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- Product number
- 15939-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15939-1-AP, RRID:AB_2231460
- Product name
- Piezo1 (extracellular domain) antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Piezo1 (extracellular domain) antibody (Cat. #15939-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Abnormal urodynamic changes in post-upper urinary tract dysfunction in ureteral obstruction rat models.
Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1.
PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes.
Increased Piezo1 expression in myofibroblasts in patients with symptomatic carotid atherosclerotic plaques undergoing carotid endarterectomy: A pilot study.
Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity.
The local mechanosensitive response of primary cardiac fibroblasts is influenced by the microenvironment mechanics.
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing.
Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis.
Magnetic Aggregation-Induced Bone-Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic-Angiogenic Coupling for Osteoporotic Bone Repair.
Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto-Active Substrates.
Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage.
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells.
Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response.
Matrix stiffness regulates macrophage polarisation via the Piezo1-YAP signalling axis.
Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca(2+) influx.
The Microbiota-Dependent Treatment of Wuzhuyu Decoction for Chronic Migraine Model Rat Associated with Anxiety-Depression Like Behavior.
Inhibition of Piezo1 Ameliorates Intestinal Inflammation and Limits the Activation of Group 3 Innate Lymphoid Cells in Experimental Colitis.
PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model.
A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.
Slowed Intestinal Transit Induced by Less Mucus in Intestinal Goblet Cell Piezo1-Deficient Mice through Impaired Epithelial Homeostasis.
Modulation of Piezo1 influences human skin architecture and oxytocin expression.
Piezo1 Activation Prevents Spheroid Formation by Malignant Melanoma SK-MEL-2 Cells.
Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorder.
PPP1R3A inhibits osteogenesis and negatively regulates intracellular calcium levels in calcific tendinopathy.
Different stimuli induce endothelial dysfunction and promote atherosclerosis through the Piezo1/YAP signaling axis.
Aloperine protects pulmonary hypertension via triggering PPARγ signaling and inhibiting calcium regulatory pathway in pulmonary arterial smooth muscle cells.
The Critical Role of The Piezo1/β-catenin/ATF4 Axis on The Stemness of Gli1(+) BMSCs During Simulated Microgravity-Induced Bone Loss.
Effects of liraglutide on ANP secretion and cardiac dynamics.
Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice.
Chemical Activation and Mechanical Sensitization of Piezo1 Enhance TRAIL-Mediated Apoptosis in Glioblastoma Cells.
A static magnetic field enhances the repair of osteoarthritic cartilage by promoting the migration of stem cells and chondrogenesis.
Proteome alterations in erythrocytes with PIEZO1 gain-of-function mutations.
Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis.
Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells.
Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.
Accelerated Bone Reconstruction by the Yoda1 Bilayer Membrane via Promotion of Osteointegration and Angiogenesis.
Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1.
Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes.
Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels.
The Mechanosensitive Ion Channel PIEZO1 in Intestinal Epithelial Cells Mediates Inflammation through the NOD-Like Receptor 3 Pathway in Crohn's Disease.
Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification.
Soft, strong, tough, and durable protein-based fiber hydrogels.
The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia.
Lipid-anchored proteasomes control membrane protein homeostasis.
Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside.
Piezo1 Regulation Involves Lipid Domains and the Cytoskeleton and Is Favored by the Stomatocyte-Discocyte-Echinocyte Transformation.
Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation.
Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis.
Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1.
Piezo1 channel-mediated Ca(2+) signaling inhibits lipopolysaccharide-induced activation of the NF-κB inflammatory signaling pathway and generation of TNF-α and IL-6 in microglial cells.
Low-Intensity Pulsed Ultrasound Attenuates Postoperative Neurocognitive Impairment and Salvages Hippocampal Synaptogenesis in Aged Mice.
Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis.
PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing.
A Novel Homozygous Missense Mutation of PIEZO1 Leading to Lymphatic Malformation-6 Identified in a Family With Three Adverse Pregnancy Outcomes due to Nonimmune Fetal Hydrops.
Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice.
TiO(2) Nanotubes Promote Osteogenic Differentiation Through Regulation of Yap and Piezo1.
High-throughput membrane-anchored proteome screening reveals PIEZO1 as a promising antibody-drug target for human esophageal squamous cell carcinoma.
Activation of Piezo1 Increases Na,K-ATPase-Mediated Ion Transport in Mouse Lens.
Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis.
Skin cells undergo asynthetic fission to expand body surfaces in zebrafish.
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.
Fluid shear stress enhances T cell activation through Piezo1.
A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation.
Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells.
Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes.
Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca(2+) Influx and Akt-eNOS Pathway.
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.
Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis.
Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation.
PIEZO1 mediates a mechanothrombotic pathway in diabetes.
Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1.
Fine-Tuning of Piezo1 Expression and Activity Ensures Efficient Myoblast Fusion during Skeletal Myogenesis.
