66059-1-Ig

antibody from Proteintech Group

Targeting: RBM15 OTT, OTT1

Provider product page for 66059-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [12]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 66059-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#66059-1-Ig, RRID:AB_11042326
Product name: RBM15 antibody
Antibody type: Monoclonal
Description: KD/KO validated RBM15 antibody (Cat. #66059-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 4A1A4
Vial size: 20ul, 150ul

RBM15 protein structure - 66059-1-Ig shown in red.

Submitted references RNA-binding motif protein 15 promotes gastric cancer growth and drug resistance via USP10-mediated deubiquitination and stabilization of nuclear NRF2.

Ma Z, Xu Z, Xu J, Chen C, Niu W, Wang Y, Qian Y, Zhang X, Yang M, Stefan SM, Gan L, Wang S, Wang B
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 May;86:101376

RBM15/YTHDF2-mediated m6A modification of HTR1D exacerbates hypoxia-induced dysfunction in trophoblast cells in preeclampsia.

Yu B, Gong H, Zhang S, Zhao M, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):1079-1090

Cuproptosis- and m6A-related lncRNA prognostic signature for breast cancer, in which Z68871.1 contributes to triple-negative breast cancer progression.

Zhang Z, Gao Z, Huang Q, Ling Z, Zhang L, Li M, Xu Y, Liu M
International journal of biological macromolecules 2025 Sep;321(Pt 2):146321

RBM15 mediates m6A methylation modification of FOSB mRNA to promote dysfunction of trophoblast cells-a potential link to preeclampsia.

Li Y, Li F, Gao Q
Hereditas 2025 Nov 21;162(1):241

M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC.

Zhi Y, Liu S, Chang X, Guan W, Li R, Liu Q, Chen J, Ling J, Zhao X, Liu A, Chen J, Zhang X, Huang Y
Cancer control : journal of the Moffitt Cancer Center 2025 Jan-Dec;32:10732748251342685

RBM15 facilitates osimertinib resistance of lung adenocarcinoma through m6A-dependent epigenetic silencing of SPOCK1.

Li H, Li Y, Zheng X, Chen F, Zhang S, Xu S, Mu Y, Shen W, Tong J, Chen H, Hu Z, Zhang J, Qiu K, Chen W, Cheng X, Xu G
Oncogene 2025 Feb;44(5):307-321

A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4.

Yong Y, Yan L, Wei J, Feng C, Yu L, Wu J, Guo M, Fan D, Yu C, Qin D, Zhou X, Wu A
Theranostics 2024;14(16):6161-6184

The m(6)A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism.

Park SH, Ju JS, Woo H, Yun HJ, Lee SB, Kim SH, Győrffy B, Kim EJ, Kim H, Han HD, Eyun SI, Lee JH, Park YY
Experimental & molecular medicine 2024 Jun;56(6):1373-1387

The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.

Li Y, Zhang X, Cai J, Ren L, Liu B, Wu M, Lu W, Li R, Zhang C, Huang C, Tong J, Liu A, Zheng Y, Ren D, Guo Y, Huang Y
The journal of gene medicine 2022 Feb;24(2):e3397

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages.

Guo Y, Liu Y, Zhao S, Xu W, Li Y, Zhao P, Wang D, Cheng H, Ke Y, Zhang X
Nature communications 2021 Dec 7;12(1):7094

The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.

Tran NT, Su H, Khodadadi-Jamayran A, Lin S, Zhang L, Zhou D, Pawlik KM, Townes TM, Chen Y, Mulloy JC, Zhao X
EMBO reports 2016 Jun;17(6):887-900

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

Zhang L, Tran NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, Laha S, Abdel-Wahab O, Levine RL, Raffel G, Liu Y, Chen D, Li H, Townes T, Wang H, Deng H, Zheng YG, Leslie C, Luo M, Zhao X
eLife 2015 Nov 17;4

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 66059-1-Ig(RBM15 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using RBM15 antibody 66059-1-lg at 1:25 dilution and Rhodamine-labeled goat anti-mouse IgG (red).
Sample type: cell line