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- Product number
- 15939-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15939-1-AP, RRID:AB_2231460
- Product name
- Piezo1 (extracellular domain) antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Piezo1 (extracellular domain) antibody (Cat. #15939-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling.
Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis.
Axolotl skin mechanics-biomimetic hydrogel promotes scarless wound healing associated with macrophage polarisation via Piezo1/YAP signalling.
Zinc finger BED-type containing 6 (ZBED6) ameliorates cardiac fibrosis by inhibiting Piezo1 transcription and YAP nuclear translocation.
Piezo1 mediates electrotaxis of alveolar epithelial cells via calcium-dependent PI3K/Akt signaling.
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development.
PIEZO1 Channels Modulate the Small Extracellular Vesicle Release in C2C12 Cells.
PIEZO1 enhances pancreatic cancer neurotropism.
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis.
Therapeutic mechanism of Changyong Decoction in suppressing colorectal cancer progression and inducing ferroptosis via the PIEZO1-PI3K/AKT signaling axis.
Mechano-Iontronic Hydrogels Generating Biomimetic Endogenous Bioelectricity for Promoting Cartilage Regeneration.
Piezo1-mediated mechanotransduction regulates diabetic osteoporosis and hyperglycemia via low-intensity pulsed ultrasound.
Piezo1 knockdown activates PI3K/AKT and enhances SPP1 to drive M2 macrophage polarization and reduce cardiac inflammation.
PIEZO1 Mediates Apoptosis of Endothelial Cells via Enhancing HMGA2 Expression Under Simulated Microgravity.
Piezo1 mediated scaffold-free rapid generation of self-mineralized bone organoids via activating Wnt signaling.
CD47 Promotes, While Exposure to Apoptotic Cells Destroys the Fusion Program of Differentiating Myoblasts.
Piezo1 specific deletion in endothelial cell protects the progression of pulmonary fibrosis in mice.
Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia.
Age-mimicking hydrogel stiffness recapitulates the mechanical niche of the hippocampus to regulate neural stem cell senescence.
Stiff matrix promotes lung cancer cell migration through down-regulating the Piezo1 channel expression to facilitate Ca(2+)-dependent filopodia formation.
Mechanosensitive Piezo1 Channels in Enamel Cells.
Mechanosensory channels mediate ER Ca(2+) transients to trigger assembly of autophagosome initiation sites for degradation of ER subdomains.
Deficiency of Epithelial PIEZO1 Alleviates Liver Steatosis Induced by High-Fat Diet in Mice.
Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization.
Activation of Piezo1 and TRPV4 channels contributes to hCMEC/D3 cell mechano-sensing.
Chronic compression induces transcriptional, metabolic, and functional state changes in macrophages that recapitulate tumor-associated phenotypes.
Shengyu decoction ameliorates knee osteoarthritis by inhibiting endoplasmic reticulum stress via Piezo1 channels.
Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1/ATP axis to accelerate wound healing.
Pathological markers of Piezo1 at distal anastomosed ureter in predicting pyeloplasty outcomes in children.
Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming.
Mechanism of Piezo1 regulating chondrocyte mitochondrial function and promoting fracture healing through β-catenin/LARS2 signaling pathway.
High matrix stiffness triggers testosterone decline in aging males by disrupting stem Leydig cell pool homeostasis.
Activation of WNK1 signaling through Piezo1.
Targeting the tyrosine kinase Src in endothelium attenuates inflammation and atherogenesis induced by disturbed flow.
PIEZO1-GPX4 Axis Mediates Mechanical Stress-Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation.
Electroacupuncture attenuates intestinal epithelial ferroptosis in inflammatory bowel disease via Piezo1-mediated mitochondrial homeostasis.
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop.
Piezo1 exacerbates psoriasis by promoting macrophage M1 polarization and inhibits autophagy via activating PI3K/AKT signaling pathway.
BK channels are indispensable for endothelial function in small pulmonary arteries.
Mechanosensor Piezo1‑mediated smooth muscular cell pyroptosis contributes to vascular calcification.
Mechanosensory activation of Piezo1 via cupping therapy: Harnessing neural networks to modulate AMPK pathway for metabolic restoration in a mouse model of psoriasis.
NF-κB-Dependent Transcriptional Regulation of Piezo1 Mediates Bacterial Clearance on Stiffened Lung Matrix.
A novel BMSC-derived Exosomal circrna promotes angiogenesis by targeting miR-34a-5p to regulate Piezo1.
Activation of the Piezo1 channel stimulates protein kinase D and migration in human aortic endothelial cells.
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia.
EGFR-mediated crosstalk between vascular endothelial cells and hepatocytes promotes Piezo1-dependent liver regeneration.
Piezo1 activation protects against sepsis-induced myocardial dysfunction in a pilot study.
Mechanosensitive Piezo1 channel is highly expressed in the age-induced fibrotic uterus.
Pyroptosis of periodontal ligament stem cells aggravates periodontitis via Piezo1 channel.
Piezo1 regulates actin cytoskeleton remodeling to drive EMT in cervical cancer through the RhoA/ROCK1/PIP2 signaling pathway.
Trimethylamine N-oxide induces cardiac diastolic dysfunction by down-regulating Piezo1 in mice with heart failure with preserved ejection fraction.
GsMTx4-blocked PIEZO1 channel promotes myogenic differentiation and alleviates myofiber damage in Duchenne muscular dystrophy.
Electrically-stimulated cellular and tissue events are coordinated through ion channel-mediated calcium influx and chromatin modifications across the cytosol-nucleus space.
PIEZO1 activation enhances myogenesis and mitigates muscle degeneration in rotator cuff tear.
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
PIEZO1 Drives Trophoblast Fusion and Placental Development.
Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-β-catenin and programming fatty acid metabolism.
Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII-dependent pathway.
Piezo1 Ion Channels Regulate the Formation and Spreading of Human Endometrial Mesenchymal Stem Cell Spheroids.
Inhibition of Piezo1 ameliorates septic cardiomyopathy by blocking calcium-dependent PANoptosis.
Piezo1 disrupts blood-brain barrier via CaMKII/Nrf2 in ischemic stroke.
Tissue geometry spatiotemporally drives bacterial infections.
PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice.
PIEZO1 promotes psoriasis-like skin inflammation in mice via NF-κB/IL-17 signaling pathway activation.
Asperosaponin VI Promotes Osteoporotic Fracture Healing by Targeting Piezo1 to Enhance the Coupling of LEPR(+) BMSCs and PODXL(+) ECs.
Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) as a Potential Prognostic Marker in Renal Clear Cell Carcinoma.
PIEZO1 drives trophoblast fusion and placental development.
Jianpi Huayu decoction enhances the antitumor effect of doxorubicin via piezo1-mediated autophagy in hepatocellular carcinoma.
Neuroligin-3 interaction with CSPG4 regulates normal and malignant glial precursors through PIEZO1.
Piezo1 participates in the tension-driven osteogenic differentiation of periodontal ligament stem cells.
Compression force promotes glioblastoma progression through the Piezo1‑GDF15‑CTLA4 axis.
RAS signaling pathway is essential in regulating PIEZO1-mediated hepatic iron overload in dehydrated hereditary stomatocytosis.
Piezo1-directed neutrophil extracellular traps regulate macrophage differentiation during influenza virus infection.
Mechanical force receptor Piezo1 regulates T(H)9 cell differentiation.
Electrical Stimulation Generates Induced Tumor-Suppressing Cells, Offering a Potential Option for Combatting Breast Cancer and Bone Metastasis.
Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis.
Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis.
Low-Intensity Pulsed Ultrasound Responsive Scaffold Promotes Intramembranous and Endochondral Ossification via Ultrasonic, Thermal, and Electrical Stimulation.
Piezo knockdown reduces 5‑hydroxytryptamine release from enterochromaffin cells and exacerbates intestinal dyskinesia in mice with functional constipation.
Magnetically guided neurite outgrowth modulated by PIEZO1 in hiPSC-derived retinal ganglion cells.
High Shear Stress-Induced Endothelial Piezo1 Downregulation Promotes Intracranial Aneurysm Formation via the PDGF-BB/PDGFRβ Paracrine Signaling Pathway.
Hyperosmolarity-induced activation of PIEZO1 engages detrimental calcium/oxidative stress signaling and adaptive catalase response in renal inner medullary collecting duct (mIMCD(3)) cells.
Loss of TRPV4 reduces pancreatic cancer growth and metastasis.
Membrane dome-based regulation mechanism of the mechanosensitive PIEZO channel.
The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the PI3K/AKT/mTORC1 Pathway in Osteoarthritis.
Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning.
SETD2 drives METTL14-mediated m(6)A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension.
Ovalbumin-induced asthma leads to bone loss with Piezo channel suppression in mice.
Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammation.
Piezo1 exacerbates inflammation-induced cartilaginous endplate degeneration by activating mitochondrial fission via the Ca(2+)/CaMKII/Drp1 axis.
Applying Ultrasound to Mechanically and Noninvasively Sensitize Prostate Tumors to TRAIL-Mediated Apoptosis.
The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells.
Potentiation of macrophage Piezo1 by atherogenic 7-ketocholesterol.
Endothelial Piezo1 stimulates angiogenesis to offer protection against intestinal ischemia-reperfusion injury in mice.
Abnormal urodynamic changes in post-upper urinary tract dysfunction in ureteral obstruction rat models.
Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1.
PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes.
Piezo1 inhibitor isoquercitrin rescues neural impairment mediated by NLRP3 after intracerebral hemorrhage.
Activation of Piezo1 by intracranial hypertension induced neuronal apoptosis via activating hippo pathway.
Quercetin ameliorates atherosclerosis by inhibiting inflammation of vascular endothelial cells via Piezo1 channels.
Guizhitongluo Tablet inhibits atherosclerosis and foam cell formation through regulating Piezo1/NLRP3 mediated macrophage pyroptosis.
Ultrasound-triggered piezoelectric polyetheretherketone with boosted osteogenesis via regulating Akt/GSK3β/β-catenin pathway.
The mechanosensitive Piezo1 channel exacerbates myocardial ischaemia/reperfusion injury by activating caspase-8-mediated PANoptosis.
Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal.
Inflammatory Signaling via PEIZO1 Engages and Enhances the LPS-Mediated Apoptosis during Clinical Mastitis.
Mechanosensitive Piezo1 channels promote neurogenic bladder fibrosis via regulating TGF-β1/smad and Hippo/YAP1 pathways.
Increased Piezo1 expression in myofibroblasts in patients with symptomatic carotid atherosclerotic plaques undergoing carotid endarterectomy: A pilot study.
Radial extracorporeal shockwave promotes osteogenesis-angiogenesis coupling of bone marrow stromal cells from senile osteoporosis via activating the Piezo1/CaMKII/CREB axis.
Aberrant overexpression of myosin 1b in glioblastoma promotes angiogenesis via VEGF-myc-myosin 1b-Piezo1 axis.
Lithospermic acid improves liver fibrosis through Piezo1-mediated oxidative stress and inflammation.
PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformations.
Activation of Piezo1 channels enhances spontaneous contractions of isolated human bladder strips via acetylcholine release from the mucosa.
Activation of PIEZO1 Attenuates Kidney Cystogenesis In Vitro and Ex Vivo.
Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis.
Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity.
The local mechanosensitive response of primary cardiac fibroblasts is influenced by the microenvironment mechanics.
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing.
Activation of Piezo1 Inhibits Kidney Cystogenesis.
Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis.
Magnetic Aggregation-Induced Bone-Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic-Angiogenic Coupling for Osteoporotic Bone Repair.
Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto-Active Substrates.
Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated Ca(2+) dynamics.
Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage.
Resistive spontaneous breathing exacerbated lipopolysaccharide-induced lung injury in mice.
Neutrophil migration participates in the side effect of recombinant human tissue plasminogen activator.
trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing.
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells.
Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response.
Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction.
Endothelial KDM5B Regulated by Piezo1 Contributes to Disturbed Flow Induced Atherosclerotic Plaque Formation.
Membrane Tension Regulation is Required for Wound Repair.
Piezo1 Regulates Stiffness-Dependent DRG Axon Regeneration via Modifying Cytoskeletal Dynamics.
Insufficient Mechanical Loading Downregulates Piezo1 in Chondrocytes and Impairs Fracture Healing Through ApoE-Induced Senescence.
Piezo1 Mediates Glycolysis-Boosted Pancreatic Ductal Adenocarcinoma Chemoresistance within a Biomimetic Three-Dimensional Matrix Stiffness.
The pivotal role of the Hes1/Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosis.
Effects of Panax notoginseng saponins on alleviating low shear induced endothelial inflammation and thrombosis via Piezo1 signalling.
Piezo1 overexpression in the uterus contributes to myometrium contraction and inflammation-associated preterm birth.
Ion channel Piezo1 induces ferroptosis of trabecular meshwork cells: a novel observation in the pathogenesis in primary open angle glaucoma.
Matrix stiffness regulates macrophage polarisation via the Piezo1-YAP signalling axis.
Pressure sensing of lysosomes enables control of TFEB responses in macrophages.
Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during aging.
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca(2+) influx.
The Microbiota-Dependent Treatment of Wuzhuyu Decoction for Chronic Migraine Model Rat Associated with Anxiety-Depression Like Behavior.
