Antibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11147-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11147-2-AP, RRID:AB_2254450
- Product name
- SEC61G antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SEC61G antibody (Cat. #11147-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis.
SEC61 translocon subunit gamma enhances low-dose cisplatin-induced cancer-stem cell properties of head and neck squamous cell carcinoma via enhancing Ca(2+)-mediated autophagy.
Identification of SEC61G as a Diagnostic and Prognostic Biomarker in Oral Squamous Cell Carcinoma.
Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.
Increased response to TPF chemotherapy promotes immune escape in hypopharyngeal squamous cell carcinoma.
Mechanism of an intramembrane chaperone for multipass membrane proteins.
SEC61G participates in endoplasmic reticulum stress by interacting with CREB3 to promote the malignant progression of lung adenocarcinoma.
High SEC61G expression predicts poor prognosis in patients with Head and Neck Squamous Cell Carcinomas.
Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.
SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.
SEC61G is upregulated and required for tumor progression in human kidney cancer.
Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes.
A scalable strategy for high-throughput GFP tagging of endogenous human proteins.
The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells.
An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.
The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells.
Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.
Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress.
Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer.
Yuan S, Liu J, Yang L, Zhang X, Zhuang K, He S
Journal of bioenergetics and biomembranes 2024 Jun;56(3):261-271
Journal of bioenergetics and biomembranes 2024 Jun;56(3):261-271
SEC61 translocon subunit gamma enhances low-dose cisplatin-induced cancer-stem cell properties of head and neck squamous cell carcinoma via enhancing Ca(2+)-mediated autophagy.
Bu X, Zhang J, Sun H, Wang W, Ma X, Sun L
Journal of dental sciences 2023 Oct;18(4):1685-1692
Journal of dental sciences 2023 Oct;18(4):1685-1692
Identification of SEC61G as a Diagnostic and Prognostic Biomarker in Oral Squamous Cell Carcinoma.
Zhang SL, Chen L, Bu LL, Yu ZL, Ma SR
Biomedicines 2023 Oct 6;11(10)
Biomedicines 2023 Oct 6;11(10)
Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.
Xu S, Li X, Geng J, Cao Y, Yu Y, Qi L
British journal of cancer 2023 Apr;128(8):1478-1490
British journal of cancer 2023 Apr;128(8):1478-1490
Increased response to TPF chemotherapy promotes immune escape in hypopharyngeal squamous cell carcinoma.
Li R, Yan L, Tian S, Zhao Y, Zhu Y, Wang X
Frontiers in pharmacology 2022;13:1097197
Frontiers in pharmacology 2022;13:1097197
Mechanism of an intramembrane chaperone for multipass membrane proteins.
Smalinskaitė L, Kim MK, Lewis AJO, Keenan RJ, Hegde RS
Nature 2022 Nov;611(7934):161-166
Nature 2022 Nov;611(7934):161-166
SEC61G participates in endoplasmic reticulum stress by interacting with CREB3 to promote the malignant progression of lung adenocarcinoma.
Zhang Q, Guo Z
Oncology letters 2022 Jul;24(1):233
Oncology letters 2022 Jul;24(1):233
High SEC61G expression predicts poor prognosis in patients with Head and Neck Squamous Cell Carcinomas.
Liang L, Huang Q, Gan M, Jiang L, Yan H, Lin Z, Zhu H, Wang R, Hu K
Journal of Cancer 2021;12(13):3887-3899
Journal of Cancer 2021;12(13):3887-3899
Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.
Zheng Q, Wang Z, Zhang M, Yu Y, Chen R, Lu T, Liu L, Ma J, Liu T, Zheng H, Li H, Li J
BMC cancer 2021 Nov 13;21(1):1216
BMC cancer 2021 Nov 13;21(1):1216
SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.
Ma J, He Z, Zhang H, Zhang W, Gao S, Ni X
Cell death & disease 2021 May 27;12(6):550
Cell death & disease 2021 May 27;12(6):550
SEC61G is upregulated and required for tumor progression in human kidney cancer.
Meng H, Jiang X, Wang J, Sang Z, Guo L, Yin G, Wang Y
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes.
Byts N, Sharma S, Laurila J, Paudel P, Miinalainen I, Ronkainen VP, Hinttala R, Törnquist K, Koivunen P, Myllyharju J
eNeuro 2021 Jan-Feb;8(1)
eNeuro 2021 Jan-Feb;8(1)
A scalable strategy for high-throughput GFP tagging of endogenous human proteins.
Leonetti MD, Sekine S, Kamiyama D, Weissman JS, Huang B
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 21;113(25):E3501-8
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 21;113(25):E3501-8
The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells.
Zehner M, Marschall AL, Bos E, Schloetel JG, Kreer C, Fehrenschild D, Limmer A, Ossendorp F, Lang T, Koster AJ, Dübel S, Burgdorf S
Immunity 2015 May 19;42(5):850-63
Immunity 2015 May 19;42(5):850-63
An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.
Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J
eLife 2014;3:e01483
eLife 2014;3:e01483
The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells.
Johnson GG, White MC, Wu JH, Vallejo M, Grimaldi M
Neuro-oncology 2014 Aug;16(8):1086-99
Neuro-oncology 2014 Aug;16(8):1086-99
Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.
Saito K, Dubreuil V, Arai Y, Wilsch-Bräuninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB
Proceedings of the National Academy of Sciences of the United States of America 2009 May 19;106(20):8350-5
Proceedings of the National Academy of Sciences of the United States of America 2009 May 19;106(20):8350-5
Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress.
Lu Z, Zhou L, Killela P, Rasheed AB, Di C, Poe WE, McLendon RE, Bigner DD, Nicchitta C, Yan H
Cancer research 2009 Dec 1;69(23):9105-11
Cancer research 2009 Dec 1;69(23):9105-11
Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer.
Tsukamoto Y, Uchida T, Karnan S, Noguchi T, Nguyen LT, Tanigawa M, Takeuchi I, Matsuura K, Hijiya N, Nakada C, Kishida T, Kawahara K, Ito H, Murakami K, Fujioka T, Seto M, Moriyama M
The Journal of pathology 2008 Dec;216(4):471-82
The Journal of pathology 2008 Dec;216(4):471-82
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 11147-2-AP(SEC61G antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SEC61G antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SEC61G. This antibody recognizes human, mouse, rat antigen. The SEC61G antibody has been validated for the following applications: ELISA, WB, IHC analysis.