Wuzhuyu Decoction relieves hyperalgesia by regulating central and peripheral 5-HT in chronic migraine model rats.
Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles.
Piezo channels contribute to the regulation of myelination in Schwann cells.
Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes.
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis.
Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling.
Piezo1 act as a potential oncogene in pancreatic cancer progression.
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone.
Mechanical force modulates macrophage proliferation via Piezo1-AKT-Cyclin D1 axis.
Mechanosensitive Piezo1 channels mediate renal fibrosis.
Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells.
Hereditary Xerocytosis: Differential Behavior of PIEZO1 Mutations in the N-Terminal Extracellular Domain Between Red Blood Cells and HEK Cells.
Piezo1 and BK(Ca) channels in human atrial fibroblasts: Interplay and remodelling in atrial fibrillation.
Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats.
Mechanical stimulation activates Piezo1 to promote mucin2 expression in goblet cells.
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation.
Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway.
Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells.
Piezo1 plays a role in optic nerve head astrocyte reactivity.
Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.
Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing.
Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients.
Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow.
Mechanical Stress Induces Ca(2+)-Dependent Signal Transduction in Erythroblasts and Modulates Erythropoiesis.
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension.
Upregulation of Piezo1 Is a Novel Prognostic Indicator in Glioma Patients.
Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells.
Tubeimoside I Antagonizes Yoda1-Evoked Piezo1 Channel Activation.
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice.
Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure.
Functional Expression of Piezo1 in Dorsal Root Ganglion (DRG) Neurons.
Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling.
PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cells.
Piezo1 is required for outflow tract and aortic valve development.
Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier.
RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis.
Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle.
A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-β1 expression.
The Mechanosensitive Ion Channel Piezo1 Significantly Mediates In Vitro Ultrasonic Stimulation of Neurons.
Mechanically Defined Microenvironment Promotes Stabilization of Microvasculature, Which Correlates with the Enrichment of a Novel Piezo-1(+) Population of Circulating CD11b(+) /CD115(+) Monocytes.
Rapid flow-induced activation of Gα(q/11) is independent of Piezo1 activation.
Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries.
The mechanosensitive Piezo1 channel is required for bone formation.
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.
Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.
PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis.
Piezo1 and G(q)/G(11) promote endothelial inflammation depending on flow pattern and integrin activation.
A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.
Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII.
Mechanical stretch triggers rapid epithelial cell division through Piezo1.
Evidence for shear-mediated Ca(2+) entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.
Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis).
Piezo1 integration of vascular architecture with physiological force.
Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures.
Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
Liu X, Li X, Liao L
Frontiers in physiology 2024;15:1341220
Frontiers in physiology 2024;15:1341220
Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1.
Zheng F, Wu T, Wang F, Li H, Tang H, Cui X, Li C, Wang Y, Jiang J
Frontiers in bioengineering and biotechnology 2024;12:1347406
Frontiers in bioengineering and biotechnology 2024;12:1347406
PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes.
Pang R, Sun W, Yang Y, Wen D, Lin F, Wang D, Li K, Zhang N, Liang J, Xiong C, Liu Y
Nature biomedical engineering 2024 Sep;8(9):1162-1176
Nature biomedical engineering 2024 Sep;8(9):1162-1176
Increased Piezo1 expression in myofibroblasts in patients with symptomatic carotid atherosclerotic plaques undergoing carotid endarterectomy: A pilot study.
Konishi T, Kamiyama K, Osato T, Yoshimoto T, Aoki T, Anzai T, Tanaka S
Vascular 2024 Oct;32(5):1063-1069
Vascular 2024 Oct;32(5):1063-1069
Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity.
Hurrell BP, Shen S, Li X, Sakano Y, Kazemi MH, Quach C, Shafiei-Jahani P, Sakano K, Ghiasi H, Akbari O
The Journal of experimental medicine 2024 May 6;221(5)
The Journal of experimental medicine 2024 May 6;221(5)
The local mechanosensitive response of primary cardiac fibroblasts is influenced by the microenvironment mechanics.
Braidotti N, Demontis G, Conti M, Andolfi L, Ciubotaru CD, Sbaizero O, Cojoc D
Scientific reports 2024 May 6;14(1):10365
Scientific reports 2024 May 6;14(1):10365
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing.
Liu Y, Zhang M, Wang C, Chen H, Su D, Yang C, Tao Y, Lv X, Zhou Z, Li J, Liao Y, You J, Wang Z, Cheng F, Yang R
ACS nano 2024 May 28;18(21):13696-13713
ACS nano 2024 May 28;18(21):13696-13713
Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis.
Abbonante V, Karkempetzaki AI, Leon C, Krishnan A, Huang N, Di Buduo CA, Cattaneo D, Ward CM, Matsuura S, Guinard I, Weber J, De Acutis A, Vozzi G, Iurlo A, Ravid K, Balduini A
American journal of hematology 2024 Mar;99(3):336-349
American journal of hematology 2024 Mar;99(3):336-349
Magnetic Aggregation-Induced Bone-Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic-Angiogenic Coupling for Osteoporotic Bone Repair.
Guan H, Wang W, Jiang Z, Zhang B, Ye Z, Zheng J, Chen W, Liao Y, Zhang Y
Advanced materials (Deerfield Beach, Fla.) 2024 Mar;36(13):e2312081
Advanced materials (Deerfield Beach, Fla.) 2024 Mar;36(13):e2312081
Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto-Active Substrates.
Gomez-Cruz C, Fernandez-de la Torre M, Lachowski D, Prados-de-Haro M, Del Río Hernández AE, Perea G, Muñoz-Barrutia A, Garcia-Gonzalez D
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(26):e2312497
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(26):e2312497
Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage.
Qi M, Liu R, Zhang F, Yao Z, Zhou ML, Jiang X, Ling S
Neuropharmacology 2024 Jun 15;251:109896
Neuropharmacology 2024 Jun 15;251:109896
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Jia C, Xiang Z, Zhang P, Liu L, Zhu X, Yu R, Liu Z, Wang S, Liu K, Wang Z, Vasilev K, Zhou S, Geng Z, Liu X, Zhao Y, Gao Y, Cheng L, Li Y
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
Brylka LJ, Alimy AR, Tschaffon-Müller MEA, Jiang S, Ballhause TM, Baranowsky A, von Kroge S, Delsmann J, Pawlus E, Eghbalian K, Püschel K, Schoppa A, Haffner-Luntzer M, Beech DJ, Beil FT, Amling M, Keller J, Ignatius A, Yorgan TA, Rolvien T, Schinke T
Bone research 2024 Feb 23;12(1):12
Bone research 2024 Feb 23;12(1):12
Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells.
Liu CSC, Mandal T, Biswas P, Hoque MA, Bandopadhyay P, Sinha BP, Sarif J, D'Rozario R, Sinha DK, Sinha B, Ganguly D
eLife 2024 Feb 23;12
eLife 2024 Feb 23;12
Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response.
Burchett A, Siri S, Li J, Lu X, Datta M
bioRxiv : the preprint server for biology 2024 Feb 17;
bioRxiv : the preprint server for biology 2024 Feb 17;
Matrix stiffness regulates macrophage polarisation via the Piezo1-YAP signalling axis.
Mei F, Guo Y, Wang Y, Zhou Y, Heng BC, Xie M, Huang X, Zhang S, Ding S, Liu F, Deng X, Chen L, Yang C
Cell proliferation 2024 Aug;57(8):e13640
Cell proliferation 2024 Aug;57(8):e13640
Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca(2+) influx.
Yan Z, Niu L, Wang S, Gao C, Pan S
Journal of translational medicine 2024 Apr 4;22(1):332
Journal of translational medicine 2024 Apr 4;22(1):332
The Microbiota-Dependent Treatment of Wuzhuyu Decoction for Chronic Migraine Model Rat Associated with Anxiety-Depression Like Behavior.
Nan N, Wang Q, Li MJ, Xu YS, Guo XM, Xu R, Ma Z, Wang SH, Li J, Zhao H, Gong MX
Oxidative medicine and cellular longevity 2023;2023:2302653
Oxidative medicine and cellular longevity 2023;2023:2302653
Inhibition of Piezo1 Ameliorates Intestinal Inflammation and Limits the Activation of Group 3 Innate Lymphoid Cells in Experimental Colitis.
Liu C, Xia Y, Fu S, Meng F, Feng B, Xu L, Li L, Zuo X
Journal of innate immunity 2023;15(1):709-723
Journal of innate immunity 2023;15(1):709-723
PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model.
Anderson DE, Broun KG, Kundu P, Jing X, Tang X, Lu C, Kotelsky A, Mannava S, Lee W
Frontiers in bioengineering and biotechnology 2023;11:1244975
Frontiers in bioengineering and biotechnology 2023;11:1244975
A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.
Shen X, Wu W, Ying Y, Zhou L, Zhu H
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 2023 Sep;49 Suppl 1:228-237
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 2023 Sep;49 Suppl 1:228-237
Slowed Intestinal Transit Induced by Less Mucus in Intestinal Goblet Cell Piezo1-Deficient Mice through Impaired Epithelial Homeostasis.
Fang F, Liu Y, Xiong Y, Li X, Li G, Jiang Y, Hou X, Song J
International journal of molecular sciences 2023 Sep 21;24(18)
International journal of molecular sciences 2023 Sep 21;24(18)
Modulation of Piezo1 influences human skin architecture and oxytocin expression.
Labarrade F, Perrin A, Ferreira Y, Botto JM, Imbert I
International journal of cosmetic science 2023 Oct;45(5):604-611
International journal of cosmetic science 2023 Oct;45(5):604-611
Piezo1 Activation Prevents Spheroid Formation by Malignant Melanoma SK-MEL-2 Cells.
