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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [18]
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- Product number
- 66424-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Prohibitin 2 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Prohibitin 2 antibody (Cat. #66424-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1D9C7
- Vial size
- 20ul, 150ul
Submitted references PHB2 ameliorates ferroptosis and aortic aneurysm/dissection through NEDD4L-dependent ubiquitination of NCOA4.
Complement protein C1q induces endothelial apoptosis through C1qBP regulation of mitochondrial function in lung endothelial cells in systemic sclerosis.
SLP2/PHB Aggregates in ALS Mouse Models and Patients: Implications Beyond CHCHD10-Associated Motor Neuron Disease.
CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation.
PHB2 protects against pressure overload-induced myocardial remodeling in mice via stabilizing TOMM40 and regulating mitochondrial morphofunctional homeostasis.
CHCHD10(S59L/+) mouse model: Behavioral and neuropathological features of frontotemporal dementia.
Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors.
Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP(+)-Induced SH-SY5Y Cells.
REC drives recombination to repair double-strand breaks in animal mtDNA.
Nonreceptor Tyrosine Kinase c-Abl-Mediated PHB2 Phosphorylation Aggravates Mitophagy Disorder in Parkinson's Disease Model.
Mechanical detection of interactions between proteins related to intermediate filament and transcriptional regulation in living cells.
A549 cells contain enlarged mitochondria with independently functional clustered mtDNA nucleoids.
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Fluoride induced mitochondrial impairment and PINK1-mediated mitophagy in Leydig cells of mice: In vivo and in vitro studies.
Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection.
Mitochondrial stress response triggered by defects in protein synthesis quality control.
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
Xiong S, Lin J, An Y, Du Y, Li YE, Du Z, Zou R, Abudureyimu M, Ge J, Zhang Y, Ren J
Redox biology 2026 May;92:104114
Redox biology 2026 May;92:104114
Complement protein C1q induces endothelial apoptosis through C1qBP regulation of mitochondrial function in lung endothelial cells in systemic sclerosis.
Yi Z, Liu K, Shabin M
Molecular medicine (Cambridge, Mass.) 2026 Mar 5;32(1)
Molecular medicine (Cambridge, Mass.) 2026 Mar 5;32(1)
SLP2/PHB Aggregates in ALS Mouse Models and Patients: Implications Beyond CHCHD10-Associated Motor Neuron Disease.
Genin EC, Lespinasse F, Mauri-Crouzet A, Dupuis L, Paquis-Flucklinger V
International journal of molecular sciences 2025 Nov 8;26(22)
International journal of molecular sciences 2025 Nov 8;26(22)
CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation.
Mei S, Ma X, Zhou L, Wuyun Q, Cai Z, Yan J, Ding H
Cell proliferation 2025 Jan;58(1):e13742
Cell proliferation 2025 Jan;58(1):e13742
PHB2 protects against pressure overload-induced myocardial remodeling in mice via stabilizing TOMM40 and regulating mitochondrial morphofunctional homeostasis.
Li D, Li JH, Guo YY, Chen YJ, Zhang M, Xu FX, Li WY, Tang QZ
Acta pharmacologica Sinica 2025 Dec;46(12):3217-3229
Acta pharmacologica Sinica 2025 Dec;46(12):3217-3229
CHCHD10(S59L/+) mouse model: Behavioral and neuropathological features of frontotemporal dementia.
Genin EC, di Borgo PP, Lorivel T, Hugues S, Farinelli M, Mauri-Crouzet A, Lespinasse F, Godin L, Paquis-Flucklinger V, Petit-Paitel A
Neurobiology of disease 2024 Jun 1;195:106498
Neurobiology of disease 2024 Jun 1;195:106498
Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors.
Chen W, Mao Y, Zhan Y, Li W, Wu J, Mao X, Xu B, Shu F
Journal of nanobiotechnology 2024 Dec 18;22(1):761
Journal of nanobiotechnology 2024 Dec 18;22(1):761
Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP(+)-Induced SH-SY5Y Cells.
Lai X, Zhang Y, Wu J, Shen M, Yin S, Yan J
Neurotoxicity research 2023 Jun;41(3):242-255
Neurotoxicity research 2023 Jun;41(3):242-255
REC drives recombination to repair double-strand breaks in animal mtDNA.
Klucnika A, Mu P, Jezek J, McCormack M, Di Y, Bradshaw CR, Ma H
The Journal of cell biology 2023 Jan 2;222(1)
The Journal of cell biology 2023 Jan 2;222(1)
Nonreceptor Tyrosine Kinase c-Abl-Mediated PHB2 Phosphorylation Aggravates Mitophagy Disorder in Parkinson's Disease Model.
Zhang Y, Wu J, Jin W, Shen M, Yin S, Lai X, Ma H, Jiang M, Sun D, Yan J
Oxidative medicine and cellular longevity 2022;2022:9233749
Oxidative medicine and cellular longevity 2022;2022:9233749
Mechanical detection of interactions between proteins related to intermediate filament and transcriptional regulation in living cells.
Yamagishi A, Mizusawa M, Uchida K, Iijima M, Kuroda S, Fukazawa K, Ishihara K, Nakamura C
Biosensors & bioelectronics 2022 Nov 15;216:114603
Biosensors & bioelectronics 2022 Nov 15;216:114603
A549 cells contain enlarged mitochondria with independently functional clustered mtDNA nucleoids.
Nasonovs A, Garcia-Diaz M, Bogenhagen DF
PloS one 2021;16(3):e0249047
PloS one 2021;16(3):e0249047
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Houston R, Sekine Y, Larsen MB, Murakami K, Mullett SJ, Wendell SG, Narendra DP, Chen BB, Sekine S
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J
eLife 2021 May 26;10
eLife 2021 May 26;10
Fluoride induced mitochondrial impairment and PINK1-mediated mitophagy in Leydig cells of mice: In vivo and in vitro studies.
Liang C, Gao Y, He Y, Han Y, Manthari RK, Tikka C, Chen C, Wang J, Zhang J
Environmental pollution (Barking, Essex : 1987) 2020 Jan;256:113438
Environmental pollution (Barking, Essex : 1987) 2020 Jan;256:113438
Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection.
Su W, Huang S, Zhu H, Zhang B, Wu X
Viruses 2020 Apr 8;12(4)
Viruses 2020 Apr 8;12(4)
Mitochondrial stress response triggered by defects in protein synthesis quality control.
Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ
Life science alliance 2019 Feb;2(1)
Life science alliance 2019 Feb;2(1)
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N
EMBO reports 2018 Dec;19(12)
EMBO reports 2018 Dec;19(12)
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