CABT-B9980
antibody from Creative Diagnostics
Targeting: CLCF1
BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6
Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B9980 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Human CLCF1 monoclonal antibody, clone 8F21
- Antibody type
- Monoclonal
- Description
- This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgM
- Antibody clone number
- 8F21
- Vial size
- 200 _l
- Storage
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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