Vasileva VY, Khairullina ZM, Chubinskiy-Nadezhdin VI
International journal of molecular sciences 2023 Oct 28;24(21)
International journal of molecular sciences 2023 Oct 28;24(21)
Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorder.
Bai F, Huang L, Long Z, Zhang M, Deng Q, Huang J, Bao X, Hao X, Li H
Functional & integrative genomics 2023 Oct 27;23(4):327
Functional & integrative genomics 2023 Oct 27;23(4):327
PPP1R3A inhibits osteogenesis and negatively regulates intracellular calcium levels in calcific tendinopathy.
Hu C, Ma L, Gao S, Yang MY, Mu MD, Chang L, Huang P, Ye X, Wang W, Tao X, Zhou BH, Chen W, Tang KL
iScience 2023 Oct 20;26(10):107784
iScience 2023 Oct 20;26(10):107784
Different stimuli induce endothelial dysfunction and promote atherosclerosis through the Piezo1/YAP signaling axis.
Mao J, Yang R, Yuan P, Wu F, Wei Y, Nie Y, Zhang C, Zhou X
Archives of biochemistry and biophysics 2023 Oct 1;747:109755
Archives of biochemistry and biophysics 2023 Oct 1;747:109755
Aloperine protects pulmonary hypertension via triggering PPARγ signaling and inhibiting calcium regulatory pathway in pulmonary arterial smooth muscle cells.
Shan X, Gegentuya, Wang J, Feng H, Zhang Z, Zheng Q, Zhang Q, Yang K, Wang J, Xu L
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1058-C1072
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1058-C1072
The Critical Role of The Piezo1/β-catenin/ATF4 Axis on The Stemness of Gli1(+) BMSCs During Simulated Microgravity-Induced Bone Loss.
Hu Y, Tian H, Chen W, Liu Y, Cao Y, Pei H, Ming C, Shan C, Chen X, Dai Z, Yang S, Shao Z, Lan S, Liu Y, Tong W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2303375
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2303375
Effects of liraglutide on ANP secretion and cardiac dynamics.
Luo S, Zuo Y, Cui X, Zhang M, Jin H, Hong L
Endocrine connections 2023 Nov 1;12(11)
Endocrine connections 2023 Nov 1;12(11)
Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice.
Qin L, Chen Z, Yang D, He T, Xu Z, Zhang P, Chen D, Yi W, Xiao G
Journal of orthopaedic translation 2023 May;40:58-71
Journal of orthopaedic translation 2023 May;40:58-71
Chemical Activation and Mechanical Sensitization of Piezo1 Enhance TRAIL-Mediated Apoptosis in Glioblastoma Cells.
Knoblauch SV, Desai SH, Dombroski JA, Sarna NS, Hope JM, King MR
ACS omega 2023 May 16;8(19):16975-16986
ACS omega 2023 May 16;8(19):16975-16986
A static magnetic field enhances the repair of osteoarthritic cartilage by promoting the migration of stem cells and chondrogenesis.
Sun Y, Fang Y, Li X, Li J, Liu D, Wei M, Liao Z, Meng Y, Zhai L, Yokota H, Yang L, Yu Y, Zhang P
Journal of orthopaedic translation 2023 Mar;39:43-54
Journal of orthopaedic translation 2023 Mar;39:43-54
Proteome alterations in erythrocytes with PIEZO1 gain-of-function mutations.
Andolfo I, Monaco V, Cozzolino F, Rosato BE, Marra R, Cerbone V, Pinto VM, Forni GL, Unal S, Iolascon A, Monti M, Russo R
Blood advances 2023 Jun 27;7(12):2681-2693
Blood advances 2023 Jun 27;7(12):2681-2693
Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis.
Zhong G, Su S, Li J, Zhao H, Hu D, Chen J, Li S, Lin Y, Wen L, Lin X, Xian G, Xu D, Zeng Q
Science advances 2023 Jun 2;9(22):eadg0478
Science advances 2023 Jun 2;9(22):eadg0478
Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells.
Li R, Wang D, Li H, Lei X, Liao W, Liu XY
Discover oncology 2023 Jun 12;14(1):95
Discover oncology 2023 Jun 12;14(1):95
Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.
Jiang M, Zhang YX, Bu WJ, Li P, Chen JH, Cao M, Dong YC, Sun ZJ, Dong DL
British journal of pharmacology 2023 Jul;180(14):1862-1877
British journal of pharmacology 2023 Jul;180(14):1862-1877
Accelerated Bone Reconstruction by the Yoda1 Bilayer Membrane via Promotion of Osteointegration and Angiogenesis.
Yang J, Yuan K, Zhang T, Zhou S, Li W, Chen Z, Wang Y
Advanced healthcare materials 2023 Jul;12(18):e2203105
Advanced healthcare materials 2023 Jul;12(18):e2203105
Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1.
Liu C, Gao X, Lou J, Li H, Chen Y, Chen M, Zhang Y, Hu Z, Chang X, Luo M, Zhai Y, Li C
Arthritis research & therapy 2023 Jul 7;25(1):117
Arthritis research & therapy 2023 Jul 7;25(1):117
Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes.
Savadipour A, Nims RJ, Rashidi N, Garcia-Castorena JM, Tang R, Marushack GK, Oswald SJ, Liedtke WB, Guilak F
Proceedings of the National Academy of Sciences of the United States of America 2023 Jul 25;120(30):e2221958120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jul 25;120(30):e2221958120
Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels.
Shin SM, Itson-Zoske B, Fan F, Gani U, Rahman M, Hogan QH, Yu H
Molecular pain 2023 Jan-Dec;19:17448069231174315
Molecular pain 2023 Jan-Dec;19:17448069231174315
The Mechanosensitive Ion Channel PIEZO1 in Intestinal Epithelial Cells Mediates Inflammation through the NOD-Like Receptor 3 Pathway in Crohn's Disease.
Liu Q, Wang D, Yang X, Ma F, Han W, Hu J, Mei Q
Inflammatory bowel diseases 2023 Jan 5;29(1):103-115
Inflammatory bowel diseases 2023 Jan 5;29(1):103-115
Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification.
Xu Y, Xiong Y, Liu Y, Li G, Bai T, Zheng G, Hou X, Song J
Cell & bioscience 2023 Jan 12;13(1):7
Cell & bioscience 2023 Jan 12;13(1):7
Soft, strong, tough, and durable protein-based fiber hydrogels.
Wang M, Sun S, Dong G, Long F, Butcher JT
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 21;120(8):e2213030120
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 21;120(8):e2213030120
The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia.
Zhu T, Guo J, Wu Y, Lei T, Zhu J, Chen H, Kala S, Wong KF, Cheung CP, Huang X, Zhao X, Yang M, Sun L
iScience 2023 Feb 17;26(2):105993
iScience 2023 Feb 17;26(2):105993
Lipid-anchored proteasomes control membrane protein homeostasis.
Zhang R, Pan S, Zheng S, Liao Q, Jiang Z, Wang D, Li X, Hu A, Li X, Zhu Y, Shen X, Lei J, Zhong S, Zhang X, Huang L, Wang X, Huang L, Shen L, Song BL, Zhao JW, Wang Z, Yang B, Guo X
Science advances 2023 Dec;9(48):eadj4605
Science advances 2023 Dec;9(48):eadj4605
Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside.
Vanderroost J, Parpaite T, Avalosse N, Henriet P, Pierreux CE, Lorent JH, Gailly P, Tyteca D
Cells 2023 Dec 7;12(24)
Cells 2023 Dec 7;12(24)
Piezo1 Regulation Involves Lipid Domains and the Cytoskeleton and Is Favored by the Stomatocyte-Discocyte-Echinocyte Transformation.
Stommen A, Ghodsi M, Cloos AS, Conrard L, Dumitru AC, Henriet P, Pierreux CE, Alsteens D, Tyteca D
Biomolecules 2023 Dec 30;14(1)
Biomolecules 2023 Dec 30;14(1)
Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation.
Lei M, Wang W, Zhang H, Gong J, Wang Z, Cai H, Yang X, Wang S, Ma C
Cell reports 2023 Dec 26;42(12):113522
Cell reports 2023 Dec 26;42(12):113522
Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis.
Hajiali H, Rotherham M, El Haj AJ
Pharmaceutics 2023 Dec 22;16(1)
Pharmaceutics 2023 Dec 22;16(1)
Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1.
Chen F, Sun M, Peng F, Lai Y, Jiang Z, Zhang W, Li T, Jing X
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Aug;41(8):1792-1802
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Aug;41(8):1792-1802
Piezo1 channel-mediated Ca(2+) signaling inhibits lipopolysaccharide-induced activation of the NF-κB inflammatory signaling pathway and generation of TNF-α and IL-6 in microglial cells.
Malko P, Jia X, Wood I, Jiang LH
Glia 2023 Apr;71(4):848-865
Glia 2023 Apr;71(4):848-865
Low-Intensity Pulsed Ultrasound Attenuates Postoperative Neurocognitive Impairment and Salvages Hippocampal Synaptogenesis in Aged Mice.
Wang Q, Liu T, Chang H, Li Z, Chen L, Mi X, Xing H, Wang X, Hong J, Liu K, Li Y, Han D, Li Y, Yang N, Li X, Li Y, Guo X
Brain sciences 2023 Apr 13;13(4)
Brain sciences 2023 Apr 13;13(4)
Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis.
Hirata Y, Cai R, Volchuk A, Steinberg BE, Saito Y, Matsuzawa A, Grinstein S, Freeman SA
Current biology : CB 2023 Apr 10;33(7):1282-1294.e5
Current biology : CB 2023 Apr 10;33(7):1282-1294.e5
PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
Chuntharpursat-Bon E, Povstyan OV, Ludlow MJ, Carrier DJ, Debant M, Shi J, Gaunt HJ, Bauer CC, Curd A, Simon Futers T, Baxter PD, Peckham M, Muench SP, Adamson A, Humphreys N, Tumova S, Bon RS, Cubbon R, Lichtenstein L, Beech DJ
Communications biology 2023 Apr 1;6(1):358
Communications biology 2023 Apr 1;6(1):358
Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing.
Liu Y, Tian H, Hu Y, Cao Y, Song H, Lan S, Dai Z, Chen W, Zhang Y, Shao Z, Liu Y, Tong W
International journal of biological sciences 2022;18(10):3961-3980
International journal of biological sciences 2022;18(10):3961-3980
A Novel Homozygous Missense Mutation of PIEZO1 Leading to Lymphatic Malformation-6 Identified in a Family With Three Adverse Pregnancy Outcomes due to Nonimmune Fetal Hydrops.
Han S, Guo X, Wang X, Lin H, Yu Y, Shu J, Dong M, Yang L
Frontiers in genetics 2022;13:856046
Frontiers in genetics 2022;13:856046
Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice.
Liu Y, Fang F, Xiong Y, Wu J, Li X, Li G, Bai T, Hou X, Song J
Frontiers in cellular and infection microbiology 2022;12:1035386
Frontiers in cellular and infection microbiology 2022;12:1035386
TiO(2) Nanotubes Promote Osteogenic Differentiation Through Regulation of Yap and Piezo1.
Kong K, Chang Y, Hu Y, Qiao H, Zhao C, Rong K, Zhang P, Zhang J, Zhai Z, Li H
Frontiers in bioengineering and biotechnology 2022;10:872088
Frontiers in bioengineering and biotechnology 2022;10:872088
High-throughput membrane-anchored proteome screening reveals PIEZO1 as a promising antibody-drug target for human esophageal squamous cell carcinoma.
Qin X, Ni Z, Jiang J, Liu X, Dong X, Li M, Miao K, Rao S, Zhang W, Cai K
Cancer medicine 2022 Oct;11(19):3700-3713
Cancer medicine 2022 Oct;11(19):3700-3713
Activation of Piezo1 Increases Na,K-ATPase-Mediated Ion Transport in Mouse Lens.
Shahidullah M, Rosales JL, Delamere N
International journal of molecular sciences 2022 Oct 25;23(21)
International journal of molecular sciences 2022 Oct 25;23(21)
Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis.
Kim OH, Choi YW, Park JH, Hong SA, Hong M, Chang IH, Lee HJ
Life sciences 2022 Nov 1;308:120936
Life sciences 2022 Nov 1;308:120936
Skin cells undergo asynthetic fission to expand body surfaces in zebrafish.
Chan KY, Yan CS, Roan HY, Hsu SC, Tseng TL, Hsiao CD, Hsu CP, Chen CH
Nature 2022 May;605(7908):119-125
Nature 2022 May;605(7908):119-125
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.
Chen J, Rodriguez M, Miao J, Liao J, Jain PP, Zhao M, Zhao T, Babicheva A, Wang Z, Parmisano S, Powers R, Matti M, Paquin C, Soroureddin Z, Shyy JY, Thistlethwaite PA, Makino A, Wang J, Yuan JX
American journal of physiology. Lung cellular and molecular physiology 2022 May 1;322(5):L737-L760
American journal of physiology. Lung cellular and molecular physiology 2022 May 1;322(5):L737-L760
Fluid shear stress enhances T cell activation through Piezo1.
Hope JM, Dombroski JA, Pereles RS, Lopez-Cavestany M, Greenlee JD, Schwager SC, Reinhart-King CA, King MR
BMC biology 2022 Mar 9;20(1):61
BMC biology 2022 Mar 9;20(1):61
A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation.
MacKay CE, Floen M, Leo MD, Hasan R, Garrud TAC, Fernández-Peña C, Singh P, Malik KU, Jaggar JH
eLife 2022 Mar 1;11
eLife 2022 Mar 1;11
Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells.
Peng Y, Du J, Günther S, Guo X, Wang S, Schneider A, Zhu L, Braun T
Redox biology 2022 Jun;52:102309
Redox biology 2022 Jun;52:102309
Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes.
Kenmochi M, Kawarasaki S, Takizawa S, Okamura K, Goto T, Uchida K
The journal of physiological sciences : JPS 2022 Jun 20;72(1):13
The journal of physiological sciences : JPS 2022 Jun 20;72(1):13
Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca(2+) Influx and Akt-eNOS Pathway.
