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- Antigen structure
- References [16]
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- Product number
- 66302-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- CHCHD2 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated CHCHD2 antibody (Cat. #66302-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2G1G10
- Vial size
- 20ul, 150ul
Submitted references A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
Age-Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics.
Clinical, neuropathological, and biochemical characterization of ALS in a large CHCHD10 R15L family.
CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology.
Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.
Alterations in coenzyme Q(10) status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis.
CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism.
A nucleolar long "non-coding" RNA encodes a novel protein that functions in response to stress.
The CHCHD2/Sirt1 corepressors involve in G9a-mediated regulation of RNase H1 expression to control R-loop.
Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10.
Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.
Thayer JA, Petersen JD, Huang X, Gruel Budet LM, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
The EMBO journal 2026 Jan;45(1):64-105
The EMBO journal 2026 Jan;45(1):64-105
Age-Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics.
Guzman SD, Fraczek PM, Itsani K, Furati EK, Juros D, Kenney G, Valdez G, Chakkalakal JV, Aguilar CA
Aging cell 2026 Jan;25(1):e70355
Aging cell 2026 Jan;25(1):e70355
Clinical, neuropathological, and biochemical characterization of ALS in a large CHCHD10 R15L family.
Kwan JY, Lantz CI, Korobeynikov VA, Snyder A, Huang X, Haselhuhn T, Dore KN, Madruga A, Danielian LE, Schindler AB, Chia R, Rasheed M, Crook J, Szabo M, Portley M, Sherer CM, King MC, Huang TH, Kosa P, Bielekova B, Ward ME, Grunseich C, Shneider NA, Traynor BJ, Narendra DP
medRxiv : the preprint server for health sciences 2025 Sep 26;
medRxiv : the preprint server for health sciences 2025 Sep 26;
CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology.
Liao SC, Kano K, Phanse S, Nguyen M, Margolis E, Fu Y, X Meng J, Moutaoufik MT, Chatterton Z, Saccon T, Broderick K, Aoki H, Simms J, Suteja FX, Sei Y, Huang EJ, McAvoy K, Manfredi G, Halliday G, Babu M, Nakamura K
Science advances 2025 Nov 14;11(46):eadu0726
Science advances 2025 Nov 14;11(46):eadu0726
Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.
Thayer JA, Petersen JD, Huang X, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
bioRxiv : the preprint server for biology 2025 Feb 20;
bioRxiv : the preprint server for biology 2025 Feb 20;
Alterations in coenzyme Q(10) status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis.
Yen HC, Hsu CT, Wu SY, Kan CC, Chang CW, Chang HM, Chien YA, Wei YH, Wu CY
Biochimica et biophysica acta. Bioenergetics 2024 Nov 1;1865(4):149492
Biochimica et biophysica acta. Bioenergetics 2024 Nov 1;1865(4):149492
CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism.
Liao SC, Kano K, Phanse S, Nguyen M, Margolis E, Fu Y, Meng J, Moutaoufik MT, Chatterton Z, Aoki H, Simms J, Hsieh I, Suteja F, Sei Y, Huang EJ, McAvoy K, Manfredi G, Halliday G, Babu M, Nakamura K
bioRxiv : the preprint server for biology 2024 Aug 31;
bioRxiv : the preprint server for biology 2024 Aug 31;
A nucleolar long "non-coding" RNA encodes a novel protein that functions in response to stress.
Feng S, Desotell A, Ross A, Jovanovic M, Manley JL
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 28;120(9):e2221109120
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 28;120(9):e2221109120
The CHCHD2/Sirt1 corepressors involve in G9a-mediated regulation of RNase H1 expression to control R-loop.
Li L, Wu Y, Dai K, Wang Q, Ye S, Shi Q, Chen Z, Huang YC, Zhao W, Li L
Cell insight 2023 Aug;2(4):100112
Cell insight 2023 Aug;2(4):100112
Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.
Nguyen MK, McAvoy K, Liao SC, Doric Z, Lo I, Li H, Manfredi G, Nakamura K
Human molecular genetics 2022 May 4;31(9):1500-1518
Human molecular genetics 2022 May 4;31(9):1500-1518
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Houston R, Sekine Y, Larsen MB, Murakami K, Mullett SJ, Wendell SG, Narendra DP, Chen BB, Sekine S
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.
Liu X, Wang Q, Yang Y, Stewart T, Shi M, Soltys D, Liu G, Thorland E, Cilento EM, Hou Y, Liu Z, Feng T, Zhang J
Acta neuropathologica communications 2021 Mar 8;9(1):37
Acta neuropathologica communications 2021 Mar 8;9(1):37
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Liu YT, Huang X, Nguyen D, Shammas MK, Wu BP, Dombi E, Springer DA, Poulton J, Sekine S, Narendra DP
Human molecular genetics 2020 Jun 3;29(9):1547-1567
Human molecular genetics 2020 Jun 3;29(9):1547-1567
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Aras S, Purandare N, Gladyck S, Somayajulu-Nitu M, Zhang K, Wallace DC, Grossman LI
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10.
Huang X, Wu BP, Nguyen D, Liu YT, Marani M, Hench J, Bénit P, Kozjak-Pavlovic V, Rustin P, Frank S, Narendra DP
Human molecular genetics 2018 Nov 15;27(22):3881-3900
Human molecular genetics 2018 Nov 15;27(22):3881-3900
Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.
Straub IR, Janer A, Weraarpachai W, Zinman L, Robertson J, Rogaeva E, Shoubridge EA
Human molecular genetics 2018 Jan 1;27(1):178-189
Human molecular genetics 2018 Jan 1;27(1):178-189
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