66617-1-Ig

antibody from Proteintech Group

Targeting: ACSL4 ACS4, FACL4, LACS4, MRX63, MRX68

Provider product page for 66617-1-Ig

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [64]
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Product number: 66617-1-Ig - Provider product page
Provider: Proteintech Group
Product name: ACSL4 antibody
Antibody type: Monoclonal
Description: KD/KO validated ACSL4 antibody (Cat. #66617-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1H5D3
Vial size: 20ul, 150ul

ACSL4 protein structure - 66617-1-Ig shown in red.

Submitted references Lactotransferrin upregulation affects the pathological changes of non-small cell lung cancer by regulating ferroptosis.

Wang Y, Xu W, Ren K, Min L
PeerJ 2026;14:e20866

Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3.

Luo N, Xiao Y, Zhai Y, Li J, Lv L, Yin H, Lin F, Wan B, Zhang K, Hu J, Liu J, Dang Y, He Y, Zhao Y, Zhang Z, Nie S, Yuan HX
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1510-1529

Elucidating the pharmacological mechanism of Yangming-Kaixin-Yizhi formula in inhibiting neuronal ferroptosis via Nrf2 in Alzheimer's disease: a study combining network pharmacology, transcriptomics, and experimental validation.

Xiong R, Liu P, Wang L, Zhang S, Liu H, Rong C, Kehriman N, Wang J, Wang J, Lai X, Tang Y
Metabolic brain disease 2026 Mar 7;41(1)

Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition.

Mi Y, Wang R, Qian J, Liu Z, Li Y, Fan H, Wang L, Kuai H, Xiong F, Wang H, Shi X, Hu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158147

Qing-Chang-Hua-Shi granule ameliorates experimental colitis by modulating Lactobacillus gasseri-mediated ferroptosis metabolic pathway.

Cheng C, Zhu L, Hu J, Feng W, Li W, Au R, Li Y, Xu F, Wu Y, Cui Y, Di Z, Li B, Miao Y, Lin Y, Ge L, Shen H
Chinese medicine 2026 Jan 26;21(1):52

Bacterial protein-oleate complexes induce ferroptosis-like cell death in colorectal cancer cells by disrupting cell membranes and inhibiting the β-catenin-GPX4 axis.

Ullah N, Yabrag A, Ali A, Nadeem A
Cell death discovery 2026 Apr 11;12(1)

PRMT5-Mediated Arginine Methylation of ACSL4 Attenuates Its Stability and Suppresses Ferroptosis in Renal Cancer.

Zhang M, Liu H, Yin R, Xu J, Fan S, Qian X, Cao M, Li S, Zhang A, Chen G, Yong H, Li Z, Bai J
Research (Washington, D.C.) 2025;8:0789

Curculigoside alleviates ferroptosis in renal interstitial fibrosis by regulating the Nrf2/HO-1 signaling pathway.

Liu T, Sui M, Yu C, Bao Y, Xing L, Hou D, Xie R
American journal of translational research 2025;17(10):7640-7658

eIF3f promotes tumour malignancy by remodelling fatty acid biosynthesis in hepatocellular carcinoma.

Zhou S, Zhang L, You Y, Yu K, Tie X, Gao Y, Chen Y, Yao F, Zhang R, Hao X, Fang C, Li X, Li Q, Wang X
Journal of hepatology 2025 Sep;83(3):712-728

The Down-Regulation of Lactoferrin Expression Induced by Cigarette Smoke can Induce Ferroptosis in COPD.

Wang Y, Xu W, Ren K, Yang J, Min L
Lung 2025 Sep 23;203(1):96

Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma.

Shan G, Bian Y, Sui Q, Liang J, Ren S, Pan B, Shi H, Zheng Z, Zeng D, Zhu J, Chen Z, Bi G, Fan H, Zhan C
Cell discovery 2025 Oct 7;11(1):81

PTBP1 functions as a suppressor of ferroptosis in endometrial carcinoma cells by stabilizing SLC7A11 mRNA.

Zhu K, Zhang K, Li H, Shen Y, Wang L, Hu Q, Xing H, Han L
Discover oncology 2025 Nov 28;16(1):2341

Ferroptosis mediated by ferritinophagy is involved in liver injury caused by sepsis.

Zhang H, Li H, Liu S, Zheng J, Li P
Scientific reports 2025 Nov 27;15(1):45489

Extracellular vesicles derived from bone marrow mesenchymal stem cells regulate SREBF2/HMGB1 axis by transporting miR-378a-3p to inhibit ferroptosis in intestinal ischemia-reperfusion injury.

