19430-1-AP

antibody from Proteintech Group

Targeting: HUWE1 Ib772, KIAA0312, UREB1

Provider product page for 19430-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [19]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 19430-1-AP - Provider product page
Provider: Proteintech Group
Product name: HUWE1 antibody
Antibody type: Polyclonal
Description: KD/KO validated HUWE1 antibody (Cat. #19430-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HUWE1 protein structure - 19430-1-AP shown in red.

Submitted references Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination.

Guo X, Lin Y, Jiang Y, Wang M, Li Y, Gao Y, Chen B, Bao Z, Tian H, Chu X, Zhang Z, Shao J, Zhang F, Wang H, Xuan J, Xu X, Zheng S
International journal of biological sciences 2026;22(3):1648-1673

UFL1-mediated UFMylation antagonizes IFT88 ubiquitination and degradation to maintain ciliary homeostasis.

Wang R, Guo G, Zhang R, Li L, Gong Y, Yin L, Li S, Wei C, Zhou J, Liu M, Ran J
Cell death and differentiation 2026 May;33(5):1065-1080

Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

Le BV, Vekariya U, Toma MM, Nieborowska-Skorska M, Caron MC, Gozdecka M, Haydar Z, Walsh M, Ghosh J, Vaughan-Williams E, Podszywalow-Bartnicka P, Kukuyan AM, Ziolkowska S, Atkins J, Hadzijusufovic E, Chandramouly G, Nejati R, Piwocka K, Pomerantz R, Vassiliou GS, Huntly BJP, Valent P, Wasik M, Bellacosa A, Masson JY, Gupta GP, Challen GA, Skorski T
Cell reports. Medicine 2026 Mar 17;7(3):102687

REEP1 Accumulation Disrupts ER Integrity and Drives Spinal Motoneuron Degeneration in Distal Hereditary Motor Neuropathy.

Bock A, Schurig M, Willoughby M, Mirecki A, Seemann E, Lohachova K, Katona I, Mittag S, Liebmann L, Franzka P, Heidari Horestani M, Khundadze M, Mosler T, Louie T, de Visser M, Weterman MAJ, Kiehntopf M, Beetz C, Nietzsche S, Huber O, Weis J, Kessels MM, Bhaskara RM, Qualmann B, Đikić I, Hübner CA
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e11483

Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling.

Wierbiłowicz K, Yang CS, Almaghasilah A, Wesołowski PA, Pracht P, Dworak NM, Masur J, Wijngaarden S, Filippov DV, Wales DJ, Kelley JB, Ratan A, Paschal BM
The EMBO journal 2025 Sep;44(17):4720-4744

DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase.

Xiong X, Chen X, Shao S, Cui D, Qu R, Wang B, Ma Y, Pan H, Sun Y, Zhao Y
Cell death and differentiation 2025 Oct;32(10):1820-1832

Role of EZH2 in regulating c-Myc stability through the E3 ubiquitin ligase HUWE1 in heart failure and its mechanisms.

Yan L, Xie D, Huang T, Zheng H, Huang J, Chen H, Xie Q, Weng G, Zheng F
Cellular signalling 2025 Nov;135:111968

Sphingosine kinase 2 regulates protein ubiquitination networks in neurons.

Diaz Escarcega R, Murambadoro K, Valencia R, Moruno-Manchon JF, Furr Stimming EE, Jung SY, Tsvetkov AS
Molecular and cellular neurosciences 2024 Sep;130:103948

DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells.

Le BV, Vekariya U, Toma MM, Nieborowska-Skorska M, Caron MC, Gozdecka M, Haydar Z, Walsh M, Ghosh J, Vaughan-Williams E, Podszywalow-Bartnicka P, Kukuyan AM, Ziolkowska S, Hadzijusufovic E, Chandramouly G, Piwocka K, Pomerantz R, Vassiliou GS, Huntly BJ, Valent P, Bellacosa A, Masson JY, Gupta GP, Challen GA, Skorski T
bioRxiv : the preprint server for biology 2024 Sep 19;

Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.

Han T, Wang Y, Cheng M, Hu Q, Wan X, Huang M, Liu Y, Xun W, Xu J, Wang L, Luo R, Yuan Y, Wang K, Wang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307834

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.

Dai W, Tian R, Yu L, Bian S, Chen Y, Yin B, Luan Y, Chen S, Fan Z, Yan R, Pan X, Hou Y, Li R, Chen J, Shu M
Nature communications 2024 Jan 2;15(1):131

DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.

Xu Y, Liu X, Zeng W, Zhu Y, Dong J, Wu F, Chen C, Sharma S, Lin Y
Life science alliance 2024 Feb;7(2)

The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair.

Wilson P, Abdelmoti L, Norcross R, Jang ER, Palayam M, Galperin E
Journal of cell science 2021 Nov 1;134(21)

WNK1 is an assembly factor for the human ER membrane protein complex.

Pleiner T, Hazu M, Tomaleri GP, Januszyk K, Oania RS, Sweredoski MJ, Moradian A, Guna A, Voorhees RM
Molecular cell 2021 Jul 1;81(13):2693-2704.e12

Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.

Cao P, Yang A, Li P, Xia X, Han Y, Zhou G, Wang R, Yang F, Li Y, Zhang Y, Cui Y, Ji H, Lu L, He F, Zhou G
Science advances 2021 Aug;7(35)

NEDD4L-mediated LTF protein degradation limits ferroptosis.

Wang Y, Liu Y, Liu J, Kang R, Tang D
Biochemical and biophysical research communications 2020 Oct 22;531(4):581-587

HUWE1 promotes EGFR ubiquitination and degradation to protect against renal tubulointerstitial fibrosis.

Zhu Q, Dong H, Bukhari AA, Zhao A, Li M, Sun Y, Zhang X, Cao C, Su D, Liang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4591-4601

Ubiquitination and inhibition of glycine receptor by HUWE1 in spinal cord dorsal horn.

Zhang ZY, Guo Z, Li HL, He YT, Duan XL, Suo ZW, Yang X, Hu XD
Neuropharmacology 2019 Apr;148:358-365

Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC.

You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, Huang Y, Li M, Qu S, Sun F, Liang X
Journal of cell science 2017 Mar 15;130(6):1027-1036

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: WB result of HUWE1 antibody (19430-1-AP, 1:1000) with 293 cells by Dr. Emilia Galperin, University of Kentucky.
Other comments: WB
Appendix: 19430-1-AP.pdf

: Show more