Antibody data
- Antibody Data
- Antigen structure
- References [72]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10587-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10587-1-AP, RRID:AB_2175757
- Product name
- RBM15 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RBM15 antibody (Cat. #10587-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references RBM15 Enhances 5-Fluorouracil Drug Sensitivity and Suppresses Gastric Cancer Progression by Modulating N6-Methyladenosine Modification of ECT2-Dependent IGF2BP3.
RNA-binding motif protein 15 promotes gastric cancer growth and drug resistance via USP10-mediated deubiquitination and stabilization of nuclear NRF2.
MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids.
Protocol for evaluating RNA-protein associations in mammalian cells with RIP-seq and RIP-qPCR.
RBM15/YTHDF2-mediated m6A modification of HTR1D exacerbates hypoxia-induced dysfunction in trophoblast cells in preeclampsia.
Systematic fusion transcript discovery in mantle cell lymphoma using long-read sequencing.
Integration of bioinformatics and identification of the role of m6A genes in NAFLD.
RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
M6A-mediated uc003pes.1 stability regulates proliferation and migration of human coronary artery smooth muscle cells via scaffolding STAT1 and USP10.
m(6)A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics.
Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathy.
Hepatitis B Virus Promotes Angiogenesis in Hepatocellular Carcinoma by Increasing m6A Modification of VEGFA mRNA via IGF2BP3.
RBM15-mediated the m6A modification of MAT2A promotes osteosarcoma cell proliferation, metastasis and suppresses ferroptosis.
Xist Repeat A coordinates an assembly of SR proteins to recruit SPEN and induce gene silencing.
Lactylation increases the stability of RBM15 to drives m6A modification in non-small-cell lung cancer cells.
RBM15 promotes m6A methylation and stability of KLF6 mRNA to accelerate pyroptosis of retinal ganglion cells in early-stage diabetic retinopathy.
Targeting METTL3 protein by proteolysis-targeting chimeras: A novel therapeutic approach for acute myeloid leukemia.
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
Autoantibody hotspots reveal origin and impact of immunogenic XIST ribonucleoprotein complex.
Aberrant splicing in Huntington's disease accompanies disrupted TDP-43 activity and altered m6A RNA modification.
GPR30 Inhibits Neuronal Apoptosis After Subarachnoid Hemorrhage by Activating the Wnt/β-Catenin Pathway in a m6A-dependent Manner.
RBM15 enhances paclitaxel resistance in triple-negative breast cancer by targeting m(6)A methylation of TNFSF9 and inducing polarization of tumor-associated macrophages to M2 phenotype.
RBM15 increase tumor-infiltrating CD4+ T cell in ESCC via modulating of PLOD3.
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma.
Overexpression of RBM15 modulated the effect of trophoblast cells by promoting the binding ability between YTHDF2 and the CD82 3'UTR to decrease the expression of CD82.
XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.
N6-methyladenosine-modified CircPSMA7 enhances bladder cancer malignancy through the miR-128-3p/MAPK1 axis.
Landscape of transcriptome-wide m(6)A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise.
N6-Methyladenosine enhances the translation of ENO1 to promote the progression of bladder cancer by inhibiting PCNA ubiquitination.
BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.
Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells.
High expression of RBM15 is associated with better prognosis in esophageal squamous cell carcinoma.
RBM15 drives the progression of lung adenocarcinoma by regulating N6-methyladenosine-mediated LDHA mRNA stability.
Identification of RBM15 as a prognostic biomarker in prostate cancer involving the regulation of prognostic m6A-related lncRNAs.
Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer.
Comprehensive analyses of m6A RNA methylation patterns and related immune microenvironment in idiopathic pulmonary arterial hypertension.
RNA methylation pattern and immune microenvironment characteristics mediated by m6A regulator in ischemic stroke.
RBFOX2 recognizes N(6)-methyladenosine to suppress transcription and block myeloid leukaemia differentiation.
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.
