferroptosis.
Li J, Gao PF, Xu YX, Gu H, Wang QX
American journal of translational research 2022;14(7):5003-5013
American journal of translational research 2022;14(7):5003-5013
Itraconazole Inhibits the Growth of Cutaneous Squamous Cell Carcinoma by Targeting HMGCS1/ACSL4 Axis.
Xu C, Zhuo Y, Liu Y, Chen H
Frontiers in pharmacology 2022;13:828983
Frontiers in pharmacology 2022;13:828983
NAT10: An RNA cytidine transferase regulates fatty acid metabolism in cancer cells.
Dalhat MH, Mohammed MRS, Alkhatabi HA, Rehan M, Ahmad A, Choudhry H, Khan MI
Clinical and translational medicine 2022 Sep;12(9):e1045
Clinical and translational medicine 2022 Sep;12(9):e1045
Context-dependent regulation of ferroptosis sensitivity.
Magtanong L, Mueller GD, Williams KJ, Billmann M, Chan K, Armenta DA, Pope LE, Moffat J, Boone C, Myers CL, Olzmann JA, Bensinger SJ, Dixon SJ
Cell chemical biology 2022 Sep 15;29(9):1409-1418.e6
Cell chemical biology 2022 Sep 15;29(9):1409-1418.e6
Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells.
Zhao Y, Zhang R, Wang Z, Chen Z, Wang G, Guan S, Lu J
Journal of agricultural and food chemistry 2022 Oct 12;70(40):12953-12967
Journal of agricultural and food chemistry 2022 Oct 12;70(40):12953-12967
α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease.
A A, W C, N N, L M, M D, Zhang DD
Free radical biology & medicine 2022 Nov 1;192:130-140
Free radical biology & medicine 2022 Nov 1;192:130-140
Amentoflavone promotes ferroptosis by regulating reactive oxygen species (ROS) /5'AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) to inhibit the malignant progression of endometrial carcinoma cells.
Sun Q, Zhen P, Li D, Liu X, Ding X, Liu H
Bioengineered 2022 May;13(5):13269-13279
Bioengineered 2022 May;13(5):13269-13279
Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.
Jo A, Bae JH, Yoon YJ, Chung TH, Lee EW, Kim YH, Joh HM, Chung JW
Cell death & disease 2022 Mar 7;13(3):212
Cell death & disease 2022 Mar 7;13(3):212
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L
Redox biology 2022 Jun;52:102292
Redox biology 2022 Jun;52:102292
Puerarin Attenuates Oxidative Stress and Ferroptosis via AMPK/PGC1α/Nrf2 Pathway after Subarachnoid Hemorrhage in Rats.
Huang Y, Wu H, Hu Y, Zhou C, Wu J, Wu Y, Wang H, Lenahan C, Huang L, Nie S, Gao X, Sun J
Antioxidants (Basel, Switzerland) 2022 Jun 27;11(7)
Antioxidants (Basel, Switzerland) 2022 Jun 27;11(7)
IRF2-ferroptosis related gene is associated with prognosis and EMT in gliomas.
Tong S, Ye L, Xu Y, Sun Q, Gao L, Cai J, Ye Z, Tian D, Chen Q
Translational oncology 2022 Dec;26:101544
Translational oncology 2022 Dec;26:101544
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming.
Chang MT, Tsai LC, Nakagawa-Goto K, Lee KH, Shyur LF
Pharmacological research 2022 Apr;178:106148
Pharmacological research 2022 Apr;178:106148
Ferroptosis is involved in PGPS-induced otitis media in C57BL/6 mice.
Yan B, Xie D, Wu Y, Wang S, Zhang X, Zhao T, Liu L, Ma P, Li G, Yang Y, Zhao Y, Zheng T, Geng R, Li B, Zheng Q
Cell death discovery 2022 Apr 21;8(1):217
Cell death discovery 2022 Apr 21;8(1):217
Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance.
Çoku J, Booth DM, Skoda J, Pedrotty MC, Vogel J, Liu K, Vu A, Carpenter EL, Ye JC, Chen MA, Dunbar P, Scadden E, Yun TD, Nakamaru-Ogiso E, Area-Gomez E, Li Y, Goldsmith KC, Reynolds CP, Hajnoczky G, Hogarty MD
The EMBO journal 2022 Apr 19;41(8):e108272
The EMBO journal 2022 Apr 19;41(8):e108272
Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling.
Liang Z, Wu Q, Wang H, Tan J, Wang H, Gou Y, Cao Y, Li Z, Zhang Z
Cell death discovery 2022 Apr 11;8(1):190
Cell death discovery 2022 Apr 11;8(1):190
The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.
Meihe L, Shan G, Minchao K, Xiaoling W, Peng A, Xili W, Jin Z, Huimin D
Frontiers in cell and developmental biology 2021;9:707959
Frontiers in cell and developmental biology 2021;9:707959
Oxalate Activates Autophagy to Induce Ferroptosis of Renal Tubular Epithelial Cells and Participates in the Formation of Kidney Stones.
Song Q, Liao W, Chen X, He Z, Li D, Li B, Liu J, Liu L, Xiong Y, Song C, Yang S
Oxidative medicine and cellular longevity 2021;2021:6630343
Oxidative medicine and cellular longevity 2021;2021:6630343
Stearoyl-CoA Desaturase 1 Potentiates Hypoxic plus Nutrient-Deprived Pancreatic Cancer Cell Ferroptosis Resistance.
Gao J, Zhang Z, Liu Y, Zhang Z, Wang M, Gong A, Xia L, Liao X, Wang D, Zhu H
Oxidative medicine and cellular longevity 2021;2021:6629804
Oxidative medicine and cellular longevity 2021;2021:6629804
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Xu J, Zhang M, Liu F, Shi L, Jiang X, Chen C, Wang J, Diao M, Khan ZU, Zhang M
Frontiers in pharmacology 2021;12:793829
Frontiers in pharmacology 2021;12:793829
Comprehensive Analysis of the Tumor Microenvironment and Ferroptosis-Related Genes Predict Prognosis with Ovarian Cancer.
Li XX, Xiong L, Wen Y, Zhang ZJ
Frontiers in genetics 2021;12:774400
Frontiers in genetics 2021;12:774400
Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway.
Shui S, Zhao Z, Wang H, Conrad M, Liu G
Redox biology 2021 Sep;45:102056
Redox biology 2021 Sep;45:102056
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
Zhang Y, Guo S, Wang S, Li X, Hou D, Li H, Wang L, Xu Y, Ma B, Wang H, Jiang X
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
Ferrostatin-1 alleviated TNBS induced colitis via the inhibition of ferroptosis.
Xu J, Liu S, Cui Z, Wang X, Ning T, Wang T, Zhang N, Xie S, Min L, Zhang S, Liang C, Zhu S
Biochemical and biophysical research communications 2021 Oct 8;573:48-54
Biochemical and biophysical research communications 2021 Oct 8;573:48-54
High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma.
Zhang Y, Li S, Li F, Lv C, Yang QK
Biology direct 2021 May 31;16(1):10
Biology direct 2021 May 31;16(1):10
Nuclear receptor coactivator 4-mediated ferritinophagy drives proliferation of dental pulp stem cells in hypoxia.
Yang A, Wang L, Jiang K, Lei L, Li H
Biochemical and biophysical research communications 2021 May 21;554:123-130
Biochemical and biophysical research communications 2021 May 21;554:123-130
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Zhao Y, Lu J, Mao A, Zhang R, Guan S
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S
Communications biology 2020 Oct 20;3(1):592
Communications biology 2020 Oct 20;3(1):592
LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p.
Jiang X, Guo S, Zhang Y, Zhao Y, Li X, Jia Y, Xu Y, Ma B
Cellular signalling 2020 Jan;65:109422
Cellular signalling 2020 Jan;65:109422
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Ndiaye H, Liu JY, Hall A, Minogue S, Morgan MY, Waugh MG
Bioscience reports 2020 Apr 30;40(4)
Bioscience reports 2020 Apr 30;40(4)
The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis.
Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL, Yuan HX
Cell death & disease 2019 Oct 7;10(10):755
Cell death & disease 2019 Oct 7;10(10):755
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.
Zhou L, Wang Z, Hu C, Zhang C, Kovatcheva-Datchary P, Yu D, Liu S, Ren F, Wang X, Li Y, Hou X, Piao H, Lu X, Zhang Y, Xu G
Journal of proteome research 2019 Mar 1;18(3):960-969
Journal of proteome research 2019 Mar 1;18(3):960-969
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Radif Y, Ndiaye H, Kalantzi V, Jacobs R, Hall A, Minogue S, Waugh MG
Molecular and cellular biochemistry 2018 Nov;448(1-2):275-286
Molecular and cellular biochemistry 2018 Nov;448(1-2):275-286
Quantitative proteomics by SWATH-MS reveals sophisticated metabolic reprogramming in hepatocellular carcinoma tissues.
Gao Y, Wang X, Sang Z, Li Z, Liu F, Mao J, Yan D, Zhao Y, Wang H, Li P, Ying X, Zhang X, He K, Wang H
Scientific reports 2017 Apr 5;7:45913
Scientific reports 2017 Apr 5;7:45913
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, Zhuang H, Zhang X, Chen H, Li S, Yang Y, Lu Y, Wang J, Zhu R, Zhang L, Sui S, Tan N, Zhao B, Zhang J, Li L, Feng D
The EMBO journal 2016 Jul 1;35(13):1368-84
The EMBO journal 2016 Jul 1;35(13):1368-84
Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer.
Ye X, Zhang Y, Wang X, Li Y, Gao Y
IUBMB life 2016 Apr;68(4):320-7
IUBMB life 2016 Apr;68(4):320-7
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y
International journal of clinical and experimental pathology 2015;8(12):15836-44
International journal of clinical and experimental pathology 2015;8(12):15836-44
Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells.
Saka HA, Thompson JW, Chen YS, Dubois LG, Haas JT, Moseley A, Valdivia RH
PloS one 2015;10(4):e0124630
PloS one 2015;10(4):e0124630
Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4.
Cui M, Xiao Z, Sun B, Wang Y, Zheng M, Ye L, Zhang X
Biochemical and biophysical research communications 2014 Mar 14;445(3):651-5
Biochemical and biophysical research communications 2014 Mar 14;445(3):651-5
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 22401-1-AP( ACSL4 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ACSL4/FACL4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ACSL4/FACL4. This antibody recognizes human antigen. The ACSL4/FACL4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