Inhibition of Piezo1 Ameliorates Intestinal Inflammation and Limits the Activation of Group 3 Innate Lymphoid Cells in Experimental Colitis.
PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model.
A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.
Slowed Intestinal Transit Induced by Less Mucus in Intestinal Goblet Cell Piezo1-Deficient Mice through Impaired Epithelial Homeostasis.
Modulation of Piezo1 influences human skin architecture and oxytocin expression.
Piezo1 Activation Prevents Spheroid Formation by Malignant Melanoma SK-MEL-2 Cells.
Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorder.
PPP1R3A inhibits osteogenesis and negatively regulates intracellular calcium levels in calcific tendinopathy.
Different stimuli induce endothelial dysfunction and promote atherosclerosis through the Piezo1/YAP signaling axis.
Aloperine protects pulmonary hypertension via triggering PPARγ signaling and inhibiting calcium regulatory pathway in pulmonary arterial smooth muscle cells.
The Critical Role of The Piezo1/β-catenin/ATF4 Axis on The Stemness of Gli1(+) BMSCs During Simulated Microgravity-Induced Bone Loss.
Effects of liraglutide on ANP secretion and cardiac dynamics.
Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice.
Chemical Activation and Mechanical Sensitization of Piezo1 Enhance TRAIL-Mediated Apoptosis in Glioblastoma Cells.
A static magnetic field enhances the repair of osteoarthritic cartilage by promoting the migration of stem cells and chondrogenesis.
Proteome alterations in erythrocytes with PIEZO1 gain-of-function mutations.
Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis.
Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells.
Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.
Accelerated Bone Reconstruction by the Yoda1 Bilayer Membrane via Promotion of Osteointegration and Angiogenesis.
Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1.
De Novo Cloning and Functional Characterization of a Mechanosensitive Piezo-Like Ion Channel in the Crayfish.
Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes.
Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels.
The Mechanosensitive Ion Channel PIEZO1 in Intestinal Epithelial Cells Mediates Inflammation through the NOD-Like Receptor 3 Pathway in Crohn's Disease.
Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification.
Soft, strong, tough, and durable protein-based fiber hydrogels.
The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia.
Lipid-anchored proteasomes control membrane protein homeostasis.
Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside.
Piezo1 Regulation Involves Lipid Domains and the Cytoskeleton and Is Favored by the Stomatocyte-Discocyte-Echinocyte Transformation.
Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation.
Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis.
Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1.
Piezo1 channel-mediated Ca(2+) signaling inhibits lipopolysaccharide-induced activation of the NF-κB inflammatory signaling pathway and generation of TNF-α and IL-6 in microglial cells.
Low-Intensity Pulsed Ultrasound Attenuates Postoperative Neurocognitive Impairment and Salvages Hippocampal Synaptogenesis in Aged Mice.
Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis.
PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing.
A Novel Homozygous Missense Mutation of PIEZO1 Leading to Lymphatic Malformation-6 Identified in a Family With Three Adverse Pregnancy Outcomes due to Nonimmune Fetal Hydrops.
Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice.
TiO(2) Nanotubes Promote Osteogenic Differentiation Through Regulation of Yap and Piezo1.
High-throughput membrane-anchored proteome screening reveals PIEZO1 as a promising antibody-drug target for human esophageal squamous cell carcinoma.
Activation of Piezo1 Increases Na,K-ATPase-Mediated Ion Transport in Mouse Lens.
Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis.
Skin cells undergo asynthetic fission to expand body surfaces in zebrafish.
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.
Fluid shear stress enhances T cell activation through Piezo1.
A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation.
Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells.
Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes.
Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca(2+) Influx and Akt-eNOS Pathway.
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.
Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis.
Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation.
PIEZO1 mediates a mechanothrombotic pathway in diabetes.
Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1.
Fine-Tuning of Piezo1 Expression and Activity Ensures Efficient Myoblast Fusion during Skeletal Myogenesis.
Wuzhuyu Decoction relieves hyperalgesia by regulating central and peripheral 5-HT in chronic migraine model rats.
Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles.
Piezo channels contribute to the regulation of myelination in Schwann cells.
Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes.
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis.
Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling.
Piezo1 act as a potential oncogene in pancreatic cancer progression.
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone.
Mechanical force modulates macrophage proliferation via Piezo1-AKT-Cyclin D1 axis.
Mechanosensitive Piezo1 channels mediate renal fibrosis.
Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells.
Hereditary Xerocytosis: Differential Behavior of PIEZO1 Mutations in the N-Terminal Extracellular Domain Between Red Blood Cells and HEK Cells.
Piezo1 and BK(Ca) channels in human atrial fibroblasts: Interplay and remodelling in atrial fibrillation.
Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats.
Mechanical stimulation activates Piezo1 to promote mucin2 expression in goblet cells.
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation.
Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway.
Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells.
Piezo1 plays a role in optic nerve head astrocyte reactivity.
Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.
Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing.
Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients.
Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow.
Mechanical Stress Induces Ca(2+)-Dependent Signal Transduction in Erythroblasts and Modulates Erythropoiesis.
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension.
Upregulation of Piezo1 Is a Novel Prognostic Indicator in Glioma Patients.
Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells.
Tubeimoside I Antagonizes Yoda1-Evoked Piezo1 Channel Activation.
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice.
Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure.
Functional Expression of Piezo1 in Dorsal Root Ganglion (DRG) Neurons.
Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling.
PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cells.
Piezo1 is required for outflow tract and aortic valve development.
Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier.
RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis.
Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle.
A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-β1 expression.
The Mechanosensitive Ion Channel Piezo1 Significantly Mediates In Vitro Ultrasonic Stimulation of Neurons.
Mechanically Defined Microenvironment Promotes Stabilization of Microvasculature, Which Correlates with the Enrichment of a Novel Piezo-1(+) Population of Circulating CD11b(+) /CD115(+) Monocytes.
Rapid flow-induced activation of Gα(q/11) is independent of Piezo1 activation.
Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries.
The mechanosensitive Piezo1 channel is required for bone formation.
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.
Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.
PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis.
Piezo1 and G(q)/G(11) promote endothelial inflammation depending on flow pattern and integrin activation.
A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.
Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII.
Mechanical stretch triggers rapid epithelial cell division through Piezo1.
Evidence for shear-mediated Ca(2+) entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.
Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis).
Piezo1 integration of vascular architecture with physiological force.
Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures.
Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
Li H, Zhang S, Feng C, Cheng F, Han Y, Wang M, Zhou S, Shao W, Chen W, Chen J, Liu K, Zhang Y, Wang J
International journal of biological sciences 2026;22(4):1834-1851
International journal of biological sciences 2026;22(4):1834-1851
Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis.
Chen J, Wu D, Huang C, Yan Z, Wang J, Li S, Chen X, Zhu Y, Zhang Y
International journal of biological sciences 2026;22(1):308-326
International journal of biological sciences 2026;22(1):308-326
Axolotl skin mechanics-biomimetic hydrogel promotes scarless wound healing associated with macrophage polarisation via Piezo1/YAP signalling.
Lin M, Cheng S, Yu Y, Fan Y, Zhu X, Li J, Jin W, Yao J, Bian Y, Lu Q, Huang Y
Biomaterials 2026 Oct;333:124194
Biomaterials 2026 Oct;333:124194
Zinc finger BED-type containing 6 (ZBED6) ameliorates cardiac fibrosis by inhibiting Piezo1 transcription and YAP nuclear translocation.
Wu H, Jiang WT, Zhao QY, Zhang XY, Pang P, Wang CL, Wang Z, Lin KY, Yao FT, Zou KK, Zhang YN, Duo TQ, Zhang F, Zeng LH, Si W, Kong X, Song JL, Pan TF, Diao HT, Yang BF, Bian Y
Acta pharmacologica Sinica 2026 May;47(5):1162-1175
Acta pharmacologica Sinica 2026 May;47(5):1162-1175
Piezo1 mediates electrotaxis of alveolar epithelial cells via calcium-dependent PI3K/Akt signaling.
Luo H, Dai Y, Lu C, Shi C, Liu W, Bi W, Du J, Li L
Chinese journal of traumatology = Zhonghua chuang shang za zhi 2026 May;29(3):179-185
Chinese journal of traumatology = Zhonghua chuang shang za zhi 2026 May;29(3):179-185
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development.
Yan Z, Wu D, Zhao H, Guan H, Chen J, Huang C, Chen X, Deng X, Hu J, Wang J, Zhang Y
Journal of orthopaedic translation 2026 Mar;57:101053
Journal of orthopaedic translation 2026 Mar;57:101053
PIEZO1 Channels Modulate the Small Extracellular Vesicle Release in C2C12 Cells.
Annalisa B, Ru ZW, Laura SS, Alessia N, Anna F, Marianna L, Marina S, Griffoni A, William RK, Giulio T, Paola L, Agenor L
Journal of cellular physiology 2026 Mar;241(3):e70155
Journal of cellular physiology 2026 Mar;241(3):e70155
PIEZO1 enhances pancreatic cancer neurotropism.
Li J, Liu Q, Xu R, Tang J, Wang L, Zheng Y, Weng S, Gao F
Cancer cell international 2026 Mar 9;26(1)
Cancer cell international 2026 Mar 9;26(1)
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis.
Zhang L, Gui X, Hou R, Jia L, Xia S, Zhang X, Fu Y, Meng QF, Luo Q, Shi X, Guo B, Liang R, Yue L, Chen X, Xu H, Wang P, Tong X, Liu L, Wang L, Li B, Chen Z, Zhou L, Zhang L, Chen R, Sun C, Xu W, Rao L, Zhou H, Ding BS, Chen S
Nature communications 2026 Mar 20;17(1)
Nature communications 2026 Mar 20;17(1)
Therapeutic mechanism of Changyong Decoction in suppressing colorectal cancer progression and inducing ferroptosis via the PIEZO1-PI3K/AKT signaling axis.
Han M, Shi S, Guan Z, Ma W, Wang X, Jiang H, Man S
Tissue & cell 2026 Jun;100:103379
Tissue & cell 2026 Jun;100:103379
Mechano-Iontronic Hydrogels Generating Biomimetic Endogenous Bioelectricity for Promoting Cartilage Regeneration.
Li L, Li Z, Yue M, Shao Y, Wang J, Song Y, Wang ZL, Zhou Y, Pu X
Advanced materials (Deerfield Beach, Fla.) 2026 Jan;38(2):e14604
Advanced materials (Deerfield Beach, Fla.) 2026 Jan;38(2):e14604
Piezo1-mediated mechanotransduction regulates diabetic osteoporosis and hyperglycemia via low-intensity pulsed ultrasound.
Cao M, Pang F, Duan X, Sun L, Fan X, Tang L, Ta D
Bone 2026 Jan;202:117664
Bone 2026 Jan;202:117664
Piezo1 knockdown activates PI3K/AKT and enhances SPP1 to drive M2 macrophage polarization and reduce cardiac inflammation.
Zhang Y, Zhang Y, Song J, Zhao Z, Ju W, Zhang H, Li S, Li H, Guo Q, Ma Y, Nong Z, Shen T, Wang Y, Pang B, Hao M, Luo C, Luo Z, Tang Y, Zhuang D, Pei J
Scientific reports 2026 Jan 8;16(1):4879
Scientific reports 2026 Jan 8;16(1):4879
PIEZO1 Mediates Apoptosis of Endothelial Cells via Enhancing HMGA2 Expression Under Simulated Microgravity.
Wang Y, Wang R, Qin X, Pan Y, Li C, Sun X
International journal of molecular sciences 2026 Jan 30;27(3)
International journal of molecular sciences 2026 Jan 30;27(3)
Piezo1 mediated scaffold-free rapid generation of self-mineralized bone organoids via activating Wnt signaling.
Zhang L, Zhang Y, Wan Z, Yuan X, Gao Y, Song R, Liu X, Sang J, Song J, Wang Y, Zhao Y, Yuan Z
Materials today. Bio 2026 Feb;36:102620
Materials today. Bio 2026 Feb;36:102620
CD47 Promotes, While Exposure to Apoptotic Cells Destroys the Fusion Program of Differentiating Myoblasts.
Ali MA, Papp AB, Garabuczi É, Gere ÁK, Dienes B, Gönczi M, Vámosi G, Köröskényi K, Csernoch L, Szondy Z, Sarang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71578
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71578
Piezo1 specific deletion in endothelial cell protects the progression of pulmonary fibrosis in mice.
He B, Tan Q, Xu H, Chen X, Wan R, Yao Y, Pan X, Liu S, Chen X, Jiang J, Luo S, An Y, Li J
Cell communication and signaling : CCS 2026 Feb 28;24(1)
Cell communication and signaling : CCS 2026 Feb 28;24(1)
Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia.
Li G, Yang L, Duan S, Chen M, Zhang Y, Liu F, Wang Y, Li J, Xu S, Wu Z, Wang M, Wang B, Zhao Z, Shi W, Lei M, Xie H, Tang Y, Deng Z, Li J
Nature communications 2026 Feb 26;17(1)
Nature communications 2026 Feb 26;17(1)
Age-mimicking hydrogel stiffness recapitulates the mechanical niche of the hippocampus to regulate neural stem cell senescence.
