HPA002548

antibody from Atlas Antibodies

Targeting: HUWE1 Ib772, KIAA0312, UREB1

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA002548

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA002548, RRID:AB_1080489

Product name

Anti-HUWE1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human HUWE1, Gene description: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, Alternative Gene Names: Ib772, KIAA0312, UREB1, Validated applications: ICC, IHC, Uniprot ID: Q7Z6Z7, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.1 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression

Yuan Y, Wang L, Zhao X, Wang J, Zhang M, Ma Q, Wei S, Yan Z, Cheng Y, Chen X, Zou H, Ge J, Wang Y, Zhang X, Cui Y, Luo T, Bian X
Cancer Communications 2022;42(9):868-886

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The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma

Crawford L, Campbell D, Morgan J, Lawson M, Down J, Chauhan D, McAvera R, Morris T, Hamilton C, Krishnan A, Rajalingam K, Chantry A, Irvine A
Oncogene 2020;39(27):5001-5014

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Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

Lee H, Li C, Ruan D, He J, Montal E, Lorenz S, Girnun G, Chan C
Nature Communications 2019;10(1)