RA0161

antibody from Oursmab

Targeting: CSF3R CD114, GCSFR

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0161

Provider

Oursmab

Product name

Anumigilimab (Biosimilar Reference Antibody) (CSF3R)

Antibody type

Monoclonal

Description

Anumigilimab (CSL-324) is a fully human monoclonal antibody of the IgG4 isotype that functions as an antagonist targeting the Granulocyte Colony-Stimulating Factor Receptor (G-CSFR). By blocking this receptor, Anumigilimab inhibits the signaling pathway triggered by its ligand, G-CSF. This action is designed to reduce G-CSF-mediated neutrophilia and neutrophil infiltration into inflamed tissues without causing systemic neutropenia (a deficiency in neutrophils). The IgG4 isotype minimizes the risk of target cell depletion via effector functions. Anumigilimab has been investigated as a therapeutic agent for various chronic inflammatory and autoimmune diseases characterized by excessive neutrophil activity and G-CSF dysregulation, such as Hidradenitis Suppurativa.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Anumigilimab (Biosimilar Reference Antibody) (CSF3R)-RA0161-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Anumigilimab (Biosimilar Reference Antibody) (CSF3R)-RA0161 in a linear range of 3.91-125 ng/mL.