11510-1-AP

antibody from Proteintech Group

Targeting: YME1L1 YME1L

Provider product page for 11510-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [71]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

Submit

Product number: 11510-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11510-1-AP, RRID:AB_2217459
Product name: YME1L1 antibody
Antibody type: Polyclonal
Description: KD/KO validated YME1L1 antibody (Cat. #11510-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

YME1L1 protein structure - 11510-1-AP shown in red.

Submitted references Brain transcriptomic, metabolic and mitohormesis properties associated with N-propargylglycine treatment: A prevention strategy against neurodegeneration.

Teramayi F, Bons J, Scott M, Scott GK, Loureiro A, Lopez-Ramirez A, Schilling B, Ellerby LM, Benz CC
Brain research 2024 Mar 1;1826:148733

Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria.

Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P
Molecular cell 2024 Jan 18;84(2):345-358.e5

Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats.

Vilela WR, Ramalho LS, Bechara LRG, Cabral-Costa JV, Serna JDC, Kowaltowski AJ, Xavier GF, Ferreira JCB, de Bem AF
Journal of bioenergetics and biomembranes 2024 Apr;56(2):87-99

Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.

Zhang A, Pan Y, Wang H, Ding R, Zou T, Guo D, Shen Y, Ji P, Huang W, Wen Q, Wang Q, Hu H, Wu J, Xiang M, Ye B
Aging cell 2024 Apr;23(4):e14091

Wnt/β-catenin Pathway Aggravates Renal Fibrosis by Activating PUM2 Transcription to Repress YME1L-mediated Mitochondrial Homeostasis.

Song J, Chen Y, Chen Y, Qiu M, Xiang W, Ke B, Fang X
Biochemical genetics 2024 Apr 2;

Knock-down of YME1L1 induces mitochondrial dysfunction during early porcine embryonic development.

Zhou D, Sun MH, Jiang WJ, Li XH, Lee SH, Heo G, Choi J, Kim KS, Cui XS
Frontiers in cell and developmental biology 2023;11:1147095

FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.

Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, Kim KH, Snyder MM, Luo N, Xu HW, Huang F, Tao WA, Kuang S
Nature communications 2023 Oct 10;14(1):6344

TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.

Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T
Cell reports 2023 May 30;42(5):112454

Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space.

Adriaenssens E, Asselbergh B, Rivera-Mejías P, Bervoets S, Vendredy L, De Winter V, Spaas K, de Rycke R, van Isterdael G, Impens F, Langer T, Timmerman V
Nature cell biology 2023 Mar;25(3):467-480

Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1.

Jian Y, Yang Y, Cheng L, Yang X, Liu H, Li W, Wan Y, Yang D
Cell proliferation 2023 Feb;56(2):e13362

Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7.

Deshwal S, Onishi M, Tatsuta T, Bartsch T, Cors E, Ried K, Lemke K, Nolte H, Giavalisco P, Langer T
Nature cell biology 2023 Feb;25(2):246-257

Physical exercise elicits UPR(mt) in the skeletal muscle: The role of c-Jun N-terminal kinase.

Gaspar RS, Katashima CK, Crisol BM, Carneiro FS, Sampaio I, Silveira LDR, Silva ASRD, Cintra DE, Pauli JR, Ropelle ER
Molecular metabolism 2023 Dec;78:101816

PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid.

Perea V, Cole C, Lebeau J, Dolina V, Baron KR, Madhavan A, Kelly JW, Grotjahn DA, Wiseman RL
The EMBO journal 2023 Aug 1;42(15):e113908

Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line.

Noguchi M, Kohno S, Pellattiero A, Machida Y, Shibata K, Shintani N, Kohno T, Gotoh N, Takahashi C, Hirao A, Scorrano L, Kasahara A
Cell death & disease 2023 Apr 5;14(4):241

Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4(+/-) mice.

Muñoz VR, Botezelli JD, Gaspar RC, da Rocha AL, Vieira RFL, Crisol BM, Braga RR, Severino MB, Nakandakari SCBR, Antunes GC, Brunetto SQ, Ramos CD, Velloso LA, Simabuco FM, de Moura LP, da Silva ASR, Ropelle ER, Cintra DE, Pauli JR
Cellular and molecular life sciences : CMLS 2023 Apr 13;80(5):122

Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex.

Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC Jr, Reisz JA, Proenza C, Chatfield KC, Tsai MF
Molecular cell 2022 Oct 6;82(19):3661-3676.e8

Increased Mobile Zinc Regulates Retinal Ganglion Cell Survival via Activating Mitochondrial OMA1 and Integrated Stress Response.

Tang J, Liu Z, Han J, Xue J, Liu L, Lin J, Wu C, Zhang Q, Wu S, Liu C, Huang H, Fu Y, Li M, Zhuo Y, Li Y
Antioxidants (Basel, Switzerland) 2022 Oct 10;11(10)

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.

