66617-1-Ig

antibody from Proteintech Group

Targeting: ACSL4 ACS4, FACL4, LACS4, MRX63, MRX68

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66617-1-Ig

Provider

Proteintech Group

Product name

ACSL4 antibody

Antibody type

Monoclonal

Description

KD/KO validated ACSL4 antibody (Cat. #66617-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1H5D3

Vial size

20ul, 150ul

References

Submitted references

Unveiling the mechanism of photothermal therapy in acne man-agement: targeting sebaceous gland ferroptosis via umbilical cord mesenchymal stem cell membrane-encapsulated Au-Ag-PDA.

Wu R, Li J, Tian H, Song D, Zhao T, Tian Y, Zouboulis CC, Jiang J, Zhu M
Frontiers in bioengineering and biotechnology 2024;12:1426477

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Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis.

Pang C, Zhang H, Liu Y, Tang N, Tian K, Mu Y, Li X, Xiao L
Journal of cellular and molecular medicine 2024 May;28(9):e18377

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Ischemia-inhibited ferric chelate reductase 1 improves ferroptosis-mediated intestinal ischemia injury via Hippo signaling.

Liang P, Xie W, Wang X, Du Z, Zheng C, Zhao H, Wang Z, Ji Z
International immunopharmacology 2024 May 10;132:111900

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KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.

Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q, Chen G, Li W, Gao SJ, Lu C
PLoS pathogens 2024 Mar;20(3):e1012082

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GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.

Chen Y, Feng Y, Lin Y, Zhou X, Wang L, Zhou Y, Lin K, Cai L
British journal of cancer 2024 Mar;130(5):755-768

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Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway.

Lu JS, Wang JH, Han K, Li N
Inflammation 2024 Jun;47(3):975-988

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MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.

Shi J, Yang MM, Yang S, Fan F, Zheng G, Miao Y, Hua Y, Zhang J, Cheng Y, Liu S, Guo Y, Guo L, Yang X, Fan G, Ma C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489

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Exploration and Validation of Ferroptosis-Associated Genes in ADAR1 Deletion-Induced NAFLD through RNA-seq Analysis.

Yin X, Mi Y, Wang X, Li Y, Zhu X, Bukhari I, Wang Q, Zheng P, Xue X, Tang Y
International immunopharmacology 2024 Jun 15;134:112177

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The clustering status of detached gastric cancer cells inhibits anoikis-induced ferroptosis to promote metastatic colonization.

Sun J, Li J, Pantopoulos K, Liu Y, He Y, Kang W, Ye X
Cancer cell international 2024 Feb 18;24(1):77

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Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc(-)-GSH-GPX4 signaling pathway in ferroptosis response.

Ni X, Gao C, Zhu X, Zhang X, Fang Y, Hao Z
Journal of applied toxicology : JAT 2024 Aug;44(8):1139-1152

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Pharmacodynamic and Toxicity Studies of 6-Isopropyldithio-2'-guanosine Analogs in Acute T-Lymphoblastic Leukemia.

Song T, Yu Z, Shen Q, Xu Y, Hu H, Liu J, Zeng K, Lei J, Yu L
Cancers 2024 Apr 23;16(9)

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Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.

Wang TX, Duan KL, Huang ZX, Xue ZA, Liang JY, Dang Y, Zhang A, Xiong Y, Ding C, Guan KL, Yuan HX
Life science alliance 2023 Jan;6(1)

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The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress/ferroptosis pathway.

Jiang Z, Sun H, Miao J, Sheng Q, Xu J, Gao Z, Zhang X, Song Y, Chen K
Biochemical and biophysical research communications 2023 Jan 15;640:183-191

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Renal transporter OAT1 and PPAR-α pathway co-contribute to icaritin-induced nephrotoxicity.

Wang D, Liu J, Chen X, Chen J, Zhao T, Du J, Wang C, Meng Q, Sun H, Wang F, Liu K, Wu J
Phytotherapy research : PTR 2023 Feb;37(2):549-562

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Targeting the Na(+)/K(+) ATPase DR-region with DR-Ab improves doxorubicin-induced cardiotoxicity.

Leng B, Deng L, Tan J, Lee WT, Cao CR, Wang ZP, Huang DJ, Nie X, Bian JS
Free radical biology & medicine 2023 Aug 1;204:38-53

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Targeting Mitochondrial ROS-Mediated Ferroptosis by Quercetin Alleviates High-Fat Diet-Induced Hepatic Lipotoxicity.

Jiang JJ, Zhang GF, Zheng JY, Sun JH, Ding SB
Frontiers in pharmacology 2022;13:876550

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Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle.

Wang H, Wu D, Gao C, Teng H, Zhao Y, He Z, Chen W, Zong Y, Du R
Journal of medicinal chemistry 2022 Jul 28;65(14):10014-10044

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ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.

Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H
Nature cancer 2022 Jan;3(1):75-89

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Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells.

He Y, Fang D, Liang T, Pang H, Nong Y, Tang L, Yang Z, Lu C, Han X, Zhao S, Mo S, Meng Y, Han C, Peng T
Annals of translational medicine 2021 Oct;9(20):1535

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Activation of NRF2/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis.

Tian H, Xiong Y, Zhang Y, Leng Y, Tao J, Li L, Qiu Z, Xia Z
Cell stress & chaperones 2021 Mar;27(2):149-164

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Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.

Wei N, Lu T, Yang L, Dong Y, Liu X
FEBS open bio 2021 Aug;11(8):2118-2126