Liu Z, Zhao Z, Xiao Z, Li M, Wang X, Huang Y, Li Y
Cell death discovery 2025 May 7;11(1):223

The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium.

Ji C, Wang Y, Ju Y, Liu S, Chen X, Wang J, Sun N, Tang Z, Gu P, Ji J
Scientific reports 2025 May 29;15(1):18949

Deciphering the Role of Ferroptosis in the Pathogenesis of Peripheral Artery Disease Myopathy.

Wilkinson T, Fletcher E, Ring A, Bradley C, Papoutsi E, Miserlis D, Smith RS, Bohannon WT, Pipinos II, Koutakis P
Biology 2025 May 12;14(5)

Discovery of novel benzo[b][1,4]oxazine derivatives as ferroptosis inhibitors.

Wan BW, Liu W, Xiao Y, Lv L, Li X, Lin F, Zhao Y, He Y, Nie S, Yang X, Yuan HX
Bioorganic chemistry 2025 Mar;156:108201

Gancao Xiexin decoction attenuated experimental colitis through suppressing ACSL4-mediated ferroptosis.

Pan Z, Gan C, Zhi S, Yang Y, Zhang Y, Li L, Zhang S, Huang Q
Journal of ethnopharmacology 2025 Mar 26;344:119532

Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4.

Liu W, Zhu Y, Ye W, Xiong J, Wang H, Gao Y, Huang S, Zhang Y, Zhou X, Zhou X, Ge X, Cai W, Zheng X
Cell death and differentiation 2025 Jun;32(6):1041-1057

Injectable deferoxamine-loaded microsphere hydrogels for inhibition of ferroptosis and promotion of third-degree burn wound healing.

Chai L, Huang J, Wang M, Huang Y, Huang Z, Zhang R, He L, Wang H, Chen D, Lei Y, Guo L
Materials today. Bio 2025 Jun;32:101806

Taurine Attenuates Neuronal Ferroptosis by CSF-Derived Exosomes of GABABR Encephalitis Through GABABR/NF2/P-YAP Pathway.

Zhang C, Zhou T, Qiao S, Lu L, Zhu M, Wang A, Zhang S
Molecular neurobiology 2025 Jul;62(7):9052-9073

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma.

Zhou J, Gao M, Zhang S, Guo WW, He W, Zhang M, Chen X, Dongzhi C, Li X, Yuan Y, Ma W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(27):e2501730

FBXO10 inhibits ferroptosis and promotes the progression of esophageal squamous cell carcinoma by post-translational mediation of ACSL4 degradation.

Feng S, Jia J, Wang K, Zhao H, Lv G
Journal of molecular histology 2025 Jul 5;56(4):214

Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways.

Liu X, Chen Y, Zhang L, Qi Z, Yang L, Huang C, Wang L, Lin D
Antioxidants (Basel, Switzerland) 2025 Jul 10;14(7)

Icariin inhibits hyperglycemia-induced cell death in penile cavernous tissue and improves erectile function in type 1 diabetic rats.

Yang H, Xiong W, Jiang J, Jiang R
Sexual medicine 2025 Feb;13(1):qfaf017

Discovery and optimization of 1,2,4-triazole derivatives as novel ferroptosis inhibitors.

Zhang J, Lin F, Xiao Y, Cen SY, Wan BW, Li X, Zhao Y, He Y, Yuan HX, Nie S
European journal of medicinal chemistry 2025 Feb 15;284:117192

Alpha-linolenic acid protects against heatstroke-induced acute lung injury by inhibiting ferroptosis through Nrf2 activation.

Wang L, Ma J, Li Z, Zhao X, Chen Y, Wang P, Li Y, Chen Y, Yao X, Yao L, Li J
Redox report : communications in free radical research 2025 Dec;30(1):2538294

The umbilical cord blood exosome MFG-E8 alleviates hypoxic-ischemic encephalopathy brain injury in neonatal rats by restoring autophagy flux and inhibiting ferroptosis through GSK3β/β-catenin signaling.

Zhao M, Wu Y, Huang L, Wang J, Zhang A
Regenerative therapy 2025 Dec;30:321-332

Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.

Zhang H, Shi H, Li X, Zhou S, Song X, Ma N, Meng M, Chang G, Shen X
Redox biology 2025 Apr;81:103557

Caffeine improves hypoxia/reoxygenation induced neuronal cell injury through inhibiting cellular ferroptosis: an in vitro study.

