17479-1-AP

antibody from Proteintech Group

Targeting: YTHDF1 C20orf21, FLJ20391

Provider product page for 17479-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [209]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 17479-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17479-1-AP, RRID:AB_2217473
Product name: YTHDF1 antibody
Antibody type: Polyclonal
Description: KD/KO validated YTHDF1 antibody (Cat. #17479-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

YTHDF1 protein structure - 17479-1-AP shown in red.

Submitted references Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis.

Chen M, Yang D, Zhou Y, Yang C, Lin W, Li J, Liu J, Ye J, Huang W, Ma W, Li W, Chen J, Zhang Y, Shi GP, Luo J, Li J, Luo S
International journal of biological sciences 2024;20(6):2092-2110

N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.

Jiang S, Gao L, Li J, Zhang F, Zhang Y, Liu J
Frontiers in cell and developmental biology 2024;12:1383232

Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.

Zhang X, Li Z, Peng Q, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Zheng X, Yan Q, Wang J, Ma J
The Journal of biological chemistry 2024 May;300(5):107226

YTHDF1 promotes gallbladder cancer progression via post-transcriptional regulation of the m6A/UHRF1 axis.

Chen J, Bai X, Zhang W, Yan Z, Liu Y, Zhou S, Wu X, He X, Yang A
Journal of cellular and molecular medicine 2024 May;28(9):e18328

High-throughput tagging of endogenous loci for rapid characterization of protein function.

Kim J, Kratz AF, Chen S, Sheng J, Kim HK, Zhang L, Singh BK, Chavez A
Science advances 2024 May 3;10(18):eadg8771

Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.

Ou X, Tan Y, Xie J, Yuan J, Deng X, Shao R, Song C, Cao X, Xie X, He R, Li Y, Tang H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063

IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.

Yuan D, Li H, Dai W, Zhou X, Zhou W, He L
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022

METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.

Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, Zhan HW, Sheng XY, Xu LH, Ren XJ, Yang F, Geng B, Xia YY
Cellular signalling 2024 Mar;115:111038

Dynamics of N6-methyladenosine modification during Alzheimer's disease development.

Gao S, Wang Y, Li X, Liang Y, Jin Z, Yang B, Yuan TF, Tian H, Peng B, Rao Y
Heliyon 2024 Mar 30;10(6):e26911

YTHDF1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells via Upregulating TCF7 mRNA Translation.

Li Y, Guo X, Liang X, Wang Z
Frontiers in bioscience (Landmark edition) 2024 Mar 20;29(3):117

METTL3-dependent m(6)A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway.

Ma L, Zhou X, Yao S, Zhang X, Mao J, Vona B, Fan L, Lou S, Li D, Wang L, Pan Y
Cell death & disease 2024 Mar 20;15(3):229

N(6)-methyladenosine modification is not a general trait of viral RNA genomes.

Baquero-Pérez B, Yonchev ID, Delgado-Tejedor A, Medina R, Puig-Torrents M, Sudbery I, Begik O, Wilson SA, Novoa EM, Díez J
Nature communications 2024 Mar 11;15(1):1964

YTHDF1 regulates immune cell infiltration in gastric cancer via interaction with p53.

Liao Q, Xiong J
Experimental and therapeutic medicine 2024 Jun;27(6):255

METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.

Wang C, Tanizawa H, Hill C, Havas A, Zhang Q, Liao L, Hao X, Lei X, Wang L, Nie H, Qi Y, Tian B, Gardini A, Kossenkov AV, Goldman A, Berger SL, Noma KI, Adams PD, Zhang R
Nature communications 2024 Jun 26;15(1):5410

Chloroprocaine antagonizes progression of breast cancer by regulating LINC00494/miR-3619-5p/MED19 axis.

Chen C, Wang N, Huang T, Cheng G, Hu Y, Wang B, Zhang Y, Wang C
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23524

N(6)-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m(6)A/PD-L1 manner.

Wang Y, Jin P, Wang X
Apoptosis : an international journal on programmed cell death 2024 Feb;29(1-2):142-153

M6A reader YTHDF1 promotes malignant progression of laryngeal squamous carcinoma through activating the EMT pathway by EIF4A3.

Guo H, Han Q, Guan X, Li Z, Wang Y, He L, Guo Y, Zhao L, Xue X, Liu H, Zhang C
Cellular signalling 2024 Feb;114:111002

Putrescine promotes MMP9-induced angiogenesis in skeletal muscle through hydrogen peroxide/METTL3 pathway.

Hu C, Ji F, Lv R, Zhou H, Hou G, Xu T
Free radical biology & medicine 2024 Feb 20;212:433-447

Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.

Xiong YW, Zhu HL, Zhang J, Geng H, Tan LL, Zheng XM, Li H, Fan LL, Wang XR, Zhang XD, Wang KW, Chang W, Zhang YF, Yuan Z, Duan ZL, Cao YX, He XJ, Xu DX, Wang H
Nature communications 2024 Feb 14;15(1):1353

METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.

Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573

RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.