Guo L, Ge L, Li Y, Wang S, Li H, Wang X, Qian W, Zhang Y, Guo L, Guo L, Cheng R, Ji W, Fu W, Zhang L, Zhang R
Materials today. Bio 2026 Apr;37:102985
Materials today. Bio 2026 Apr;37:102985
Stiff matrix promotes lung cancer cell migration through down-regulating the Piezo1 channel expression to facilitate Ca(2+)-dependent filopodia formation.
Jia X, Zhao L, Bai J, Wen L, Meng Q, Wang H, Men J, Shao H, Guo Y, Chen X, Chen X, Jiang LH, Fan Y, Liu H
Materials today. Bio 2026 Apr;37:102786
Materials today. Bio 2026 Apr;37:102786
Mechanosensitive Piezo1 Channels in Enamel Cells.
Bomfim GHS, Zou A, Echeverry FA, Bui AT, de Oliveira Sousa E, Graciliano Silva BL, Witek L, Coetzee WA, Lacruz RS
Calcified tissue international 2026 Apr 27;117(1)
Calcified tissue international 2026 Apr 27;117(1)
Mechanosensory channels mediate ER Ca(2+) transients to trigger assembly of autophagosome initiation sites for degradation of ER subdomains.
Ma X, Cheng Z, Zhao H, Zhang H, Xiao K, Xie J, Feng Y, Yang C, Feng Y, Wang X, Xiang Y, Hu J, Zheng Q, Ji W, Zhang H
Molecular cell 2026 Apr 2;86(7):1377-1396.e6
Molecular cell 2026 Apr 2;86(7):1377-1396.e6
Deficiency of Epithelial PIEZO1 Alleviates Liver Steatosis Induced by High-Fat Diet in Mice.
Xu Z, Xu S, Liu X, Cheng L, Liu X, Xie X, Zhou D, Wang D, Chen J, Deng X, Zhang L, He R, Li Y, Cheng M, Yang L, Hou X, Bai T
International journal of biological sciences 2025;21(2):745-757
International journal of biological sciences 2025;21(2):745-757
Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization.
Sun Z, Liu J, Ge P, Cao Y, Liu J, Wen H, Luo X, Pei B, Jin Z, Li H, Xun L, Luo Y, Yang Q, Chen H
Journal of inflammation research 2025;18:1395-1412
Journal of inflammation research 2025;18:1395-1412
Activation of Piezo1 and TRPV4 channels contributes to hCMEC/D3 cell mechano-sensing.
An W, Sun M, Zhang X, Huang L, Liu H, Cui B
Frontiers in physiology 2025;16:1633251
Frontiers in physiology 2025;16:1633251
Chronic compression induces transcriptional, metabolic, and functional state changes in macrophages that recapitulate tumor-associated phenotypes.
Burchett Darantiere A, Chen H, Najera J, Howard S, Datta M
Frontiers in immunology 2025;16:1626024
Frontiers in immunology 2025;16:1626024
Shengyu decoction ameliorates knee osteoarthritis by inhibiting endoplasmic reticulum stress via Piezo1 channels.
Song X, Liu Y, Shen X, Zhang L, Kong H, Chen S, Sheng L, Sun R
Frontiers in pharmacology 2025;16:1592818
Frontiers in pharmacology 2025;16:1592818
Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1/ATP axis to accelerate wound healing.
Xiao Y, Shi Z, Yuan Y, Yao D, Feng R, Zhang Y, Zhao D, Zhang H, Sun P, Liu Y, Li Y, Shen X, Wang Z, Hu D, Guan H, Wang H
Theranostics 2025;15(18):9862-9884
Theranostics 2025;15(18):9862-9884
Pathological markers of Piezo1 at distal anastomosed ureter in predicting pyeloplasty outcomes in children.
Zhou J, Lu X, Huang L, Guo Y
Frontiers in pediatrics 2025;13:1612706
Frontiers in pediatrics 2025;13:1612706
Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming.
Zhang X, Zhu B, Yan J, Chen X, Wu D, Wang Z, Guan X, Huang Y, Zhao Y, Yang Y, Guo Y
Regenerative biomaterials 2025;12:rbaf056
Regenerative biomaterials 2025;12:rbaf056
Mechanism of Piezo1 regulating chondrocyte mitochondrial function and promoting fracture healing through β-catenin/LARS2 signaling pathway.
Zhang T, Lv H, Jia S, Wang L, Liu W, Ding K, Du X, Hou G, Hou Z, Zhang Y, Zou W, Chen W, Zhu Y
Bone research 2025 Sep 24;13(1):79
Bone research 2025 Sep 24;13(1):79
High matrix stiffness triggers testosterone decline in aging males by disrupting stem Leydig cell pool homeostasis.
Huang J, Sun L, Yin Y, Yang H, Zeng K, Huang P, Liang X, Wu J, Xiang AP, Wang J
Cell reports 2025 Sep 23;44(9):116207
Cell reports 2025 Sep 23;44(9):116207
Activation of WNK1 signaling through Piezo1.
Jung JU, Stippec S, Cobb MH
Proceedings of the National Academy of Sciences of the United States of America 2025 Sep 2;122(35):e2513155122
Proceedings of the National Academy of Sciences of the United States of America 2025 Sep 2;122(35):e2513155122
Targeting the tyrosine kinase Src in endothelium attenuates inflammation and atherogenesis induced by disturbed flow.
Ding H, Jiang M, Chan AM, Xia Y, Ma RCW, Yao X, Wang L, Huang Y
British journal of pharmacology 2025 Oct;182(20):4861-4875
British journal of pharmacology 2025 Oct;182(20):4861-4875
PIEZO1-GPX4 Axis Mediates Mechanical Stress-Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation.
Chen F, Peng F, Chen S, Du Y, Li J, Fan Y, Cui Z, Gu G, Zhang H, Jiang Z, Wang G, Jing X, Dong J, Li T, Xi Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02052
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02052
Electroacupuncture attenuates intestinal epithelial ferroptosis in inflammatory bowel disease via Piezo1-mediated mitochondrial homeostasis.
He H, Zhou J, Cao S, Liu W, Mei Z, Liu M
Chinese medicine 2025 Oct 6;20(1):161
Chinese medicine 2025 Oct 6;20(1):161
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop.
Wang B, Liu J, Wang Q, Arhatte M, Cheong LY, Glogowska E, Jiang X, Chung SK, Jin L, Hu Q, Wang Y, Honoré E, Xu A
Signal transduction and targeted therapy 2025 Oct 28;10(1):357
Signal transduction and targeted therapy 2025 Oct 28;10(1):357
Piezo1 exacerbates psoriasis by promoting macrophage M1 polarization and inhibits autophagy via activating PI3K/AKT signaling pathway.
Liu X, Du S, Jiang Y, Chen Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Oct 22;74(1):149
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Oct 22;74(1):149
BK channels are indispensable for endothelial function in small pulmonary arteries.
Guntur D, Jeremic D, Csaki R, Myronenko O, Biasin V, Kolb D, Michalick L, Kuebler WM, Enyedi P, Olschewski H, Olschewski A, Nagaraj C
Cell communication and signaling : CCS 2025 Oct 21;23(1):448
Cell communication and signaling : CCS 2025 Oct 21;23(1):448
Mechanosensor Piezo1‑mediated smooth muscular cell pyroptosis contributes to vascular calcification.
Tao J, You D, Feng Z, Li H, Zhang Y, Cui Y, Lin K, Luo B, Yin S, Tan H
International journal of molecular medicine 2025 Nov;56(5)
International journal of molecular medicine 2025 Nov;56(5)
Mechanosensory activation of Piezo1 via cupping therapy: Harnessing neural networks to modulate AMPK pathway for metabolic restoration in a mouse model of psoriasis.
Xi RF, Liu X, Wang Y, Lu HZ, Yuan SJ, Guo DJ, Zhu JY, Li FL, Duan YJ
Journal of integrative medicine 2025 Nov;23(6):721-732
Journal of integrative medicine 2025 Nov;23(6):721-732
NF-κB-Dependent Transcriptional Regulation of Piezo1 Mediates Bacterial Clearance on Stiffened Lung Matrix.
Orsini EM, Boulton AM, Abraham S, Brown A, Ricci H, Ahuja A, Pant B, Snyder CM, Reinhardt A, Attaway AH, Musich R, Grove LM, Olman MA, Vachharajani V, Scheraga RG
bioRxiv : the preprint server for biology 2025 Nov 7;
bioRxiv : the preprint server for biology 2025 Nov 7;
A novel BMSC-derived Exosomal circrna promotes angiogenesis by targeting miR-34a-5p to regulate Piezo1.
Wu T, Zhou Y, Jiang Y, Li X, Shi W, Wang Z, Guo S, Wang Y, Li T
Stem cell research & therapy 2025 Nov 25;16(1):659
Stem cell research & therapy 2025 Nov 25;16(1):659
Activation of the Piezo1 channel stimulates protein kinase D and migration in human aortic endothelial cells.
Lone M, Singh P, Sinnett-Smith J, Jin YP, Reed EF, Rozengurt E
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1652-C1665
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1652-C1665
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia.
Zhang FR, Tang J, Lai Y, Mo SQ, Lin ZM, Lei QQ, Han CC, Zhou AD, Lv XF, Wang C, Ou JS, Zhou JG, Pang RP
British journal of pharmacology 2025 May;182(9):2031-2048
British journal of pharmacology 2025 May;182(9):2031-2048
EGFR-mediated crosstalk between vascular endothelial cells and hepatocytes promotes Piezo1-dependent liver regeneration.
Hu Y, Du G, Li C, Wang R, Liu J, Wang Y, Dong J
Genes & diseases 2025 May;12(3):101321
Genes & diseases 2025 May;12(3):101321
Piezo1 activation protects against sepsis-induced myocardial dysfunction in a pilot study.
Gong A, Dai J, Zhao Y, Hu H, Guan C, Yu H, Wang K, Jin S, Wu Y, Xiao B
Scientific reports 2025 May 8;15(1):15975
Scientific reports 2025 May 8;15(1):15975
Mechanosensitive Piezo1 channel is highly expressed in the age-induced fibrotic uterus.
Wang Y, Liu X, Wang M, Kang J, Zhang Y
Molecular biology reports 2025 May 28;52(1):510
Molecular biology reports 2025 May 28;52(1):510
Pyroptosis of periodontal ligament stem cells aggravates periodontitis via Piezo1 channel.
Chen P, Liu D, Zhou YK, Jiang JH, Yang RL
iScience 2025 May 16;28(5):112395
iScience 2025 May 16;28(5):112395
Piezo1 regulates actin cytoskeleton remodeling to drive EMT in cervical cancer through the RhoA/ROCK1/PIP2 signaling pathway.
Deng J, Li Y, Zhang L, Liao W, Liu T, Shen F
Discover oncology 2025 May 16;16(1):787
Discover oncology 2025 May 16;16(1):787
Trimethylamine N-oxide induces cardiac diastolic dysfunction by down-regulating Piezo1 in mice with heart failure with preserved ejection fraction.
Chen Q, Zhang H, Chen Y, Peng Y, Yao Y, Xue H, Guo Q, Tian D, Xiao L, Teng X, Zheng M, Xiao B, Wu Y, Jin S
Life sciences 2025 May 15;369:123554
Life sciences 2025 May 15;369:123554
GsMTx4-blocked PIEZO1 channel promotes myogenic differentiation and alleviates myofiber damage in Duchenne muscular dystrophy.
Wang W, Huang M, Huang X, Ma K, Luo M, Yang N
Skeletal muscle 2025 May 14;15(1):13
Skeletal muscle 2025 May 14;15(1):13
Electrically-stimulated cellular and tissue events are coordinated through ion channel-mediated calcium influx and chromatin modifications across the cytosol-nucleus space.
Karunasagara S, Bayarkhangai B, Shim HW, Bae HJ, Lee H, Taghizadeh A, Ji Y, Mandakhbayar N, Kim HS, Hyun J, Kim TJ, Lee JH, Kim HW
Biomaterials 2025 Mar;314:122854
Biomaterials 2025 Mar;314:122854
PIEZO1 activation enhances myogenesis and mitigates muscle degeneration in rotator cuff tear.
Wang T, Feng S, Zhou H, Mao W, Bai R, Xia Y, Huang J, Zhang R, Lin F
Regenerative therapy 2025 Mar;28:143-152
Regenerative therapy 2025 Mar;28:143-152
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
Peng F, Sun M, Jing X, Chen F, Cao T, Li Z, Li T
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
PIEZO1 Drives Trophoblast Fusion and Placental Development.
Zhang Y, Shan KZ, Liang P, Lowry AJ, Feng L, Yang H
bioRxiv : the preprint server for biology 2025 Mar 26;
bioRxiv : the preprint server for biology 2025 Mar 26;
Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-β-catenin and programming fatty acid metabolism.
Fang F, Li G, Li X, Wu J, Liu Y, Xin H, Wang Z, Fang J, Jiang Y, Qian W, Hou X, Song J
Cell reports 2025 Mar 25;44(3):115400
Cell reports 2025 Mar 25;44(3):115400
Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII-dependent pathway.
Li Z, Jiang Q, Wei J, Dang D, Meng Z, Wu H
Communications biology 2025 Mar 12;8(1):417
Communications biology 2025 Mar 12;8(1):417
Piezo1 Ion Channels Regulate the Formation and Spreading of Human Endometrial Mesenchymal Stem Cell Spheroids.