CSTF2 mediated mRNA N(6)-methyladenosine modification drives pancreatic ductal adenocarcinoma m(6)A subtypes.
Identification of osteosarcoma m6A-related prognostic biomarkers using artificial intelligence: RBM15.
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4.
A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.
m6A Regulatory Gene-Mediated Methylation Modification in Glioma Survival Prediction.
Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.
Analysis and identification of m(6)A RNA methylation regulators in metastatic osteosarcoma.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.
Cross talk between RNA modification writers and tumor development as a basis for guiding personalized therapy of gastric cancer.
Methylation and Expression of the Exercise-Related TLR1 Gene Is Associated With Low Grade Glioma Prognosis and Outcome.
mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.
METTL3 regulates heterochromatin in mouse embryonic stem cells.
N(6)-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.
Integrated analysis of m(6)A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.
RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent.
The role of the Xist 5' m6A region and RBM15 in X chromosome inactivation.
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
RBM15 Modulates the Function of Chromatin Remodeling Factor BAF155 Through RNA Methylation in Developing Cortex.
Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.
Multiple regions of Kaposi's sarcoma-associated herpesvirus ORF59 RNA are required for its expression mediated by viral ORF57 and cellular RBM15.
Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi sarcoma-associated herpesvirus ORF57 protein is required for RNA splicing.
Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.
Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.
Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57.
The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA.
Zhu X, Chen H, Xu K, Liu Y, Li H, Sang Y, Zhao Y, Liu X, Wang X, Cui X, Cai B, Shang L, Jing C, Chong W, Li L
Research (Washington, D.C.) 2026;9:1108
Research (Washington, D.C.) 2026;9:1108
RNA-binding motif protein 15 promotes gastric cancer growth and drug resistance via USP10-mediated deubiquitination and stabilization of nuclear NRF2.
Ma Z, Xu Z, Xu J, Chen C, Niu W, Wang Y, Qian Y, Zhang X, Yang M, Stefan SM, Gan L, Wang S, Wang B
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 May;86:101376
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 May;86:101376
MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids.
Uhl L, Aziba A, Löbbert S, Russell T, Krenz B, Montesinos F, Kannan T, Valanju OR, Schülein-Völk C, de Martines T, Bolz M, Fleischhauer D, Cossa G, Endres T, Solvie D, Gallant P, Rosenwald A, Maric HM, Papadopoulos D, Vos SM, Eilers M
Cell 2026 Mar 5;189(5):1371-1388.e29
Cell 2026 Mar 5;189(5):1371-1388.e29
Protocol for evaluating RNA-protein associations in mammalian cells with RIP-seq and RIP-qPCR.
Trotman JB, Li S, Eberhard QE, Zhang Z, Calabrese JM
STAR protocols 2026 Mar 20;7(1):104298
STAR protocols 2026 Mar 20;7(1):104298
RBM15/YTHDF2-mediated m6A modification of HTR1D exacerbates hypoxia-induced dysfunction in trophoblast cells in preeclampsia.
Yu B, Gong H, Zhang S, Zhao M, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):1079-1090
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):1079-1090
Systematic fusion transcript discovery in mantle cell lymphoma using long-read sequencing.
Pasipamire L, Rashid J, Lukan C, Das N, Li J, Masamha CP
bioRxiv : the preprint server for biology 2026 Jan 20;
bioRxiv : the preprint server for biology 2026 Jan 20;
Integration of bioinformatics and identification of the role of m6A genes in NAFLD.
Ma J, Xu R, Li R, Fu Y, Xu J, Zhou L, Qi Y
PloS one 2025;20(5):e0321757
PloS one 2025;20(5):e0321757
RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.