Jia H, Fan H, Liang J, He R
Neurological research 2025 Apr;47(4):242-250

Dapagliflozin alleviates high-fat-induced obesity cardiomyopathy by inhibiting ferroptosis.

Chen D, Shi J, Wu Y, Miao L, Wang Z, Wang Y, Xu S, Lou Y
ESC heart failure 2025 Apr;12(2):1358-1373

VIPAS39 confers ferroptosis resistance in epithelial ovarian cancer through exporting ACSL4.

Jiang Y, Li J, Wang T, Gu X, Li X, Liu Z, Yue W, Li M
EBioMedicine 2025 Apr;114:105646

Short-term effects of subacute ruminal acidosis on ferroptosis and iron metabolism in the livers of lactating sheep fed a high-grain diet.

Zhang H, Shi H, Zhou S, Meng M, Ma N, Chang G, Shen X
Journal of dairy science 2025 Apr;108(4):4365-4380

Protocadherin 17 weakens the lenvatinib resistance of liver cancer through inducing ferroptosis.

Yang J, Hu B, Zhang G, Wu K, Zhang X, Ji M, Zhang B, Shi H, Li D
Experimental cell research 2025 Apr 1;447(1):114495

Unveiling the mechanism of photothermal therapy in acne man-agement: targeting sebaceous gland ferroptosis via umbilical cord mesenchymal stem cell membrane-encapsulated Au-Ag-PDA.

Wu R, Li J, Tian H, Song D, Zhao T, Tian Y, Zouboulis CC, Jiang J, Zhu M
Frontiers in bioengineering and biotechnology 2024;12:1426477

TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer.

Wang L, Wu Z, Wang Y, Chen C, Li Y, Dong H, Yao T, Jin G, Wang Z
Cell biochemistry and biophysics 2024 Sep;82(3):2717-2726

RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis.

Zhou X, Nie M, Xin X, Hua T, Zhang J, Shi R, Dong K, Shu W, Yan B, Wang H
Cell death & disease 2024 Sep 6;15(9):655

Knocking down macrophages Caspase-6 through HMGB1 coordinates macrophage trophoblast crosstalk to suppress ferroptosis and alleviate preeclampsia.

Deng Y, Yu L, Lai W, Xiao S, Zhang W
International immunopharmacology 2024 Oct 25;140:112859

SGK1 contributes to ferroptosis in coronary heart disease through the NEDD4L/NF-κB pathway.

Peng Y, Jiang Y, Zhou Q, Jia Z, Tang H
Journal of molecular and cellular cardiology 2024 Nov;196:71-83

Repurposed genipin targeting UCP2 exhibits antitumor activity through inducing ferroptosis in glioblastoma.

Dong H, Sun K, Wang X, Cui M, Ma Y, Li K, Duan W, Zhang H, Zhang L, Sheng Z, He M, Zhang B
Acta biochimica et biophysica Sinica 2024 Nov 8;57(3):403-414

Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis.

Pang C, Zhang H, Liu Y, Tang N, Tian K, Mu Y, Li X, Xiao L
Journal of cellular and molecular medicine 2024 May;28(9):e18377

Ischemia-inhibited ferric chelate reductase 1 improves ferroptosis-mediated intestinal ischemia injury via Hippo signaling.

Liang P, Xie W, Wang X, Du Z, Zheng C, Zhao H, Wang Z, Ji Z
International immunopharmacology 2024 May 10;132:111900

KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.

Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q, Chen G, Li W, Gao SJ, Lu C
PLoS pathogens 2024 Mar;20(3):e1012082

GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.

Chen Y, Feng Y, Lin Y, Zhou X, Wang L, Zhou Y, Lin K, Cai L
British journal of cancer 2024 Mar;130(5):755-768

Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway.

Lu JS, Wang JH, Han K, Li N
Inflammation 2024 Jun;47(3):975-988

MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.

Shi J, Yang MM, Yang S, Fan F, Zheng G, Miao Y, Hua Y, Zhang J, Cheng Y, Liu S, Guo Y, Guo L, Yang X, Fan G, Ma C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489

Exploration and Validation of Ferroptosis-Associated Genes in ADAR1 Deletion-Induced NAFLD through RNA-seq Analysis.