Khairullina ZM, Vasileva VY, Chubinskiy-Nadezhdin VI
International journal of molecular sciences 2025 Mar 10;26(6)
International journal of molecular sciences 2025 Mar 10;26(6)
Inhibition of Piezo1 ameliorates septic cardiomyopathy by blocking calcium-dependent PANoptosis.
Zhang YT, Li HH, Teng F
European journal of pharmacology 2025 Jun 5;996:177438
European journal of pharmacology 2025 Jun 5;996:177438
Piezo1 disrupts blood-brain barrier via CaMKII/Nrf2 in ischemic stroke.
Fu H, Yu Y, Wang S, Xu P, Sun Y, Li J, Ge X, Pan S
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):259
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):259
Tissue geometry spatiotemporally drives bacterial infections.
Han Y, Liu X, Qu S, Duan X, Xiang Y, Jiang N, Yang S, Fang X, Xu L, Wen H, Yu Y, Huang S, Huang J, Zhu K
Cell 2025 Jun 26;188(13):3459-3476.e21
Cell 2025 Jun 26;188(13):3459-3476.e21
PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice.
Xu L, Li T, Cao Y, He Y, Shao Z, Liu S, Wang B, Su A, Tian H, Li Y, Liang G, Wang C, Shyy J, Xiong Y, Chen F, Yuan JX, Liu J, Zhou B, Wettschureck N, Offermanns S, Yan Y, Yuan Z, Wang S
The Journal of clinical investigation 2025 Jun 2;135(11)
The Journal of clinical investigation 2025 Jun 2;135(11)
PIEZO1 promotes psoriasis-like skin inflammation in mice via NF-κB/IL-17 signaling pathway activation.
Li W, Ze K, He X, Yang L, Zhang H, Yuan W, Wang W
Molecular medicine (Cambridge, Mass.) 2025 Jun 10;31(1):225
Molecular medicine (Cambridge, Mass.) 2025 Jun 10;31(1):225
Asperosaponin VI Promotes Osteoporotic Fracture Healing by Targeting Piezo1 to Enhance the Coupling of LEPR(+) BMSCs and PODXL(+) ECs.
Dong R, Wei J, Tian S, Ma Y, Wang J, Tu X, Li G, Liu Y
Phytotherapy research : PTR 2025 Jul;39(7):3148-3166
Phytotherapy research : PTR 2025 Jul;39(7):3148-3166
Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) as a Potential Prognostic Marker in Renal Clear Cell Carcinoma.
Antosik P, Szachniewicz M, Baran M, Bonowicz K, Jerka D, Motylewska E, Kwiatkowski M, Gagat M, Grzanka D
International journal of molecular sciences 2025 Jul 9;26(14)
International journal of molecular sciences 2025 Jul 9;26(14)
PIEZO1 drives trophoblast fusion and placental development.
Zhang Y, Shan KZ, Liang P, Lowry AJ, Feng L, Yang H
Nature communications 2025 Jul 26;16(1):6895
Nature communications 2025 Jul 26;16(1):6895
Jianpi Huayu decoction enhances the antitumor effect of doxorubicin via piezo1-mediated autophagy in hepatocellular carcinoma.
Fang C, Liu S, Zhang S, Zheng H, Fang G, Chen C, Zhang Y, Yao R, Chen X, Luo R, Li J, Zhong C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156908
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156908
Neuroligin-3 interaction with CSPG4 regulates normal and malignant glial precursors through PIEZO1.
Gillespie SM, Seok Kim Y, Geraghty AC, Yalçın B, Mancusi R, Hysinger J, English Ivec A, Reed J, Drexler R, Quezada M, Malacon K, Woo P, Mount C, Yang A, Lam M, Pan Y, Bradley Zuchero J, Trotter J, Monje M
bioRxiv : the preprint server for biology 2025 Jul 17;
bioRxiv : the preprint server for biology 2025 Jul 17;
Piezo1 participates in the tension-driven osteogenic differentiation of periodontal ligament stem cells.
Du Y, Zheng J, Xu B, Peng C, Yang K
BMC oral health 2025 Jul 13;25(1):1155
BMC oral health 2025 Jul 13;25(1):1155
Compression force promotes glioblastoma progression through the Piezo1‑GDF15‑CTLA4 axis.
Kim OH, Tulip IJ, Kang H, Chang ES, Lee HJ
Oncology reports 2025 Jan;53(1)
Oncology reports 2025 Jan;53(1)
RAS signaling pathway is essential in regulating PIEZO1-mediated hepatic iron overload in dehydrated hereditary stomatocytosis.
Rosato BE, D'Onofrio V, Marra R, Nostroso A, Esposito FM, Iscaro A, Lasorsa VA, Capasso M, Iolascon A, Russo R, Andolfo I
American journal of hematology 2025 Jan;100(1):52-65
American journal of hematology 2025 Jan;100(1):52-65
Piezo1-directed neutrophil extracellular traps regulate macrophage differentiation during influenza virus infection.
Wang Y, Yang Q, Dong Y, Wang L, Zhang Z, Niu R, Wang Y, Bi Y, Liu G
Cell death & disease 2025 Jan 31;16(1):60
Cell death & disease 2025 Jan 31;16(1):60
Mechanical force receptor Piezo1 regulates T(H)9 cell differentiation.
Yang Q, Cao Y, Wang L, Dong Y, Zhao L, Geng Z, Bi Y, Liu G
Cell reports 2025 Jan 28;44(1):115136
Cell reports 2025 Jan 28;44(1):115136
Electrical Stimulation Generates Induced Tumor-Suppressing Cells, Offering a Potential Option for Combatting Breast Cancer and Bone Metastasis.
Cui C, Xu Y, Xiong X, Aryal UK, Chen A, Chien S, You L, Li B, Yokota H
International journal of molecular sciences 2025 Jan 25;26(3)
International journal of molecular sciences 2025 Jan 25;26(3)
Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis.
Zeng Y, Wu Z, Xiong M, Liang Z, Chen Z, Huang H, Yang H, Chen Q
Communications biology 2025 Jan 21;8(1):96
Communications biology 2025 Jan 21;8(1):96
Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis.
Yang J, Zhong J, Fu Z, He D, Zhang J, Yuan J
Investigative ophthalmology & visual science 2025 Jan 2;66(1):33
Investigative ophthalmology & visual science 2025 Jan 2;66(1):33
Low-Intensity Pulsed Ultrasound Responsive Scaffold Promotes Intramembranous and Endochondral Ossification via Ultrasonic, Thermal, and Electrical Stimulation.
Jia W, Wang T, Chen F, Liu Z, Hou X, Cao W, Zhao X, Lu B, Hu Y, Dong Y, Zhou J, Zhou Z, Zhan W
ACS nano 2025 Feb 4;19(4):4422-4439
ACS nano 2025 Feb 4;19(4):4422-4439
Piezo knockdown reduces 5‑hydroxytryptamine release from enterochromaffin cells and exacerbates intestinal dyskinesia in mice with functional constipation.
Yan X, Ma P, Wang W, Zeng W, Li Y, Hou Y, Ye J, Zheng Q, Zhang W, Yao J, Li Y
International journal of molecular medicine 2025 Dec;56(6)
International journal of molecular medicine 2025 Dec;56(6)
Magnetically guided neurite outgrowth modulated by PIEZO1 in hiPSC-derived retinal ganglion cells.
Chen IT, Chu PH, Hu SH, Chen SK, Chiao CC, Yang TC
Materials today. Bio 2025 Dec;35:102446
Materials today. Bio 2025 Dec;35:102446
High Shear Stress-Induced Endothelial Piezo1 Downregulation Promotes Intracranial Aneurysm Formation via the PDGF-BB/PDGFRβ Paracrine Signaling Pathway.
Lu Z, Li S, Xu F, Tang H, Zhu S, Wang C, Yang X, Huang Q
CNS neuroscience & therapeutics 2025 Dec;31(12):e70715
CNS neuroscience & therapeutics 2025 Dec;31(12):e70715
Hyperosmolarity-induced activation of PIEZO1 engages detrimental calcium/oxidative stress signaling and adaptive catalase response in renal inner medullary collecting duct (mIMCD(3)) cells.
Probst S, Romanova N, Herbrechter R, Kern T, Bergmeier M, Lee WK, Thévenod F
Biochimica et biophysica acta. Molecular cell research 2025 Dec;1872(8):120041
Biochimica et biophysica acta. Molecular cell research 2025 Dec;1872(8):120041
Loss of TRPV4 reduces pancreatic cancer growth and metastasis.
Romac JM, Swain SM, Mullappilly N, Bindhani B, Liddle RA
JCI insight 2025 Dec 8;10(23)
JCI insight 2025 Dec 8;10(23)
Membrane dome-based regulation mechanism of the mechanosensitive PIEZO channel.
Liu Y, Liu B, Zhan W, Zhang L, Shi A, Lin L, Jiang M, Guo YR
Cell reports 2025 Dec 23;44(12):116651
Cell reports 2025 Dec 23;44(12):116651
The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the PI3K/AKT/mTORC1 Pathway in Osteoarthritis.
Han Y, Cheng F, Li X, Yu J, Li G, Chen W, Zhang J, Feng C, Zhang Y, Wang J
Journal of cellular and molecular medicine 2025 Aug;29(15):e70734
Journal of cellular and molecular medicine 2025 Aug;29(15):e70734
Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning.
Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S, Luo S, Zhang C, Peng G, Li J, Yu J, Ling Y, Fan Z, Mo W, Yang Y, Zhang J
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Aug;21(8):e70331
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Aug;21(8):e70331
SETD2 drives METTL14-mediated m(6)A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension.
Zhao SS, Yuan C, Liu JL, Wu QC, Zhou XL
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):302
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):302
Ovalbumin-induced asthma leads to bone loss with Piezo channel suppression in mice.
Gao W, Sawada T, Cao A, Yoshimoto RU, Yamaguchi Y, Takahashi Y, Fukuda T, Ohsaki Y, Aijima R, Kadowaki T, Tsukuba T, Kido MA
Communications biology 2025 Aug 29;8(1):1309
Communications biology 2025 Aug 29;8(1):1309
Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammation.
Fukuoka S, Adachi N, Ouchi E, Ikemoto H, Okumo T, Ishikawa F, Onda H, Sunagawa M
The ocular surface 2025 Apr;36:56-68
The ocular surface 2025 Apr;36:56-68
Piezo1 exacerbates inflammation-induced cartilaginous endplate degeneration by activating mitochondrial fission via the Ca(2+)/CaMKII/Drp1 axis.
Lin Z, Xu G, Lu X, Wang H, Lu F, Xia X, Song J, Jiang J, Ma X, Zou F
Aging cell 2025 Apr;24(4):e14440
Aging cell 2025 Apr;24(4):e14440
Applying Ultrasound to Mechanically and Noninvasively Sensitize Prostate Tumors to TRAIL-Mediated Apoptosis.
Fabiano AR, Newman MW, Dombroski JA, Rowland SJ, Knoblauch SV, Kusunose J, Gibson-Corley KN, Kaufman BG, Ren L, Caskey CF, King MR
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412995
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412995
The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells.
Liu T, Liang H, Li Y, Liao W, Deng J, Zhang L, Shen F
Discover oncology 2025 Apr 30;16(1):644
Discover oncology 2025 Apr 30;16(1):644
Potentiation of macrophage Piezo1 by atherogenic 7-ketocholesterol.
Glogowska E, Jose GP, Dias Araújo AR, Arhatte M, Divita R, Borowczyk C, Barouillet T, Wang B, Brau F, Peyronnet R, Patel A, Mesmin B, Harayama T, Antonny B, Xu A, Yvan-Charvet L, Honoré E
Cell reports 2025 Apr 22;44(4):115542
Cell reports 2025 Apr 22;44(4):115542
Endothelial Piezo1 stimulates angiogenesis to offer protection against intestinal ischemia-reperfusion injury in mice.
Wang C, Luo S, Yan Y, Li J, Niu W, Hong T, Hao K, Sun X, Liu J, An R, Li J
Molecular medicine (Cambridge, Mass.) 2025 Apr 22;31(1):147
Molecular medicine (Cambridge, Mass.) 2025 Apr 22;31(1):147
Abnormal urodynamic changes in post-upper urinary tract dysfunction in ureteral obstruction rat models.
Liu X, Li X, Liao L
Frontiers in physiology 2024;15:1341220
Frontiers in physiology 2024;15:1341220
Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1.
Zheng F, Wu T, Wang F, Li H, Tang H, Cui X, Li C, Wang Y, Jiang J
Frontiers in bioengineering and biotechnology 2024;12:1347406
Frontiers in bioengineering and biotechnology 2024;12:1347406
PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes.
Pang R, Sun W, Yang Y, Wen D, Lin F, Wang D, Li K, Zhang N, Liang J, Xiong C, Liu Y
Nature biomedical engineering 2024 Sep;8(9):1162-1176
Nature biomedical engineering 2024 Sep;8(9):1162-1176
Piezo1 inhibitor isoquercitrin rescues neural impairment mediated by NLRP3 after intracerebral hemorrhage.