Wang C, Chen M, Chen P, Han J, Hu H, Chen J, Wu Q, Zhao D, Wang T, Zhou J, Li Q, Zhou R, Wen Y, Yang J, Shi M, Wang Y
Frontiers in immunology 2025;16:1515568
Frontiers in immunology 2025;16:1515568
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Sun H, Qiao X, Peng X, Zhu H, Zhang L, Jiang L, Wang L, Xue C, Yang J, Yi W, Zhang B, Liu J, Duan W
Theranostics 2025;15(8):3532-3550
Theranostics 2025;15(8):3532-3550
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
Yan Z, Cao H, Zhang X, Wang Y, Chang Q
International immunopharmacology 2025 Sep 23;162:115141
International immunopharmacology 2025 Sep 23;162:115141
M6A-mediated uc003pes.1 stability regulates proliferation and migration of human coronary artery smooth muscle cells via scaffolding STAT1 and USP10.
Jiang R, Jia Q, Li C, He S, Zhou H, Ren M, Liang L, Jia E
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120023
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120023
m(6)A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics.
Wei G, Coker H, Rodermund L, Almeida M, Roach HL, Nesterova TB, Brockdorff N
Nature structural & molecular biology 2025 Nov;32(11):2242-2251
Nature structural & molecular biology 2025 Nov;32(11):2242-2251
Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathy.
Dong Q, Dong L, Zhu Y, Wang X, Yan X
Functional & integrative genomics 2025 Nov 17;25(1):244
Functional & integrative genomics 2025 Nov 17;25(1):244
Hepatitis B Virus Promotes Angiogenesis in Hepatocellular Carcinoma by Increasing m6A Modification of VEGFA mRNA via IGF2BP3.
Xu X, Zhang Y, Wu S, Wu Y, Lin X, Chen K, Lin X
Journal of medical virology 2025 May;97(5):e70356
Journal of medical virology 2025 May;97(5):e70356
RBM15-mediated the m6A modification of MAT2A promotes osteosarcoma cell proliferation, metastasis and suppresses ferroptosis.
Huang Z, Chen P, Liu Y
Molecular and cellular biochemistry 2025 May;480(5):2923-2933
Molecular and cellular biochemistry 2025 May;480(5):2923-2933
Xist Repeat A coordinates an assembly of SR proteins to recruit SPEN and induce gene silencing.
Trotman JB, Porrello A, Schactler SA, DeLeon LE, Eberhard QE, Boyson SP, Zhang Z, Lee DM, Kirik SE, Sultana N, Nguyen SN, Beltejar MG, Shinn MK, Ong SE, Gonzalez-Perez MP, Shaffer SA, Dominguez D, Shechner DM, Calabrese JM
bioRxiv : the preprint server for biology 2025 May 26;
bioRxiv : the preprint server for biology 2025 May 26;
Lactylation increases the stability of RBM15 to drives m6A modification in non-small-cell lung cancer cells.
Zhao Z, Zhang Z, Cai Q, Yang R, Liang H, Qian B, Xiao B, Jiang Y, Wang L, Wang X, Cai J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 31;39(6):e70493
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 31;39(6):e70493
RBM15 promotes m6A methylation and stability of KLF6 mRNA to accelerate pyroptosis of retinal ganglion cells in early-stage diabetic retinopathy.
Zhou L, Zhang C, Cheng Q, Ma M, Fan X, Han Y, Zha X, Zhang Y
Journal of molecular histology 2025 Jun 4;56(3):183
Journal of molecular histology 2025 Jun 4;56(3):183
Targeting METTL3 protein by proteolysis-targeting chimeras: A novel therapeutic approach for acute myeloid leukemia.
Nar R, Wu Z, Li Y, Smith A, Zhang Y, Wang J, Yu F, Gao S, Yu C, Huo Z, Zheng G, Qian Z
Genes & diseases 2025 Jul;12(4):101452
Genes & diseases 2025 Jul;12(4):101452
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I
Cell reports 2025 Jul 22;44(7):115826
Cell reports 2025 Jul 22;44(7):115826
Autoantibody hotspots reveal origin and impact of immunogenic XIST ribonucleoprotein complex.