Yin X, Mi Y, Wang X, Li Y, Zhu X, Bukhari I, Wang Q, Zheng P, Xue X, Tang Y
International immunopharmacology 2024 Jun 15;134:112177

The clustering status of detached gastric cancer cells inhibits anoikis-induced ferroptosis to promote metastatic colonization.

Sun J, Li J, Pantopoulos K, Liu Y, He Y, Kang W, Ye X
Cancer cell international 2024 Feb 18;24(1):77

Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc(-)-GSH-GPX4 signaling pathway in ferroptosis response.

Ni X, Gao C, Zhu X, Zhang X, Fang Y, Hao Z
Journal of applied toxicology : JAT 2024 Aug;44(8):1139-1152

Crizotinib and its enantiomer suppress ferroptosis by decreasing PE-O-PUFA content.

Cen SY, Lin F, Li X, Hu Y, Liu JP, Xue Z, Gao Y, Sun YP, Zhu S, Dang Y, Zhao Y, Yuan HX
Cell death discovery 2024 Aug 12;10(1):360

A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic-Gas Therapy.

Wang W, Gao Y, Xu J, Zou T, Yang B, Hu S, Cheng X, Xia Y, Zheng Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307143

Pharmacodynamic and Toxicity Studies of 6-Isopropyldithio-2'-guanosine Analogs in Acute T-Lymphoblastic Leukemia.

Song T, Yu Z, Shen Q, Xu Y, Hu H, Liu J, Zeng K, Lei J, Yu L
Cancers 2024 Apr 23;16(9)

The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.

Huang S, Zhang Q, Zhao M, Wang X, Zhang Y, Gan B, Zhang P
The Journal of cell biology 2023 Nov 6;222(11)

Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.

Wang TX, Duan KL, Huang ZX, Xue ZA, Liang JY, Dang Y, Zhang A, Xiong Y, Ding C, Guan KL, Yuan HX
Life science alliance 2023 Jan;6(1)

The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress/ferroptosis pathway.

Jiang Z, Sun H, Miao J, Sheng Q, Xu J, Gao Z, Zhang X, Song Y, Chen K
Biochemical and biophysical research communications 2023 Jan 15;640:183-191

Renal transporter OAT1 and PPAR-α pathway co-contribute to icaritin-induced nephrotoxicity.

Wang D, Liu J, Chen X, Chen J, Zhao T, Du J, Wang C, Meng Q, Sun H, Wang F, Liu K, Wu J
Phytotherapy research : PTR 2023 Feb;37(2):549-562

Targeting the Na(+)/K(+) ATPase DR-region with DR-Ab improves doxorubicin-induced cardiotoxicity.

Leng B, Deng L, Tan J, Lee WT, Cao CR, Wang ZP, Huang DJ, Nie X, Bian JS
Free radical biology & medicine 2023 Aug 1;204:38-53

Targeting Mitochondrial ROS-Mediated Ferroptosis by Quercetin Alleviates High-Fat Diet-Induced Hepatic Lipotoxicity.

Jiang JJ, Zhang GF, Zheng JY, Sun JH, Ding SB
Frontiers in pharmacology 2022;13:876550

Inhibition of Fatty Acid Translocase (FAT/CD36) Palmitoylation Enhances Hepatic Fatty Acid β-Oxidation by Increasing Its Localization to Mitochondria and Interaction with Long-Chain Acyl-CoA Synthetase 1.

Zeng S, Wu F, Chen M, Li Y, You M, Zhang Y, Yang P, Wei L, Ruan XZ, Zhao L, Chen Y
Antioxidants & redox signaling 2022 Jun;36(16-18):1081-1100

Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle.

Wang H, Wu D, Gao C, Teng H, Zhao Y, He Z, Chen W, Zong Y, Du R
Journal of medicinal chemistry 2022 Jul 28;65(14):10014-10044

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.

Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H
Nature cancer 2022 Jan;3(1):75-89

Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells.

He Y, Fang D, Liang T, Pang H, Nong Y, Tang L, Yang Z, Lu C, Han X, Zhao S, Mo S, Meng Y, Han C, Peng T
Annals of translational medicine 2021 Oct;9(20):1535

Activation of NRF2/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis.

Tian H, Xiong Y, Zhang Y, Leng Y, Tao J, Li L, Qiu Z, Xia Z
Cell stress & chaperones 2021 Mar;27(2):149-164

Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.

Wei N, Lu T, Yang L, Dong Y, Liu X
FEBS open bio 2021 Aug;11(8):2118-2126

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