ATP1B4

This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Description

ATPase Na+/K+ transporting family member beta 4

Tissue specificity

Group enriched (skeletal muscle, tongue)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

X (120362085 - 120383249)

Ensembl ID

ENSG00000101892  (ver. 103.38)

Orthologs

Mouse Atp1b4: ENSMUSG00000016327

UniProt

Q9UN42

neXtProt

NX_Q9UN42

Human splice variants
Mouse splice variants

Protein structure