Bussi C, Heunis T, Pellegrino E, Bernard EM, Bah N, Dos Santos MS, Santucci P, Aylan B, Rodgers A, Fearns A, Mitschke J, Moore C, MacRae JI, Greco M, Reinheckel T, Trost M, Gutierrez MG
Nature communications 2022 Nov 28;13(1):7338

Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.

Purandare N, Kunji Y, Xi Y, Romero R, Gomez-Lopez N, Fribley A, Grossman LI, Aras S
iScience 2022 Nov 18;25(11):105342

CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.

Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q
Cell death & disease 2022 Feb 16;13(2):156

Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L.

Wani GA, Sprenger HG, Ndoci K, Chandragiri S, Acton RJ, Schatton D, Kochan SMV, Sakthivelu V, Jevtic M, Seeger JM, Müller S, Giavalisco P, Rugarli EI, Motori E, Langer T, Bergami M
Cell reports 2022 Feb 15;38(7):110370

Regulation of mitochondrial proteostasis by the proton gradient.

Patron M, Tarasenko D, Nolte H, Kroczek L, Ghosh M, Ohba Y, Lasarzewski Y, Ahmadi ZA, Cabrera-Orefice A, Eyiama A, Kellermann T, Rugarli EI, Brandt U, Meinecke M, Langer T
The EMBO journal 2022 Aug 16;41(16):e110476

Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons.

Li X, Li H, Xu Z, Ma C, Wang T, You W, Yu Z, Shen H, Chen G
Cell death & disease 2022 Apr 8;13(4):321

Prohibitin-1 plays a regulatory role in Leydig cell steroidogenesis.

Bassi G, Mishra S
iScience 2022 Apr 15;25(4):104165

Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPR(mt) and Norepinephrine-miR- 18a-5p-HIF-1α Axis.

Nandi SS, Katsurada K, Mahata SK, Patel KP
Frontiers in physiology 2021;12:718982

Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.

Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M
Molecular cell 2021 Oct 21;81(20):4191-4208.e8

C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly.

Wang T, Liu H, Itoh K, Oh S, Zhao L, Murata D, Sesaki H, Hartung T, Na CH, Wang J
Cell metabolism 2021 Mar 2;33(3):531-546.e9

Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells.

Haschler TN, Horsley H, Balys M, Anderson G, Taanman JW, Unwin RJ, Norman JT
Scientific reports 2021 Jul 30;11(1):15510

Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.

Kakehashi A, Suzuki S, Shiota M, Raymo N, Gi M, Tachibana T, Stefanov V, Wanibuchi H
Cancers 2021 Jul 19;13(14)

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.

Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827

Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion.

Wang R, Mishra P, Garbis SD, Moradian A, Sweredoski MJ, Chan DC
Molecular biology of the cell 2021 Jan 15;32(2):157-168

Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing.

Douida A, Batista F, Boto P, Regdon Z, Robaszkiewicz A, Tar K
International journal of molecular sciences 2021 Feb 5;22(4)

Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR(mt) in the hypothalamus of mice.

Braga RR, Crisol BM, Brícola RS, Sant'ana MR, Nakandakari SCBR, Costa SO, Prada PO, da Silva ASR, Moura LP, Pauli JR, Cintra DE, Ropelle ER
Scientific reports 2021 Feb 15;11(1):3813

N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.

Scott GK, Mahoney S, Scott M, Loureiro A, Lopez-Ramirez A, Tanner JJ, Ellerby LM, Benz CC
Amino acids 2021 Dec;53(12):1927-1939

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.

König T, Nolte H, Aaltonen MJ, Tatsuta T, Krols M, Stroh T, Langer T, McBride HM
Nature cell biology 2021 Dec;23(12):1271-1286

NAD(+) precursor increases aerobic performance in mice.

Crisol BM, Veiga CB, Braga RR, Lenhare L, Baptista IL, Gaspar RC, Muñoz VR, Cordeiro AV, da Silva ASR, Cintra DE, Moura LP, Pauli JR, Ropelle ER
European journal of nutrition 2020 Sep;59(6):2427-2437

Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes.

Aishwarya R, Alam S, Abdullah CS, Morshed M, Nitu SS, Panchatcharam M, Miriyala S, Kevil CG, Bhuiyan MS
Redox biology 2020 Sep;36:101660

A High-Density Human Mitochondrial Proximity Interaction Network.

Antonicka H, Lin ZY, Janer A, Aaltonen MJ, Weraarpachai W, Gingras AC, Shoubridge EA
Cell metabolism 2020 Sep 1;32(3):479-497.e9

Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space.

Thevarajan I, Zolkiewski M, Zolkiewska A
The international journal of biochemistry & cell biology 2020 Oct;127:105841

OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.

Hu C, Shu L, Huang X, Yu J, Li L, Gong L, Yang M, Wu Z, Gao Z, Zhao Y, Chen L, Song Z
Cell death & disease 2020 Oct 31;11(10):940

CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.

Liu T, Woo JA, Bukhari MZ, LePochat P, Chacko A, Selenica MB, Yan Y, Kotsiviras P, Buosi SC, Zhao X, Kang DE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8493-8509

Prohibitin levels regulate OMA1 activity and turnover in neurons.

Anderson CJ, Kahl A, Fruitman H, Qian L, Zhou P, Manfredi G, Iadecola C
Cell death and differentiation 2020 Jun;27(6):1896-1906

p32/C1QBP regulates OMA1-dependent proteolytic processing of OPA1 to maintain mitochondrial connectivity related to mitochondrial dysfunction and apoptosis.

Noh S, Phorl S, Naskar R, Oeum K, Seo Y, Kim E, Kweon HS, Lee JY
Scientific reports 2020 Jun 30;10(1):10618

Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.

Tang J, Zhang K, Dong J, Yan C, Hu C, Ji H, Chen L, Chen S, Zhao H, Song Z
Cell death and differentiation 2020 Jan;27(1):146-160

The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts.

Horibata Y, Mitsuhashi S, Shimizu H, Maejima S, Sakamoto H, Aoyama C, Ando H, Sugimoto H
Scientific reports 2020 Feb 18;10(1):2845

Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.

Aras S, Purandare N, Gladyck S, Somayajulu-Nitu M, Zhang K, Wallace DC, Grossman LI
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.

Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A
EMBO molecular medicine 2019 May;11(5)

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.

Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ
Molecular cell 2019 Mar 7;73(5):1028-1043.e5

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X
Nature communications 2019 Mar 26;10(1):1371

Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.

Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T
EMBO molecular medicine 2019 Jan;11(1)

Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.

Nakazawa H, Ikeda K, Shinozaki S, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Yorozu T, Inoue S, Kaneki M
FEBS open bio 2019 Feb;9(2):348-363

ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.

Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P
The Journal of cell biology 2019 Feb 4;218(2):598-614

LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response.

Zurita Rendón O, Shoubridge EA
Molecular and cellular biology 2018 Oct 15;38(20)

Laminar shear stress promotes mitochondrial homeostasis in endothelial cells.

Wu LH, Chang HC, Ting PC, Wang DL
Journal of cellular physiology 2018 Jun;233(6):5058-5069

PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria.

Saita S, Tatsuta T, Lampe PA, König T, Ohba Y, Langer T
The EMBO journal 2018 Feb 15;37(4)

m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics.

Consolato F, Maltecca F, Tulli S, Sambri I, Casari G
Journal of cell science 2018 Apr 9;131(7)

Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.

Vukotic M, Nolte H, König T, Saita S, Ananjew M, Krüger M, Tatsuta T, Langer T
Molecular cell 2017 Aug 3;67(3):471-483.e7

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T
Nature cell biology 2017 Apr;19(4):318-328

Proteolytic control of the mitochondrial calcium uniporter complex.

Tsai CW, Wu Y, Pao PC, Phillips CB, Williams C, Miller C, Ranaghan M, Tsai MF
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4388-4393

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.

Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.

Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T
EMBO reports 2016 Dec;17(12):1844-1856

Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.

Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD
Journal of molecular and cellular cardiology 2016 Aug;97:1-14

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.

Baburamani AA, Hurling C, Stolp H, Sobotka K, Gressens P, Hagberg H, Thornton C
International journal of molecular sciences 2015 Sep 17;16(9):22509-26

Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.

Richter U, Lahtinen T, Marttinen P, Suomi F, Battersby BJ
The Journal of cell biology 2015 Oct 26;211(2):373-89

DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.

Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, Langer T
Cell metabolism 2014 Jul 1;20(1):158-71

Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.

Mishra P, Carelli V, Manfredi G, Chan DC
Cell metabolism 2014 Apr 1;19(4):630-41

Loss of Yme1L perturbates mitochondrial dynamics.

Ruan Y, Li H, Zhang K, Jian F, Tang J, Song Z
Cell death & disease 2013 Oct 31;4(10):e896

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.

Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ
The EMBO journal 2012 Mar 7;31(5):1293-307

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.

Greene AW, Grenier K, Aguileta MA, Muise S, Farazifard R, Haque ME, McBride HM, Park DS, Fon EA
EMBO reports 2012 Apr;13(4):378-85

SLP-2 is required for stress-induced mitochondrial hyperfusion.

Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, Youle R, Langer T, Martinou JC
The EMBO journal 2009 Jun 3;28(11):1589-600

Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1.

Ehses S, Raschke I, Mancuso G, Bernacchia A, Geimer S, Tondera D, Martinou JC, Westermann B, Rugarli EI, Langer T
The Journal of cell biology 2009 Dec 28;187(7):1023-36

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse heart tissue were subjected to SDS PAGE followed by western blot with 11510-1-AP(YME1L1 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The YME1L1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human YME1L1. This antibody recognizes human,mouse,rat antigen. The YME1L1 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 11510-1-AP.pdf

: Show more

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 11510-1-AP(YME1L1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue