12690-1-AP

antibody from Proteintech Group

Targeting: MOG BTN6, BTNL11

Provider product page for 12690-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
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Validations
Western blot [1]

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Product number: 12690-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12690-1-AP, RRID:AB_2145527
Product name: MOG antibody
Antibody type: Polyclonal
Description: MOG antibody (Cat. #12690-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MOG protein structure - 12690-1-AP shown in red.

Submitted references Understanding Glioblastoma Dynamics Using 3D Organoids and Engineered Extracellular Matrix.

McManis A, Jimenez CA, Shirolkar A, Raza Ur Rehman S, Mallick S, Murphy M, Gaharwar AK, Singh I
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(24):e22926

Understanding proneural-mesenchymal transition using patient-derived glioma stem-like cell (GSC) organoids and engineered extracellular matrix.

McManis A, Jimenez CA, Shirolkar A, Rehman SRU, Mallick S, Murphy M, Gaharwar AK, Singh I
bioRxiv : the preprint server for biology 2025 Sep 20;

Acute Particulate Matter (PM(10)) Exposure Selectively Triggers Behavioral Alterations in the Presymptomatic Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model of Multiple Sclerosis.

Bonato M, Montarolo F, Parolisi R, Caudana M, Abbadessa G, Cardinale V, Nato G, Pandino C, Di Cintio N, Schiavo V, Giustetto M, Luzzati F, De Francia S, Bertolotto A, Buffo A, Boda E
The European journal of neuroscience 2025 Nov;62(10):e70304

Electroacupuncture ameliorates cognitive impairment and white matter injury in vascular dementia rats via activating HIF-1α/VEGF/VEGFR2 pathway.

Yang Y, Rao T, Jiang Y, Zhan Y, Cheng J, Yin Z, Ma K, Zhong X, Guo X, Yang S
Neuroscience 2025 May 7;573:364-380

The mechanism of exosomes of BMSCs modified with Bu Shen Yi Sui capsule in promoting remyelination via regulating miR-15b/Wnt signaling pathway-mediated differentiation of oligodendrocytes.

Liu SS, Zha Z, Li C, Li CY, Wang L
Journal of ethnopharmacology 2025 Jan 31;340:119283

SIRT6 modulates lesion microenvironment in LPC induced demyelination by targeting astrocytic CHI3L1.

Du J, Yin Y, Wu D, Diao C, Zhao T, Peng F, Li N, Wang D, Shi J, Wang L, Kong L, Zhou W, Hao A
Journal of neuroinflammation 2024 Sep 28;21(1):243

From Organotypic Mouse Brain Slices to Human Alzheimer's Plasma Biomarkers: A Focus on Nerve Fiber Outgrowth.

Yilmaz SN, Steiner K, Marksteiner J, Faserl K, Villunger M, Sarg B, Humpel C
Biomolecules 2024 Oct 18;14(10)

Brain Slice Derived Nerve Fibers Grow along Microcontact Prints and are Stimulated by Beta-Amyloid(42).

Steiner K, Humpel C
Frontiers in bioscience (Landmark edition) 2024 Jun 24;29(6):232

Selective bioaccumulation of polystyrene nanoplastics in fetal rat brain and damage to myelin development.

Zhang Y, Tian L, Chen J, Liu X, Li K, Liu H, Lai W, Shi Y, Lin B, Xi Z
Ecotoxicology and environmental safety 2024 Jun 15;278:116393

RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination.

Li Y, Wan LP, Song NN, Ding YQ, Zhao S, Niu J, Mao B, Sheng N, Ma P
Science advances 2024 Feb 9;10(6):eadk3931

Agomelatine promotes differentiation of oligodendrocyte precursor cells and preserves white matter integrity after cerebral ischemic stroke.

Wang S, Li C, Kang X, Su X, Liu Y, Wang Y, Liu S, Deng X, Huang H, Li T, Lu D, Cai W, Lu Z, Wei L, Lu T
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2024 Dec;44(12):1487-1500

Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus.

Song W, Yao Y, Zhang H, Hao X, Zhou L, Song Z, Wei T, Chi T, Liu P, Ji X, Zou L
Molecules (Basel, Switzerland) 2023 Jan 2;28(1)

Neural stem cell‑derived exosomes transfer miR‑124‑3p into cells to inhibit glioma growth by targeting FLOT2.

Qian C, Wang Y, Ji Y, Chen D, Wang C, Zhang G, Wang Y
International journal of oncology 2022 Oct;61(4)

Ginsenoside Rg1 promotes remyelination and functional recovery in demyelinating disease by enhancing oligodendrocyte precursor cells-mediated myelin repair.

Liu L, Du X, Yang Q, Li M, Ran Q, Liu Q, Yang L, Sun L, Guo Y, Li Y, Chen Y, Zhu X, Li Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154309

Quercetin Alleviates Demyelination Through Regulating Microglial Phenotype Transformation to Mitigate Neuropsychiatric Symptoms in Mice with Vascular Dementia.

Tan Z, Yang G, Qiu J, Yan W, Liu Y, Ma Z, Li J, Liu J, Shan N
Molecular neurobiology 2022 May;59(5):3140-3158

Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices.

Uçar B, Stefanova N, Humpel C
Biomolecules 2022 Jan 19;12(2)

Peripheral neuropathy and MOG-IgG: A clinical and neuropathological retrospective study.

Dinoto A, Licciardi NM, Reindl M, Chiodega V, Schanda K, Carta S, Höftberger R, Ferrari S, Mariotto S
Multiple sclerosis and related disorders 2022 Dec;68:104214

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation.

Lim RG, Al-Dalahmah O, Wu J, Gold MP, Reidling JC, Tang G, Adam M, Dansu DK, Park HJ, Casaccia P, Miramontes R, Reyes-Ortiz AM, Lau A, Hickman RA, Khan F, Paryani F, Tang A, Ofori K, Miyoshi E, Michael N, McClure N, Flowers XE, Vonsattel JP, Davidson S, Menon V, Swarup V, Fraenkel E, Goldman JE, Thompson LM
Nature communications 2022 Dec 21;13(1):7791

Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures.

Korde DS, Humpel C
Biomolecules 2022 Aug 23;12(9)

Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor.

Desole C, Gallo S, Vitacolonna A, Vigna E, Basilico C, Montarolo F, Zuppini F, Casanova E, Miggiano R, Ferraris DM, Bertolotto A, Comoglio PM, Crepaldi T
Frontiers in immunology 2021;12:775151

Hippocampal Transcriptome Changes After Subarachnoid Hemorrhage in Mice.

Regnier-Golanov AS, Dündar F, Zumbo P, Betel D, Hernandez MS, Peterson LE, Lo EH, Golanov EV, Britz GW
Frontiers in neurology 2021;12:691631

Activity-dependent modulation of synapse-regulating genes in astrocytes.

Farhy-Tselnicker I, Boisvert MM, Liu H, Dowling C, Erikson GA, Blanco-Suarez E, Farhy C, Shokhirev MN, Ecker JR, Allen NJ
eLife 2021 Sep 8;10

Overexpression of the ubiquitin-editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system inflammation.

Perga S, Montarolo F, Martire S, Bonaldo B, Bono G, Bertolo J, Magliozzi R, Bertolotto A
Brain pathology (Zurich, Switzerland) 2021 Mar;31(2):283-296

c-Jun N-terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination.

Lorenzati M, Boda E, Parolisi R, Bonato M, Borsello T, Herdegen T, Buffo A, Vercelli A
Scientific reports 2021 Mar 31;11(1):7264

Spreading of Beta-Amyloid in Organotypic Mouse Brain Slices and Microglial Elimination and Effects on Cholinergic Neurons.

Moelgg K, Jummun F, Humpel C
Biomolecules 2021 Mar 15;11(3)

The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients.

Angelini J, Marangon D, Raffaele S, Lecca D, Abbracchio MP
International journal of molecular sciences 2021 Apr 27;22(9)

Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain.

Donninelli G, Saraf-Sinik I, Mazziotti V, Capone A, Grasso MG, Battistini L, Reynolds R, Magliozzi R, Volpe E
Journal of neuroinflammation 2020 May 6;17(1):149

ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons.

Szewczyk LM, Brozko N, Nagalski A, Röckle I, Werneburg S, Hildebrandt H, Wisniewska MB, Kuznicki J
Glia 2017 Jan;65(1):34-49

Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8mnd : implications to delayed myelination and oligodendrocyte maturation.

Kuronen M, Hermansson M, Manninen O, Zech I, Talvitie M, Laitinen T, Gröhn O, Somerharju P, Eckhardt M, Cooper JD, Lehesjoki AE, Lahtinen U, Kopra O
Neuropathology and applied neurobiology 2012 Aug;38(5):471-86

Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus.

Cong H, Jiang Y, Tien P
Journal of virology 2011 Nov;85(21):11038-47

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MOG antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MOG. This antibody recognizes human,mouse,rat antigen. The MOG antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 12690-1-AP.pdf

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