Guo T, Chen G, Yang L, Deng J, Pan Y
Experimental neurology 2024 Sep;379:114852
Experimental neurology 2024 Sep;379:114852
Activation of Piezo1 by intracranial hypertension induced neuronal apoptosis via activating hippo pathway.
Zeng J, Fang Z, Duan J, Zhang Z, Wang Y, Wang Y, Chen L, Wang J, Liu F
CNS neuroscience & therapeutics 2024 Sep;30(9):e14872
CNS neuroscience & therapeutics 2024 Sep;30(9):e14872
Quercetin ameliorates atherosclerosis by inhibiting inflammation of vascular endothelial cells via Piezo1 channels.
Wang YM, Chu TJ, Wan RT, Niu WP, Bian YF, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155865
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155865
Guizhitongluo Tablet inhibits atherosclerosis and foam cell formation through regulating Piezo1/NLRP3 mediated macrophage pyroptosis.
Pan X, Xu H, Ding Z, Luo S, Li Z, Wan R, Jiang J, Chen X, Liu S, Chen Z, Chen X, He B, Deng M, Zhu X, Xian S, Li J, Wang L, Fang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155827
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155827
Ultrasound-triggered piezoelectric polyetheretherketone with boosted osteogenesis via regulating Akt/GSK3β/β-catenin pathway.
Li Y, Fan Y, Zhao S, Cheng B
Journal of nanobiotechnology 2024 Sep 5;22(1):539
Journal of nanobiotechnology 2024 Sep 5;22(1):539
The mechanosensitive Piezo1 channel exacerbates myocardial ischaemia/reperfusion injury by activating caspase-8-mediated PANoptosis.
Li PB, Bai JQ, Jiang WX, Li HH, Li CM
International immunopharmacology 2024 Sep 30;139:112664
International immunopharmacology 2024 Sep 30;139:112664
Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal.
Kuck L, McNamee AP, Bordukova M, Sadafi A, Marr C, Peart JN, Simmonds MJ
Proceedings of the National Academy of Sciences of the United States of America 2024 Sep 3;121(36):e2407765121
Proceedings of the National Academy of Sciences of the United States of America 2024 Sep 3;121(36):e2407765121
Inflammatory Signaling via PEIZO1 Engages and Enhances the LPS-Mediated Apoptosis during Clinical Mastitis.
Wang J, Li M, Wu W, Zhang H, Yang Y, Usman M, Aernouts B, Loor JJ, Xu C
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20321-20330
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20321-20330
Mechanosensitive Piezo1 channels promote neurogenic bladder fibrosis via regulating TGF-β1/smad and Hippo/YAP1 pathways.
Feng S, Yu Z, Yang Y, Xiong Q, Yan X, Bi Y
Experimental cell research 2024 Sep 1;442(1):114218
Experimental cell research 2024 Sep 1;442(1):114218
Increased Piezo1 expression in myofibroblasts in patients with symptomatic carotid atherosclerotic plaques undergoing carotid endarterectomy: A pilot study.
Konishi T, Kamiyama K, Osato T, Yoshimoto T, Aoki T, Anzai T, Tanaka S
Vascular 2024 Oct;32(5):1063-1069
Vascular 2024 Oct;32(5):1063-1069
Radial extracorporeal shockwave promotes osteogenesis-angiogenesis coupling of bone marrow stromal cells from senile osteoporosis via activating the Piezo1/CaMKII/CREB axis.
Wang B, Shao W, Zhao Y, Li Z, Wang P, Lv X, Chen Y, Chen X, Zhu Y, Ma Y, Han L, Wu W, Feng Y
Bone 2024 Oct;187:117196
Bone 2024 Oct;187:117196
Aberrant overexpression of myosin 1b in glioblastoma promotes angiogenesis via VEGF-myc-myosin 1b-Piezo1 axis.
Lv W, Yang F, Ge Z, Xin L, Zhang L, Zhai Y, Liu X, Guo Q, Mao X, Luo P, Zhang L, Jiang X, Zhang Y
The Journal of biological chemistry 2024 Nov;300(11):107807
The Journal of biological chemistry 2024 Nov;300(11):107807
Lithospermic acid improves liver fibrosis through Piezo1-mediated oxidative stress and inflammation.
Luo S, Yang B, Xu H, Pan X, Chen X, Jue X, Liu S, Wan R, Tan Q, Yao Y, Chen X, Jiang J, Deng B, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155974
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155974
PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformations.
Park H, Lee S, Furtado J, Robinson M, Schwartz M, Young L, Eichmann A
bioRxiv : the preprint server for biology 2024 Nov 28;
bioRxiv : the preprint server for biology 2024 Nov 28;
Activation of Piezo1 channels enhances spontaneous contractions of isolated human bladder strips via acetylcholine release from the mucosa.
Liu H, Li P, Zhao M, Ma T, Lv G, Liu L, Wen J, Liu J, Yan J, Li J, Xiao Z, Wang W, Wang H, Xiao P, Zhang X
European journal of pharmacology 2024 Nov 15;983:176954
European journal of pharmacology 2024 Nov 15;983:176954
Activation of PIEZO1 Attenuates Kidney Cystogenesis In Vitro and Ex Vivo.
Fan Q, Hadla M, Peterson Z, Nelson G, Ye H, Wang X, Mardirossian JM, Harris PC, Alper SL, Prakash YS, Beyder A, Torres VE, Chebib FT
Kidney360 2024 Nov 1;5(11):1601-1612
Kidney360 2024 Nov 1;5(11):1601-1612
Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis.
Zhu J, Wu Y, Zhang L, Bai B, Han W, Wang H, Mei Q
Free radical biology & medicine 2024 Nov 1;224:272-286
Free radical biology & medicine 2024 Nov 1;224:272-286
Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity.
Hurrell BP, Shen S, Li X, Sakano Y, Kazemi MH, Quach C, Shafiei-Jahani P, Sakano K, Ghiasi H, Akbari O
The Journal of experimental medicine 2024 May 6;221(5)
The Journal of experimental medicine 2024 May 6;221(5)
The local mechanosensitive response of primary cardiac fibroblasts is influenced by the microenvironment mechanics.
Braidotti N, Demontis G, Conti M, Andolfi L, Ciubotaru CD, Sbaizero O, Cojoc D
Scientific reports 2024 May 6;14(1):10365
Scientific reports 2024 May 6;14(1):10365
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing.
Liu Y, Zhang M, Wang C, Chen H, Su D, Yang C, Tao Y, Lv X, Zhou Z, Li J, Liao Y, You J, Wang Z, Cheng F, Yang R
ACS nano 2024 May 28;18(21):13696-13713
ACS nano 2024 May 28;18(21):13696-13713
Activation of Piezo1 Inhibits Kidney Cystogenesis.
Fan Q, Hadla M, Peterson Z, Nelson G, Ye H, Wang X, Mardirossian JM, Harris PC, Alper SL, Prakash YS, Beyder A, Torres VE, Chebib FT
bioRxiv : the preprint server for biology 2024 May 14;
bioRxiv : the preprint server for biology 2024 May 14;
Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis.
Abbonante V, Karkempetzaki AI, Leon C, Krishnan A, Huang N, Di Buduo CA, Cattaneo D, Ward CM, Matsuura S, Guinard I, Weber J, De Acutis A, Vozzi G, Iurlo A, Ravid K, Balduini A
American journal of hematology 2024 Mar;99(3):336-349
American journal of hematology 2024 Mar;99(3):336-349
Magnetic Aggregation-Induced Bone-Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic-Angiogenic Coupling for Osteoporotic Bone Repair.
Guan H, Wang W, Jiang Z, Zhang B, Ye Z, Zheng J, Chen W, Liao Y, Zhang Y
Advanced materials (Deerfield Beach, Fla.) 2024 Mar;36(13):e2312081
Advanced materials (Deerfield Beach, Fla.) 2024 Mar;36(13):e2312081
Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto-Active Substrates.
Gomez-Cruz C, Fernandez-de la Torre M, Lachowski D, Prados-de-Haro M, Del Río Hernández AE, Perea G, Muñoz-Barrutia A, Garcia-Gonzalez D
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(26):e2312497
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(26):e2312497
Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated Ca(2+) dynamics.
Johansen CG, Holcomb K, Sela A, Morrall S, Park D, Farnsworth NL
Matrix biology plus 2024 Jun;22:100148
Matrix biology plus 2024 Jun;22:100148
Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage.
Qi M, Liu R, Zhang F, Yao Z, Zhou ML, Jiang X, Ling S
Neuropharmacology 2024 Jun 15;251:109896
Neuropharmacology 2024 Jun 15;251:109896
Resistive spontaneous breathing exacerbated lipopolysaccharide-induced lung injury in mice.
Cai Z, Zhang H, Guo X, Song L
Biochemistry and biophysics reports 2024 Jul;38:101726
Biochemistry and biophysics reports 2024 Jul;38:101726
Neutrophil migration participates in the side effect of recombinant human tissue plasminogen activator.
Huang Y, Han Z, Shen T, Zheng Y, Yang Z, Fan J, Wang R, Yan F, Tao Z, Luo Y, Liu P
CNS neuroscience & therapeutics 2024 Jul;30(7):e14825
CNS neuroscience & therapeutics 2024 Jul;30(7):e14825
trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing.
Mukhopadhyay A, Tsukasaki Y, Chan WC, Le JP, Kwok ML, Zhou J, Natarajan V, Mostafazadeh N, Maienschein-Cline M, Papautsky I, Tiruppathi C, Peng Z, Rehman J, Ganesh B, Komarova Y, Malik AB
Immunity 2024 Jan 9;57(1):52-67.e10
Immunity 2024 Jan 9;57(1):52-67.e10
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Jia C, Xiang Z, Zhang P, Liu L, Zhu X, Yu R, Liu Z, Wang S, Liu K, Wang Z, Vasilev K, Zhou S, Geng Z, Liu X, Zhao Y, Gao Y, Cheng L, Li Y
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
Brylka LJ, Alimy AR, Tschaffon-Müller MEA, Jiang S, Ballhause TM, Baranowsky A, von Kroge S, Delsmann J, Pawlus E, Eghbalian K, Püschel K, Schoppa A, Haffner-Luntzer M, Beech DJ, Beil FT, Amling M, Keller J, Ignatius A, Yorgan TA, Rolvien T, Schinke T
Bone research 2024 Feb 23;12(1):12
Bone research 2024 Feb 23;12(1):12
Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells.
Liu CSC, Mandal T, Biswas P, Hoque MA, Bandopadhyay P, Sinha BP, Sarif J, D'Rozario R, Sinha DK, Sinha B, Ganguly D
eLife 2024 Feb 23;12
eLife 2024 Feb 23;12
Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response.
Burchett A, Siri S, Li J, Lu X, Datta M
bioRxiv : the preprint server for biology 2024 Feb 17;
bioRxiv : the preprint server for biology 2024 Feb 17;
Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction.
Zhang Y, Lv L, Zhou Z, Zhang H, Li Q, Yang S, Wen Y, Wang Q, Feng J, Lu W, Jia W, Wen JG
Renal failure 2024 Dec;46(2):2415519
Renal failure 2024 Dec;46(2):2415519
Endothelial KDM5B Regulated by Piezo1 Contributes to Disturbed Flow Induced Atherosclerotic Plaque Formation.
Wu L, Jiang S, Zhou X, Li W, Ke J, Liu Z, Ren L, Lu Q, Li F, Tang C, Zhu L
Journal of cellular and molecular medicine 2024 Dec;28(23):e70237
Journal of cellular and molecular medicine 2024 Dec;28(23):e70237
Membrane Tension Regulation is Required for Wound Repair.
Raj N, Weiß MS, Vos BE, Weischer S, Brinkmann F, Betz T, Trappmann B, Gerke V
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2402317
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2402317
Piezo1 Regulates Stiffness-Dependent DRG Axon Regeneration via Modifying Cytoskeletal Dynamics.
Lei M, Wang W, Zhang H, Gong J, Cai H, Wang Z, Zhu L, Yang X, Wang S, Ma C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2405705
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2405705
Insufficient Mechanical Loading Downregulates Piezo1 in Chondrocytes and Impairs Fracture Healing Through ApoE-Induced Senescence.
Jia S, Liu W, Zhang M, Wang L, Ren C, Feng C, Zhang T, Lv H, Hou Z, Zou W, Zhang Y, Tong W, Wang J, Chen W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(46):e2400502
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(46):e2400502
Piezo1 Mediates Glycolysis-Boosted Pancreatic Ductal Adenocarcinoma Chemoresistance within a Biomimetic Three-Dimensional Matrix Stiffness.
Pan H, Zhang X, Zhu S, Zhu B, Wu D, Yan J, Guan X, Huang Y, Zhao Y, Yang Y, Guo Y
ACS biomaterials science & engineering 2024 Dec 9;10(12):7632-7646
ACS biomaterials science & engineering 2024 Dec 9;10(12):7632-7646
The pivotal role of the Hes1/Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosis.
Ochiai N, Etani Y, Noguchi T, Miura T, Kurihara T, Fukuda Y, Hamada H, Uemura K, Takashima K, Tamaki M, Ishibashi T, Ito S, Yamakawa S, Kanamoto T, Okada S, Nakata K, Ebina K
JCI insight 2024 Dec 6;9(23)
JCI insight 2024 Dec 6;9(23)
Effects of Panax notoginseng saponins on alleviating low shear induced endothelial inflammation and thrombosis via Piezo1 signalling.