Yan B, Lee J, Srinivasan S, Shi Q, Dou DR, Davuluri S, Nandyala S, Woods A, Leatherman G, Zhao Y, Reggiardo RE, Sawant M, Thiam HR, Shah AA, Fiorentino DF, Chung LS, Chang HY
bioRxiv : the preprint server for biology 2025 Jan 20;
bioRxiv : the preprint server for biology 2025 Jan 20;
Aberrant splicing in Huntington's disease accompanies disrupted TDP-43 activity and altered m6A RNA modification.
Nguyen TB, Miramontes R, Chillon-Marinas C, Maimon R, Vazquez-Sanchez S, Lau AL, McClure NR, Wu Z, Wang KQ, England WE, Singha M, Stocksdale JT, Heath M, Jang KH, Jung S, Ling K, Jafar-Nejad P, McKnight JI, Ho LN, Dalahmah OA, Faull RLM, Steffan JS, Reidling JC, Jang C, Lee G, Cleveland DW, Lagier-Tourenne C, Spitale RC, Thompson LM
Nature neuroscience 2025 Feb;28(2):280-292
Nature neuroscience 2025 Feb;28(2):280-292
GPR30 Inhibits Neuronal Apoptosis After Subarachnoid Hemorrhage by Activating the Wnt/β-Catenin Pathway in a m6A-dependent Manner.
Peng J, He J, Hu X, Xia Y
Molecular neurobiology 2025 Aug;62(8):9638-9650
Molecular neurobiology 2025 Aug;62(8):9638-9650
RBM15 enhances paclitaxel resistance in triple-negative breast cancer by targeting m(6)A methylation of TNFSF9 and inducing polarization of tumor-associated macrophages to M2 phenotype.
Fu J, Wei C, Chen Y, He X, Zhang K
Hereditas 2025 Aug 19;162(1):167
Hereditas 2025 Aug 19;162(1):167
RBM15 increase tumor-infiltrating CD4+ T cell in ESCC via modulating of PLOD3.
Lin X, Han X, Zhou W, Gong X, Zhou Y, Wang Q, Zhang C
American journal of cancer research 2024;14(11):5486-5503
American journal of cancer research 2024;14(11):5486-5503
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma.
Xu X, Wu S, Zhang Y, Fan W, Lin X, Chen K, Lin X
Molecular carcinogenesis 2024 Nov;63(11):2174-2189
Molecular carcinogenesis 2024 Nov;63(11):2174-2189
Overexpression of RBM15 modulated the effect of trophoblast cells by promoting the binding ability between YTHDF2 and the CD82 3'UTR to decrease the expression of CD82.
You G, Li Z, Li L, Xu C
Heliyon 2024 May 15;10(9):e30702
Heliyon 2024 May 15;10(9):e30702
XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.
Wang K, Bhattacharya A, Haratake N, Daimon T, Nakashoji A, Ozawa H, Peng B, Li W, Kufe D
Cell death & disease 2024 May 13;15(5):330
Cell death & disease 2024 May 13;15(5):330
N6-methyladenosine-modified CircPSMA7 enhances bladder cancer malignancy through the miR-128-3p/MAPK1 axis.
Yi J, Ma X, Ying Y, Liu Z, Tang Y, Shu X, Sun J, Wu Y, Lu D, Wang X, Luo J, Liu B, Zheng X, Lin Y, Li J, Xie L
Cancer letters 2024 Mar 31;585:216613
Cancer letters 2024 Mar 31;585:216613
Landscape of transcriptome-wide m(6)A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise.
Chen C, Jiang C, Lin T, Hu Y, Wu H, Xiang Q, Yang M, Wang S, Han X, Tao J
Acta physiologica (Oxford, England) 2024 Jun;240(6):e14154
Acta physiologica (Oxford, England) 2024 Jun;240(6):e14154
N6-Methyladenosine enhances the translation of ENO1 to promote the progression of bladder cancer by inhibiting PCNA ubiquitination.
Shen C, Liu J, Xie F, Yu Y, Ma X, Hu D, Liu C, Wang Y
Cancer letters 2024 Jul 28;595:217002
Cancer letters 2024 Jul 28;595:217002
BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.
Fan Y, Pan Y, Jia L, Gu S, Liu B, Mei Z, Lv C, Huang H, Zhu G, Deng Q
Cancer medicine 2024 Jan;13(1):e6811
Cancer medicine 2024 Jan;13(1):e6811
Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells.
Guo X, Qiu W, Wang C, Qi Y, Li B, Wang S, Zhao R, Cheng B, Han X, Du H, Gao Z, Pan Z, Zhao S, Li G, Xue H
Cancer research 2024 Feb 1;84(3):372-387
Cancer research 2024 Feb 1;84(3):372-387
High expression of RBM15 is associated with better prognosis in esophageal squamous cell carcinoma.
Liu Y, Pu Y, Kuang X, Jiang Y, Liu J, Dai N, Li M, Li K, Xu M
Journal of gastrointestinal oncology 2024 Dec 31;15(6):2400-2412
Journal of gastrointestinal oncology 2024 Dec 31;15(6):2400-2412
RBM15 drives the progression of lung adenocarcinoma by regulating N6-methyladenosine-mediated LDHA mRNA stability.
Shi S, Wang C, Cai Q, Yang R, Peng M, Liang H, Qian B, Jiang Y, Xiao B, Wang L, Tao Y, Cai J, Zhao Z
Life sciences 2024 Dec 1;358:123146
Life sciences 2024 Dec 1;358:123146
Identification of RBM15 as a prognostic biomarker in prostate cancer involving the regulation of prognostic m6A-related lncRNAs.
Hu B, Lin D, Liu Z, Chen R, Liu J, Wu Y, Wang T
European journal of medical research 2024 Aug 8;29(1):411
European journal of medical research 2024 Aug 8;29(1):411
Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer.
Ying Y, Wu Y, Zhang F, Tang Y, Yi J, Ma X, Li J, Chen D, Wang X, Liu X, Liu B, Luo J, Zheng X, Xie L
Molecular cancer 2024 Apr 24;23(1):79
Molecular cancer 2024 Apr 24;23(1):79
Comprehensive analyses of m6A RNA methylation patterns and related immune microenvironment in idiopathic pulmonary arterial hypertension.
Gao G, Chen A, Gong J, Lin W, Wu W, Mohammad Ismail Hajary S, Lian G, Luo L, Xie L
Frontiers in genetics 2023;14:1222368
Frontiers in genetics 2023;14:1222368
RNA methylation pattern and immune microenvironment characteristics mediated by m6A regulator in ischemic stroke.
Jia K, Xia W, Su Q, Yang S, Zhang Y, Ni X, Su Z, Meng D
Frontiers in genetics 2023;14:1148510
Frontiers in genetics 2023;14:1148510
RBFOX2 recognizes N(6)-methyladenosine to suppress transcription and block myeloid leukaemia differentiation.
Dou X, Xiao Y, Shen C, Wang K, Wu T, Liu C, Li Y, Yu X, Liu J, Dai Q, Pajdzik K, Ye C, Ge R, Gao B, Yu J, Sun S, Chen M, Chen J, He C
Nature cell biology 2023 Sep;25(9):1359-1368
Nature cell biology 2023 Sep;25(9):1359-1368
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
Yu Z, Zheng L, Geng Y, Zhang Y, Wang Y, You G, Cai M, Li M, Cheng X, Zan J
Cellular signalling 2023 Sep;109:110751
Cellular signalling 2023 Sep;109:110751
RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.
Yuan J, Guan W, Li X, Wang F, Liu H, Xu G
International journal of oncology 2023 Oct;63(4)
International journal of oncology 2023 Oct;63(4)
CSTF2 mediated mRNA N(6)-methyladenosine modification drives pancreatic ductal adenocarcinoma m(6)A subtypes.
Zheng Y, Li X, Deng S, Zhao H, Ye Y, Zhang S, Huang X, Bai R, Zhuang L, Zhou Q, Li M, Su J, Li R, Bao X, Zeng L, Chen R, Zheng J, Lin D, He C, Zhang J, Zuo Z
Nature communications 2023 Oct 10;14(1):6334
Nature communications 2023 Oct 10;14(1):6334
Identification of osteosarcoma m6A-related prognostic biomarkers using artificial intelligence: RBM15.
Jiang J, Qu H, Zhan X, Liu D, Liang T, Chen L, Huang S, Sun X, Chen J, Chen T, Li H, Yao Y, Liu C
Scientific reports 2023 Mar 31;13(1):5255
Scientific reports 2023 Mar 31;13(1):5255
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4.
Fang J, Wu X, He J, Zhang H, Chen X, Zhang H, Novakovic B, Qi H, Yu X
Molecular medicine (Cambridge, Mass.) 2023 Feb 20;29(1):23
Molecular medicine (Cambridge, Mass.) 2023 Feb 20;29(1):23
A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.
Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui XL, Zou Z, Yue Z, Emch MJ, Hawse JR, Wang L, He HH, Xia S, Han B, He C, Huang H
Molecular cell 2023 Aug 3;83(15):2692-2708.e7
Molecular cell 2023 Aug 3;83(15):2692-2708.e7
m6A Regulatory Gene-Mediated Methylation Modification in Glioma Survival Prediction.
Zhang G, Zheng P, Lv Y, Shi Z, Shi F
Frontiers in genetics 2022;13:873764
Frontiers in genetics 2022;13:873764
Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.
Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131
Discover oncology 2022 Nov 25;13(1):131
Analysis and identification of m(6)A RNA methylation regulators in metastatic osteosarcoma.
Huang H, Cui X, Qin X, Li K, Yan G, Lu D, Zheng M, Hu Z, Lei D, Lan N, Zheng L, Yuan Z, Zhu B, Zhao J
Molecular therapy. Nucleic acids 2022 Mar 8;27:577-592
Molecular therapy. Nucleic acids 2022 Mar 8;27:577-592
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.
N'Da Konan S, Ségéral E, Bejjani F, Bendoumou M, Ait Said M, Gallois-Montbrun S, Emiliani S
Retrovirology 2022 Jan 31;19(1):4
Retrovirology 2022 Jan 31;19(1):4
Cross talk between RNA modification writers and tumor development as a basis for guiding personalized therapy of gastric cancer.
Zhang S, Kuang G, Huang Y, Huang X, Wang W, Wang G
Human genomics 2022 Apr 22;16(1):14
Human genomics 2022 Apr 22;16(1):14
Methylation and Expression of the Exercise-Related TLR1 Gene Is Associated With Low Grade Glioma Prognosis and Outcome.
Lu L, Hu Y, Wang C, Jiang F, Wu C
Frontiers in molecular biosciences 2021;8:747933
Frontiers in molecular biosciences 2021;8:747933
mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.
Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I
Molecular cell 2021 May 20;81(10):2076-2093.e9
Molecular cell 2021 May 20;81(10):2076-2093.e9
METTL3 regulates heterochromatin in mouse embryonic stem cells.
Xu W, Li J, He C, Wen J, Ma H, Rong B, Diao J, Wang L, Wang J, Wu F, Tan L, Shi YG, Shi Y, Shen H
Nature 2021 Mar;591(7849):317-321
Nature 2021 Mar;591(7849):317-321
N(6)-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.
Wang X, Liu C, Zhang S, Yan H, Zhang L, Jiang A, Liu Y, Feng Y, Li D, Guo Y, Hu X, Lin Y, Bu P, Li D
Developmental cell 2021 Mar 8;56(5):702-715.e8
Developmental cell 2021 Mar 8;56(5):702-715.e8
Integrated analysis of m(6)A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.
Zeng Y, Huang T, Zuo W, Wang D, Xie Y, Wang X, Xiao Z, Chen Z, Liu Q, Liu N, Xiao Y
Aging 2021 Jul 26;13(14):18238-18256
Aging 2021 Jul 26;13(14):18238-18256
RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent.
Wang X, Tian L, Li Y, Wang J, Yan B, Yang L, Li Q, Zhao R, Liu M, Wang P, Sun Y
Journal of experimental & clinical cancer research : CR 2021 Feb 26;40(1):80
Journal of experimental & clinical cancer research : CR 2021 Feb 26;40(1):80
The role of the Xist 5' m6A region and RBM15 in X chromosome inactivation.
Coker H, Wei G, Moindrot B, Mohammed S, Nesterova T, Brockdorff N
Wellcome open research 2020;5:31
Wellcome open research 2020;5:31
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
RBM15 Modulates the Function of Chromatin Remodeling Factor BAF155 Through RNA Methylation in Developing Cortex.
Xie Y, Castro-Hernández R, Sokpor G, Pham L, Narayanan R, Rosenbusch J, Staiger JF, Tuoc T
Molecular neurobiology 2019 Nov;56(11):7305-7320
Molecular neurobiology 2019 Nov;56(11):7305-7320
Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.
Jin S, Su H, Tran NT, Song J, Lu SS, Li Y, Huang S, Abdel-Wahab O, Liu Y, Zhao X
PloS one 2017;12(5):e0175523
PloS one 2017;12(5):e0175523
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
Zhang L, Tran NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, Laha S, Abdel-Wahab O, Levine RL, Raffel G, Liu Y, Chen D, Li H, Townes T, Wang H, Deng H, Zheng YG, Leslie C, Luo M, Zhao X
eLife 2015 Nov 17;4
eLife 2015 Nov 17;4
A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.
Moindrot B, Cerase A, Coker H, Masui O, Grijzenhout A, Pintacuda G, Schermelleh L, Nesterova TB, Brockdorff N
Cell reports 2015 Jul 28;12(4):562-72
Cell reports 2015 Jul 28;12(4):562-72
Multiple regions of Kaposi's sarcoma-associated herpesvirus ORF59 RNA are required for its expression mediated by viral ORF57 and cellular RBM15.
Massimelli MJ, Majerciak V, Kang JG, Liewehr DJ, Steinberg SM, Zheng ZM
Viruses 2015 Feb 3;7(2):496-510
Viruses 2015 Feb 3;7(2):496-510
Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi sarcoma-associated herpesvirus ORF57 protein is required for RNA splicing.
Majerciak V, Lu M, Li X, Zheng ZM
RNA (New York, N.Y.) 2014 Nov;20(11):1747-58
RNA (New York, N.Y.) 2014 Nov;20(11):1747-58
Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.
Lee JH, Skalnik DG
PloS one 2012;7(8):e42965
PloS one 2012;7(8):e42965
Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.
Majerciak V, Uranishi H, Kruhlak M, Pilkington GR, Massimelli MJ, Bear J, Pavlakis GN, Felber BK, Zheng ZM
Journal of virology 2011 Feb;85(4):1528-40
Journal of virology 2011 Feb;85(4):1528-40
Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57.
Majerciak V, Deng M, Zheng ZM
Virology 2010 Nov 25;407(2):206-12
Virology 2010 Nov 25;407(2):206-12
The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
Uranishi H, Zolotukhin AS, Lindtner S, Warming S, Zhang GM, Bear J, Copeland NG, Jenkins NA, Pavlakis GN, Felber BK
The Journal of biological chemistry 2009 Sep 18;284(38):26106-16
The Journal of biological chemistry 2009 Sep 18;284(38):26106-16
Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA.
Zolotukhin AS, Uranishi H, Lindtner S, Bear J, Pavlakis GN, Felber BK
Nucleic acids research 2009 Nov;37(21):7151-62
Nucleic acids research 2009 Nov;37(21):7151-62
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10587-1-AP(RBM15 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunofluorescent analysis of HepG2 cells, using RBM15 antibody 10587-1-AP at 1:100 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10587-1-AP(RBM15 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue