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- Product number
- 17479-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17479-1-AP, RRID:AB_2217473
- Product name
- YTHDF1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated YTHDF1 antibody (Cat. #17479-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Machine Learning and Experimental Validation of m6A RNA Methylation Related Signatures for Risk Prediction, Diagnostic Biomarkers, and Immune Subtypes in Chronic Kidney Disease.
YTHDF2 promotes m6A-modified HSPA2 translation to restrict Newcastle Disease Virus.
m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop.
METTL3-based epitranscriptomic editing screening identifies functional m(6)A sites in cancers.
METTL5 reprograms glycolytic metabolism and promotes non-small cell lung cancer progression by modifying PGAM1.
N(6)-methyladenosine attenuates tumor-associated macrophages M2 polarization via suppressing the translation of Snail.
m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.
YTHDC1 Orchestrates Telomerase Assembly via Scaffold-Mediated TERT-TERC Interaction.
Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival.
Jianpi Jiedu formula modulates glutamine metabolism to inhibit colorectal cancer liver metastasis.
METTL3-mediated m(6)A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca(2+) signaling.
N6-methyladenosine (m(6)A) modification of TXNIP in 3'UTR instigates abdominal aorta aneurysm in mice.
Chiral Fe(3)O(4)/GelMA hydrogels regulate the osteoimmune microenvironment via Itgb3-mediated macrophage polarization to combat peri-implantitis.
m(6)A reader Ythdf proteins control retrotransposon B2 repeat expression and safeguard early embryo development.
Erianin facilitates pyroptosis in endometrial cancer via targeting m6A reader YTHDF1.
YTHDF1/SLC39A4 signaling axis promotes gastric cancer cell proliferation by suppressing cuproptosis ex vivo and in vitro.
m(6)A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis.
Targeting m(6)A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti-PD-L1 Efficacy in Intrahepatic Cholangiocarcinoma.
METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.
Notch-Driven Cholangiocarcinogenesis Involves the Hippo Pathway Effector TAZ via METTL3-m6A-YTHDF1.
Repetitive transcranial magnetic stimulation alleviates neuropathic pain via microglial polarization by modulating the METTL3/NMDAR2B/NLRP3 pathway.
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
YTHDF3 recognizes DNA N6-methyladenine and recruits ALKBH1 for 6mA removal from genomic DNA.
METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA.
A nanovaccine targeting cancer stem cells and bulk cancer cells for postoperative cancer immunotherapy.
METTL3/ALKBH5-Mediated N6-Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3-TASL-IRF5 Signaling Axis in Psoriasis.
The role of YTHDF1 in the diagnosis and prognosis of lung adenocarcinoma and its inhibitor LY-411575 in the targeted intervention of lung adenocarcinoma growth.
YTHDF proteins and m(6)A-RNA clients undergo autophagic turnover during contact inhibition.
YTHDF1-mediated mitochondrial dysfunction and allergic airway inflammation by interaction with β-catenin/TCF4 signaling.
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
RHBDF2 governs microglial neuroinflammation during cerebral ischemia-reperfusion injury and is positively regulated by the m6A reader YTHDF1.
YTHDF1 regulates the proliferation and differentiation of keratinocytes via the PI3K/AKT signaling pathway in atopic dermatitis.
m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.
METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.
ALKBH5 regulates ACSL4 to sensitize erastin-induced ferroptosis via YTHDF2-dependent m(6)A modification in hypoxic pulmonary hypertension.
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
m6A-induced DEAD-box RNA helicase 21 enhances lipid metabolism via 3‑hydroxy-3-methylglutaryl-CoA synthases 1 in colorectal cancer.
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
YTHDF2 suppresses the 2C-like state in mouse embryonic stem cells via the DUX-ZSCAN4 molecular circuit.
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor.
YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response.
Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis.
Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells.
An Investigation of the RNA Modification m(6)A and Its Regulatory Enzymes in Rat Brains Affected by Chronic Morphine Treatment and Withdrawal.
METTL3 inhibits primed-to-naïve transition of pluripotent stem cells through m(6)A-YTHDF2-pluripotency/Gstp1 mRNA degradation axis.
YTHDF1-targeting nanoassembly reverses tumoral immune evasion through epigenetics and cell cycle modulation.
Targeting ADAR1 with a small molecule for the treatment of prostate cancer.
Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1.
Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy.
YTHDF1-mediated m6A modification promotes cisplatin resistance in ovarian cancer via the FZD7/Wnt/β-catenin pathway.
Loss of Epitranscriptomic Modification N(6)-Methyladenosine (m(6)A) Reader YTHDF1 Exacerbates Ischemic Brain Injury in a Sexually Dimorphic Manner.
Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence.
The cardiac METTL3/m6A pathway regulates the systemic response to Western diet.
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC)-stabilized lncRNA small nucleolar RNA host gene 15 (Snhg15) modulates hematopoietic injury induced by γ-ray irradiation via m(6)A modification.
m(6)A RNA methylation-mediated control of global APC expression is required for local translation of β-actin and axon development.
The RNA-stability-independent role of the RNA m(6)A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance.
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.
Hypoxia-Inducible Factor HIF1α Regulates the Expression of SLC7A1 to Mediate Erastin-Induced Ferroptosis in Cervical Cancer Cells.
The m6A demethylase FTO regulates TNF-α expression in human macrophages following Toxoplasma gondii infection.
IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.
METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through m(6)A-dependent binding.
POU4F1 enhances lung cancer gemcitabine resistance by regulating METTL3-dependent TWF1 mRNA N6 adenosine methylation.
N6-methyladenosine-modified circRPS6KC1 regulated cellular senescence in prostate cancer via FOXM1/PCNA axis.
N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.
RNA m(6)A-mediated post-transcriptional repression of glucocorticoid receptor in LPS-activated Kupffer cells on broilers.
M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC.
YTH N(6)-methyladenosine RNA Binding Protein 1 Inhibits Smooth Muscle Cell Phenotypic Modulation and Neointimal Hyperplasia.
Diosmetin-7-O-β-D-glucopyranoside from Pogostemonis Herba alleviated SARS-CoV-2-induced pneumonia by reshaping macrophage polarization and limiting viral replication.
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation.
Endurance exercise remodels skeletal muscle by suppressing Ythdf1-mediated myostatin expression.
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
The m6A reader YTHDF1 facilitates nasopharyngeal carcinoma proliferation and migration via c-MYC.
Downregulated Smad3 signaling impairs the maturation of MO-MDSC in colorectal cancer.
ZNF831-YTHDF1-DNMT1/3a feedback loop regulates lung carcinogenesis and progression through WNT7B-FZD5-β-catenin signalling axis.
Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD.
Epstein-Barr Virus Promotes Gastric Cancer Progression by Modulating m6A-Dependent YTHDF1-TSC22D1 Axis.
m6A-YTHDF1 Mediated Regulation of GRIN2D in Bladder Cancer Progression and Aerobic Glycolysis.
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Curdione inhibits the proliferation of human uterine leiomyomas by targeting YTHDF1.
Pyrrolidinium Fullerenes as YTHDF1 Inhibitors for Targeted Tumor Therapy.
Treponema pallidum lipoprotein TpF1 regulates METTL14-mediated NF-κB signaling pathway to promote macrophage M2 polarization.
TDP-43 binds to RNA G-quadruplex structure and regulates mRNA stability and translation.
Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation.
Mechanistic study of METTL3 inducing ferroptosis to promote cervical cancer progression through mediating m6A modification of COTE-1.
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response.
m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis.
METTL3 Plays Regulatory Roles in Acute Pneumonia during Staphylococcus aureus Infection.
Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis.
The METTL3/m6A Reader Protein YTHDF1 Regulates Endothelial Cell Pyroptosis by Enhancing NLRP3 Expression to Affect Soft Tissue Injury.
Prognostic analysis of patients with gastric cancer based on N(6)-methyladenosine modification patterns and tumor microenvironment characterization.
N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
hucMSC-Ex alleviates inflammatory bowel disease in mice by enhancing M2-type macrophage polarization via the METTL3-Slc37a2-YTHDF1 axis.
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.
YTHDF1 facilitates esophageal cancer progression via augmenting m6A-dependent TINAGL1 translation.
YTHDF1-regulated ALOX5 in retinal pigment epithelial cells under hypoxia enhances VEGF expression and promotes viability, migration, and angiogenesis of vascular endothelial cells.
The YTHDF Proteins Shape the Brain Gene Signatures of Alzheimer's Disease.
YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner.
CircSSR1 regulates pyroptosis of pulmonary artery smooth muscle cells through parental protein SSR1 mediating endoplasmic reticulum stress.
ZNF740 facilitates the malignant progression of hepatocellular carcinoma via the METTL3/HIF‑1A signaling axis.
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma.
Targeting CircAURKA prevents colorectal cancer progression via enhancing CTNNB1 protein degradation.
Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy.
RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells.
Infection with novel duck reovirus induces stress granule and methylation-mediated host translational shutoff in Muscovy ducklings.
RNA reading protein YTHDF2 mediates Benzo(k)fluoranthene induced male reproductive injury by regulating the stability of BCL2.
DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m(6)A reader YTHDF1.
Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.
YTHDF1 promotes gallbladder cancer progression via post-transcriptional regulation of the m6A/UHRF1 axis.
High-throughput tagging of endogenous loci for rapid characterization of protein function.
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.
Dynamics of N6-methyladenosine modification during Alzheimer's disease development.
YTHDF1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells via Upregulating TCF7 mRNA Translation.
METTL3-dependent m(6)A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway.
N(6)-methyladenosine modification is not a general trait of viral RNA genomes.
YTHDF1 regulates immune cell infiltration in gastric cancer via interaction with p53.
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation.
m(6)A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation.
YTHDF1's grip on CRC vasculature: insights into LINC01106 and miR-449b-5p-VEGFA axis.
METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.
N6-Methyladenosine enhances the translation of ENO1 to promote the progression of bladder cancer by inhibiting PCNA ubiquitination.
Chloroprocaine antagonizes progression of breast cancer by regulating LINC00494/miR-3619-5p/MED19 axis.
m6A-modified RIPK4 facilitates proliferation and cisplatin resistance in epithelial ovarian cancer.
N(6)-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m(6)A/PD-L1 manner.
M6A reader YTHDF1 promotes malignant progression of laryngeal squamous carcinoma through activating the EMT pathway by EIF4A3.
Putrescine promotes MMP9-induced angiogenesis in skeletal muscle through hydrogen peroxide/METTL3 pathway.
Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.
Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication.
Methyltransferase-Like 3-Driven N6-Methyladenosine Modification of Recombination Signal Binding Protein for Immunoglobulin Kappa J Region Promotes Vascular Remodeling in Pulmonary Hypertension.
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
Host RNA N(6)-methyladenosine and incoming DNA N(6)-methyldeoxyadenosine modifications cooperatively elevate the condensation potential of DNA to activate immune surveillance.
N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1.
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.
WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
YTHDF1 is pivotal for maintenance of cardiac homeostasis.
Unraveling the molecular complexity: Wtap/Ythdf1 and Lcn2 in novel traumatic brain injury secondary injury mechanisms.
YTHDF1 promotes the osteolytic bone metastasis of breast cancer via inducing EZH2 and CDH11 translation.
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification.
Construction and validation of a T cell proliferation regulator-related signature for predicting prognosis and immunotherapy response in lung adenocarcinoma.
Pseudorabies virus exploits N(6)-methyladenosine modification to promote viral replication.
HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.
Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats.
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
Multi-Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging.
Propofol suppresses OGD/R-induced ferroptosis in neurons by inhibiting the HIF-1α/YTHDF1/BECN1 axis.
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.
The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis.
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
YTHDF1 shapes "cold" tumor and inhibits CD8(+) T cells infiltration and function in breast cancer.
m(6)A-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition.
Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer's disease pathology in mice.
YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression.
YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m(6)A/mRNA pathway in spermatogonial stem cells/progenitors.
RNA binding protein YTHDF1 mediates bisphenol S-induced Leydig cell damage by regulating the mitochondrial pathway of BCL2 and the expression of CDK2-CyclinE1.
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
O-GlcNAcylation promotes the cytosolic localization of the m(6)A reader YTHDF1 and colorectal cancer tumorigenesis.
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
The m(6)A Reader YTHDF1 Promotes Lung Carcinoma Progression via Regulating Ferritin Mediate Ferroptosis in an m(6)A-Dependent Manner.
METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.
Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.
m(6) A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.
Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68.
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis.
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.
YTHDF2 in dentate gyrus is the m(6)A reader mediating m(6)A modification in hippocampus-dependent learning and memory.
Profiling of N6-methyladenosine methylation in porcine longissimus dorsi muscle and unravelling the hub gene ADIPOQ promotes adipogenesis in an m(6)A-YTHDF1-dependent manner.
Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association.
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.
N(6)-Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication.
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N(6)-Methyladenosine-Modified Yap Expression.
The Effects of Moxibustion on Learning and Memory and m6A RNA Methylation in APP/PS1 Mice.
N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
Novel insight of N(6)-methyladenosine modified subtypes in abdominal aortic aneurysm.
Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma.
m(6)A regulation of cortical and retinal neurogenesis is mediated by the redundant m(6)A readers YTHDFs.
m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.
Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N (6)-Methyladenosine-Modified RNAs.
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.
m(6)A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation.
METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.
Lactylation-driven METTL3-mediated RNA m(6)A modification promotes immunosuppression of tumor-infiltrating myeloid cells.
UPF1 promotes rapid degradation of m(6)A-containing RNAs.
m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer.
YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis.
Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.
Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.
YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.
ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.
m(6)A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m(6)A modification.
Intermittent Fasting Improves High-Fat Diet-Induced Obesity Cardiomyopathy via Alleviating Lipid Deposition and Apoptosis and Decreasing m6A Methylation in the Heart.
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.
The m(6)A methyltransferase METTL3 regulates muscle maintenance and growth in mice.
Involvement of YTHDF1 in renal fibrosis progression via up-regulating YAP.
The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.
Methyltransferase-like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1.
YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner.
METTL3-m(6)A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.
The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.
TBK1-METTL3 axis facilitates antiviral immunity.
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
GMEB2 Promotes the Growth of Colorectal Cancer by Activating ADRM1 Transcription and NF-κB Signalling and Is Positively Regulated by the m(6)A Reader YTHDF1.
The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray.
YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis.
METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.
FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells.
Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.
Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.
RNA m(6)A methylation regulates dissemination of cancer cells by modulating expression and membrane localization of β-catenin.
METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.
N6-methyladenosine regulates ATM expression and downstream signaling.
YTHDF1 Aggravates the Progression of Cervical Cancer Through m(6)A-Mediated Up-Regulation of RANBP2.
YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.
Insufficient Radiofrequency Ablation Promotes Hepatocellular Carcinoma Metastasis Through N6-Methyladenosine mRNA Methylation-Dependent Mechanism.
Vitamin B(12) Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.
Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation.
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.
Streptozotocin-Induced Astrocyte Mitochondrial Dysfunction Is Ameliorated by FTO Inhibitor MO-I-500.
The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
The m(6)A "reader" YTHDF1 promotes osteogenesis of bone marrow mesenchymal stem cells through translational control of ZNF839.
WNT/β-catenin-suppressed FTO expression increases m(6)A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis.
Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m(6) A-dependent manner.
YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.
m(6)A RNA methylation regulates the fate of endogenous retroviruses.
Comparison of RNA m(6)A and DNA methylation profiles between mouse female germline stem cells and STO cells.
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine.
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.
YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition.
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding.
YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.
N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.
Integrated analysis of m(6)A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
YTHDF1 Promotes Cyclin B1 Translation through m(6)A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation.
Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
ALKBH5 suppresses tumor progression via an m(6)A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.
Relaxed initiation pausing of ribosomes drives oncogenic translation.
m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
METTL3-dependent N(6)-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium.
Endothelial METTL3 (Methyltransferase-Like 3) Inhibits Fibrinolysis by Promoting PAI-1 (Plasminogen Activator Inhibitor-1) Expression Through Enhancing Jun Proto-Oncogene N6-Methyladenosine Modification.
GR-mediated transcriptional regulation of m(6)A metabolic genes contributes to diet-induced fatty liver in hens.
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
m(6)A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.
METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay.
Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.
m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.
m(6)A-binding YTHDF proteins promote stress granule formation.
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Context-dependent functional compensation between Ythdf m(6)A reader proteins.
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP.
A Unified Model for the Function of YTHDF Proteins in Regulating m(6)A-Modified mRNA.
ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
N(6)-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
YTHDF1 Facilitates the Progression of Hepatocellular Carcinoma by Promoting FZD5 mRNA Translation in an m6A-Dependent Manner.
N(6)-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism.
Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.
Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.
Epitranscriptomic N(6)-Methyladenosine Modification Is Required for Direct Lineage Reprogramming into Neurons.
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.
N(6)-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification.
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation.
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma.
Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.
The Tudor SND1 protein is an m(6)A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.
The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression.
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.
Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.
m(6)A enhances the phase separation potential of mRNA.
Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis.
A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination.
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells.
m(6)A modification controls the innate immune response to infection by targeting type I interferons.
m(6)A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm.
Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer.
m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1.
mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
METTL3-mediated N(6)-methyladenosine mRNA modification enhances long-term memory consolidation.
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.
Synaptic N(6)-methyladenosine (m(6)A) epitranscriptome reveals functional partitioning of localized transcripts.
Oncogene c-Myc promotes epitranscriptome m(6)A reader YTHDF1 expression in colorectal cancer.
Epitranscriptomic m(6)A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection.
YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.
The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.
N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.
Chen J, Wang Z, Liao Y, Ding W
Journal of inflammation research 2026;19:553934
Journal of inflammation research 2026;19:553934
YTHDF2 promotes m6A-modified HSPA2 translation to restrict Newcastle Disease Virus.
Wang Z, Yin B, Hou Y, Zhao Y, Chen L, Ren T, Yuan W
Veterinary microbiology 2026 May;316:110960
Veterinary microbiology 2026 May;316:110960
m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop.
Yi Q, Zhong K, Chen Z, Ouyang X, Zhu W, Liang L, Zhong J
Molecular immunology 2026 May;193:50-67
Molecular immunology 2026 May;193:50-67
METTL3-based epitranscriptomic editing screening identifies functional m(6)A sites in cancers.
Xu X, Wang Y, Zhu H, Lam M, Luo W, Teng M, Liu Y, Guo WY, Aastha A, Xu X, Chen S, Ci X, Wang S, Zeng Y, Zhu G, Kislinger T, Lupien M, Tsao MS, He HH
Nature cancer 2026 Mar;7(3):469-483
Nature cancer 2026 Mar;7(3):469-483
METTL5 reprograms glycolytic metabolism and promotes non-small cell lung cancer progression by modifying PGAM1.
Shan Y, Duan X, Yuan K, Lou M, Wu Q, Gao Z
Oncology letters 2026 Jun;31(6):254
Oncology letters 2026 Jun;31(6):254
N(6)-methyladenosine attenuates tumor-associated macrophages M2 polarization via suppressing the translation of Snail.
Tian Y, Peng J, Zhou J, Yang W, Peng Y, Li J, Rui Y, Zhang H, Xie G, Wang H, Wang J, Li J, Huang Z, Ma X, Wang H, He J
Science China. Life sciences 2026 Jan;69(1):119-135
Science China. Life sciences 2026 Jan;69(1):119-135
m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.
Zhao B, Cao Z, Zhang K, Xiao S, Shen X, Li F, Wu Y, Zhang B, Wang Q, Zhang H, Chuai X, Chiu S
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804
YTHDC1 Orchestrates Telomerase Assembly via Scaffold-Mediated TERT-TERC Interaction.
Cheng X, Wang S, Yu Y, Xu J, Wang Q, Wei Y, Jin Z, Qi X, Jian D, Shi Y, Li Z, Ma Z, Wang W, Xia T, Xing J, Gu X, Tang H
Aging cell 2026 Jan;25(1):e70332
Aging cell 2026 Jan;25(1):e70332
Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival.
Jiang X, Wang Y, Zhang X, Deng H, Fang L, Tafadzwa C, Yao J, Chen H, Ye A, Zhou K, Ling X, Xiao J
Clinical and translational medicine 2026 Jan;16(1):e70565
Clinical and translational medicine 2026 Jan;16(1):e70565
Jianpi Jiedu formula modulates glutamine metabolism to inhibit colorectal cancer liver metastasis.
Han Y, Ouyang Y, Pu Y, Zhou P, Yang L, Deng W, Song Q, Ji Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157680
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157680
METTL3-mediated m(6)A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca(2+) signaling.
Chen C, Xiong K, Liang F, Zhong Y, Qin X, Huang N, Fang Y, Zhu B, Cheng J, Wei Q, Zheng L, Zhao J
Molecular cancer 2026 Jan 19;25(1)
Molecular cancer 2026 Jan 19;25(1)
N6-methyladenosine (m(6)A) modification of TXNIP in 3'UTR instigates abdominal aorta aneurysm in mice.
Hantelys F, Yin W, Zou MH
iScience 2026 Feb 20;29(2):114630
iScience 2026 Feb 20;29(2):114630
Chiral Fe(3)O(4)/GelMA hydrogels regulate the osteoimmune microenvironment via Itgb3-mediated macrophage polarization to combat peri-implantitis.
Shi D, Mu X, Cao H, Hao F, Xu X, Wu L
Bioactive materials 2026 Aug;62:776-797
Bioactive materials 2026 Aug;62:776-797
m(6)A reader Ythdf proteins control retrotransposon B2 repeat expression and safeguard early embryo development.
Su R, Gao D, Du Z, Meng TG, Li C, Chen LN, Lin X, Cao C, Fan LH, Dong Y, Li S, Luo SM, Jiang S, Guo Z, Tian Y, Sun QY, Ou XH
The EMBO journal 2026 Apr;45(8):2494-2522
The EMBO journal 2026 Apr;45(8):2494-2522
Erianin facilitates pyroptosis in endometrial cancer via targeting m6A reader YTHDF1.
Shu W, Zhou X, Zhao R, Dong K, Shen X, Chen G, Cheng S, Zhang Q, Zhou T, Zhang J, Zhang T, Yu S, Li H, Yao Y, Liu Y, Zhang J, Wang H
Chinese medicine 2026 Apr 7;21(1)
Chinese medicine 2026 Apr 7;21(1)
YTHDF1/SLC39A4 signaling axis promotes gastric cancer cell proliferation by suppressing cuproptosis ex vivo and in vitro.
Su J, Qi J, Xu B, Wang J, Chaulagain RP, Chen H, Li N, Jiang X, Xu L, Li F, Mao W, Jin S
Cancer gene therapy 2026 Apr 29;
Cancer gene therapy 2026 Apr 29;
m(6)A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis.
Gong W, Yang X, Fan N, Wang H, Fu S, Tian Y, Li L
Scientific reports 2026 Apr 18;
Scientific reports 2026 Apr 18;
Targeting m(6)A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti-PD-L1 Efficacy in Intrahepatic Cholangiocarcinoma.
Luo L, Liu Z, Song Z, Zhang D, Liang C, Fang F, Lei K, Wang L, Chen W, Shen S, Kuang M, Li X, Yu J, Wang S, Xu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 13;:e20403
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 13;:e20403
METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.
Li J, Luo Q, Lu M, Lu C, Xu C, Ding J, Zhan T, Zhu J, Qian M, Lin S, Chang L, Li J, Wang K
International journal of biological sciences 2025;21(11):4782-4797
International journal of biological sciences 2025;21(11):4782-4797
Notch-Driven Cholangiocarcinogenesis Involves the Hippo Pathway Effector TAZ via METTL3-m6A-YTHDF1.
Ma W, Zhang J, Chen W, Liu N, Wu T
Cellular and molecular gastroenterology and hepatology 2025;19(1):101417
Cellular and molecular gastroenterology and hepatology 2025;19(1):101417
Repetitive transcranial magnetic stimulation alleviates neuropathic pain via microglial polarization by modulating the METTL3/NMDAR2B/NLRP3 pathway.
Zhu J, Li L, Shi R, Xing F, Yang Y, Xu Z, Wang Q, Deng Q, Li D, Huang M, Wang J
Frontiers in immunology 2025;16:1666920
Frontiers in immunology 2025;16:1666920
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Sun H, Qiao X, Peng X, Zhu H, Zhang L, Jiang L, Wang L, Xue C, Yang J, Yi W, Zhang B, Liu J, Duan W
Theranostics 2025;15(8):3532-3550
Theranostics 2025;15(8):3532-3550
YTHDF3 recognizes DNA N6-methyladenine and recruits ALKBH1 for 6mA removal from genomic DNA.
Chen XH, Wang ZL, Yang J, Chen M, Zhao SY, Guo KX, Zheng X, Zhao Z, Chen X, Li J, Zhang MM, Ran L, Zhu H, Gu XF, Yan GR
The EMBO journal 2025 Sep;44(17):4899-4917
The EMBO journal 2025 Sep;44(17):4899-4917
METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA.
Wang J, Yu Y, Xiong Z, Wang P, Wang Z, Du A, Han S, Wang X, Zhang L
Biochemical pharmacology 2025 Sep;239:117016
Biochemical pharmacology 2025 Sep;239:117016
A nanovaccine targeting cancer stem cells and bulk cancer cells for postoperative cancer immunotherapy.
You Q, Wu G, Li H, Liu J, Cao F, Ding L, Liang F, Zhou B, Ma L, Zhu L, Wang C, Yang Y, Chen X
Nature nanotechnology 2025 Sep;20(9):1298-1311
Nature nanotechnology 2025 Sep;20(9):1298-1311
METTL3/ALKBH5-Mediated N6-Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3-TASL-IRF5 Signaling Axis in Psoriasis.
Huang T, Chen S, Ding K, Yuan L, Lv W, Chen K, Liu Y, Ma D, Zhang X, Wang X, Luo G, Yang B, Lin Y, Rong Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e01408
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e01408
The role of YTHDF1 in the diagnosis and prognosis of lung adenocarcinoma and its inhibitor LY-411575 in the targeted intervention of lung adenocarcinoma growth.
Wang L, Li C, Huang S, Fan B, Wang C, Yao Z, Yang Y, Han L, Jia D, Yang Z
Translational cancer research 2025 Sep 30;14(9):5884-5905
Translational cancer research 2025 Sep 30;14(9):5884-5905
YTHDF proteins and m(6)A-RNA clients undergo autophagic turnover during contact inhibition.
Ho-Xuan H, Bruckmann A, Natali L, Prieto-Garcia C, Stuke JFM, Brunello L, Vicente A, Pfab A, Wesseling H, Cano-Franco S, Khatri A, Larivera S, Sanz-Martinez P, de la Cruz-Thea B, Jacomin AC, Prochazka J, Feederle R, Dötsch V, Sedlacek R, Hummer G, Kaiser S, Dikic I, Musri MM, Meister G, Stolz A
Cell reports 2025 Sep 23;44(9):116188
Cell reports 2025 Sep 23;44(9):116188
YTHDF1-mediated mitochondrial dysfunction and allergic airway inflammation by interaction with β-catenin/TCF4 signaling.
Xie C, Huang J, Chen Y, Huang B, Chen Y, Li Y, Gong Z, Ma Y, Xu M, Fan K, Hu D, Zhao X, Huang P, Peng X, Cai S, Zhao W, Zhao H
International immunopharmacology 2025 Sep 23;162:115181
International immunopharmacology 2025 Sep 23;162:115181
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
Yan Z, Cao H, Zhang X, Wang Y, Chang Q
International immunopharmacology 2025 Sep 23;162:115141
International immunopharmacology 2025 Sep 23;162:115141
RHBDF2 governs microglial neuroinflammation during cerebral ischemia-reperfusion injury and is positively regulated by the m6A reader YTHDF1.
Xu L, Zhang R, Zhang X, Liu B, Shang X, Huang D
Molecular medicine (Cambridge, Mass.) 2025 Sep 2;31(1):284
Molecular medicine (Cambridge, Mass.) 2025 Sep 2;31(1):284
YTHDF1 regulates the proliferation and differentiation of keratinocytes via the PI3K/AKT signaling pathway in atopic dermatitis.
Huang M, Dong L, He Y, Cai X, Lu Y, Xu J, Xiao F
Allergology international : official journal of the Japanese Society of Allergology 2025 Oct;74(4):591-604
Allergology international : official journal of the Japanese Society of Allergology 2025 Oct;74(4):591-604
m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.
Yin L, Zhang Y, Zhang B, Zhang J, Xiong M, Jiang N, Xiao J, Gao H, Xiong W, Wang X, Wang F, Yuan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600
METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.
Tang Y, Li Z, Zhao X, Niu X, Ning S, Liu L, Liu Z, Zhang J, Zhao Q, Han L
Reproduction (Cambridge, England) 2025 Oct 1;170(4)
Reproduction (Cambridge, England) 2025 Oct 1;170(4)
ALKBH5 regulates ACSL4 to sensitize erastin-induced ferroptosis via YTHDF2-dependent m(6)A modification in hypoxic pulmonary hypertension.
Shi Y, Xu Y, Li Y, Yan C, Ying K, Jin H, Wang L, Zhang X
Free radical biology & medicine 2025 Nov;239:280-297
Free radical biology & medicine 2025 Nov;239:280-297
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
Wang J, Deng J, Sun B, Qiao G, Yang J, Gao Z, Zhang Q, Dong M, Qu P, Wang Z
Cellular signalling 2025 Nov;135:112024
Cellular signalling 2025 Nov;135:112024
m6A-induced DEAD-box RNA helicase 21 enhances lipid metabolism via 3‑hydroxy-3-methylglutaryl-CoA synthases 1 in colorectal cancer.
Gao H, Zheng S, Liang J, Wang Y, Chen L, Li H, Chen Y, Zhang F, Shi H, Han A
Translational oncology 2025 May;55:102373
Translational oncology 2025 May;55:102373
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
Zhu ZM, Huo FC, Shi C, Li MT, Zhou Y, Zhang LS, Pei DS
International journal of biological macromolecules 2025 May;309(Pt 2):142880
International journal of biological macromolecules 2025 May;309(Pt 2):142880
YTHDF2 suppresses the 2C-like state in mouse embryonic stem cells via the DUX-ZSCAN4 molecular circuit.
Wu X, Cai W, He J, Zhang S, Wang S, Huang L, Zhang H, Sun X, Zhou J, Liu XM
The Journal of biological chemistry 2025 May;301(5):108479
The Journal of biological chemistry 2025 May;301(5):108479
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
Chang K, Hong F, Liu H, Fang Y, Wang H, Song N, Ning Y, Lu Z, Jin S, Dai Y, Ding X
Biochemical pharmacology 2025 May;235:116819
Biochemical pharmacology 2025 May;235:116819
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor.
Kim JS, Cho S, Jeong MY, Rivera-Piza A, Kim Y, Wu C, Yoon YE, Lee I, Choi JW, Lee HL, Shin SW, Shin J, Gil H, Lee MG, Keum N, Kim JA, Lee D, Jung YH, Chung S, Shin MJ, Hong S, Chi SG, Lee SJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156599
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156599
YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response.
Li H, Yu K, Zhang X, Li J, Hu H, Deng X, Zeng S, Dong X, Zhao J, Zhang Y
Genes & diseases 2025 May;12(3):101327
Genes & diseases 2025 May;12(3):101327
Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis.
Dong Z, Jin Y, Shen Y, Huang J, Tan J, Feng Q, Gong Z, Zhu S, Chen H, Yu F, Li W, Jia Y, Kong W, Fu Y
Cardiovascular research 2025 May 6;121(4):568-584
Cardiovascular research 2025 May 6;121(4):568-584
Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells.
Zhang X, Tang Y, Wang J, Yang M, Jiang J, Xue H, Wang Y, Zhang J, Wang X
Journal of hazardous materials 2025 May 5;488:137432
Journal of hazardous materials 2025 May 5;488:137432
An Investigation of the RNA Modification m(6)A and Its Regulatory Enzymes in Rat Brains Affected by Chronic Morphine Treatment and Withdrawal.
Hronova A, Pritulova E, Hejnova L, Novotny J
International journal of molecular sciences 2025 May 4;26(9)
International journal of molecular sciences 2025 May 4;26(9)
METTL3 inhibits primed-to-naïve transition of pluripotent stem cells through m(6)A-YTHDF2-pluripotency/Gstp1 mRNA degradation axis.
Li S, Hao J, Hong G, Dong H, Liu H, Jin L, Zhang Z, Wu H, Hu M, Huang R, Luo G, He J, Chen J, Wu K
Cell regeneration (London, England) 2025 May 27;14(1):19
Cell regeneration (London, England) 2025 May 27;14(1):19
YTHDF1-targeting nanoassembly reverses tumoral immune evasion through epigenetics and cell cycle modulation.
Liu H, Zhang X, Ding F, Pan J, Zhu H, Zhou Z, Sun M
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113574
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113574
Targeting ADAR1 with a small molecule for the treatment of prostate cancer.
Wang X, Li J, Zhu Y, Shen H, Ding J, Zeng T, Min W, Liang SQ, Huang L, Shi Z, Shen H, Huang F, Yuan K, Kuang W, Ji M, Sun C, Hou Y, Wang L, Chen W, Jiang Y, Hao H, Xiao Y, Yang P
Nature cancer 2025 Mar;6(3):474-492
Nature cancer 2025 Mar;6(3):474-492
Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.
Zhong Y, Zhang R, Lu L, Tan H, You Y, Mao Y, Yuan Y
Cell communication and signaling : CCS 2025 Mar 8;23(1):126
Cell communication and signaling : CCS 2025 Mar 8;23(1):126
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1.
Zhou SM, Shi Y, Li JY, Wang N, Zeng Y, Chen HQ, Tan YP, Deng SW, Liu QQ, Huang XQ, Wang YQ, Zhou ZY, Liu WB
Free radical biology & medicine 2025 Mar 1;229:364-373
Free radical biology & medicine 2025 Mar 1;229:364-373
Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy.
Wang J, Ran Y, Li Z, Zhao T, Zhang F, Wang J, Liu Z, Chen X
Neural regeneration research 2025 Mar 1;20(3):887-899
Neural regeneration research 2025 Mar 1;20(3):887-899
YTHDF1-mediated m6A modification promotes cisplatin resistance in ovarian cancer via the FZD7/Wnt/β-catenin pathway.
Miao J, Jiang X, Wang S
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1525-1546
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1525-1546
Loss of Epitranscriptomic Modification N(6)-Methyladenosine (m(6)A) Reader YTHDF1 Exacerbates Ischemic Brain Injury in a Sexually Dimorphic Manner.
Chokkalla AK, Arruri V, Mehta SL, Vemuganti R
Translational stroke research 2025 Jun;16(3):831-847
Translational stroke research 2025 Jun;16(3):831-847
Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence.
Luo T, Chen Z, Zhang F, Liu H, Huang F, Zhang X, Feng J, Ding S, Liu L, Guan W, Zeng A, Hao H
Viruses 2025 Jun 9;17(6)
Viruses 2025 Jun 9;17(6)
The cardiac METTL3/m6A pathway regulates the systemic response to Western diet.
Rabolli C, Longenecker JZ, Naarmann-de Vries IS, Serrano J, Petrosino JM, Kyriazis GA, Dieterich C, Accornero F
JCI insight 2025 Jun 9;10(11)
JCI insight 2025 Jun 9;10(11)
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Xu C, Yu C, Zhang J, Zhang Z, Zhang J, Meng Y, Wang M, Wen M, Chen J, Ning Y, Chen X, Gu J, Su W, Liu B
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC)-stabilized lncRNA small nucleolar RNA host gene 15 (Snhg15) modulates hematopoietic injury induced by γ-ray irradiation via m(6)A modification.
Zhang S, Cheng Y, Gao Y, Xu F, Wang Y, Zhang J, Shang Y, Li D, Fan S
Molecular biomedicine 2025 Jun 25;6(1):44
Molecular biomedicine 2025 Jun 25;6(1):44
m(6)A RNA methylation-mediated control of global APC expression is required for local translation of β-actin and axon development.
Broix L, Roy R, Shohayeb B, Oomoto I, Umeshima H, Wang DO
Cell reports 2025 Jun 24;44(6):115727
Cell reports 2025 Jun 24;44(6):115727
The RNA-stability-independent role of the RNA m(6)A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance.
Liu T, Yang D, Wei Q, Wang Y, Tian L, Liu X, Yang Y, Luo Q, Xu J, Liu Y, Yang C, Zuo X, Luo F, Luo X, Zhao H, Li L, Xu J, Yu J, Ma S, Yu J, Yi P
Molecular cell 2025 Jun 19;85(12):2320-2336.e9
Molecular cell 2025 Jun 19;85(12):2320-2336.e9
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.
Zhu C, Li R, You X, Xu J, Wang J, Dong D, Chen X, Wang K
NPJ precision oncology 2025 Jun 17;9(1):193
NPJ precision oncology 2025 Jun 17;9(1):193
Hypoxia-Inducible Factor HIF1α Regulates the Expression of SLC7A1 to Mediate Erastin-Induced Ferroptosis in Cervical Cancer Cells.
Huang Y, Lei Y, Li Y
The journal of gene medicine 2025 Jul;27(7):e70027
The journal of gene medicine 2025 Jul;27(7):e70027
The m6A demethylase FTO regulates TNF-α expression in human macrophages following Toxoplasma gondii infection.
Qin M, Gao N, Sun J, Lin S, Hu T, Liu X, Zhang R, Wang Y, Qiu J
PLoS neglected tropical diseases 2025 Jul;19(7):e0013289
PLoS neglected tropical diseases 2025 Jul;19(7):e0013289
IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.
Luo X, Wei Q, Xie L, Chen N, Gu B, Xu J, Jiang X, Zuo X, Zhao H, Liu X, Yang Y, Liu T, Zhu Y, Yi P, Xu J
Clinical and translational medicine 2025 Jul;15(7):e70388
Clinical and translational medicine 2025 Jul;15(7):e70388
METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.
Liao X, Hu T
Mutation research 2025 Jul-Dec;831:111910
Mutation research 2025 Jul-Dec;831:111910
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I
Cell reports 2025 Jul 22;44(7):115826
Cell reports 2025 Jul 22;44(7):115826
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through m(6)A-dependent binding.
Chang X, Li B, Huang W, Chen A, Zhu S, Liu Y, Liu X, Yang J, Wang DO
Cell biology and toxicology 2025 Jul 1;41(1):112
Cell biology and toxicology 2025 Jul 1;41(1):112
POU4F1 enhances lung cancer gemcitabine resistance by regulating METTL3-dependent TWF1 mRNA N6 adenosine methylation.
Tang J, Liu Z, Xie G, Wang C, Jiang Y
3 Biotech 2025 Jan;15(1):7
3 Biotech 2025 Jan;15(1):7
N6-methyladenosine-modified circRPS6KC1 regulated cellular senescence in prostate cancer via FOXM1/PCNA axis.
Shu X, Yi J, Li J, Ying Y, Tang Y, Chen Z, Wang J, Zhang F, Lu D, Wu Y, Sun J, Lin S, Qi Z, Chen D, Wang X, Chen H, Xie L, Ma X, Luo J
Cellular signalling 2025 Jan;125:111510
Cellular signalling 2025 Jan;125:111510
N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.
Rui Y, Zhang H, Yu K, Qiao S, Gao C, Wang X, Yang W, Asadikaram G, Li Z, Zhang K, Peng J, Li J, He J, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488
RNA m(6)A-mediated post-transcriptional repression of glucocorticoid receptor in LPS-activated Kupffer cells on broilers.
Zhao Y, Jiang Y, Feng Y, Zhao R
Poultry science 2025 Jan;104(1):104393
Poultry science 2025 Jan;104(1):104393
M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC.
Zhi Y, Liu S, Chang X, Guan W, Li R, Liu Q, Chen J, Ling J, Zhao X, Liu A, Chen J, Zhang X, Huang Y
Cancer control : journal of the Moffitt Cancer Center 2025 Jan-Dec;32:10732748251342685
Cancer control : journal of the Moffitt Cancer Center 2025 Jan-Dec;32:10732748251342685
YTH N(6)-methyladenosine RNA Binding Protein 1 Inhibits Smooth Muscle Cell Phenotypic Modulation and Neointimal Hyperplasia.
Tian K, Cai D, Yang S, Zhao W, Mei X, Chen SY
Cells 2025 Jan 22;14(3)
Cells 2025 Jan 22;14(3)
Diosmetin-7-O-β-D-glucopyranoside from Pogostemonis Herba alleviated SARS-CoV-2-induced pneumonia by reshaping macrophage polarization and limiting viral replication.
Xu YL, Li XJ, Cai W, Yu WY, Chen J, Lee Q, Choi YJ, Wu F, Lou YJ, Ying HZ, Yu CH, Wu QF
Journal of ethnopharmacology 2025 Jan 10;336:118704
Journal of ethnopharmacology 2025 Jan 10;336:118704
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
Zhang Y, Shen G, Zhang D, Meng T, Lv Z, Chen L, Li J, Li K
Clinical and translational medicine 2025 Feb;15(2):e70228
Clinical and translational medicine 2025 Feb;15(2):e70228
USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation.
Shao N, Xi L, Lv Y, Idris M, Zhang L, Cao Y, Xiang J, Xu X, Ong BX, Zhang Q, Peng X, Yue X, Xu F, Liu C
Nature communications 2025 Feb 3;16(1):1313
Nature communications 2025 Feb 3;16(1):1313
Endurance exercise remodels skeletal muscle by suppressing Ythdf1-mediated myostatin expression.
Huang X, Xu C, Zhang J, Wu W, Wang Z, Pang Q, Liu Z, Liu B
Cell death & disease 2025 Feb 13;16(1):96
Cell death & disease 2025 Feb 13;16(1):96
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455
Renal failure 2025 Dec;47(1):2521455
The m6A reader YTHDF1 facilitates nasopharyngeal carcinoma proliferation and migration via c-MYC.
Han P, Xiao Z, Xia T, Wu T, Li S, Ye Y, Zeng H, Zeng M, Zhong Q, Huang X
The Journal of biological chemistry 2025 Dec;301(12):110833
The Journal of biological chemistry 2025 Dec;301(12):110833
Downregulated Smad3 signaling impairs the maturation of MO-MDSC in colorectal cancer.
Li M, Zha X, Gao Z, Zhao Y, Ma J, Tian J, Mao Z, Wang S
Cell death & disease 2025 Dec 8;16(1):880
Cell death & disease 2025 Dec 8;16(1):880
ZNF831-YTHDF1-DNMT1/3a feedback loop regulates lung carcinogenesis and progression through WNT7B-FZD5-β-catenin signalling axis.
Chen D, Chen H, Zeng Y, Shi Y, Guo F, Fan J, Zhang Z, Zhou S, Wang N, Deng S, Liu J, Cao J, Liu W
Free radical biology & medicine 2025 Dec 16;241:338-352
Free radical biology & medicine 2025 Dec 16;241:338-352
Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD.
Li M, Ou Q, Qin Q, Chen J, Yang S, Zhao J, Meng H, Li X, Xu P, Ye C, Wang X
Nature communications 2025 Dec 12;16(1):11092
Nature communications 2025 Dec 12;16(1):11092
Epstein-Barr Virus Promotes Gastric Cancer Progression by Modulating m6A-Dependent YTHDF1-TSC22D1 Axis.
An YR, Jung J, Kwon KM, Kim JY, Lee MH, Lee JY, Lee M, Lee SK
Microorganisms 2025 Dec 11;13(12)
Microorganisms 2025 Dec 11;13(12)
m6A-YTHDF1 Mediated Regulation of GRIN2D in Bladder Cancer Progression and Aerobic Glycolysis.
Le M, Qing M, Zeng X, Cheng S
Biochemical genetics 2025 Aug;63(4):3220-3239
Biochemical genetics 2025 Aug;63(4):3220-3239
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Liu X, Cui Y, Gong J, Yu X, Cui Y, Xuan Y
Oncogene 2025 Aug;44(29):2474-2489
Oncogene 2025 Aug;44(29):2474-2489
Curdione inhibits the proliferation of human uterine leiomyomas by targeting YTHDF1.
Yang X, Zuo J, Qiu T, Ren H, Qian R, Luo W, Chen Z, Li D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156938
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156938
Pyrrolidinium Fullerenes as YTHDF1 Inhibitors for Targeted Tumor Therapy.
Wang X, Zhang W, Huo J, Wang Z, Liu Y, Yang L, Zhang S, Chen S, Xu Y, Qi H, Sun J, Pan Y, Lu Y, Li B, Wang Y, Liu M, Li J, Li S, Zhao C, Li Y, Yu F, Wang Z, Guo Q, Li J, Wang C
Advanced healthcare materials 2025 Aug;14(22):e2501360
Advanced healthcare materials 2025 Aug;14(22):e2501360
Treponema pallidum lipoprotein TpF1 regulates METTL14-mediated NF-κB signaling pathway to promote macrophage M2 polarization.
Cao Q, Zhou X, Zou F, He R, He L, Chen J, Li Y, Cao T, Li Y, Lan X, Liu S
Journal of leukocyte biology 2025 Aug 5;117(8)
Journal of leukocyte biology 2025 Aug 5;117(8)
TDP-43 binds to RNA G-quadruplex structure and regulates mRNA stability and translation.
Zhao J, Yang F, Zhang Y, Wang H, Kwok CK
Nucleic acids research 2025 Aug 27;53(16)
Nucleic acids research 2025 Aug 27;53(16)
Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation.
Zheng Y, Wang K, Mao W, Zhang G, Han X, Li H, Wang Y
International journal of oncology 2025 Apr;66(4)
International journal of oncology 2025 Apr;66(4)
Mechanistic study of METTL3 inducing ferroptosis to promote cervical cancer progression through mediating m6A modification of COTE-1.
Min L, Huo F, Zhu Z, Din L, Zhang L, Xu Y, Xing X, Zhang P, Wang Q
Cellular signalling 2025 Apr;128:111649
Cellular signalling 2025 Apr;128:111649
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response.
Hou J, Gao Y, Han B, Yan S, Wei S, Gao X
Science advances 2025 Apr 18;11(16):eado7660
Science advances 2025 Apr 18;11(16):eado7660
m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis.
Hu Y, Yang L, Huang L, Zeng C, Ren S
Cellular and molecular life sciences : CMLS 2025 Apr 12;82(1):157
Cellular and molecular life sciences : CMLS 2025 Apr 12;82(1):157
METTL3 Plays Regulatory Roles in Acute Pneumonia during Staphylococcus aureus Infection.
Wu M, Nie Q, Zhang Y, Qin J, Ye L, Zhao R, Dai M, Wu M
ACS infectious diseases 2025 Apr 11;11(4):905-916
ACS infectious diseases 2025 Apr 11;11(4):905-916
Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis.
Chen M, Yang D, Zhou Y, Yang C, Lin W, Li J, Liu J, Ye J, Huang W, Ma W, Li W, Chen J, Zhang Y, Shi GP, Luo J, Li J, Luo S
International journal of biological sciences 2024;20(6):2092-2110
International journal of biological sciences 2024;20(6):2092-2110
The METTL3/m6A Reader Protein YTHDF1 Regulates Endothelial Cell Pyroptosis by Enhancing NLRP3 Expression to Affect Soft Tissue Injury.
Xie X, Fang F
Journal of inflammation research 2024;17:11331-11346
Journal of inflammation research 2024;17:11331-11346
Prognostic analysis of patients with gastric cancer based on N(6)-methyladenosine modification patterns and tumor microenvironment characterization.
Huo M, Zhang M, Zhang J, Wang Y, Hu T, Ma T, Wang Y, Yuan B, Qin H, Teng X, Yu H, Huang W, Wang Y
Frontiers in pharmacology 2024;15:1445321
Frontiers in pharmacology 2024;15:1445321
N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.
Jiang S, Gao L, Li J, Zhang F, Zhang Y, Liu J
Frontiers in cell and developmental biology 2024;12:1383232
Frontiers in cell and developmental biology 2024;12:1383232
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
Cai Y, Zhou J, Xu A, Huang J, Zhang H, Xie G, Zhong K, Wu Y, Ye P, Wang H, Niu H
The Journal of biological chemistry 2024 Sep;300(9):107598
The Journal of biological chemistry 2024 Sep;300(9):107598
hucMSC-Ex alleviates inflammatory bowel disease in mice by enhancing M2-type macrophage polarization via the METTL3-Slc37a2-YTHDF1 axis.
Xu X, Peng J, Wang N, Ocansey DKW, Zhang X, Mao F
Cell biology and toxicology 2024 Sep 11;40(1):74
Cell biology and toxicology 2024 Sep 11;40(1):74
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.
Zhao H, Gao Z, Sun J, Qiao H, Zhao Y, Cui Y, Zhao B, Wang W, Chiu S, Chuai X
Viruses 2024 Sep 11;16(9)
Viruses 2024 Sep 11;16(9)
YTHDF1 facilitates esophageal cancer progression via augmenting m6A-dependent TINAGL1 translation.
Zhang L, Cai E, Xu Y, Liu Z, Zheng M, Sun Z, Pei D, Wang Q
Cellular signalling 2024 Oct;122:111332
Cellular signalling 2024 Oct;122:111332
YTHDF1-regulated ALOX5 in retinal pigment epithelial cells under hypoxia enhances VEGF expression and promotes viability, migration, and angiogenesis of vascular endothelial cells.
Dong Y, Qian C, Yan P, Wan G
Scientific reports 2024 Oct 5;14(1):23226
Scientific reports 2024 Oct 5;14(1):23226
The YTHDF Proteins Shape the Brain Gene Signatures of Alzheimer's Disease.
Tasaki S, Avey DR, Kearns NA, Iatrou A, Yu C, De Tissera S, Vyas H, Xu J, Flood DJ, Rothamel K, Wingo AP, Wingo TS, Seyfried NT, De Jager PL, Yeo G, Gaiteri C, Bennett DA, Wang Y
bioRxiv : the preprint server for biology 2024 Oct 23;
bioRxiv : the preprint server for biology 2024 Oct 23;
YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner.
Han Y, Pu Y, Liu X, Liu Z, Chen Y, Tang L, Zhou J, Song Q, Ji Q
Cancer letters 2024 Oct 1;601:217186
Cancer letters 2024 Oct 1;601:217186
CircSSR1 regulates pyroptosis of pulmonary artery smooth muscle cells through parental protein SSR1 mediating endoplasmic reticulum stress.
Guan X, Du H, Wang X, Zhu X, Ma C, Zhang L, He S, Bai J, Liu H, Yuan H, Wang S, Wan K, Yu H, Zhu D
Respiratory research 2024 Oct 1;25(1):355
Respiratory research 2024 Oct 1;25(1):355
ZNF740 facilitates the malignant progression of hepatocellular carcinoma via the METTL3/HIF‑1A signaling axis.
Zhang H, Han B, Tian S, Gong Y, Liu L
International journal of oncology 2024 Nov;65(5)
International journal of oncology 2024 Nov;65(5)
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma.
Xu X, Wu S, Zhang Y, Fan W, Lin X, Chen K, Lin X
Molecular carcinogenesis 2024 Nov;63(11):2174-2189
Molecular carcinogenesis 2024 Nov;63(11):2174-2189
Targeting CircAURKA prevents colorectal cancer progression via enhancing CTNNB1 protein degradation.
Sun Z, Dang P, Guo Y, Liu S, Hu S, Sun H, Xu Y, Wang W, Chen C, Liu J, Ji Z, Liu Y, Hu J
Oncogene 2024 Nov;43(46):3388-3401
Oncogene 2024 Nov;43(46):3388-3401
Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy.
Wu K, Li S, Hong G, Dong H, Tang T, Liu H, Jin L, Lin S, Ji J, Hu M, Chen S, Wu H, Luo G, Wu H, Kong X, Chen J, He J, Wu H
Clinical and translational medicine 2024 Nov;14(11):e70089
Clinical and translational medicine 2024 Nov;14(11):e70089
RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells.
Zhang X, Zhu C, Zhang L, Tan L, Cheng W, Li M, Zhang X, Zhang W, Zhang W
Food science & nutrition 2024 Nov;12(11):9238-9251
Food science & nutrition 2024 Nov;12(11):9238-9251
Infection with novel duck reovirus induces stress granule and methylation-mediated host translational shutoff in Muscovy ducklings.
Yun T, Hua J, Chen L, Ye W, Ni Z, Zhu Y, Zhang C
Communications biology 2024 Nov 21;7(1):1549
Communications biology 2024 Nov 21;7(1):1549
RNA reading protein YTHDF2 mediates Benzo(k)fluoranthene induced male reproductive injury by regulating the stability of BCL2.
Li YW, Wang DD, Chen HQ, Zeng Y, Wang N, Shi Y, Li JY, Zhou NY, Wang DP, Chen Q, Han X, Cao J, Liu WB
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124889
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124889
DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m(6)A reader YTHDF1.
Zhang Y, Zhao J, Chen X, Qiao Y, Kang J, Guo X, Yang F, Lyu K, Ding Y, Zhao Y, Sun H, Kwok CK, Wang H
Nature communications 2024 Nov 15;15(1):9890
Nature communications 2024 Nov 15;15(1):9890
Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.
Zhang X, Li Z, Peng Q, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Zheng X, Yan Q, Wang J, Ma J
The Journal of biological chemistry 2024 May;300(5):107226
The Journal of biological chemistry 2024 May;300(5):107226
YTHDF1 promotes gallbladder cancer progression via post-transcriptional regulation of the m6A/UHRF1 axis.
Chen J, Bai X, Zhang W, Yan Z, Liu Y, Zhou S, Wu X, He X, Yang A
Journal of cellular and molecular medicine 2024 May;28(9):e18328
Journal of cellular and molecular medicine 2024 May;28(9):e18328
High-throughput tagging of endogenous loci for rapid characterization of protein function.
Kim J, Kratz AF, Chen S, Sheng J, Kim HK, Zhang L, Singh BK, Chavez A
Science advances 2024 May 3;10(18):eadg8771
Science advances 2024 May 3;10(18):eadg8771
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Ou X, Tan Y, Xie J, Yuan J, Deng X, Shao R, Song C, Cao X, Xie X, He R, Li Y, Tang H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
Yuan D, Li H, Dai W, Zhou X, Zhou W, He L
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.
Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, Zhan HW, Sheng XY, Xu LH, Ren XJ, Yang F, Geng B, Xia YY
Cellular signalling 2024 Mar;115:111038
Cellular signalling 2024 Mar;115:111038
Dynamics of N6-methyladenosine modification during Alzheimer's disease development.
Gao S, Wang Y, Li X, Liang Y, Jin Z, Yang B, Yuan TF, Tian H, Peng B, Rao Y
Heliyon 2024 Mar 30;10(6):e26911
Heliyon 2024 Mar 30;10(6):e26911
YTHDF1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells via Upregulating TCF7 mRNA Translation.
Li Y, Guo X, Liang X, Wang Z
Frontiers in bioscience (Landmark edition) 2024 Mar 20;29(3):117
Frontiers in bioscience (Landmark edition) 2024 Mar 20;29(3):117
METTL3-dependent m(6)A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway.
Ma L, Zhou X, Yao S, Zhang X, Mao J, Vona B, Fan L, Lou S, Li D, Wang L, Pan Y
Cell death & disease 2024 Mar 20;15(3):229
Cell death & disease 2024 Mar 20;15(3):229
N(6)-methyladenosine modification is not a general trait of viral RNA genomes.
Baquero-Pérez B, Yonchev ID, Delgado-Tejedor A, Medina R, Puig-Torrents M, Sudbery I, Begik O, Wilson SA, Novoa EM, Díez J
Nature communications 2024 Mar 11;15(1):1964
Nature communications 2024 Mar 11;15(1):1964
YTHDF1 regulates immune cell infiltration in gastric cancer via interaction with p53.
Liao Q, Xiong J
Experimental and therapeutic medicine 2024 Jun;27(6):255
Experimental and therapeutic medicine 2024 Jun;27(6):255
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation.
Yin H, Ju Z, Zhang X, Zuo W, Yang Y, Zheng M, Zhang X, Liu Y, Peng Y, Xing Y, Yang A, Zhang R
Cellular & molecular immunology 2024 Jun;21(6):589-603
Cellular & molecular immunology 2024 Jun;21(6):589-603
m(6)A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation.
Wu H, Jiang W, Pang P, Si W, Kong X, Zhang X, Xiong Y, Wang C, Zhang F, Song J, Yang Y, Zeng L, Liu K, Jia Y, Wang Z, Ju J, Diao H, Bian Y, Yang B
Frontiers of medicine 2024 Jun;18(3):499-515
Frontiers of medicine 2024 Jun;18(3):499-515
YTHDF1's grip on CRC vasculature: insights into LINC01106 and miR-449b-5p-VEGFA axis.
Ma RT, Wang Y, Ji F, Chen JN, Wang TJ, Liu Y, Hou MX, Guo ZG
Cancer cell international 2024 Jun 4;24(1):195
Cancer cell international 2024 Jun 4;24(1):195
METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.
Wang C, Tanizawa H, Hill C, Havas A, Zhang Q, Liao L, Hao X, Lei X, Wang L, Nie H, Qi Y, Tian B, Gardini A, Kossenkov AV, Goldman A, Berger SL, Noma KI, Adams PD, Zhang R
Nature communications 2024 Jun 26;15(1):5410
Nature communications 2024 Jun 26;15(1):5410
N6-Methyladenosine enhances the translation of ENO1 to promote the progression of bladder cancer by inhibiting PCNA ubiquitination.
Shen C, Liu J, Xie F, Yu Y, Ma X, Hu D, Liu C, Wang Y
Cancer letters 2024 Jul 28;595:217002
Cancer letters 2024 Jul 28;595:217002
Chloroprocaine antagonizes progression of breast cancer by regulating LINC00494/miR-3619-5p/MED19 axis.
Chen C, Wang N, Huang T, Cheng G, Hu Y, Wang B, Zhang Y, Wang C
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23524
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23524
m6A-modified RIPK4 facilitates proliferation and cisplatin resistance in epithelial ovarian cancer.
Yin X, Zhao S, Zhang M, Xing J, Zhou J, Gao W, Chen L, Zhang Y, Lin L, Lu M, Li W, Shang J, Zhu X
Gynecologic oncology 2024 Jan;180:99-110
Gynecologic oncology 2024 Jan;180:99-110
N(6)-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m(6)A/PD-L1 manner.
Wang Y, Jin P, Wang X
Apoptosis : an international journal on programmed cell death 2024 Feb;29(1-2):142-153
Apoptosis : an international journal on programmed cell death 2024 Feb;29(1-2):142-153
M6A reader YTHDF1 promotes malignant progression of laryngeal squamous carcinoma through activating the EMT pathway by EIF4A3.
Guo H, Han Q, Guan X, Li Z, Wang Y, He L, Guo Y, Zhao L, Xue X, Liu H, Zhang C
Cellular signalling 2024 Feb;114:111002
Cellular signalling 2024 Feb;114:111002
Putrescine promotes MMP9-induced angiogenesis in skeletal muscle through hydrogen peroxide/METTL3 pathway.
Hu C, Ji F, Lv R, Zhou H, Hou G, Xu T
Free radical biology & medicine 2024 Feb 20;212:433-447
Free radical biology & medicine 2024 Feb 20;212:433-447
Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.
Xiong YW, Zhu HL, Zhang J, Geng H, Tan LL, Zheng XM, Li H, Fan LL, Wang XR, Zhang XD, Wang KW, Chang W, Zhang YF, Yuan Z, Duan ZL, Cao YX, He XJ, Xu DX, Wang H
Nature communications 2024 Feb 14;15(1):1353
Nature communications 2024 Feb 14;15(1):1353
Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication.
Liu B, Tian X, Li L, Zhang R, Wu J, Jiang N, Yuan M, Chen D, Su A, Xu S, Wu Z
EMBO reports 2024 Dec;25(12):5599-5619
EMBO reports 2024 Dec;25(12):5599-5619
Methyltransferase-Like 3-Driven N6-Methyladenosine Modification of Recombination Signal Binding Protein for Immunoglobulin Kappa J Region Promotes Vascular Remodeling in Pulmonary Hypertension.
Du Q, Zhang C, Qu T, Zhou X, Liu Y, Chen Z, Shen Z, Chen P, Zhang R
The American journal of pathology 2024 Dec;194(12):2252-2271
The American journal of pathology 2024 Dec;194(12):2252-2271
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
Li F, Wang F, Wang L, Wang J, Wei S, Meng J, Li Y, Feng L, Jiang P
Epigenetics 2024 Dec;19(1):2326868
Epigenetics 2024 Dec;19(1):2326868
Host RNA N(6)-methyladenosine and incoming DNA N(6)-methyldeoxyadenosine modifications cooperatively elevate the condensation potential of DNA to activate immune surveillance.
Wang N, Liu Q, Wang B, Yang Z, Li S, Li R, Liang X, Fan J, Wang H, Sun Z, Dong L, Hou Y, Wang S, Song C, Wang Y, Quan C, Yang Q, Wang L
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4418-4434
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4418-4434
N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1.
Xu L, Chen S, Fan Q, Zhu Y, Mei H, Wang J, Yu H, Chen Y, Liu F
BMC biology 2024 Dec 31;22(1):302
BMC biology 2024 Dec 31;22(1):302
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.
Wen C, Wang L, Piffkó A, Chen D, Yu X, Zawieracz K, Bugno J, Yang K, Naccasha EZ, Ji F, Wang J, Huang X, Luo SY, Tan L, Shen B, Luo C, McNerney ME, Chmura SJ, Arina A, Pitroda S, He C, Liang HL, Weichselbaum RR
The Journal of clinical investigation 2024 Dec 2;134(23)
The Journal of clinical investigation 2024 Dec 2;134(23)
WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.
Fu K, Jing C, Shi J, Mao S, Lu R, Yang M, Chen Y, Qian B, Wang Y, Li L
Biochemical and biophysical research communications 2024 Dec 17;738:150524
Biochemical and biophysical research communications 2024 Dec 17;738:150524
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
Xu XF, Chen J, Long LH, Zhang AM, Yang JW, Li YJ, Chen L, Zhong XL, Xu Y, Cao WY
Journal of affective disorders 2024 Dec 1;366:262-272
Journal of affective disorders 2024 Dec 1;366:262-272
YTHDF1 is pivotal for maintenance of cardiac homeostasis.
Golubeva VA, Das AS, Rabolli CP, Dorn LE, van Berlo JH, Accornero F
Journal of molecular and cellular cardiology 2024 Aug;193:25-35
Journal of molecular and cellular cardiology 2024 Aug;193:25-35
Unraveling the molecular complexity: Wtap/Ythdf1 and Lcn2 in novel traumatic brain injury secondary injury mechanisms.
Ma C, Gou C, Sun S, Wang J, Wei X, Xing F, Xing N, Yuan J, Wang Z
Cell biology and toxicology 2024 Aug 7;40(1):65
Cell biology and toxicology 2024 Aug 7;40(1):65
YTHDF1 promotes the osteolytic bone metastasis of breast cancer via inducing EZH2 and CDH11 translation.
Wang S, Xu L, Wang D, Zhao S, Li K, Ma F, Yao Q, Zhang Y, Wu Z, Shao Y, Song S, Yan W
Cancer letters 2024 Aug 10;597:217047
Cancer letters 2024 Aug 10;597:217047
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573
Cancer gene therapy 2024 Apr;31(4):562-573
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
Sun Y, Chen D, Sun S, Ren M, Zhou L, Chen C, Zhao J, Wei H, Zhao Q, Qi Y, Zhang J, Zhang G, Liu H, Yang Q, Liu Q, Wang Y, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, Li T, Zhao X, Lei L, Zhao Q, Liu D, Wang B, Wu X
Cell reports 2024 Apr 23;43(4):114032
Cell reports 2024 Apr 23;43(4):114032
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
Wang J, Yin H, Li G, Wu D, Xu Y, Chen Y, Wang X, Xing Y, Zhang T, Fei D, Yang P, Fang F, Tao Y, Li X, Yu J, Yang Y, Li Z, Shi L, Zhang Z, Pan J
Cell death discovery 2024 Apr 22;10(1):186
Cell death discovery 2024 Apr 22;10(1):186
Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification.
Cheng W, Tan L, Yu S, Song J, Li Z, Peng X, Wei Q, He Z, Zhang W, Yang X
International immunopharmacology 2024 Apr 20;131:111820
International immunopharmacology 2024 Apr 20;131:111820
Construction and validation of a T cell proliferation regulator-related signature for predicting prognosis and immunotherapy response in lung adenocarcinoma.
Chang W, Li H, Cheng Y, He H, Ou W, Wang SY
Frontiers in immunology 2023;14:1171145
Frontiers in immunology 2023;14:1171145
Pseudorabies virus exploits N(6)-methyladenosine modification to promote viral replication.
Yu PL, Wu R, Cao SJ, Wen YP, Huang XB, Zhao S, Lang YF, Zhao Q, Lin JC, Du SY, Yu SM, Yan QG
Frontiers in microbiology 2023;14:1087484
Frontiers in microbiology 2023;14:1087484
HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.
Huo FC, Zhu ZM, Du WQ, Pan YJ, Jiang X, Kang MJ, Liu BW, Mou J, Pei DS
Pharmacological research 2023 Sep;195:106863
Pharmacological research 2023 Sep;195:106863
Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats.
Zou K, Dong H, Li M, Zhang Y, Zhang K, Song D, Chu C
Genomics 2023 Sep;115(5):110687
Genomics 2023 Sep;115(5):110687
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
Yu Z, Zheng L, Geng Y, Zhang Y, Wang Y, You G, Cai M, Li M, Cheng X, Zan J
Cellular signalling 2023 Sep;109:110751
Cellular signalling 2023 Sep;109:110751
Multi-Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging.
Huang J, Chen P, Jia L, Li T, Yang X, Liang Q, Zeng Y, Liu J, Wu T, Hu W, Kee K, Zeng H, Liang X, Zhou C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(26):e2301538
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(26):e2301538
Propofol suppresses OGD/R-induced ferroptosis in neurons by inhibiting the HIF-1α/YTHDF1/BECN1 axis.
Ma H, Ye D, Liu Y, Wu P, Yu L, Guo L, Gao Y, Liu Y, Yan H, Shi J
Brain injury 2023 Sep 19;37(11):1285-1293
Brain injury 2023 Sep 19;37(11):1285-1293
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181
Cell biology and toxicology 2023 Oct;39(5):2165-2181
YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.
Hwang HJ, Park TL, Kim HI, Park Y, Kim G, Song C, Cho WK, Kim YK
Nature communications 2023 Oct 6;14(1):6248
Nature communications 2023 Oct 6;14(1):6248
The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
Liu N, Zhang J, Chen W, Ma W, Wu T
Journal of experimental & clinical cancer research : CR 2023 Oct 11;42(1):263
Journal of experimental & clinical cancer research : CR 2023 Oct 11;42(1):263
Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis.
Wang L, Zhu L, Liang C, Huang X, Liu Z, Huo J, Zhang Y, Zhang Y, Chen L, Xu H, Li X, Xu L, Kuang M, Wong CC, Yu J
Journal of hepatology 2023 Nov;79(5):1185-1200
Journal of hepatology 2023 Nov;79(5):1185-1200
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
Yang W, Zhang M, Li J, Qu S, Zhou F, Liu M, Li L, Liu Z, Zen K
Redox biology 2023 Nov;67:102921
Redox biology 2023 Nov;67:102921
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
Chen Y, Wan R, Zou Z, Lao L, Shao G, Zheng Y, Tang L, Yuan Y, Ge Y, He C, Lin S
Nature cell biology 2023 Nov;25(11):1676-1690
Nature cell biology 2023 Nov;25(11):1676-1690
YTHDF1 shapes "cold" tumor and inhibits CD8(+) T cells infiltration and function in breast cancer.
Jing L, Zhou K, Wang Z, Li Y, Fan Y, Liu T, Shan Z, Lin Y
Experimental cell research 2023 Nov 15;432(2):113778
Experimental cell research 2023 Nov 15;432(2):113778
m(6)A-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition.
Benavides-Serrato A, Saunders JT, Kumar S, Holmes B, Benavides KE, Bashir MT, Nishimura RN, Gera J
Cancer letters 2023 May 28;562:216178
Cancer letters 2023 May 28;562:216178
Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer's disease pathology in mice.
Yin H, Ju Z, Zheng M, Zhang X, Zuo W, Wang Y, Ding X, Zhang X, Peng Y, Li J, Yang A, Zhang R
PLoS biology 2023 Mar;21(3):e3002017
PLoS biology 2023 Mar;21(3):e3002017
YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.
Hesser CR, Walsh D
Journal of virology 2023 Mar 30;97(3):e0175822
Journal of virology 2023 Mar 30;97(3):e0175822
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185
Nature communications 2023 Mar 2;14(1):1185
The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression.
Hong YG, Yang Z, Chen Y, Liu T, Zheng Y, Zhou C, Wu GC, Chen Y, Xia J, Wen R, Liu W, Zhao Y, Chen J, Gao X, Chen Z
Cancer research 2023 Mar 15;83(6):845-860
Cancer research 2023 Mar 15;83(6):845-860
YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m(6)A/mRNA pathway in spermatogonial stem cells/progenitors.
Li T, Zheng Y, Wu Z, Guo M, Liu R, Zeng W, Lv Y
Toxicology letters 2023 Mar 15;377:38-50
Toxicology letters 2023 Mar 15;377:38-50
RNA binding protein YTHDF1 mediates bisphenol S-induced Leydig cell damage by regulating the mitochondrial pathway of BCL2 and the expression of CDK2-CyclinE1.
Li JZ, Zhou SM, Yuan WB, Chen HQ, Zeng Y, Fan J, Zhang Z, Wang N, Cao J, Liu WB
Environmental pollution (Barking, Essex : 1987) 2023 Mar 15;321:121144
Environmental pollution (Barking, Essex : 1987) 2023 Mar 15;321:121144
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.
Yan S, Zhou X, Wu C, Gao Y, Qian Y, Hou J, Xie R, Han B, Chen Z, Wei S, Gao X
Nature communications 2023 Mar 13;14(1):1379
Nature communications 2023 Mar 13;14(1):1379
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
O-GlcNAcylation promotes the cytosolic localization of the m(6)A reader YTHDF1 and colorectal cancer tumorigenesis.
Li J, Ahmad M, Sang L, Zhan Y, Wang Y, Yan Y, Liu Y, Mi W, Lu M, Dai Y, Zhang R, Dong MQ, Yang YG, Wang X, Sun J, Li J
The Journal of biological chemistry 2023 Jun;299(6):104738
The Journal of biological chemistry 2023 Jun;299(6):104738
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747
Veterinary microbiology 2023 Jun;281:109747
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
Chen W, He Q, Liu J, Li N, Xiao K, Chen H
Carcinogenesis 2023 Jun 24;44(4):328-340
Carcinogenesis 2023 Jun 24;44(4):328-340
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
Zhong J, Wu X, Gao Y, Chen J, Zhang M, Zhou H, Yang J, Xiao F, Yang X, Huang N, Qi H, Wang X, Bai F, Shi Y, Zhang N
Nature communications 2023 Jul 25;14(1):4467
Nature communications 2023 Jul 25;14(1):4467
The m(6)A Reader YTHDF1 Promotes Lung Carcinoma Progression via Regulating Ferritin Mediate Ferroptosis in an m(6)A-Dependent Manner.
Diao H, Tan H, Hu Y, Wang R, Cai P, Huang B, Shao X, Yan M, Yin C, Zhang Y
Pharmaceuticals (Basel, Switzerland) 2023 Jan 25;16(2)
Pharmaceuticals (Basel, Switzerland) 2023 Jan 25;16(2)
METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.
Li D, He J, Fang C, Zhang Y, He M, Zhang Z, Hou J, Xu Q
International journal of molecular sciences 2023 Jan 11;24(2)
International journal of molecular sciences 2023 Jan 11;24(2)
Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.
Yang F, Zhang A
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634
m(6) A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.
You Q, Wang F, Du R, Pi J, Wang H, Huo Y, Liu J, Wang C, Yu J, Yang Y, Zhu L
Advanced materials (Deerfield Beach, Fla.) 2023 Feb;35(8):e2204910
Advanced materials (Deerfield Beach, Fla.) 2023 Feb;35(8):e2204910
Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.
Li SJ, Zhang LX, Zou GJ, Ma MH, Zhou SF, Lu XY, Li F, Li CQ
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1814-1825
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1814-1825
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503
Nature chemical biology 2023 Dec;19(12):1492-1503
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
Zhang J, Song J, Liu S, Zhang Y, Qiu T, Jiang L, Bai J, Yao X, Wang N, Yang G, Sun X
The Science of the total environment 2023 Dec 20;905:167202
The Science of the total environment 2023 Dec 20;905:167202
RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68.
Nie Q, Wu X, Huang Y, Guo T, Kuang J, Du C
European journal of medical research 2023 Dec 2;28(1):552
European journal of medical research 2023 Dec 2;28(1):552
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Zhang G, Mi W, Wang C, Li J, Zhang Y, Liu N, Jiang M, Jia G, Wang F, Yang G, Zhang L, Wang J, Fu Y, Zhang Y
Cell death discovery 2023 Dec 15;9(1):457
Cell death discovery 2023 Dec 15;9(1):457
USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis.
Wang A, Huang H, Shi JH, Yu X, Ding R, Zhang Y, Han Q, Ni ZY, Li X, Zhao R, Zou Q
The Journal of clinical investigation 2023 Dec 1;133(23)
The Journal of clinical investigation 2023 Dec 1;133(23)
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.
Park J, Wu Y, Shao W, Gendron TF, van der Spek SJF, Sultanakhmetov G, Basu A, Castellanos Otero P, Jones CJ, Jansen-West K, Daughrity LM, Phanse S, Del Rosso G, Tong J, Castanedes-Casey M, Jiang L, Libera J, Oskarsson B, Dickson DW, Sanders DW, Brangwynne CP, Emili A, Wolozin B, Petrucelli L, Zhang YJ
Cell reports 2023 Aug 29;42(8):112822
Cell reports 2023 Aug 29;42(8):112822
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.
Jansens RJJ, Olarerin-George A, Verhamme R, Mirza A, Jaffrey S, Favoreel HW
iScience 2023 Aug 18;26(8):107310
iScience 2023 Aug 18;26(8):107310
YTHDF2 in dentate gyrus is the m(6)A reader mediating m(6)A modification in hippocampus-dependent learning and memory.
Zhuang M, Geng X, Han P, Che P, Liang F, Liu C, Yang L, Yu J, Zhang Z, Dong W, Ji SJ
Molecular psychiatry 2023 Apr;28(4):1679-1691
Molecular psychiatry 2023 Apr;28(4):1679-1691
Profiling of N6-methyladenosine methylation in porcine longissimus dorsi muscle and unravelling the hub gene ADIPOQ promotes adipogenesis in an m(6)A-YTHDF1-dependent manner.
Gong H, Gong T, Liu Y, Wang Y, Wang X
Journal of animal science and biotechnology 2023 Apr 6;14(1):50
Journal of animal science and biotechnology 2023 Apr 6;14(1):50
Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association.
Anadolu MN, Sun J, Kailasam S, Chalkiadaki K, Krimbacher K, Li JT, Markova T, Jafarnejad SM, Lefebvre F, Ortega J, Gkogkas CG, Sossin WS
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 5;43(14):2440-2459
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 5;43(14):2440-2459
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.
Fang Q, Tian GG, Wang Q, Liu M, He L, Li S, Wu J
Cell reports 2023 Apr 25;42(4):112403
Cell reports 2023 Apr 25;42(4):112403
N(6)-Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication.
Khan O, Tanuj GN, Choravada DR, Rajak KK, Chandra Sekar S, Lingaraju MC, Dhara SK, Gupta PK, Mishra BP, Dutt T, Gandham RK, Sajjanar B
Microbiology spectrum 2023 Apr 13;11(2):e0266622
Microbiology spectrum 2023 Apr 13;11(2):e0266622
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
Ji D, Hu C, Ning J, Ying X, Zhang H, Zhang B, Liu B, Liu Q, Ji W, Zhang R
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N(6)-Methyladenosine-Modified Yap Expression.
Wang L, Yu P, Wang J, Xu G, Wang T, Feng J, Bei Y, Xu J, Wang H, Das S, Xiao J
Research (Washington, D.C.) 2022;2022:9825916
Research (Washington, D.C.) 2022;2022:9825916
The Effects of Moxibustion on Learning and Memory and m6A RNA Methylation in APP/PS1 Mice.
Huang Q, Li CY, Zhang N, Zhang Q, Li HY, Shen Y, Xie LS, Yu SG, Wu QF
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2998301
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2998301
N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.
Hu Z, Li Y, Yuan W, Jin L, Leung WK, Zhang C, Yang Y
International journal of biological sciences 2022;18(15):5753-5769
International journal of biological sciences 2022;18(15):5753-5769
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
Li Z, Teng M, Jiang Y, Zhang L, Luo X, Liao Y, Yang B
Frontiers in immunology 2022;13:857727
Frontiers in immunology 2022;13:857727
Novel insight of N(6)-methyladenosine modified subtypes in abdominal aortic aneurysm.
Wang K, Kan Q, Ye Y, Qiu J, Huang L, Wu R, Yao C
Frontiers in genetics 2022;13:1055396
Frontiers in genetics 2022;13:1055396
Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma.
Koh YW, Han JH, Haam S, Lee HW
Frontiers in oncology 2022;12:996634
Frontiers in oncology 2022;12:996634
m(6)A regulation of cortical and retinal neurogenesis is mediated by the redundant m(6)A readers YTHDFs.
Niu F, Che P, Yang Z, Zhang J, Yang L, Zhuang M, Ou X, Ji SJ
iScience 2022 Sep 16;25(9):104908
iScience 2022 Sep 16;25(9):104908
m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.
Wang L, Zhan G, Maimaitiyiming Y, Su Y, Lin S, Liu J, Su K, Lin J, Shen S, He W, Wang F, Chen J, Sun S, Xue Y, Gu J, Chen X, Zhang J, Zhang L, Wang Q, Chang KJ, Chiou SH, Björklund M, Naranmandura H, Cheng X, Hsu CH
Cell reports 2022 Oct 25;41(4):111546
Cell reports 2022 Oct 25;41(4):111546
Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N (6)-Methyladenosine-Modified RNAs.
Micaelli M, Dalle Vedove A, Cerofolini L, Vigna J, Sighel D, Zaccara S, Bonomo I, Poulentzas G, Rosatti EF, Cazzanelli G, Alunno L, Belli R, Peroni D, Dassi E, Murakami S, Jaffrey SR, Fragai M, Mancini I, Lolli G, Quattrone A, Provenzani A
ACS pharmacology & translational science 2022 Oct 14;5(10):872-891
ACS pharmacology & translational science 2022 Oct 14;5(10):872-891
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.
Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554
The Journal of biological chemistry 2022 Nov;298(11):102554
m(6)A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation.
Huang J, Jiang B, Li GW, Zheng D, Li M, Xie X, Pan Y, Wei M, Liu X, Jiang X, Zhang X, Yang L, Bao L, Wang B
Cell reports 2022 Nov 22;41(8):111693
Cell reports 2022 Nov 22;41(8):111693
METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.
Cai Y, Yu R, Kong Y, Feng Z, Xu Q
Cellular signalling 2022 May;93:110283
Cellular signalling 2022 May;93:110283
Lactylation-driven METTL3-mediated RNA m(6)A modification promotes immunosuppression of tumor-infiltrating myeloid cells.
Xiong J, He J, Zhu J, Pan J, Liao W, Ye H, Wang H, Song Y, Du Y, Cui B, Xue M, Zheng W, Kong X, Jiang K, Ding K, Lai L, Wang Q
Molecular cell 2022 May 5;82(9):1660-1677.e10
Molecular cell 2022 May 5;82(9):1660-1677.e10
UPF1 promotes rapid degradation of m(6)A-containing RNAs.
Boo SH, Ha H, Lee Y, Shin MK, Lee S, Kim YK
Cell reports 2022 May 24;39(8):110861
Cell reports 2022 May 24;39(8):110861
m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer.
Duan X, Yang L, Wang L, Liu Q, Zhang K, Liu S, Liu C, Gao Q, Li L, Qin G, Zhang Y
Cell & bioscience 2022 May 14;12(1):60
Cell & bioscience 2022 May 14;12(1):60
YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis.
Yao X, Li W, Li L, Li M, Zhao Y, Fang D, Zeng X, Luo Z
Cell death & disease 2022 Mar 23;13(3):258
Cell death & disease 2022 Mar 23;13(3):258
Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.
Qi Z, Wang S, Li J, Wen Y, Cui R, Zhang K, Liu Y, Yang X, Zhang L, Xu B, Liu W, Xu Z, Deng Y
Journal of hazardous materials 2022 Mar 15;426:128099
Journal of hazardous materials 2022 Mar 15;426:128099
Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.
Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248
Nature communications 2022 Mar 10;13(1):1248
YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.
Huang X, Zhu L, Wang L, Huang W, Tan L, Liu H, Huo J, Su T, Zhang M, Kuang M, Li X, Dai Z, Xu L
Journal of gastroenterology and hepatology 2022 Jun;37(6):1156-1168
Journal of gastroenterology and hepatology 2022 Jun;37(6):1156-1168
ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.
Li A, Cao C, Gan Y, Wang X, Wu T, Zhang Q, Liu Y, Yao L, Zhang Q
Clinical and translational medicine 2022 Jun;12(6):e906
Clinical and translational medicine 2022 Jun;12(6):e906
m(6)A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration.
Liu Y, Song R, Zhao L, Lu Z, Li Y, Zhan X, Lu F, Yang J, Niu Y, Cao X
Signal transduction and targeted therapy 2022 Jun 29;7(1):194
Signal transduction and targeted therapy 2022 Jun 29;7(1):194
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m(6)A modification.
Xu Y, Lv D, Yan C, Su H, Zhang X, Shi Y, Ying K
Cancer cell international 2022 Jan 7;22(1):11
Cancer cell international 2022 Jan 7;22(1):11
Intermittent Fasting Improves High-Fat Diet-Induced Obesity Cardiomyopathy via Alleviating Lipid Deposition and Apoptosis and Decreasing m6A Methylation in the Heart.
Xu Z, Qin Y, Lv B, Tian Z, Zhang B
Nutrients 2022 Jan 7;14(2)
Nutrients 2022 Jan 7;14(2)
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.
N'Da Konan S, Ségéral E, Bejjani F, Bendoumou M, Ait Said M, Gallois-Montbrun S, Emiliani S
Retrovirology 2022 Jan 31;19(1):4
Retrovirology 2022 Jan 31;19(1):4
The m(6)A methyltransferase METTL3 regulates muscle maintenance and growth in mice.
Petrosino JM, Hinger SA, Golubeva VA, Barajas JM, Dorn LE, Iyer CC, Sun HL, Arnold WD, He C, Accornero F
Nature communications 2022 Jan 10;13(1):168
Nature communications 2022 Jan 10;13(1):168
Involvement of YTHDF1 in renal fibrosis progression via up-regulating YAP.
Xing J, He YC, Wang KY, Wan PZ, Zhai XY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Feb;36(2):e22144
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Feb;36(2):e22144
The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.
Li Y, Zhang X, Cai J, Ren L, Liu B, Wu M, Lu W, Li R, Zhang C, Huang C, Tong J, Liu A, Zheng Y, Ren D, Guo Y, Huang Y
The journal of gene medicine 2022 Feb;24(2):e3397
The journal of gene medicine 2022 Feb;24(2):e3397
Methyltransferase-like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1.
Liu T, Wang H, Fu Z, Wang Z, Wang J, Gan X, Wang A, Wang L
Cancer science 2022 Feb;113(2):446-458
Cancer science 2022 Feb;113(2):446-458
YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner.
Chen H, Yu Y, Yang M, Huang H, Ma S, Hu J, Xi Z, Guo H, Yao G, Yang L, Huang X, Zhang F, Tan G, Wu H, Zheng W, Li L
Cell & bioscience 2022 Feb 23;12(1):19
Cell & bioscience 2022 Feb 23;12(1):19
METTL3-m(6)A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.
Peng Z, Gong Y, Wang X, He W, Wu L, Zhang L, Xiong L, Huang Y, Su L, Shi P, Cao X, Liu R, Li Y, Xiao H
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Feb 2;30(2):932-946
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Feb 2;30(2):932-946
The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.
Niu F, Han P, Zhang J, She Y, Yang L, Yu J, Zhuang M, Tang K, Shi Y, Yang B, Liu C, Peng B, Ji SJ
eLife 2022 Feb 18;11
eLife 2022 Feb 18;11
TBK1-METTL3 axis facilitates antiviral immunity.
Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F
Cell reports 2022 Feb 15;38(7):110373
Cell reports 2022 Feb 15;38(7):110373
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766
Brain research 2022 Feb 15;1777:147766
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176
GMEB2 Promotes the Growth of Colorectal Cancer by Activating ADRM1 Transcription and NF-κB Signalling and Is Positively Regulated by the m(6)A Reader YTHDF1.
Ning Z, Wu Z, Zhang F, Yang M, Lu Z, Yu B, Long F, Guo Y, Yang K, Hu G, Zhang Y, Li X, Li L, Lin C
Cancers 2022 Dec 8;14(24)
Cancers 2022 Dec 8;14(24)
The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray.
Ouyang H, Zhang J, Chi D, Zhang K, Huang Y, Huang J, Huang W, Bai X
Journal of neuroinflammation 2022 Dec 22;19(1):310
Journal of neuroinflammation 2022 Dec 22;19(1):310
YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis.
He M, Li D, Fang C, Xu Q
Archives of biochemistry and biophysics 2022 Dec 15;732:109464
Archives of biochemistry and biophysics 2022 Dec 15;732:109464
METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.
Li HB, Huang G, Tu J, Lv DM, Jin QL, Chen JK, Zou YT, Lee DF, Shen JN, Xie XB
EBioMedicine 2022 Aug;82:104142
EBioMedicine 2022 Aug;82:104142
FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells.
Zhao F, Ge F, Xie M, Li Z, Zang C, Kong L, Pu Y, Zheng X, Tan Y
Clinical & experimental metastasis 2022 Aug;39(4):623-639
Clinical & experimental metastasis 2022 Aug;39(4):623-639
Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.
Wu F, Zhang L, Lai C, Peng X, Yu S, Zhou C, Zhang B, Zhang W
International journal of molecular sciences 2022 Aug 17;23(16)
International journal of molecular sciences 2022 Aug 17;23(16)
Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.
Zhang L, Cheng Y, Xue Z, Li J, Wu N, Yan J, Wang J, Wang C, Chen W, Zhou T, Qiu Z, Jiang H
Cell biology and toxicology 2022 Apr;38(2):347-369
Cell biology and toxicology 2022 Apr;38(2):347-369
RNA m(6)A methylation regulates dissemination of cancer cells by modulating expression and membrane localization of β-catenin.
Li J, Xie G, Tian Y, Li W, Wu Y, Chen F, Lin Y, Lin X, Wing-Ngor Au S, Cao J, He W, Wang H
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1578-1596
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1578-1596
METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.
Zhu Y, Peng X, Zhou Q, Tan L, Zhang C, Lin S, Long M
Cell death & disease 2022 Apr 18;13(4):358
Cell death & disease 2022 Apr 18;13(4):358
N6-methyladenosine regulates ATM expression and downstream signaling.
Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051
Journal of Cancer 2021;12(23):7041-7051
YTHDF1 Aggravates the Progression of Cervical Cancer Through m(6)A-Mediated Up-Regulation of RANBP2.
Wang H, Luo Q, Kang J, Wei Q, Yang Y, Yang D, Liu X, Liu T, Yi P
Frontiers in oncology 2021;11:650383
Frontiers in oncology 2021;11:650383
YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.
Tsuchiya K, Yoshimura K, Inoue Y, Iwashita Y, Yamada H, Kawase A, Watanabe T, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H
Oncoimmunology 2021;10(1):1962656
Oncoimmunology 2021;10(1):1962656
Insufficient Radiofrequency Ablation Promotes Hepatocellular Carcinoma Metastasis Through N6-Methyladenosine mRNA Methylation-Dependent Mechanism.
Su T, Huang M, Liao J, Lin S, Yu P, Yang J, Cai Y, Zhu S, Xu L, Peng Z, Peng S, Chen S, Kuang M
Hepatology (Baltimore, Md.) 2021 Sep;74(3):1339-1356
Hepatology (Baltimore, Md.) 2021 Sep;74(3):1339-1356
Vitamin B(12) Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.
Mosca P, Robert A, Alberto JM, Meyer M, Kundu U, Hergalant S, Umoret R, Coelho D, Guéant JL, Leheup B, Dreumont N
Molecular nutrition & food research 2021 Sep;65(17):e2100206
Molecular nutrition & food research 2021 Sep;65(17):e2100206
Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation.
Wang S, Zhang J, Wu X, Lin X, Liu XM, Zhou J
RNA biology 2021 Sep;18(9):1354-1363
RNA biology 2021 Sep;18(9):1354-1363
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X
Molecular neurodegeneration 2021 Sep 30;16(1):70
Molecular neurodegeneration 2021 Sep 30;16(1):70
METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.
He B, Wang J
Aging 2021 Oct 5;13(19):23108-23118
Aging 2021 Oct 5;13(19):23108-23118
Streptozotocin-Induced Astrocyte Mitochondrial Dysfunction Is Ameliorated by FTO Inhibitor MO-I-500.
Cockova Z, Honc O, Telensky P, Olsen MJ, Novotny J
ACS chemical neuroscience 2021 Oct 20;12(20):3818-3828
ACS chemical neuroscience 2021 Oct 20;12(20):3818-3828
The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.
Yu J, She Y, Yang L, Zhuang M, Han P, Liu J, Lin X, Wang N, Chen M, Jiang C, Zhang Y, Yuan Y, Ji SJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101329
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101329
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
He RZ, Jiang J, Hu X, Lei M, Li J, Luo W, Duan L, Hu Z, Mo YY, Luo DX, Peng WX
Cancer cell international 2021 Nov 22;21(1):616
Cancer cell international 2021 Nov 22;21(1):616
The m(6)A "reader" YTHDF1 promotes osteogenesis of bone marrow mesenchymal stem cells through translational control of ZNF839.
Liu T, Zheng X, Wang C, Wang C, Jiang S, Li B, Chen P, Xu W, Zheng H, Yang R, Huang X, Zhang X, Jiang L
Cell death & disease 2021 Nov 12;12(11):1078
Cell death & disease 2021 Nov 12;12(11):1078
WNT/β-catenin-suppressed FTO expression increases m(6)A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis.
Yang X, Shao F, Guo D, Wang W, Wang J, Zhu R, Gao Y, He J, Lu Z
Cell death & disease 2021 May 8;12(5):462
Cell death & disease 2021 May 8;12(5):462
Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m(6) A-dependent manner.
Chen Y, Wu R, Chen W, Liu Y, Liao X, Zeng B, Guo G, Lou F, Xiang Y, Wang Y, Wang X
EMBO reports 2021 May 5;22(5):e52146
EMBO reports 2021 May 5;22(5):e52146
YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.
Pi J, Wang W, Ji M, Wang X, Wei X, Jin J, Liu T, Qiang J, Qi Z, Li F, Liu Y, Ma Y, Si Y, Huo Y, Gao Y, Chen Y, Dong L, Su R, Chen J, Rao S, Yi P, Yu S, Wang F, Yu J
Cancer research 2021 May 15;81(10):2651-2665
Cancer research 2021 May 15;81(10):2651-2665
m(6)A RNA methylation regulates the fate of endogenous retroviruses.
Chelmicki T, Roger E, Teissandier A, Dura M, Bonneville L, Rucli S, Dossin F, Fouassier C, Lameiras S, Bourc'his D
Nature 2021 Mar;591(7849):312-316
Nature 2021 Mar;591(7849):312-316
Comparison of RNA m(6)A and DNA methylation profiles between mouse female germline stem cells and STO cells.
Zhao X, Tian GG, Fang Q, Pei X, Wang Z, Wu J
Molecular therapy. Nucleic acids 2021 Mar 5;23:431-439
Molecular therapy. Nucleic acids 2021 Mar 5;23:431-439
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
Wu G, Suo C, Yang Y, Shen S, Sun L, Li ST, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang YG, Cao J, Gao P
EMBO reports 2021 Mar 3;22(3):e51519
EMBO reports 2021 Mar 3;22(3):e51519
Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine.
McFadden MJ, McIntyre ABR, Mourelatos H, Abell NS, Gokhale NS, Ipas H, Xhemalçe B, Mason CE, Horner SM
Cell reports 2021 Mar 2;34(9):108798
Cell reports 2021 Mar 2;34(9):108798
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.
Yin H, Zhang X, Yang P, Zhang X, Peng Y, Li D, Yu Y, Wu Y, Wang Y, Zhang J, Ding X, Wang X, Yang A, Zhang R
Nature communications 2021 Mar 2;12(1):1394
Nature communications 2021 Mar 2;12(1):1394
YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition.
Luo X, Cao M, Gao F, He X
Experimental hematology & oncology 2021 Jun 4;10(1):35
Experimental hematology & oncology 2021 Jun 4;10(1):35
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding.
Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, Gao S, Gao Y, He J, Lu Z
Nature communications 2021 Jun 21;12(1):3803
Nature communications 2021 Jun 21;12(1):3803
YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.
Jiang D, Hou J, Qian Y, Gao Y, Gao X, Wei S
Biochemical and biophysical research communications 2021 Jun 11;557:85-89
Biochemical and biophysical research communications 2021 Jun 11;557:85-89
N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.
Terajima H, Lu M, Zhang L, Cui Q, Shi Y, Li J, He C
PLoS biology 2021 Jul;19(7):e3001292
PLoS biology 2021 Jul;19(7):e3001292
Integrated analysis of m(6)A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.
Zeng Y, Huang T, Zuo W, Wang D, Xie Y, Wang X, Xiao Z, Chen Z, Liu Q, Liu N, Xiao Y
Aging 2021 Jul 26;13(14):18238-18256
Aging 2021 Jul 26;13(14):18238-18256
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q
Nucleic acids research 2021 Jul 21;49(13):7361-7374
Nucleic acids research 2021 Jul 21;49(13):7361-7374
YTHDF1 Promotes Cyclin B1 Translation through m(6)A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation.
Lou X, Ning J, Liu W, Li K, Qian B, Xu D, Wu Y, Zhang D, Cui W
Cells 2021 Jul 2;10(7)
Cells 2021 Jul 2;10(7)
Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Wang YJ, Yang B, Lai Q, Shi JF, Peng JY, Zhang Y, Hu KS, Li YQ, Peng JW, Yang ZZ, Li YT, Pan Y, Koeffler HP, Liao JY, Yin D
RNA biology 2021 Jan;18(1):131-143
RNA biology 2021 Jan;18(1):131-143
ALKBH5 suppresses tumor progression via an m(6)A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.
Yuan Y, Yan G, He M, Lei H, Li L, Wang Y, He X, Li G, Wang Q, Gao Y, Qu Z, Mei Z, Shen Z, Pu J, Wang A, Zhao W, Jiang H, Du W, Yang L
Cell death & disease 2021 Jan 11;12(1):60
Cell death & disease 2021 Jan 11;12(1):60
Relaxed initiation pausing of ribosomes drives oncogenic translation.
Dong L, Mao Y, Zhou A, Liu XM, Zhou J, Wan J, Qian SB
Science advances 2021 Feb;7(8)
Science advances 2021 Feb;7(8)
m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Chen Y, Wang J, Xu D, Xiang Z, Ding J, Yang X, Li D, Han X
Autophagy 2021 Feb;17(2):457-475
Autophagy 2021 Feb;17(2):457-475
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
Li Q, Ni Y, Zhang L, Jiang R, Xu J, Yang H, Hu Y, Qiu J, Pu L, Tang J, Wang X
Signal transduction and targeted therapy 2021 Feb 23;6(1):76
Signal transduction and targeted therapy 2021 Feb 23;6(1):76
METTL3-dependent N(6)-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium.
Chien CS, Li JY, Chien Y, Wang ML, Yarmishyn AA, Tsai PH, Juan CC, Nguyen P, Cheng HM, Huo TI, Chiou SH, Chien S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Endothelial METTL3 (Methyltransferase-Like 3) Inhibits Fibrinolysis by Promoting PAI-1 (Plasminogen Activator Inhibitor-1) Expression Through Enhancing Jun Proto-Oncogene N6-Methyladenosine Modification.
Bai Q, Lu Y, Chen Y, Zhang H, Zhang W, Wu H, Wen A
Arteriosclerosis, thrombosis, and vascular biology 2021 Dec;41(12):2877-2889
Arteriosclerosis, thrombosis, and vascular biology 2021 Dec;41(12):2877-2889
GR-mediated transcriptional regulation of m(6)A metabolic genes contributes to diet-induced fatty liver in hens.
Feng Y, Li Y, Jiang W, Hu Y, Jia Y, Zhao R
Journal of animal science and biotechnology 2021 Dec 7;12(1):117
Journal of animal science and biotechnology 2021 Dec 7;12(1):117
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
Wang H, Wei W, Zhang ZY, Liu Y, Shi B, Zhong W, Zhang HS, Fang X, Sun CL, Wang JB, Liu LX
Cell death & disease 2021 Dec 17;13(1):3
Cell death & disease 2021 Dec 17;13(1):3
m(6)A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.
Zhang JX, Huang PJ, Wang DP, Yang WY, Lu J, Zhu Y, Meng XX, Wu X, Lin QH, Lv H, Xie H, Wang RL
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448
METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Yang Z, Yang S, Cui YH, Wei J, Shah P, Park G, Cui X, He C, He YY
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 31;118(35)
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 31;118(35)
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
Ma S, Yan J, Barr T, Zhang J, Chen Z, Wang LS, Sun JC, Chen J, Caligiuri MA, Yu J
The Journal of experimental medicine 2021 Aug 2;218(8)
The Journal of experimental medicine 2021 Aug 2;218(8)
N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay.
Xia TL, Li X, Wang X, Zhu YJ, Zhang H, Cheng W, Chen ML, Ye Y, Li Y, Zhang A, Dai DL, Zhu QY, Yuan L, Zheng J, Huang H, Chen SQ, Xiao ZW, Wang HB, Roy G, Zhong Q, Lin D, Zeng YX, Wang J, Zhao B, Gewurz BE, Chen J, Zuo Z, Zeng MS
EMBO reports 2021 Apr 7;22(4):e50128
EMBO reports 2021 Apr 7;22(4):e50128
Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.
Kastan JP, Tremblay MW, Brown MC, Trimarco JD, Dobrikova EY, Dobrikov MI, Gromeier M
mBio 2021 Apr 13;12(2)
mBio 2021 Apr 13;12(2)
m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.
He JJ, Li Z, Rong ZX, Gao J, Mu Y, Guan YD, Ren XX, Zi YY, Liu LY, Fan Q, Zhou M, Duan YM, Zhou Q, Deng YZ, Sun LQ
Frontiers in oncology 2020;10:1166
Frontiers in oncology 2020;10:1166
m(6)A-binding YTHDF proteins promote stress granule formation.
Fu Y, Zhuang X
Nature chemical biology 2020 Sep;16(9):955-963
Nature chemical biology 2020 Sep;16(9):955-963
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
Liu J, Gao M, Xu S, Chen Y, Wu K, Liu H, Wang J, Yang X, Wang J, Liu W, Bao X, Chen J
Cell reports 2020 Sep 8;32(10):108120
Cell reports 2020 Sep 8;32(10):108120
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514
The EMBO journal 2020 Oct 15;39(20):e104514
Context-dependent functional compensation between Ythdf m(6)A reader proteins.
Lasman L, Krupalnik V, Viukov S, Mor N, Aguilera-Castrejon A, Schneir D, Bayerl J, Mizrahi O, Peles S, Tawil S, Sathe S, Nachshon A, Shani T, Zerbib M, Kilimnik I, Aigner S, Shankar A, Mueller JR, Schwartz S, Stern-Ginossar N, Yeo GW, Geula S, Novershtern N, Hanna JH
Genes & development 2020 Oct 1;34(19-20):1373-1391
Genes & development 2020 Oct 1;34(19-20):1373-1391
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP.
Kim B, Arcos S, Rothamel K, Jian J, Rose KL, McDonald WH, Bian Y, Reasoner S, Barrows NJ, Bradrick S, Garcia-Blanco MA, Ascano M
Molecular cell 2020 May 21;78(4):624-640.e7
Molecular cell 2020 May 21;78(4):624-640.e7
A Unified Model for the Function of YTHDF Proteins in Regulating m(6)A-Modified mRNA.
Zaccara S, Jaffrey SR
Cell 2020 Jun 25;181(7):1582-1595.e18
Cell 2020 Jun 25;181(7):1582-1595.e18
ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
Tian J, Ying P, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, Wang X, Mei S, Zhang Y, Wang C, Zhong R, Chang J, Miao X
International journal of cancer 2020 Jun 15;146(12):3281-3293
International journal of cancer 2020 Jun 15;146(12):3281-3293
m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.
Wang X, Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Shi H, Wang F, Wang Y
Autophagy 2020 Jul;16(7):1221-1235
Autophagy 2020 Jul;16(7):1221-1235
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550
Carcinogenesis 2020 Jul 10;41(5):541-550
N(6)-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR Jr, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A
Nature genetics 2020 Jan;52(1):48-55
Nature genetics 2020 Jan;52(1):48-55
Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Gokhale NS, McIntyre ABR, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM
Molecular cell 2020 Feb 6;77(3):542-555.e8
Molecular cell 2020 Feb 6;77(3):542-555.e8
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
YTHDF1 Facilitates the Progression of Hepatocellular Carcinoma by Promoting FZD5 mRNA Translation in an m6A-Dependent Manner.
Liu X, Qin J, Gao T, Li C, He B, Pan B, Xu X, Chen X, Zeng K, Xu M, Zhu C, Pan Y, Sun H, Sun L, Xu T, Wang S
Molecular therapy. Nucleic acids 2020 Dec 4;22:750-765
Molecular therapy. Nucleic acids 2020 Dec 4;22:750-765
N(6)-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Du J, Liao W, Liu W, Deb DK, He L, Hsu PJ, Nguyen T, Zhang L, Bissonnette M, He C, Li YC
Developmental cell 2020 Dec 21;55(6):737-753.e7
Developmental cell 2020 Dec 21;55(6):737-753.e7
Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism.
Liu X, Gonzalez G, Dai X, Miao W, Yuan J, Huang M, Bade D, Li L, Sun Y, Wang Y
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Dec 2;28(12):2593-2604
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Dec 2;28(12):2593-2604
Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.
Yarmishyn AA, Yang YP, Lu KH, Chen YC, Chien Y, Chou SJ, Tsai PH, Ma HI, Chien CS, Chen MT, Wang ML
Cancer cell international 2020 Dec 14;20(1):597
Cancer cell international 2020 Dec 14;20(1):597
Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.
Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J, Cui J, Zhao W
Science advances 2020 Aug;6(34):eaba0647
Science advances 2020 Aug;6(34):eaba0647
Epitranscriptomic N(6)-Methyladenosine Modification Is Required for Direct Lineage Reprogramming into Neurons.
Choi H, Baek S, Cho B, Kim S, Kim J, Chang Y, Shin J, Kim J
ACS chemical biology 2020 Aug 21;15(8):2087-2097
ACS chemical biology 2020 Aug 21;15(8):2087-2097
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
Lee AK, Klein J, Fon Tacer K, Lord T, Oatley MJ, Oatley JM, Porter SN, Pruett-Miller SM, Tikhonova EB, Karamyshev AL, Wang YD, Yang P, Korff A, Kim HJ, Taylor JP, Potts PR
Molecular cell 2020 Aug 20;79(4):645-659.e9
Molecular cell 2020 Aug 20;79(4):645-659.e9
A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.
Liu H, Xu Y, Yao B, Sui T, Lai L, Li Z
Cell death & disease 2020 Aug 13;11(8):613
Cell death & disease 2020 Aug 13;11(8):613
N(6)-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
Lu M, Zhang Z, Xue M, Zhao BS, Harder O, Li A, Liang X, Gao TZ, Xu Y, Zhou J, Feng Z, Niewiesk S, Peeples ME, He C, Li J
Nature microbiology 2020 Apr;5(4):584-598
Nature microbiology 2020 Apr;5(4):584-598
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z
Nature communications 2020 Apr 3;11(1):1648
Nature communications 2020 Apr 3;11(1):1648
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification.
Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation.
Liu T, Wei Q, Jin J, Luo Q, Liu Y, Yang Y, Cheng C, Li L, Pi J, Si Y, Xiao H, Li L, Rao S, Wang F, Yu J, Yu J, Zou D, Yi P
Nucleic acids research 2020 Apr 17;48(7):3816-3831
Nucleic acids research 2020 Apr 17;48(7):3816-3831
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.
Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q, Yu J, Martin EW, Mittag T, Kim HJ, Taylor JP
Cell 2020 Apr 16;181(2):325-345.e28
Cell 2020 Apr 16;181(2):325-345.e28
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma.
Bai Y, Yang C, Wu R, Huang L, Song S, Li W, Yan P, Lin C, Li D, Zhang Y
Frontiers in oncology 2019;9:332
Frontiers in oncology 2019;9:332
Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.
Xue M, Zhao BS, Zhang Z, Lu M, Harder O, Chen P, Lu Z, Li A, Ma Y, Xu Y, Liang X, Zhou J, Niewiesk S, Peeples ME, He C, Li J
Nature communications 2019 Oct 9;10(1):4595
Nature communications 2019 Oct 9;10(1):4595
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.
Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, Yang Z, Zhou J, Gao J, Zhou H, Xu S, Ji H, Shi P, Wu DD, Yang C, Chen Y
Nature communications 2019 Oct 25;10(1):4892
Nature communications 2019 Oct 25;10(1):4892
The Tudor SND1 protein is an m(6)A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.
Baquero-Perez B, Antanaviciute A, Yonchev ID, Carr IM, Wilson SA, Whitehouse A
eLife 2019 Oct 24;8
eLife 2019 Oct 24;8
The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression.
Zhuang M, Li X, Zhu J, Zhang J, Niu F, Liang F, Chen M, Li D, Han P, Ji SJ
Nucleic acids research 2019 May 21;47(9):4765-4777
Nucleic acids research 2019 May 21;47(9):4765-4777
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.
Liu J, Zhang X, Chen K, Cheng Y, Liu S, Xia M, Chen Y, Zhu H, Li Z, Cao X
Immunity 2019 Mar 19;50(3):600-615.e15
Immunity 2019 Mar 19;50(3):600-615.e15
Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.
Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W, Lin S, Ji W
Oncogene 2019 Jun;38(24):4755-4772
Oncogene 2019 Jun;38(24):4755-4772
m(6)A enhances the phase separation potential of mRNA.
Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR
Nature 2019 Jul;571(7765):424-428
Nature 2019 Jul;571(7765):424-428
Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis.
Barrows NJ, Anglero-Rodriguez Y, Kim B, Jamison SF, Le Sommer C, McGee CE, Pearson JL, Dimopoulos G, Ascano M, Bradrick SS, Garcia-Blanco MA
Scientific reports 2019 Jul 4;9(1):9711
Scientific reports 2019 Jul 4;9(1):9711
A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination.
Wu R, Li A, Sun B, Sun JG, Zhang J, Zhang T, Chen Y, Xiao Y, Gao Y, Zhang Q, Ma J, Yang X, Liao Y, Lai WY, Qi X, Wang S, Shu Y, Wang HL, Wang F, Yang YG, Yuan Z
Cell research 2019 Jan;29(1):23-41
Cell research 2019 Jan;29(1):23-41
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Hao H, Hao S, Chen H, Chen Z, Zhang Y, Wang J, Wang H, Zhang B, Qiu J, Deng F, Guan W
Nucleic acids research 2019 Jan 10;47(1):362-374
Nucleic acids research 2019 Jan 10;47(1):362-374
Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells.
Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, Huang X, Liu Y, Wang J, Dougherty U, Bissonnette MB, Shen B, Weichselbaum RR, Xu MM, He C
Nature 2019 Feb;566(7743):270-274
Nature 2019 Feb;566(7743):270-274
m(6)A modification controls the innate immune response to infection by targeting type I interferons.
Winkler R, Gillis E, Lasman L, Safra M, Geula S, Soyris C, Nachshon A, Tai-Schmiedel J, Friedman N, Le-Trilling VTK, Trilling M, Mandelboim M, Hanna JH, Schwartz S, Stern-Ginossar N
Nature immunology 2019 Feb;20(2):173-182
Nature immunology 2019 Feb;20(2):173-182
m(6)A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Wang F, Wang Y, Wang X
Cell death & disease 2019 Feb 20;10(3):171
Cell death & disease 2019 Feb 20;10(3):171
Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm.
He Y, Xing J, Wang S, Xin S, Han Y, Zhang J
Annals of translational medicine 2019 Dec;7(24):797
Annals of translational medicine 2019 Dec;7(24):797
Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer.
Zhang C, Zhang M, Ge S, Huang W, Lin X, Gao J, Gong J, Shen L
Cancer medicine 2019 Aug;8(10):4766-4781
Cancer medicine 2019 Aug;8(10):4766-4781
m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Liu J, Eckert MA, Harada BT, Liu SM, Lu Z, Yu K, Tienda SM, Chryplewicz A, Zhu AC, Yang Y, Huang JT, Chen SM, Xu ZG, Leng XH, Yu XC, Cao J, Zhang Z, Liu J, Lengyel E, He C
Nature cell biology 2018 Sep;20(9):1074-1083
Nature cell biology 2018 Sep;20(9):1074-1083
m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1.
Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T
Nature 2018 Nov;563(7730):249-253
Nature 2018 Nov;563(7730):249-253
mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
METTL3-mediated N(6)-methyladenosine mRNA modification enhances long-term memory consolidation.
Zhang Z, Wang M, Xie D, Huang Z, Zhang L, Yang Y, Ma D, Li W, Zhou Q, Yang YG, Wang XJ
Cell research 2018 Nov;28(11):1050-1061
Cell research 2018 Nov;28(11):1050-1061
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.
Zhang F, Kang Y, Wang M, Li Y, Xu T, Yang W, Song H, Wu H, Shu Q, Jin P
Human molecular genetics 2018 Nov 15;27(22):3936-3950
Human molecular genetics 2018 Nov 15;27(22):3936-3950
Synaptic N(6)-methyladenosine (m(6)A) epitranscriptome reveals functional partitioning of localized transcripts.
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO
Nature neuroscience 2018 Jul;21(7):1004-1014
Nature neuroscience 2018 Jul;21(7):1004-1014
Oncogene c-Myc promotes epitranscriptome m(6)A reader YTHDF1 expression in colorectal cancer.
Nishizawa Y, Konno M, Asai A, Koseki J, Kawamoto K, Miyoshi N, Takahashi H, Nishida N, Haraguchi N, Sakai D, Kudo T, Hata T, Matsuda C, Mizushima T, Satoh T, Doki Y, Mori M, Ishii H
Oncotarget 2018 Jan 26;9(7):7476-7486
Oncotarget 2018 Jan 26;9(7):7476-7486
Epitranscriptomic m(6)A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, Dore LC, Dong Q, Zheng W, Jin P, Wu H, Shen B, Zhuang X, He C, Liu K, Song H, Ming GL
Neuron 2018 Jan 17;97(2):313-325.e6
Neuron 2018 Jan 17;97(2):313-325.e6
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484
Genes & development 2018 Dec 1;32(23-24):1472-1484
N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection.
Hesser CR, Karijolich J, Dominissini D, He C, Glaunsinger BA
PLoS pathogens 2018 Apr;14(4):e1006995
PLoS pathogens 2018 Apr;14(4):e1006995
YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.
Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C, He C
Cell research 2017 Mar;27(3):315-328
Cell research 2017 Mar;27(3):315-328
The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.
Simsek D, Tiu GC, Flynn RA, Byeon GW, Leppek K, Xu AF, Chang HY, Barna M
Cell 2017 Jun 1;169(6):1051-1065.e18
Cell 2017 Jun 1;169(6):1051-1065.e18
N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.
Gokhale NS, McIntyre ABR, McFadden MJ, Roder AE, Kennedy EM, Gandara JA, Hopcraft SE, Quicke KM, Vazquez C, Willer J, Ilkayeva OR, Law BA, Holley CL, Garcia-Blanco MA, Evans MJ, Suthar MS, Bradrick SS, Mason CE, Horner SM
Cell host & microbe 2016 Nov 9;20(5):654-665
Cell host & microbe 2016 Nov 9;20(5):654-665
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 17479-1-AP(YTHDF1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 17479-1-AP(YTHDF1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The YTHDF1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human YTHDF1. This antibody recognizes human, mouse, rat antigen. The YTHDF1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