Liu L, Li J, Wang Y, Gong P, Feng J, Xiao S, Xu J, Yin X, Liao F, You Y
Journal of ethnopharmacology 2024 Dec 5;335:118639
Journal of ethnopharmacology 2024 Dec 5;335:118639
Piezo1 overexpression in the uterus contributes to myometrium contraction and inflammation-associated preterm birth.
Bi Y, Li H, Diao M, Liu Q, Huang L, Tao Y, Wan Y, Lin X
Journal of translational medicine 2024 Dec 23;22(1):1140
Journal of translational medicine 2024 Dec 23;22(1):1140
Ion channel Piezo1 induces ferroptosis of trabecular meshwork cells: a novel observation in the pathogenesis in primary open angle glaucoma.
Liu K, Xu J, Yang R, Wang F, Su Y
American journal of physiology. Cell physiology 2024 Dec 1;327(6):C1591-C1603
American journal of physiology. Cell physiology 2024 Dec 1;327(6):C1591-C1603
Matrix stiffness regulates macrophage polarisation via the Piezo1-YAP signalling axis.
Mei F, Guo Y, Wang Y, Zhou Y, Heng BC, Xie M, Huang X, Zhang S, Ding S, Liu F, Deng X, Chen L, Yang C
Cell proliferation 2024 Aug;57(8):e13640
Cell proliferation 2024 Aug;57(8):e13640
Pressure sensing of lysosomes enables control of TFEB responses in macrophages.
Cai R, Scott O, Ye G, Le T, Saran E, Kwon W, Inpanathan S, Sayed BA, Botelho RJ, Saric A, Uderhardt S, Freeman SA
Nature cell biology 2024 Aug;26(8):1247-1260
Nature cell biology 2024 Aug;26(8):1247-1260
Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during aging.
Rivera CF, Farra YM, Silvestro M, Medvedovsky S, Matz J, Pratama MY, Vlahos J, Ramkhelawon B, Bellini C
Aging cell 2024 Aug;23(8):e14197
Aging cell 2024 Aug;23(8):e14197
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
Hou J, Lin Y, Zhu C, Chen Y, Lin R, Lin H, Liu D, Guan D, Yu B, Wang J, Wu H, Cui Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca(2+) influx.
Yan Z, Niu L, Wang S, Gao C, Pan S
Journal of translational medicine 2024 Apr 4;22(1):332
Journal of translational medicine 2024 Apr 4;22(1):332
The Microbiota-Dependent Treatment of Wuzhuyu Decoction for Chronic Migraine Model Rat Associated with Anxiety-Depression Like Behavior.
Nan N, Wang Q, Li MJ, Xu YS, Guo XM, Xu R, Ma Z, Wang SH, Li J, Zhao H, Gong MX
Oxidative medicine and cellular longevity 2023;2023:2302653
Oxidative medicine and cellular longevity 2023;2023:2302653
Inhibition of Piezo1 Ameliorates Intestinal Inflammation and Limits the Activation of Group 3 Innate Lymphoid Cells in Experimental Colitis.
Liu C, Xia Y, Fu S, Meng F, Feng B, Xu L, Li L, Zuo X
Journal of innate immunity 2023;15(1):709-723
Journal of innate immunity 2023;15(1):709-723
PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model.
Anderson DE, Broun KG, Kundu P, Jing X, Tang X, Lu C, Kotelsky A, Mannava S, Lee W
Frontiers in bioengineering and biotechnology 2023;11:1244975
Frontiers in bioengineering and biotechnology 2023;11:1244975
A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.
Shen X, Wu W, Ying Y, Zhou L, Zhu H
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 2023 Sep;49 Suppl 1:228-237
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 2023 Sep;49 Suppl 1:228-237
Slowed Intestinal Transit Induced by Less Mucus in Intestinal Goblet Cell Piezo1-Deficient Mice through Impaired Epithelial Homeostasis.
Fang F, Liu Y, Xiong Y, Li X, Li G, Jiang Y, Hou X, Song J
International journal of molecular sciences 2023 Sep 21;24(18)
International journal of molecular sciences 2023 Sep 21;24(18)
Modulation of Piezo1 influences human skin architecture and oxytocin expression.
Labarrade F, Perrin A, Ferreira Y, Botto JM, Imbert I
International journal of cosmetic science 2023 Oct;45(5):604-611
International journal of cosmetic science 2023 Oct;45(5):604-611
Piezo1 Activation Prevents Spheroid Formation by Malignant Melanoma SK-MEL-2 Cells.
Vasileva VY, Khairullina ZM, Chubinskiy-Nadezhdin VI
International journal of molecular sciences 2023 Oct 28;24(21)
International journal of molecular sciences 2023 Oct 28;24(21)
Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorder.
Bai F, Huang L, Long Z, Zhang M, Deng Q, Huang J, Bao X, Hao X, Li H
Functional & integrative genomics 2023 Oct 27;23(4):327
Functional & integrative genomics 2023 Oct 27;23(4):327
PPP1R3A inhibits osteogenesis and negatively regulates intracellular calcium levels in calcific tendinopathy.
Hu C, Ma L, Gao S, Yang MY, Mu MD, Chang L, Huang P, Ye X, Wang W, Tao X, Zhou BH, Chen W, Tang KL
iScience 2023 Oct 20;26(10):107784
iScience 2023 Oct 20;26(10):107784
Different stimuli induce endothelial dysfunction and promote atherosclerosis through the Piezo1/YAP signaling axis.
Mao J, Yang R, Yuan P, Wu F, Wei Y, Nie Y, Zhang C, Zhou X
Archives of biochemistry and biophysics 2023 Oct 1;747:109755
Archives of biochemistry and biophysics 2023 Oct 1;747:109755
Aloperine protects pulmonary hypertension via triggering PPARγ signaling and inhibiting calcium regulatory pathway in pulmonary arterial smooth muscle cells.
Shan X, Gegentuya, Wang J, Feng H, Zhang Z, Zheng Q, Zhang Q, Yang K, Wang J, Xu L
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1058-C1072
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1058-C1072
The Critical Role of The Piezo1/β-catenin/ATF4 Axis on The Stemness of Gli1(+) BMSCs During Simulated Microgravity-Induced Bone Loss.
Hu Y, Tian H, Chen W, Liu Y, Cao Y, Pei H, Ming C, Shan C, Chen X, Dai Z, Yang S, Shao Z, Lan S, Liu Y, Tong W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2303375
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2303375
Effects of liraglutide on ANP secretion and cardiac dynamics.
Luo S, Zuo Y, Cui X, Zhang M, Jin H, Hong L
Endocrine connections 2023 Nov 1;12(11)
Endocrine connections 2023 Nov 1;12(11)
Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice.
Qin L, Chen Z, Yang D, He T, Xu Z, Zhang P, Chen D, Yi W, Xiao G
Journal of orthopaedic translation 2023 May;40:58-71
Journal of orthopaedic translation 2023 May;40:58-71
Chemical Activation and Mechanical Sensitization of Piezo1 Enhance TRAIL-Mediated Apoptosis in Glioblastoma Cells.
Knoblauch SV, Desai SH, Dombroski JA, Sarna NS, Hope JM, King MR
ACS omega 2023 May 16;8(19):16975-16986
ACS omega 2023 May 16;8(19):16975-16986
A static magnetic field enhances the repair of osteoarthritic cartilage by promoting the migration of stem cells and chondrogenesis.
Sun Y, Fang Y, Li X, Li J, Liu D, Wei M, Liao Z, Meng Y, Zhai L, Yokota H, Yang L, Yu Y, Zhang P
Journal of orthopaedic translation 2023 Mar;39:43-54
Journal of orthopaedic translation 2023 Mar;39:43-54
Proteome alterations in erythrocytes with PIEZO1 gain-of-function mutations.
Andolfo I, Monaco V, Cozzolino F, Rosato BE, Marra R, Cerbone V, Pinto VM, Forni GL, Unal S, Iolascon A, Monti M, Russo R
Blood advances 2023 Jun 27;7(12):2681-2693
Blood advances 2023 Jun 27;7(12):2681-2693
Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis.
Zhong G, Su S, Li J, Zhao H, Hu D, Chen J, Li S, Lin Y, Wen L, Lin X, Xian G, Xu D, Zeng Q
Science advances 2023 Jun 2;9(22):eadg0478
Science advances 2023 Jun 2;9(22):eadg0478
Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells.
Li R, Wang D, Li H, Lei X, Liao W, Liu XY
Discover oncology 2023 Jun 12;14(1):95
Discover oncology 2023 Jun 12;14(1):95
Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.
Jiang M, Zhang YX, Bu WJ, Li P, Chen JH, Cao M, Dong YC, Sun ZJ, Dong DL
British journal of pharmacology 2023 Jul;180(14):1862-1877
British journal of pharmacology 2023 Jul;180(14):1862-1877
Accelerated Bone Reconstruction by the Yoda1 Bilayer Membrane via Promotion of Osteointegration and Angiogenesis.
Yang J, Yuan K, Zhang T, Zhou S, Li W, Chen Z, Wang Y
Advanced healthcare materials 2023 Jul;12(18):e2203105
Advanced healthcare materials 2023 Jul;12(18):e2203105
Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1.
Liu C, Gao X, Lou J, Li H, Chen Y, Chen M, Zhang Y, Hu Z, Chang X, Luo M, Zhai Y, Li C
Arthritis research & therapy 2023 Jul 7;25(1):117
Arthritis research & therapy 2023 Jul 7;25(1):117
De Novo Cloning and Functional Characterization of a Mechanosensitive Piezo-Like Ion Channel in the Crayfish.
Ergin B, Saglam B, Arslan K, Coskun Beyatli N, Taskiran ZE, Bastug T, Purali N
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2023 Jul 29;57(4):226-237
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2023 Jul 29;57(4):226-237
Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes.
Savadipour A, Nims RJ, Rashidi N, Garcia-Castorena JM, Tang R, Marushack GK, Oswald SJ, Liedtke WB, Guilak F
Proceedings of the National Academy of Sciences of the United States of America 2023 Jul 25;120(30):e2221958120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jul 25;120(30):e2221958120
Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels.
Shin SM, Itson-Zoske B, Fan F, Gani U, Rahman M, Hogan QH, Yu H
Molecular pain 2023 Jan-Dec;19:17448069231174315
Molecular pain 2023 Jan-Dec;19:17448069231174315
The Mechanosensitive Ion Channel PIEZO1 in Intestinal Epithelial Cells Mediates Inflammation through the NOD-Like Receptor 3 Pathway in Crohn's Disease.
Liu Q, Wang D, Yang X, Ma F, Han W, Hu J, Mei Q
Inflammatory bowel diseases 2023 Jan 5;29(1):103-115
Inflammatory bowel diseases 2023 Jan 5;29(1):103-115
Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification.
Xu Y, Xiong Y, Liu Y, Li G, Bai T, Zheng G, Hou X, Song J
Cell & bioscience 2023 Jan 12;13(1):7
Cell & bioscience 2023 Jan 12;13(1):7
Soft, strong, tough, and durable protein-based fiber hydrogels.
Wang M, Sun S, Dong G, Long F, Butcher JT
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 21;120(8):e2213030120
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 21;120(8):e2213030120
The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia.
Zhu T, Guo J, Wu Y, Lei T, Zhu J, Chen H, Kala S, Wong KF, Cheung CP, Huang X, Zhao X, Yang M, Sun L
iScience 2023 Feb 17;26(2):105993
iScience 2023 Feb 17;26(2):105993
Lipid-anchored proteasomes control membrane protein homeostasis.
Zhang R, Pan S, Zheng S, Liao Q, Jiang Z, Wang D, Li X, Hu A, Li X, Zhu Y, Shen X, Lei J, Zhong S, Zhang X, Huang L, Wang X, Huang L, Shen L, Song BL, Zhao JW, Wang Z, Yang B, Guo X
Science advances 2023 Dec;9(48):eadj4605
Science advances 2023 Dec;9(48):eadj4605
Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside.
Vanderroost J, Parpaite T, Avalosse N, Henriet P, Pierreux CE, Lorent JH, Gailly P, Tyteca D
Cells 2023 Dec 7;12(24)
Cells 2023 Dec 7;12(24)
Piezo1 Regulation Involves Lipid Domains and the Cytoskeleton and Is Favored by the Stomatocyte-Discocyte-Echinocyte Transformation.
Stommen A, Ghodsi M, Cloos AS, Conrard L, Dumitru AC, Henriet P, Pierreux CE, Alsteens D, Tyteca D
Biomolecules 2023 Dec 30;14(1)
Biomolecules 2023 Dec 30;14(1)
Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation.
Lei M, Wang W, Zhang H, Gong J, Wang Z, Cai H, Yang X, Wang S, Ma C
Cell reports 2023 Dec 26;42(12):113522
Cell reports 2023 Dec 26;42(12):113522
Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis.
Hajiali H, Rotherham M, El Haj AJ
Pharmaceutics 2023 Dec 22;16(1)
Pharmaceutics 2023 Dec 22;16(1)
Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1.
Chen F, Sun M, Peng F, Lai Y, Jiang Z, Zhang W, Li T, Jing X
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Aug;41(8):1792-1802
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Aug;41(8):1792-1802
Piezo1 channel-mediated Ca(2+) signaling inhibits lipopolysaccharide-induced activation of the NF-κB inflammatory signaling pathway and generation of TNF-α and IL-6 in microglial cells.
Malko P, Jia X, Wood I, Jiang LH
Glia 2023 Apr;71(4):848-865
Glia 2023 Apr;71(4):848-865
Low-Intensity Pulsed Ultrasound Attenuates Postoperative Neurocognitive Impairment and Salvages Hippocampal Synaptogenesis in Aged Mice.
Wang Q, Liu T, Chang H, Li Z, Chen L, Mi X, Xing H, Wang X, Hong J, Liu K, Li Y, Han D, Li Y, Yang N, Li X, Li Y, Guo X
Brain sciences 2023 Apr 13;13(4)
Brain sciences 2023 Apr 13;13(4)
Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis.
Hirata Y, Cai R, Volchuk A, Steinberg BE, Saito Y, Matsuzawa A, Grinstein S, Freeman SA
Current biology : CB 2023 Apr 10;33(7):1282-1294.e5
Current biology : CB 2023 Apr 10;33(7):1282-1294.e5
PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
Chuntharpursat-Bon E, Povstyan OV, Ludlow MJ, Carrier DJ, Debant M, Shi J, Gaunt HJ, Bauer CC, Curd A, Simon Futers T, Baxter PD, Peckham M, Muench SP, Adamson A, Humphreys N, Tumova S, Bon RS, Cubbon R, Lichtenstein L, Beech DJ
Communications biology 2023 Apr 1;6(1):358
Communications biology 2023 Apr 1;6(1):358
Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing.
Liu Y, Tian H, Hu Y, Cao Y, Song H, Lan S, Dai Z, Chen W, Zhang Y, Shao Z, Liu Y, Tong W
International journal of biological sciences 2022;18(10):3961-3980
International journal of biological sciences 2022;18(10):3961-3980
A Novel Homozygous Missense Mutation of PIEZO1 Leading to Lymphatic Malformation-6 Identified in a Family With Three Adverse Pregnancy Outcomes due to Nonimmune Fetal Hydrops.
Han S, Guo X, Wang X, Lin H, Yu Y, Shu J, Dong M, Yang L
Frontiers in genetics 2022;13:856046
Frontiers in genetics 2022;13:856046
Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice.
Liu Y, Fang F, Xiong Y, Wu J, Li X, Li G, Bai T, Hou X, Song J
Frontiers in cellular and infection microbiology 2022;12:1035386
Frontiers in cellular and infection microbiology 2022;12:1035386
TiO(2) Nanotubes Promote Osteogenic Differentiation Through Regulation of Yap and Piezo1.
Kong K, Chang Y, Hu Y, Qiao H, Zhao C, Rong K, Zhang P, Zhang J, Zhai Z, Li H
Frontiers in bioengineering and biotechnology 2022;10:872088
Frontiers in bioengineering and biotechnology 2022;10:872088
High-throughput membrane-anchored proteome screening reveals PIEZO1 as a promising antibody-drug target for human esophageal squamous cell carcinoma.
Qin X, Ni Z, Jiang J, Liu X, Dong X, Li M, Miao K, Rao S, Zhang W, Cai K
Cancer medicine 2022 Oct;11(19):3700-3713
Cancer medicine 2022 Oct;11(19):3700-3713
Activation of Piezo1 Increases Na,K-ATPase-Mediated Ion Transport in Mouse Lens.
Shahidullah M, Rosales JL, Delamere N
International journal of molecular sciences 2022 Oct 25;23(21)
International journal of molecular sciences 2022 Oct 25;23(21)
Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis.
Kim OH, Choi YW, Park JH, Hong SA, Hong M, Chang IH, Lee HJ
Life sciences 2022 Nov 1;308:120936
Life sciences 2022 Nov 1;308:120936
Skin cells undergo asynthetic fission to expand body surfaces in zebrafish.
Chan KY, Yan CS, Roan HY, Hsu SC, Tseng TL, Hsiao CD, Hsu CP, Chen CH
Nature 2022 May;605(7908):119-125
Nature 2022 May;605(7908):119-125
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.
Chen J, Rodriguez M, Miao J, Liao J, Jain PP, Zhao M, Zhao T, Babicheva A, Wang Z, Parmisano S, Powers R, Matti M, Paquin C, Soroureddin Z, Shyy JY, Thistlethwaite PA, Makino A, Wang J, Yuan JX
American journal of physiology. Lung cellular and molecular physiology 2022 May 1;322(5):L737-L760
American journal of physiology. Lung cellular and molecular physiology 2022 May 1;322(5):L737-L760
Fluid shear stress enhances T cell activation through Piezo1.
Hope JM, Dombroski JA, Pereles RS, Lopez-Cavestany M, Greenlee JD, Schwager SC, Reinhart-King CA, King MR
BMC biology 2022 Mar 9;20(1):61
BMC biology 2022 Mar 9;20(1):61
A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation.
MacKay CE, Floen M, Leo MD, Hasan R, Garrud TAC, Fernández-Peña C, Singh P, Malik KU, Jaggar JH
eLife 2022 Mar 1;11
eLife 2022 Mar 1;11
Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells.
Peng Y, Du J, Günther S, Guo X, Wang S, Schneider A, Zhu L, Braun T
Redox biology 2022 Jun;52:102309
Redox biology 2022 Jun;52:102309
Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes.
Kenmochi M, Kawarasaki S, Takizawa S, Okamura K, Goto T, Uchida K
The journal of physiological sciences : JPS 2022 Jun 20;72(1):13
The journal of physiological sciences : JPS 2022 Jun 20;72(1):13
Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca(2+) Influx and Akt-eNOS Pathway.
Porto Ribeiro T, Barbeau S, Baudrimont I, Vacher P, Freund-Michel V, Cardouat G, Berger P, Guibert C, Ducret T, Quignard JF
Cells 2022 Jul 30;11(15)
Cells 2022 Jul 30;11(15)
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.
Ye Y, Barghouth M, Dou H, Luan C, Wang Y, Karagiannopoulos A, Jiang X, Krus U, Fex M, Zhang Q, Eliasson L, Rorsman P, Zhang E, Renström E
Nature communications 2022 Jul 22;13(1):4237
Nature communications 2022 Jul 22;13(1):4237
Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis.
Wang S, Wang B, Shi Y, Möller T, Stegmeyer RI, Strilic B, Li T, Yuan Z, Wang C, Wettschureck N, Vestweber D, Offermanns S
Blood 2022 Jul 21;140(3):171-183
Blood 2022 Jul 21;140(3):171-183
Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation.
Yang Y, Wang D, Zhang C, Yang W, Li C, Gao Z, Pei K, Li Y
Human cell 2022 Jan;35(1):51-62
Human cell 2022 Jan;35(1):51-62
PIEZO1 mediates a mechanothrombotic pathway in diabetes.
Zhu W, Guo S, Homilius M, Nsubuga C, Wright SH, Quan D, Kc A, Eddy SS, Victorio RA, Beerens M, Flaumenhaft R, Deo RC, MacRae CA
Science translational medicine 2022 Jan 5;14(626):eabk1707
Science translational medicine 2022 Jan 5;14(626):eabk1707
Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1.
Qian W, Hadi T, Silvestro M, Ma X, Rivera CF, Bajpai A, Li R, Zhang Z, Qu H, Tellaoui RS, Corsica A, Zias AL, Garg K, Maldonado T, Ramkhelawon B, Chen W
Nature communications 2022 Jan 26;13(1):512
Nature communications 2022 Jan 26;13(1):512
Fine-Tuning of Piezo1 Expression and Activity Ensures Efficient Myoblast Fusion during Skeletal Myogenesis.
Ortuste Quiroga HP, Ganassi M, Yokoyama S, Nakamura K, Yamashita T, Raimbach D, Hagiwara A, Harrington O, Breach-Teji J, Asakura A, Suzuki Y, Tominaga M, Zammit PS, Goto K
Cells 2022 Jan 24;11(3)
Cells 2022 Jan 24;11(3)
Wuzhuyu Decoction relieves hyperalgesia by regulating central and peripheral 5-HT in chronic migraine model rats.
Nan N, Gong MX, Wang Q, Li MJ, Xu R, Ma Z, Wang SH, Zhao H, Xu YS
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153905
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153905
Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles.
Song Y, Chen J, Zhang C, Xin L, Li Q, Liu Y, Zhang C, Li S, Huang P
iScience 2022 Feb 18;25(2):103733
iScience 2022 Feb 18;25(2):103733
Piezo channels contribute to the regulation of myelination in Schwann cells.
Acheta J, Bhatia U, Haley J, Hong J, Rich K, Close R, Bechler ME, Belin S, Poitelon Y
Glia 2022 Dec;70(12):2276-2289
Glia 2022 Dec;70(12):2276-2289
Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes.
Liu Z, Tang Y, He L, Geng B, Lu F, He J, Yi Q, Liu X, Zhang K, Wang L, Xia Y, Jiang J
Channels (Austin, Tex.) 2022 Dec;16(1):127-136
Channels (Austin, Tex.) 2022 Dec;16(1):127-136
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis.
Yang X, Zeng H, Wang L, Luo S, Zhou Y
Cell & bioscience 2022 Dec 5;12(1):197
Cell & bioscience 2022 Dec 5;12(1):197
Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling.
Zhang S, Cao S, Gong M, Zhang W, Zhang W, Zhu Z, Wu S, Yue Y, Qian W, Ma Q, Wang S, Wang Z
Cancer biology & therapy 2022 Dec 31;23(1):336-347
Cancer biology & therapy 2022 Dec 31;23(1):336-347
Piezo1 act as a potential oncogene in pancreatic cancer progression.
Zhu Z, Li W, Gong M, Wang L, Yue Y, Qian W, Zhou C, Duan W, Han L, Li L, Wu Z, Ma Q, Lin M, Wang S, Wang Z
Life sciences 2022 Dec 1;310:121035
Life sciences 2022 Dec 1;310:121035
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone.
Zeng Y, Riquelme MA, Hua R, Zhang J, Acosta FM, Gu S, Jiang JX
Cell & bioscience 2022 Dec 1;12(1):191
Cell & bioscience 2022 Dec 1;12(1):191
Mechanical force modulates macrophage proliferation via Piezo1-AKT-Cyclin D1 axis.
Xu H, Guan J, Jin Z, Yin C, Wu S, Sun W, Zhang H, Yan B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22423
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22423
Mechanosensitive Piezo1 channels mediate renal fibrosis.
Zhao X, Kong Y, Liang B, Xu J, Lin Y, Zhou N, Li J, Jiang B, Cheng J, Li C, Wang W
JCI insight 2022 Apr 8;7(7)
JCI insight 2022 Apr 8;7(7)
Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells.
Chen L, Yan Y, Kong F, Wang J, Zeng J, Fang Z, Wang Z, Liu Z, Liu F
Cancers 2022 Apr 18;14(8)
Cancers 2022 Apr 18;14(8)
Hereditary Xerocytosis: Differential Behavior of PIEZO1 Mutations in the N-Terminal Extracellular Domain Between Red Blood Cells and HEK Cells.
Yamaguchi Y, Allegrini B, Rapetti-Mauss R, Picard V, Garçon L, Kohl P, Soriani O, Peyronnet R, Guizouarn H
Frontiers in physiology 2021;12:736585
Frontiers in physiology 2021;12:736585
Piezo1 and BK(Ca) channels in human atrial fibroblasts: Interplay and remodelling in atrial fibrillation.
Jakob D, Klesen A, Allegrini B, Darkow E, Aria D, Emig R, Chica AS, Rog-Zielinska EA, Guth T, Beyersdorf F, Kari FA, Proksch S, Hatem SN, Karck M, Künzel SR, Guizouarn H, Schmidt C, Kohl P, Ravens U, Peyronnet R
Journal of molecular and cellular cardiology 2021 Sep;158:49-62
Journal of molecular and cellular cardiology 2021 Sep;158:49-62
Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats.
Zhang Y, Jiang L, Huang T, Lu D, Song Y, Wang L, Gao J
Respiratory research 2021 Sep 21;22(1):250
Respiratory research 2021 Sep 21;22(1):250
Mechanical stimulation activates Piezo1 to promote mucin2 expression in goblet cells.
Xu Y, Bai T, Xiong Y, Liu C, Liu Y, Hou X, Song J
Journal of gastroenterology and hepatology 2021 Nov;36(11):3127-3139
Journal of gastroenterology and hepatology 2021 Nov;36(11):3127-3139
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation.
Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S
The Journal of clinical investigation 2021 Nov 1;131(21)
The Journal of clinical investigation 2021 Nov 1;131(21)
Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway.
Liu S, Xu X, Fang Z, Ning Y, Deng B, Pan X, He Y, Yang Z, Huang K, Li J
Cell calcium 2021 May;95:102367
Cell calcium 2021 May;95:102367
Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells.
Zhang M, Yan S, Xu X, Yu T, Guo Z, Ma M, Zhang Y, Gu Z, Feng Y, Du C, Wan M, Hu K, Han X, Gu N
Biomaterials 2021 Mar;270:120687
Biomaterials 2021 Mar;270:120687
Piezo1 plays a role in optic nerve head astrocyte reactivity.
Liu J, Yang Y, Liu Y
Experimental eye research 2021 Mar;204:108445
Experimental eye research 2021 Mar;204:108445
Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.
Lee W, Nims RJ, Savadipour A, Zhang Q, Leddy HA, Liu F, McNulty AL, Chen Y, Guilak F, Liedtke WB
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 30;118(13)
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 30;118(13)
Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing.
Emig R, Knodt W, Krussig MJ, Zgierski-Johnston CM, Gorka O, Groß O, Kohl P, Ravens U, Peyronnet R
Cells 2021 Mar 16;10(3)
Cells 2021 Mar 16;10(3)
Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients.
Liao J, Lu W, Chen Y, Duan X, Zhang C, Luo X, Lin Z, Chen J, Liu S, Yan H, Chen Y, Feng H, Zhou D, Chen X, Zhang Z, Yang Q, Liu X, Tang H, Li J, Makino A, Yuan JX, Zhong N, Yang K, Wang J
Hypertension (Dallas, Tex. : 1979) 2021 Jun;77(6):1974-1989
Hypertension (Dallas, Tex. : 1979) 2021 Jun;77(6):1974-1989
Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow.
Yarishkin O, Phuong TTT, Baumann JM, De Ieso ML, Vazquez-Chona F, Rudzitis CN, Sundberg C, Lakk M, Stamer WD, Križaj D
The Journal of physiology 2021 Jan;599(2):571-592
The Journal of physiology 2021 Jan;599(2):571-592
Mechanical Stress Induces Ca(2+)-Dependent Signal Transduction in Erythroblasts and Modulates Erythropoiesis.
Aglialoro F, Abay A, Yagci N, Rab MAE, Kaestner L, van Wijk R, von Lindern M, van den Akker E
International journal of molecular sciences 2021 Jan 19;22(2)
International journal of molecular sciences 2021 Jan 19;22(2)
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
Wang X, Cheng G, Miao Y, Qiu F, Bai L, Gao Z, Huang Y, Dong L, Niu X, Wang X, Li Y, Tang H, Xu Y, Song X
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.
Huo L, Gao Y, Zhang D, Wang S, Han Y, Men H, Yang Z, Qin X, Wang R, Kong D, Bai H, Zhang H, Zhang W, Jia Z
Pharmacological research 2021 Feb;164:105391
Pharmacological research 2021 Feb;164:105391
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension.
Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, Ravellette KS, Wu L, Balistrieri F, Tang H, Wu X, Zhao T, Black SM, Desai AA, Garcia JGN, Sun X, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Wang J, Yuan JX
American journal of physiology. Cell physiology 2021 Dec 1;321(6):C1010-C1027
American journal of physiology. Cell physiology 2021 Dec 1;321(6):C1010-C1027
Upregulation of Piezo1 Is a Novel Prognostic Indicator in Glioma Patients.
Qu S, Li S, Hu Z
Cancer management and research 2020;12:3527-3536
Cancer management and research 2020;12:3527-3536
Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells.
Kuntze A, Goetsch O, Fels B, Najder K, Unger A, Wilhelmi M, Sargin S, Schimmelpfennig S, Neumann I, Schwab A, Pethő Z
Frontiers in physiology 2020;11:89
Frontiers in physiology 2020;11:89
Tubeimoside I Antagonizes Yoda1-Evoked Piezo1 Channel Activation.
Liu S, Pan X, Cheng W, Deng B, He Y, Zhang L, Ning Y, Li J
Frontiers in pharmacology 2020;11:768
Frontiers in pharmacology 2020;11:768
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice.
Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S
Nature communications 2020 May 8;11(1):2303
Nature communications 2020 May 8;11(1):2303
Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure.
MacKay CE, Leo MD, Fernández-Peña C, Hasan R, Yin W, Mata-Daboin A, Bulley S, Gammons J, Mancarella S, Jaggar JH
eLife 2020 May 4;9
eLife 2020 May 4;9
Functional Expression of Piezo1 in Dorsal Root Ganglion (DRG) Neurons.
Roh J, Hwang SM, Lee SH, Lee K, Kim YH, Park CK
International journal of molecular sciences 2020 May 28;21(11)
International journal of molecular sciences 2020 May 28;21(11)
Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling.
Mousawi F, Peng H, Li J, Ponnambalam S, Roger S, Zhao H, Yang X, Jiang LH
Stem cells (Dayton, Ohio) 2020 Mar;38(3):410-421
Stem cells (Dayton, Ohio) 2020 Mar;38(3):410-421
PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cells.
Caulier A, Jankovsky N, Demont Y, Ouled-Haddou H, Demagny J, Guitton C, Merlusca L, Lebon D, Vong P, Aubry A, Lahary A, Rose C, Gréaume S, Cardon E, Platon J, Ouadid-Ahidouch H, Rochette J, Marolleau JP, Picard V, Garçon L
Haematologica 2020 Mar;105(3):610-622
Haematologica 2020 Mar;105(3):610-622
Piezo1 is required for outflow tract and aortic valve development.
Faucherre A, Moha Ou Maati H, Nasr N, Pinard A, Theron A, Odelin G, Desvignes JP, Salgado D, Collod-Béroud G, Avierinos JF, Lebon G, Zaffran S, Jopling C
Journal of molecular and cellular cardiology 2020 Jun;143:51-62
Journal of molecular and cellular cardiology 2020 Jun;143:51-62
Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier.
Zhong M, Wu W, Kang H, Hong Z, Xiong S, Gao X, Rehman J, Komarova YA, Malik AB
American journal of respiratory cell and molecular biology 2020 Feb;62(2):168-177
American journal of respiratory cell and molecular biology 2020 Feb;62(2):168-177
RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis.
Sugisawa E, Takayama Y, Takemura N, Kondo T, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, Maruyama K
Cell 2020 Aug 6;182(3):609-624.e21
Cell 2020 Aug 6;182(3):609-624.e21
Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle.
Han Y, Liu C, Zhang D, Men H, Huo L, Geng Q, Wang S, Gao Y, Zhang W, Zhang Y, Jia Z
International journal of oncology 2019 Sep;55(3):629-644
International journal of oncology 2019 Sep;55(3):629-644
A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-β1 expression.
Saleh A, Marhuenda E, Fabre C, Hassani Z, Weille J, Boukhaddaoui H, Guelfi S, Maldonado IL, Hugnot JP, Duffau H, Bauchet L, Cornu D, Bakalara N
Scientific reports 2019 Oct 10;9(1):14612
Scientific reports 2019 Oct 10;9(1):14612
The Mechanosensitive Ion Channel Piezo1 Significantly Mediates In Vitro Ultrasonic Stimulation of Neurons.
Qiu Z, Guo J, Kala S, Zhu J, Xian Q, Qiu W, Li G, Zhu T, Meng L, Zhang R, Chan HC, Zheng H, Sun L
iScience 2019 Nov 22;21:448-457
iScience 2019 Nov 22;21:448-457
Mechanically Defined Microenvironment Promotes Stabilization of Microvasculature, Which Correlates with the Enrichment of a Novel Piezo-1(+) Population of Circulating CD11b(+) /CD115(+) Monocytes.
Forget A, Gianni-Barrera R, Uccelli A, Sarem M, Kohler E, Fogli B, Muraro MG, Bichet S, Aumann K, Banfi A, Shastri VP
Advanced materials (Deerfield Beach, Fla.) 2019 May;31(21):e1808050
Advanced materials (Deerfield Beach, Fla.) 2019 May;31(21):e1808050
Rapid flow-induced activation of Gα(q/11) is independent of Piezo1 activation.
Dela Paz NG, Frangos JA
American journal of physiology. Cell physiology 2019 May 1;316(5):C741-C752
American journal of physiology. Cell physiology 2019 May 1;316(5):C741-C752
Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries.
Lhomme A, Gilbert G, Pele T, Deweirdt J, Henrion D, Baudrimont I, Campagnac M, Marthan R, Guibert C, Ducret T, Savineau JP, Quignard JF
American journal of respiratory cell and molecular biology 2019 Jun;60(6):650-658
American journal of respiratory cell and molecular biology 2019 Jun;60(6):650-658
The mechanosensitive Piezo1 channel is required for bone formation.
Sun W, Chi S, Li Y, Ling S, Tan Y, Xu Y, Jiang F, Li J, Liu C, Zhong G, Cao D, Jin X, Zhao D, Gao X, Liu Z, Xiao B, Li Y
eLife 2019 Jul 10;8
eLife 2019 Jul 10;8
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.
Kang H, Hong Z, Zhong M, Klomp J, Bayless KJ, Mehta D, Karginov AV, Hu G, Malik AB
American journal of physiology. Cell physiology 2019 Jan 1;316(1):C92-C103
American journal of physiology. Cell physiology 2019 Jan 1;316(1):C92-C103
Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.
Tao H, Zhu M, Lau K, Whitley OKW, Samani M, Xiao X, Chen XX, Hahn NA, Liu W, Valencia M, Wu M, Wang X, Fenelon KD, Pasiliao CC, Hu D, Wu J, Spring S, Ferguson J, Karuna EP, Henkelman RM, Dunn A, Huang H, Ho HH, Atit R, Goyal S, Sun Y, Hopyan S
Nature communications 2019 Apr 12;10(1):1703
Nature communications 2019 Apr 12;10(1):1703
PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis.
Zhang J, Zhou Y, Huang T, Wu F, Liu L, Kwan JSH, Cheng ASL, Yu J, To KF, Kang W
Molecular carcinogenesis 2018 Sep;57(9):1144-1155
Molecular carcinogenesis 2018 Sep;57(9):1144-1155
Piezo1 and G(q)/G(11) promote endothelial inflammation depending on flow pattern and integrin activation.
Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S
The Journal of experimental medicine 2018 Oct 1;215(10):2655-2672
The Journal of experimental medicine 2018 Oct 1;215(10):2655-2672
A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.
Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan JJ, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida MM, Dirks PB, Song Y, Hui CC, Sun Y, Wang LY, Li X, Huang X
Neuron 2018 Nov 21;100(4):799-815.e7
Neuron 2018 Nov 21;100(4):799-815.e7
Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII.
Liang J, Huang B, Yuan G, Chen Y, Liang F, Zeng H, Zheng S, Cao L, Geng D, Zhou S
American journal of translational research 2017;9(6):2945-2955
American journal of translational research 2017;9(6):2945-2955
Mechanical stretch triggers rapid epithelial cell division through Piezo1.
Gudipaty SA, Lindblom J, Loftus PD, Redd MJ, Edes K, Davey CF, Krishnegowda V, Rosenblatt J
Nature 2017 Mar 2;543(7643):118-121
Nature 2017 Mar 2;543(7643):118-121
Evidence for shear-mediated Ca(2+) entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.
Ilkan Z, Wright JR, Goodall AH, Gibbins JM, Jones CI, Mahaut-Smith MP
The Journal of biological chemistry 2017 Jun 2;292(22):9204-9217
The Journal of biological chemistry 2017 Jun 2;292(22):9204-9217
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S
The Journal of clinical investigation 2016 Dec 1;126(12):4527-4536
The Journal of clinical investigation 2016 Dec 1;126(12):4527-4536
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.
Fotiou E, Martin-Almedina S, Simpson MA, Lin S, Gordon K, Brice G, Atton G, Jeffery I, Rees DC, Mignot C, Vogt J, Homfray T, Snyder MP, Rockson SG, Jeffery S, Mortimer PS, Mansour S, Ostergaard P
Nature communications 2015 Sep 3;6:8085
Nature communications 2015 Sep 3;6:8085
Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis).
Andolfo I, Russo R, Manna F, Shmukler BE, Gambale A, Vitiello G, De Rosa G, Brugnara C, Alper SL, Snyder LM, Iolascon A
American journal of hematology 2015 Oct;90(10):921-6
American journal of hematology 2015 Oct;90(10):921-6
Piezo1 integration of vascular architecture with physiological force.
Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ
Nature 2014 Nov 13;515(7526):279-282
Nature 2014 Nov 13;515(7526):279-282
Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures.
Miyamoto T, Mochizuki T, Nakagomi H, Kira S, Watanabe M, Takayama Y, Suzuki Y, Koizumi S, Takeda M, Tominaga M
The Journal of biological chemistry 2014 Jun 6;289(23):16565-75
The Journal of biological chemistry 2014 Jun 6;289(23):16565-75
Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.
Andolfo I, Alper SL, De Franceschi L, Auriemma C, Russo R, De Falco L, Vallefuoco F, Esposito MR, Vandorpe DH, Shmukler BE, Narayan R, Montanaro D, D'Armiento M, Vetro A, Limongelli I, Zuffardi O, Glader BE, Schrier SL, Brugnara C, Stewart GW, Delaunay J, Iolascon A
Blood 2013 May 9;121(19):3925-35, S1-12
Blood 2013 May 9;121(19):3925-35, S1-12
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
Eisenhoffer GT, Loftus PD, Yoshigi M, Otsuna H, Chien CB, Morcos PA, Rosenblatt J
Nature 2012 Apr 15;484(7395):546-9
Nature 2012 Apr 15;484(7395):546-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Piezo1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Piezo1. This antibody recognizes human antigen. The Piezo1 antibody has been validated for the following applications: ELISA, WB analysis.
