46-1149-42

antibody from Invitrogen Antibodies
Targeting: CSF3R CD114, GCSFR
Provider product page for 46-1149-42

Antibody data

Product number
46-1149-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD114 (G-CSFR) Monoclonal Antibody (LMM741), PerCP-eFluor™ 710, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This LMM741 monoclonal antibody reacts with human CD114, which is also known as granulocyte colony-stimulating factor receptor (G-CSFR). A type I hematopoietin cytokine receptor, CD114 is expressed on granulocytes such as neutrophils, myeloid cells, monocytes, and leukemic cells. This receptor is absent from lymphocytes, erythrocytes, and eosinophils. CD114 can also be detected on non-hematopoietic cells, including neurons, endothelial cells, and cardiomyocytes. Studies demonstrate that expression of CD114 can be downregulated by LPS, TNF, phorbol ester, and G-CSF itself. Binding of G-CSF binding induces homodimerization of the receptor that activates signaling transduction (e.g., the JAK/STAT and Erk1/2 pathways) to mediate cell proliferation, survival, and differentiation.
Antibody clone number
LMM741
Concentration
5 µL/Test
CSF3R protein structure - 46-1149-42 shown in red.