Sun Y, Chen D, Sun S, Ren M, Zhou L, Chen C, Zhao J, Wei H, Zhao Q, Qi Y, Zhang J, Zhang G, Liu H, Yang Q, Liu Q, Wang Y, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122

A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.

Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, Li T, Zhao X, Lei L, Zhao Q, Liu D, Wang B, Wu X
Cell reports 2024 Apr 23;43(4):114032

Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification.

Cheng W, Tan L, Yu S, Song J, Li Z, Peng X, Wei Q, He Z, Zhang W, Yang X
International immunopharmacology 2024 Apr 20;131:111820

Pseudorabies virus exploits N(6)-methyladenosine modification to promote viral replication.

Yu PL, Wu R, Cao SJ, Wen YP, Huang XB, Zhao S, Lang YF, Zhao Q, Lin JC, Du SY, Yu SM, Yan QG
Frontiers in microbiology 2023;14:1087484

HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.

Huo FC, Zhu ZM, Du WQ, Pan YJ, Jiang X, Kang MJ, Liu BW, Mou J, Pei DS
Pharmacological research 2023 Sep;195:106863

Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats.

Zou K, Dong H, Li M, Zhang Y, Zhang K, Song D, Chu C
Genomics 2023 Sep;115(5):110687

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.

Yu Z, Zheng L, Geng Y, Zhang Y, Wang Y, You G, Cai M, Li M, Cheng X, Zan J
Cellular signalling 2023 Sep;109:110751

Multi-Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging.

Huang J, Chen P, Jia L, Li T, Yang X, Liang Q, Zeng Y, Liu J, Wu T, Hu W, Kee K, Zeng H, Liang X, Zhou C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(26):e2301538

Propofol suppresses OGD/R-induced ferroptosis in neurons by inhibiting the HIF-1α/YTHDF1/BECN1 axis.

Ma H, Ye D, Liu Y, Wu P, Yu L, Guo L, Gao Y, Liu Y, Yan H, Shi J
Brain injury 2023 Sep 19;37(11):1285-1293

AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.

Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181

YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.

Hwang HJ, Park TL, Kim HI, Park Y, Kim G, Song C, Cho WK, Kim YK
Nature communications 2023 Oct 6;14(1):6248

The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.

Liu N, Zhang J, Chen W, Ma W, Wu T
Journal of experimental & clinical cancer research : CR 2023 Oct 11;42(1):263

Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis.

Wang L, Zhu L, Liang C, Huang X, Liu Z, Huo J, Zhang Y, Zhang Y, Chen L, Xu H, Li X, Xu L, Kuang M, Wong CC, Yu J
Journal of hepatology 2023 Nov;79(5):1185-1200

YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.

Yang W, Zhang M, Li J, Qu S, Zhou F, Liu M, Li L, Liu Z, Zen K
Redox biology 2023 Nov;67:102921

O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.

Chen Y, Wan R, Zou Z, Lao L, Shao G, Zheng Y, Tang L, Yuan Y, Ge Y, He C, Lin S
Nature cell biology 2023 Nov;25(11):1676-1690

YTHDF1 shapes "cold" tumor and inhibits CD8(+) T cells infiltration and function in breast cancer.

Jing L, Zhou K, Wang Z, Li Y, Fan Y, Liu T, Shan Z, Lin Y
Experimental cell research 2023 Nov 15;432(2):113778

m(6)A-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition.

Benavides-Serrato A, Saunders JT, Kumar S, Holmes B, Benavides KE, Bashir MT, Nishimura RN, Gera J
Cancer letters 2023 May 28;562:216178

Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer's disease pathology in mice.

Yin H, Ju Z, Zheng M, Zhang X, Zuo W, Wang Y, Ding X, Zhang X, Peng Y, Li J, Yang A, Zhang R
PLoS biology 2023 Mar;21(3):e3002017

YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.

Hesser CR, Walsh D
Journal of virology 2023 Mar 30;97(3):e0175822

N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185

The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression.

Hong YG, Yang Z, Chen Y, Liu T, Zheng Y, Zhou C, Wu GC, Chen Y, Xia J, Wen R, Liu W, Zhao Y, Chen J, Gao X, Chen Z
Cancer research 2023 Mar 15;83(6):845-860

YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m(6)A/mRNA pathway in spermatogonial stem cells/progenitors.

Li T, Zheng Y, Wu Z, Guo M, Liu R, Zeng W, Lv Y
Toxicology letters 2023 Mar 15;377:38-50

RNA binding protein YTHDF1 mediates bisphenol S-induced Leydig cell damage by regulating the mitochondrial pathway of BCL2 and the expression of CDK2-CyclinE1.

Li JZ, Zhou SM, Yuan WB, Chen HQ, Zeng Y, Fan J, Zhang Z, Wang N, Cao J, Liu WB
Environmental pollution (Barking, Essex : 1987) 2023 Mar 15;321:121144

Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.

Yan S, Zhou X, Wu C, Gao Y, Qian Y, Hou J, Xie R, Han B, Chen Z, Wei S, Gao X
Nature communications 2023 Mar 13;14(1):1379

The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.

Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822

O-GlcNAcylation promotes the cytosolic localization of the m(6)A reader YTHDF1 and colorectal cancer tumorigenesis.

Li J, Ahmad M, Sang L, Zhan Y, Wang Y, Yan Y, Liu Y, Mi W, Lu M, Dai Y, Zhang R, Dong MQ, Yang YG, Wang X, Sun J, Li J
The Journal of biological chemistry 2023 Jun;299(6):104738

Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.

Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747

PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.

Chen W, He Q, Liu J, Li N, Xiao K, Chen H
Carcinogenesis 2023 Jun 24;44(4):328-340

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.

Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151

Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.

Zhong J, Wu X, Gao Y, Chen J, Zhang M, Zhou H, Yang J, Xiao F, Yang X, Huang N, Qi H, Wang X, Bai F, Shi Y, Zhang N
Nature communications 2023 Jul 25;14(1):4467

The m(6)A Reader YTHDF1 Promotes Lung Carcinoma Progression via Regulating Ferritin Mediate Ferroptosis in an m(6)A-Dependent Manner.

Diao H, Tan H, Hu Y, Wang R, Cai P, Huang B, Shao X, Yan M, Yin C, Zhang Y
Pharmaceuticals (Basel, Switzerland) 2023 Jan 25;16(2)

METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.

Li D, He J, Fang C, Zhang Y, He M, Zhang Z, Hou J, Xu Q
International journal of molecular sciences 2023 Jan 11;24(2)

Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.

Yang F, Zhang A
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634

m(6) A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.

You Q, Wang F, Du R, Pi J, Wang H, Huo Y, Liu J, Wang C, Yu J, Yang Y, Zhu L
Advanced materials (Deerfield Beach, Fla.) 2023 Feb;35(8):e2204910

Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.

Li SJ, Zhang LX, Zou GJ, Ma MH, Zhou SF, Lu XY, Li F, Li CQ
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1814-1825

ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.

Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503

m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.

Zhang J, Song J, Liu S, Zhang Y, Qiu T, Jiang L, Bai J, Yao X, Wang N, Yang G, Sun X
The Science of the total environment 2023 Dec 20;905:167202

RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68.

Nie Q, Wu X, Huang Y, Guo T, Kuang J, Du C
European journal of medical research 2023 Dec 2;28(1):552

Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.

Zhang G, Mi W, Wang C, Li J, Zhang Y, Liu N, Jiang M, Jia G, Wang F, Yang G, Zhang L, Wang J, Fu Y, Zhang Y
Cell death discovery 2023 Dec 15;9(1):457

USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis.

Wang A, Huang H, Shi JH, Yu X, Ding R, Zhang Y, Han Q, Ni ZY, Li X, Zhao R, Zou Q
The Journal of clinical investigation 2023 Dec 1;133(23)

Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.

Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821

Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.

Park J, Wu Y, Shao W, Gendron TF, van der Spek SJF, Sultanakhmetov G, Basu A, Castellanos Otero P, Jones CJ, Jansen-West K, Daughrity LM, Phanse S, Del Rosso G, Tong J, Castanedes-Casey M, Jiang L, Libera J, Oskarsson B, Dickson DW, Sanders DW, Brangwynne CP, Emili A, Wolozin B, Petrucelli L, Zhang YJ
Cell reports 2023 Aug 29;42(8):112822

Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.

Jansens RJJ, Olarerin-George A, Verhamme R, Mirza A, Jaffrey S, Favoreel HW
iScience 2023 Aug 18;26(8):107310

YTHDF2 in dentate gyrus is the m(6)A reader mediating m(6)A modification in hippocampus-dependent learning and memory.

Zhuang M, Geng X, Han P, Che P, Liang F, Liu C, Yang L, Yu J, Zhang Z, Dong W, Ji SJ
Molecular psychiatry 2023 Apr;28(4):1679-1691

Profiling of N6-methyladenosine methylation in porcine longissimus dorsi muscle and unravelling the hub gene ADIPOQ promotes adipogenesis in an m(6)A-YTHDF1-dependent manner.

Gong H, Gong T, Liu Y, Wang Y, Wang X
Journal of animal science and biotechnology 2023 Apr 6;14(1):50

Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association.

Anadolu MN, Sun J, Kailasam S, Chalkiadaki K, Krimbacher K, Li JT, Markova T, Jafarnejad SM, Lefebvre F, Ortega J, Gkogkas CG, Sossin WS
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 5;43(14):2440-2459

Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.

Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120

YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.

Fang Q, Tian GG, Wang Q, Liu M, He L, Li S, Wu J
Cell reports 2023 Apr 25;42(4):112403

N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.

Ji D, Hu C, Ning J, Ying X, Zhang H, Zhang B, Liu B, Liu Q, Ji W, Zhang R
Ecotoxicology and environmental safety 2023 Apr 1;254:114755

Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N(6)-Methyladenosine-Modified Yap Expression.

Wang L, Yu P, Wang J, Xu G, Wang T, Feng J, Bei Y, Xu J, Wang H, Das S, Xiao J
Research (Washington, D.C.) 2022;2022:9825916

The Effects of Moxibustion on Learning and Memory and m6A RNA Methylation in APP/PS1 Mice.

Huang Q, Li CY, Zhang N, Zhang Q, Li HY, Shen Y, Xie LS, Yu SG, Wu QF
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2998301

N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.

Hu Z, Li Y, Yuan W, Jin L, Leung WK, Zhang C, Yang Y
International journal of biological sciences 2022;18(15):5753-5769

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.

Li Z, Teng M, Jiang Y, Zhang L, Luo X, Liao Y, Yang B
Frontiers in immunology 2022;13:857727

Novel insight of N(6)-methyladenosine modified subtypes in abdominal aortic aneurysm.

Wang K, Kan Q, Ye Y, Qiu J, Huang L, Wu R, Yao C
Frontiers in genetics 2022;13:1055396

Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma.

Koh YW, Han JH, Haam S, Lee HW
Frontiers in oncology 2022;12:996634

m(6)A regulation of cortical and retinal neurogenesis is mediated by the redundant m(6)A readers YTHDFs.

Niu F, Che P, Yang Z, Zhang J, Yang L, Zhuang M, Ou X, Ji SJ
iScience 2022 Sep 16;25(9):104908

m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.

Wang L, Zhan G, Maimaitiyiming Y, Su Y, Lin S, Liu J, Su K, Lin J, Shen S, He W, Wang F, Chen J, Sun S, Xue Y, Gu J, Chen X, Zhang J, Zhang L, Wang Q, Chang KJ, Chiou SH, Björklund M, Naranmandura H, Cheng X, Hsu CH
Cell reports 2022 Oct 25;41(4):111546

Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N (6)-Methyladenosine-Modified RNAs.

Micaelli M, Dalle Vedove A, Cerofolini L, Vigna J, Sighel D, Zaccara S, Bonomo I, Poulentzas G, Rosatti EF, Cazzanelli G, Alunno L, Belli R, Peroni D, Dassi E, Murakami S, Jaffrey SR, Fragai M, Mancini I, Lolli G, Quattrone A, Provenzani A
ACS pharmacology & translational science 2022 Oct 14;5(10):872-891

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554

m(6)A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation.

Huang J, Jiang B, Li GW, Zheng D, Li M, Xie X, Pan Y, Wei M, Liu X, Jiang X, Zhang X, Yang L, Bao L, Wang B
Cell reports 2022 Nov 22;41(8):111693

METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.

Cai Y, Yu R, Kong Y, Feng Z, Xu Q
Cellular signalling 2022 May;93:110283

Lactylation-driven METTL3-mediated RNA m(6)A modification promotes immunosuppression of tumor-infiltrating myeloid cells.

Xiong J, He J, Zhu J, Pan J, Liao W, Ye H, Wang H, Song Y, Du Y, Cui B, Xue M, Zheng W, Kong X, Jiang K, Ding K, Lai L, Wang Q
Molecular cell 2022 May 5;82(9):1660-1677.e10

UPF1 promotes rapid degradation of m(6)A-containing RNAs.

Boo SH, Ha H, Lee Y, Shin MK, Lee S, Kim YK
Cell reports 2022 May 24;39(8):110861

m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer.

Duan X, Yang L, Wang L, Liu Q, Zhang K, Liu S, Liu C, Gao Q, Li L, Qin G, Zhang Y
Cell & bioscience 2022 May 14;12(1):60

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis.

Yao X, Li W, Li L, Li M, Zhao Y, Fang D, Zeng X, Luo Z
Cell death & disease 2022 Mar 23;13(3):258

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.

Qi Z, Wang S, Li J, Wen Y, Cui R, Zhang K, Liu Y, Yang X, Zhang L, Xu B, Liu W, Xu Z, Deng Y
Journal of hazardous materials 2022 Mar 15;426:128099

Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.

Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248

YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.

Huang X, Zhu L, Wang L, Huang W, Tan L, Liu H, Huo J, Su T, Zhang M, Kuang M, Li X, Dai Z, Xu L
Journal of gastroenterology and hepatology 2022 Jun;37(6):1156-1168

ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.

Li A, Cao C, Gan Y, Wang X, Wu T, Zhang Q, Liu Y, Yao L, Zhang Q
Clinical and translational medicine 2022 Jun;12(6):e906

m(6)A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration.

Liu Y, Song R, Zhao L, Lu Z, Li Y, Zhan X, Lu F, Yang J, Niu Y, Cao X
Signal transduction and targeted therapy 2022 Jun 29;7(1):194

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m(6)A modification.

Xu Y, Lv D, Yan C, Su H, Zhang X, Shi Y, Ying K
Cancer cell international 2022 Jan 7;22(1):11

Intermittent Fasting Improves High-Fat Diet-Induced Obesity Cardiomyopathy via Alleviating Lipid Deposition and Apoptosis and Decreasing m6A Methylation in the Heart.

Xu Z, Qin Y, Lv B, Tian Z, Zhang B
Nutrients 2022 Jan 7;14(2)

YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.

N'Da Konan S, Ségéral E, Bejjani F, Bendoumou M, Ait Said M, Gallois-Montbrun S, Emiliani S
Retrovirology 2022 Jan 31;19(1):4

The m(6)A methyltransferase METTL3 regulates muscle maintenance and growth in mice.

Petrosino JM, Hinger SA, Golubeva VA, Barajas JM, Dorn LE, Iyer CC, Sun HL, Arnold WD, He C, Accornero F
Nature communications 2022 Jan 10;13(1):168

Involvement of YTHDF1 in renal fibrosis progression via up-regulating YAP.

Xing J, He YC, Wang KY, Wan PZ, Zhai XY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Feb;36(2):e22144

The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.

Li Y, Zhang X, Cai J, Ren L, Liu B, Wu M, Lu W, Li R, Zhang C, Huang C, Tong J, Liu A, Zheng Y, Ren D, Guo Y, Huang Y
The journal of gene medicine 2022 Feb;24(2):e3397

Methyltransferase-like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1.

Liu T, Wang H, Fu Z, Wang Z, Wang J, Gan X, Wang A, Wang L
Cancer science 2022 Feb;113(2):446-458

YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner.

Chen H, Yu Y, Yang M, Huang H, Ma S, Hu J, Xi Z, Guo H, Yao G, Yang L, Huang X, Zhang F, Tan G, Wu H, Zheng W, Li L
Cell & bioscience 2022 Feb 23;12(1):19

METTL3-m(6)A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.

Peng Z, Gong Y, Wang X, He W, Wu L, Zhang L, Xiong L, Huang Y, Su L, Shi P, Cao X, Liu R, Li Y, Xiao H
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Feb 2;30(2):932-946

The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

Niu F, Han P, Zhang J, She Y, Yang L, Yu J, Zhuang M, Tang K, Shi Y, Yang B, Liu C, Peng B, Ji SJ
eLife 2022 Feb 18;11

TBK1-METTL3 axis facilitates antiviral immunity.

Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F
Cell reports 2022 Feb 15;38(7):110373

The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176

GMEB2 Promotes the Growth of Colorectal Cancer by Activating ADRM1 Transcription and NF-κB Signalling and Is Positively Regulated by the m(6)A Reader YTHDF1.

Ning Z, Wu Z, Zhang F, Yang M, Lu Z, Yu B, Long F, Guo Y, Yang K, Hu G, Zhang Y, Li X, Li L, Lin C
Cancers 2022 Dec 8;14(24)

The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray.

Ouyang H, Zhang J, Chi D, Zhang K, Huang Y, Huang J, Huang W, Bai X
Journal of neuroinflammation 2022 Dec 22;19(1):310

YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis.

He M, Li D, Fang C, Xu Q
Archives of biochemistry and biophysics 2022 Dec 15;732:109464

METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.

Li HB, Huang G, Tu J, Lv DM, Jin QL, Chen JK, Zou YT, Lee DF, Shen JN, Xie XB
EBioMedicine 2022 Aug;82:104142

FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells.

Zhao F, Ge F, Xie M, Li Z, Zang C, Kong L, Pu Y, Zheng X, Tan Y
Clinical & experimental metastasis 2022 Aug;39(4):623-639

Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.

Wu F, Zhang L, Lai C, Peng X, Yu S, Zhou C, Zhang B, Zhang W
International journal of molecular sciences 2022 Aug 17;23(16)

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Zhang L, Cheng Y, Xue Z, Li J, Wu N, Yan J, Wang J, Wang C, Chen W, Zhou T, Qiu Z, Jiang H
Cell biology and toxicology 2022 Apr;38(2):347-369

RNA m(6)A methylation regulates dissemination of cancer cells by modulating expression and membrane localization of β-catenin.

Li J, Xie G, Tian Y, Li W, Wu Y, Chen F, Lin Y, Lin X, Wing-Ngor Au S, Cao J, He W, Wang H
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1578-1596

METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.

Zhu Y, Peng X, Zhou Q, Tan L, Zhang C, Lin S, Long M
Cell death & disease 2022 Apr 18;13(4):358

N6-methyladenosine regulates ATM expression and downstream signaling.

Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051

YTHDF1 Aggravates the Progression of Cervical Cancer Through m(6)A-Mediated Up-Regulation of RANBP2.

Wang H, Luo Q, Kang J, Wei Q, Yang Y, Yang D, Liu X, Liu T, Yi P
Frontiers in oncology 2021;11:650383

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.

Tsuchiya K, Yoshimura K, Inoue Y, Iwashita Y, Yamada H, Kawase A, Watanabe T, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H
Oncoimmunology 2021;10(1):1962656

Insufficient Radiofrequency Ablation Promotes Hepatocellular Carcinoma Metastasis Through N6-Methyladenosine mRNA Methylation-Dependent Mechanism.

Su T, Huang M, Liao J, Lin S, Yu P, Yang J, Cai Y, Zhu S, Xu L, Peng Z, Peng S, Chen S, Kuang M
Hepatology (Baltimore, Md.) 2021 Sep;74(3):1339-1356

Vitamin B(12) Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.

Mosca P, Robert A, Alberto JM, Meyer M, Kundu U, Hergalant S, Umoret R, Coelho D, Guéant JL, Leheup B, Dreumont N
Molecular nutrition & food research 2021 Sep;65(17):e2100206

Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation.

Wang S, Zhang J, Wu X, Lin X, Liu XM, Zhou J
RNA biology 2021 Sep;18(9):1354-1363

METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X
Molecular neurodegeneration 2021 Sep 30;16(1):70

METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.

He B, Wang J
Aging 2021 Oct 5;13(19):23108-23118

Streptozotocin-Induced Astrocyte Mitochondrial Dysfunction Is Ameliorated by FTO Inhibitor MO-I-500.

Cockova Z, Honc O, Telensky P, Olsen MJ, Novotny J
ACS chemical neuroscience 2021 Oct 20;12(20):3818-3828

The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.

Yu J, She Y, Yang L, Zhuang M, Han P, Liu J, Lin X, Wang N, Chen M, Jiang C, Zhang Y, Yuan Y, Ji SJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101329

Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.

He RZ, Jiang J, Hu X, Lei M, Li J, Luo W, Duan L, Hu Z, Mo YY, Luo DX, Peng WX
Cancer cell international 2021 Nov 22;21(1):616

The m(6)A "reader" YTHDF1 promotes osteogenesis of bone marrow mesenchymal stem cells through translational control of ZNF839.

Liu T, Zheng X, Wang C, Wang C, Jiang S, Li B, Chen P, Xu W, Zheng H, Yang R, Huang X, Zhang X, Jiang L
Cell death & disease 2021 Nov 12;12(11):1078

WNT/β-catenin-suppressed FTO expression increases m(6)A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis.

Yang X, Shao F, Guo D, Wang W, Wang J, Zhu R, Gao Y, He J, Lu Z
Cell death & disease 2021 May 8;12(5):462

Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m(6) A-dependent manner.

Chen Y, Wu R, Chen W, Liu Y, Liao X, Zeng B, Guo G, Lou F, Xiang Y, Wang Y, Wang X
EMBO reports 2021 May 5;22(5):e52146

YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.

Pi J, Wang W, Ji M, Wang X, Wei X, Jin J, Liu T, Qiang J, Qi Z, Li F, Liu Y, Ma Y, Si Y, Huo Y, Gao Y, Chen Y, Dong L, Su R, Chen J, Rao S, Yi P, Yu S, Wang F, Yu J
Cancer research 2021 May 15;81(10):2651-2665

m(6)A RNA methylation regulates the fate of endogenous retroviruses.

Chelmicki T, Roger E, Teissandier A, Dura M, Bonneville L, Rucli S, Dossin F, Fouassier C, Lameiras S, Bourc'his D
Nature 2021 Mar;591(7849):312-316

Comparison of RNA m(6)A and DNA methylation profiles between mouse female germline stem cells and STO cells.

Zhao X, Tian GG, Fang Q, Pei X, Wang Z, Wu J
Molecular therapy. Nucleic acids 2021 Mar 5;23:431-439

MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.

Wu G, Suo C, Yang Y, Shen S, Sun L, Li ST, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang YG, Cao J, Gao P
EMBO reports 2021 Mar 3;22(3):e51519

Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine.

McFadden MJ, McIntyre ABR, Mourelatos H, Abell NS, Gokhale NS, Ipas H, Xhemalçe B, Mason CE, Horner SM
Cell reports 2021 Mar 2;34(9):108798

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.

Yin H, Zhang X, Yang P, Zhang X, Peng Y, Li D, Yu Y, Wu Y, Wang Y, Zhang J, Ding X, Wang X, Yang A, Zhang R
Nature communications 2021 Mar 2;12(1):1394

YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition.

Luo X, Cao M, Gao F, He X
Experimental hematology & oncology 2021 Jun 4;10(1):35

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding.

Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, Gao S, Gao Y, He J, Lu Z
Nature communications 2021 Jun 21;12(1):3803

YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.

Jiang D, Hou J, Qian Y, Gao Y, Gao X, Wei S
Biochemical and biophysical research communications 2021 Jun 11;557:85-89

N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.

Terajima H, Lu M, Zhang L, Cui Q, Shi Y, Li J, He C
PLoS biology 2021 Jul;19(7):e3001292

Integrated analysis of m(6)A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.

Zeng Y, Huang T, Zuo W, Wang D, Xie Y, Wang X, Xiao Z, Chen Z, Liu Q, Liu N, Xiao Y
Aging 2021 Jul 26;13(14):18238-18256

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.

Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q
Nucleic acids research 2021 Jul 21;49(13):7361-7374

YTHDF1 Promotes Cyclin B1 Translation through m(6)A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation.

Lou X, Ning J, Liu W, Li K, Qian B, Xu D, Wu Y, Zhang D, Cui W
Cells 2021 Jul 2;10(7)

Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.

Wang YJ, Yang B, Lai Q, Shi JF, Peng JY, Zhang Y, Hu KS, Li YQ, Peng JW, Yang ZZ, Li YT, Pan Y, Koeffler HP, Liao JY, Yin D
RNA biology 2021 Jan;18(1):131-143

ALKBH5 suppresses tumor progression via an m(6)A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.

Yuan Y, Yan G, He M, Lei H, Li L, Wang Y, He X, Li G, Wang Q, Gao Y, Qu Z, Mei Z, Shen Z, Pu J, Wang A, Zhao W, Jiang H, Du W, Yang L
Cell death & disease 2021 Jan 11;12(1):60

Relaxed initiation pausing of ribosomes drives oncogenic translation.

Dong L, Mao Y, Zhou A, Liu XM, Zhou J, Wan J, Qian SB
Science advances 2021 Feb;7(8)

m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Chen Y, Wang J, Xu D, Xiang Z, Ding J, Yang X, Li D, Han X
Autophagy 2021 Feb;17(2):457-475

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.

Li Q, Ni Y, Zhang L, Jiang R, Xu J, Yang H, Hu Y, Qiu J, Pu L, Tang J, Wang X
Signal transduction and targeted therapy 2021 Feb 23;6(1):76

METTL3-dependent N(6)-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium.

Chien CS, Li JY, Chien Y, Wang ML, Yarmishyn AA, Tsai PH, Juan CC, Nguyen P, Cheng HM, Huo TI, Chiou SH, Chien S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)

Endothelial METTL3 (Methyltransferase-Like 3) Inhibits Fibrinolysis by Promoting PAI-1 (Plasminogen Activator Inhibitor-1) Expression Through Enhancing Jun Proto-Oncogene N6-Methyladenosine Modification.

Bai Q, Lu Y, Chen Y, Zhang H, Zhang W, Wu H, Wen A
Arteriosclerosis, thrombosis, and vascular biology 2021 Dec;41(12):2877-2889

GR-mediated transcriptional regulation of m(6)A metabolic genes contributes to diet-induced fatty liver in hens.

Feng Y, Li Y, Jiang W, Hu Y, Jia Y, Zhao R
Journal of animal science and biotechnology 2021 Dec 7;12(1):117

TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.

Wang H, Wei W, Zhang ZY, Liu Y, Shi B, Zhong W, Zhang HS, Fang X, Sun CL, Wang JB, Liu LX
Cell death & disease 2021 Dec 17;13(1):3

m(6)A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.

Zhang JX, Huang PJ, Wang DP, Yang WY, Lu J, Zhu Y, Meng XX, Wu X, Lin QH, Lv H, Xie H, Wang RL
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448

METTL14 facilitates global genome repair and suppresses skin tumorigenesis.

Yang Z, Yang S, Cui YH, Wei J, Shah P, Park G, Cui X, He C, He YY
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 31;118(35)

The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.

Ma S, Yan J, Barr T, Zhang J, Chen Z, Wang LS, Sun JC, Chen J, Caligiuri MA, Yu J
The Journal of experimental medicine 2021 Aug 2;218(8)

N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay.

Xia TL, Li X, Wang X, Zhu YJ, Zhang H, Cheng W, Chen ML, Ye Y, Li Y, Zhang A, Dai DL, Zhu QY, Yuan L, Zheng J, Huang H, Chen SQ, Xiao ZW, Wang HB, Roy G, Zhong Q, Lin D, Zeng YX, Wang J, Zhao B, Gewurz BE, Chen J, Zuo Z, Zeng MS
EMBO reports 2021 Apr 7;22(4):e50128

Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.

Kastan JP, Tremblay MW, Brown MC, Trimarco JD, Dobrikova EY, Dobrikov MI, Gromeier M
mBio 2021 Apr 13;12(2)

m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.

He JJ, Li Z, Rong ZX, Gao J, Mu Y, Guan YD, Ren XX, Zi YY, Liu LY, Fan Q, Zhou M, Duan YM, Zhou Q, Deng YZ, Sun LQ
Frontiers in oncology 2020;10:1166

m(6)A-binding YTHDF proteins promote stress granule formation.

Fu Y, Zhuang X
Nature chemical biology 2020 Sep;16(9):955-963

YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.

Liu J, Gao M, Xu S, Chen Y, Wu K, Liu H, Wang J, Yang X, Wang J, Liu W, Bao X, Chen J
Cell reports 2020 Sep 8;32(10):108120

m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.

Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514

Context-dependent functional compensation between Ythdf m(6)A reader proteins.

Lasman L, Krupalnik V, Viukov S, Mor N, Aguilera-Castrejon A, Schneir D, Bayerl J, Mizrahi O, Peles S, Tawil S, Sathe S, Nachshon A, Shani T, Zerbib M, Kilimnik I, Aigner S, Shankar A, Mueller JR, Schwartz S, Stern-Ginossar N, Yeo GW, Geula S, Novershtern N, Hanna JH
Genes & development 2020 Oct 1;34(19-20):1373-1391

Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP.

Kim B, Arcos S, Rothamel K, Jian J, Rose KL, McDonald WH, Bian Y, Reasoner S, Barrows NJ, Bradrick S, Garcia-Blanco MA, Ascano M
Molecular cell 2020 May 21;78(4):624-640.e7

A Unified Model for the Function of YTHDF Proteins in Regulating m(6)A-Modified mRNA.

Zaccara S, Jaffrey SR
Cell 2020 Jun 25;181(7):1582-1595.e18

ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.

Tian J, Ying P, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, Wang X, Mei S, Zhang Y, Wang C, Zhong R, Chang J, Miao X
International journal of cancer 2020 Jun 15;146(12):3281-3293

m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.

Wang X, Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Shi H, Wang F, Wang Y
Autophagy 2020 Jul;16(7):1221-1235

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550

N(6)-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.

Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR Jr, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A
Nature genetics 2020 Jan;52(1):48-55

Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.

Gokhale NS, McIntyre ABR, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM
Molecular cell 2020 Feb 6;77(3):542-555.e8

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644

YTHDF1 Facilitates the Progression of Hepatocellular Carcinoma by Promoting FZD5 mRNA Translation in an m6A-Dependent Manner.

Liu X, Qin J, Gao T, Li C, He B, Pan B, Xu X, Chen X, Zeng K, Xu M, Zhu C, Pan Y, Sun H, Sun L, Xu T, Wang S
Molecular therapy. Nucleic acids 2020 Dec 4;22:750-765

N(6)-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.

Du J, Liao W, Liu W, Deb DK, He L, Hsu PJ, Nguyen T, Zhang L, Bissonnette M, He C, Li YC
Developmental cell 2020 Dec 21;55(6):737-753.e7

Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism.

Liu X, Gonzalez G, Dai X, Miao W, Yuan J, Huang M, Bade D, Li L, Sun Y, Wang Y
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Dec 2;28(12):2593-2604

Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.

Yarmishyn AA, Yang YP, Lu KH, Chen YC, Chien Y, Chou SJ, Tsai PH, Ma HI, Chien CS, Chen MT, Wang ML
Cancer cell international 2020 Dec 14;20(1):597

Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.

Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J, Cui J, Zhao W
Science advances 2020 Aug;6(34):eaba0647

Epitranscriptomic N(6)-Methyladenosine Modification Is Required for Direct Lineage Reprogramming into Neurons.

Choi H, Baek S, Cho B, Kim S, Kim J, Chang Y, Shin J, Kim J
ACS chemical biology 2020 Aug 21;15(8):2087-2097

Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.

Lee AK, Klein J, Fon Tacer K, Lord T, Oatley MJ, Oatley JM, Porter SN, Pruett-Miller SM, Tikhonova EB, Karamyshev AL, Wang YD, Yang P, Korff A, Kim HJ, Taylor JP, Potts PR
Molecular cell 2020 Aug 20;79(4):645-659.e9

A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.

Liu H, Xu Y, Yao B, Sui T, Lai L, Li Z
Cell death & disease 2020 Aug 13;11(8):613

N(6)-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.

Lu M, Zhang Z, Xue M, Zhao BS, Harder O, Li A, Liang X, Gao TZ, Xu Y, Zhou J, Feng Z, Niewiesk S, Peeples ME, He C, Li J
Nature microbiology 2020 Apr;5(4):584-598

METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.

Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z
Nature communications 2020 Apr 3;11(1):1648

Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification.

Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation.

Liu T, Wei Q, Jin J, Luo Q, Liu Y, Yang Y, Cheng C, Li L, Pi J, Si Y, Xiao H, Li L, Rao S, Wang F, Yu J, Yu J, Zou D, Yi P
Nucleic acids research 2020 Apr 17;48(7):3816-3831

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.

Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q, Yu J, Martin EW, Mittag T, Kim HJ, Taylor JP
Cell 2020 Apr 16;181(2):325-345.e28

YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma.

Bai Y, Yang C, Wu R, Huang L, Song S, Li W, Yan P, Lin C, Li D, Zhang Y
Frontiers in oncology 2019;9:332

Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.

Xue M, Zhao BS, Zhang Z, Lu M, Harder O, Chen P, Lu Z, Li A, Ma Y, Xu Y, Liang X, Zhou J, Niewiesk S, Peeples ME, He C, Li J
Nature communications 2019 Oct 9;10(1):4595

YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.

Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, Yang Z, Zhou J, Gao J, Zhou H, Xu S, Ji H, Shi P, Wu DD, Yang C, Chen Y
Nature communications 2019 Oct 25;10(1):4892

The Tudor SND1 protein is an m(6)A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.

Baquero-Perez B, Antanaviciute A, Yonchev ID, Carr IM, Wilson SA, Whitehouse A
eLife 2019 Oct 24;8

The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression.

Zhuang M, Li X, Zhu J, Zhang J, Niu F, Liang F, Chen M, Li D, Han P, Ji SJ
Nucleic acids research 2019 May 21;47(9):4765-4777

CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.

Liu J, Zhang X, Chen K, Cheng Y, Liu S, Xia M, Chen Y, Zhu H, Li Z, Cao X
Immunity 2019 Mar 19;50(3):600-615.e15

Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.

Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W, Lin S, Ji W
Oncogene 2019 Jun;38(24):4755-4772

m(6)A enhances the phase separation potential of mRNA.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 17479-1-AP(YTHDF1 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 17479-1-AP(YTHDF1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The YTHDF1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human YTHDF1. This antibody recognizes human, mouse, rat antigen. The YTHDF1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 17479-1-AP.pdf

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