Porto Ribeiro T, Barbeau S, Baudrimont I, Vacher P, Freund-Michel V, Cardouat G, Berger P, Guibert C, Ducret T, Quignard JF
Cells 2022 Jul 30;11(15)
Cells 2022 Jul 30;11(15)
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.
Ye Y, Barghouth M, Dou H, Luan C, Wang Y, Karagiannopoulos A, Jiang X, Krus U, Fex M, Zhang Q, Eliasson L, Rorsman P, Zhang E, Renström E
Nature communications 2022 Jul 22;13(1):4237
Nature communications 2022 Jul 22;13(1):4237
Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis.
Wang S, Wang B, Shi Y, Möller T, Stegmeyer RI, Strilic B, Li T, Yuan Z, Wang C, Wettschureck N, Vestweber D, Offermanns S
Blood 2022 Jul 21;140(3):171-183
Blood 2022 Jul 21;140(3):171-183
Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation.
Yang Y, Wang D, Zhang C, Yang W, Li C, Gao Z, Pei K, Li Y
Human cell 2022 Jan;35(1):51-62
Human cell 2022 Jan;35(1):51-62
PIEZO1 mediates a mechanothrombotic pathway in diabetes.
Zhu W, Guo S, Homilius M, Nsubuga C, Wright SH, Quan D, Kc A, Eddy SS, Victorio RA, Beerens M, Flaumenhaft R, Deo RC, MacRae CA
Science translational medicine 2022 Jan 5;14(626):eabk1707
Science translational medicine 2022 Jan 5;14(626):eabk1707
Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1.
Qian W, Hadi T, Silvestro M, Ma X, Rivera CF, Bajpai A, Li R, Zhang Z, Qu H, Tellaoui RS, Corsica A, Zias AL, Garg K, Maldonado T, Ramkhelawon B, Chen W
Nature communications 2022 Jan 26;13(1):512
Nature communications 2022 Jan 26;13(1):512
Fine-Tuning of Piezo1 Expression and Activity Ensures Efficient Myoblast Fusion during Skeletal Myogenesis.
Ortuste Quiroga HP, Ganassi M, Yokoyama S, Nakamura K, Yamashita T, Raimbach D, Hagiwara A, Harrington O, Breach-Teji J, Asakura A, Suzuki Y, Tominaga M, Zammit PS, Goto K
Cells 2022 Jan 24;11(3)
Cells 2022 Jan 24;11(3)
Wuzhuyu Decoction relieves hyperalgesia by regulating central and peripheral 5-HT in chronic migraine model rats.
Nan N, Gong MX, Wang Q, Li MJ, Xu R, Ma Z, Wang SH, Zhao H, Xu YS
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153905
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153905
Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles.
Song Y, Chen J, Zhang C, Xin L, Li Q, Liu Y, Zhang C, Li S, Huang P
iScience 2022 Feb 18;25(2):103733
iScience 2022 Feb 18;25(2):103733
Piezo channels contribute to the regulation of myelination in Schwann cells.
Acheta J, Bhatia U, Haley J, Hong J, Rich K, Close R, Bechler ME, Belin S, Poitelon Y
Glia 2022 Dec;70(12):2276-2289
Glia 2022 Dec;70(12):2276-2289
Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes.
Liu Z, Tang Y, He L, Geng B, Lu F, He J, Yi Q, Liu X, Zhang K, Wang L, Xia Y, Jiang J
Channels (Austin, Tex.) 2022 Dec;16(1):127-136
Channels (Austin, Tex.) 2022 Dec;16(1):127-136
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis.
Yang X, Zeng H, Wang L, Luo S, Zhou Y
Cell & bioscience 2022 Dec 5;12(1):197
Cell & bioscience 2022 Dec 5;12(1):197
Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling.
Zhang S, Cao S, Gong M, Zhang W, Zhang W, Zhu Z, Wu S, Yue Y, Qian W, Ma Q, Wang S, Wang Z
Cancer biology & therapy 2022 Dec 31;23(1):336-347
Cancer biology & therapy 2022 Dec 31;23(1):336-347
Piezo1 act as a potential oncogene in pancreatic cancer progression.
Zhu Z, Li W, Gong M, Wang L, Yue Y, Qian W, Zhou C, Duan W, Han L, Li L, Wu Z, Ma Q, Lin M, Wang S, Wang Z
Life sciences 2022 Dec 1;310:121035
Life sciences 2022 Dec 1;310:121035
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone.
Zeng Y, Riquelme MA, Hua R, Zhang J, Acosta FM, Gu S, Jiang JX
Cell & bioscience 2022 Dec 1;12(1):191
Cell & bioscience 2022 Dec 1;12(1):191
Mechanical force modulates macrophage proliferation via Piezo1-AKT-Cyclin D1 axis.
Xu H, Guan J, Jin Z, Yin C, Wu S, Sun W, Zhang H, Yan B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22423
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22423
Mechanosensitive Piezo1 channels mediate renal fibrosis.
Zhao X, Kong Y, Liang B, Xu J, Lin Y, Zhou N, Li J, Jiang B, Cheng J, Li C, Wang W
JCI insight 2022 Apr 8;7(7)
JCI insight 2022 Apr 8;7(7)
Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells.
Chen L, Yan Y, Kong F, Wang J, Zeng J, Fang Z, Wang Z, Liu Z, Liu F
Cancers 2022 Apr 18;14(8)
Cancers 2022 Apr 18;14(8)
Hereditary Xerocytosis: Differential Behavior of PIEZO1 Mutations in the N-Terminal Extracellular Domain Between Red Blood Cells and HEK Cells.
Yamaguchi Y, Allegrini B, Rapetti-Mauss R, Picard V, Garçon L, Kohl P, Soriani O, Peyronnet R, Guizouarn H
Frontiers in physiology 2021;12:736585
Frontiers in physiology 2021;12:736585
Piezo1 and BK(Ca) channels in human atrial fibroblasts: Interplay and remodelling in atrial fibrillation.
Jakob D, Klesen A, Allegrini B, Darkow E, Aria D, Emig R, Chica AS, Rog-Zielinska EA, Guth T, Beyersdorf F, Kari FA, Proksch S, Hatem SN, Karck M, Künzel SR, Guizouarn H, Schmidt C, Kohl P, Ravens U, Peyronnet R
Journal of molecular and cellular cardiology 2021 Sep;158:49-62
Journal of molecular and cellular cardiology 2021 Sep;158:49-62
Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats.
Zhang Y, Jiang L, Huang T, Lu D, Song Y, Wang L, Gao J
Respiratory research 2021 Sep 21;22(1):250
Respiratory research 2021 Sep 21;22(1):250
Mechanical stimulation activates Piezo1 to promote mucin2 expression in goblet cells.
Xu Y, Bai T, Xiong Y, Liu C, Liu Y, Hou X, Song J
Journal of gastroenterology and hepatology 2021 Nov;36(11):3127-3139
Journal of gastroenterology and hepatology 2021 Nov;36(11):3127-3139
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation.
Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S
The Journal of clinical investigation 2021 Nov 1;131(21)
The Journal of clinical investigation 2021 Nov 1;131(21)
Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway.
Liu S, Xu X, Fang Z, Ning Y, Deng B, Pan X, He Y, Yang Z, Huang K, Li J
Cell calcium 2021 May;95:102367
Cell calcium 2021 May;95:102367
Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells.
Zhang M, Yan S, Xu X, Yu T, Guo Z, Ma M, Zhang Y, Gu Z, Feng Y, Du C, Wan M, Hu K, Han X, Gu N
Biomaterials 2021 Mar;270:120687
Biomaterials 2021 Mar;270:120687
Piezo1 plays a role in optic nerve head astrocyte reactivity.
Liu J, Yang Y, Liu Y
Experimental eye research 2021 Mar;204:108445
Experimental eye research 2021 Mar;204:108445
Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.
Lee W, Nims RJ, Savadipour A, Zhang Q, Leddy HA, Liu F, McNulty AL, Chen Y, Guilak F, Liedtke WB
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 30;118(13)
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 30;118(13)
Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing.
Emig R, Knodt W, Krussig MJ, Zgierski-Johnston CM, Gorka O, Groß O, Kohl P, Ravens U, Peyronnet R
Cells 2021 Mar 16;10(3)
Cells 2021 Mar 16;10(3)
Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients.
Liao J, Lu W, Chen Y, Duan X, Zhang C, Luo X, Lin Z, Chen J, Liu S, Yan H, Chen Y, Feng H, Zhou D, Chen X, Zhang Z, Yang Q, Liu X, Tang H, Li J, Makino A, Yuan JX, Zhong N, Yang K, Wang J
Hypertension (Dallas, Tex. : 1979) 2021 Jun;77(6):1974-1989
Hypertension (Dallas, Tex. : 1979) 2021 Jun;77(6):1974-1989
Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow.
Yarishkin O, Phuong TTT, Baumann JM, De Ieso ML, Vazquez-Chona F, Rudzitis CN, Sundberg C, Lakk M, Stamer WD, Križaj D
The Journal of physiology 2021 Jan;599(2):571-592
The Journal of physiology 2021 Jan;599(2):571-592
Mechanical Stress Induces Ca(2+)-Dependent Signal Transduction in Erythroblasts and Modulates Erythropoiesis.
Aglialoro F, Abay A, Yagci N, Rab MAE, Kaestner L, van Wijk R, von Lindern M, van den Akker E
International journal of molecular sciences 2021 Jan 19;22(2)
International journal of molecular sciences 2021 Jan 19;22(2)
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
Wang X, Cheng G, Miao Y, Qiu F, Bai L, Gao Z, Huang Y, Dong L, Niu X, Wang X, Li Y, Tang H, Xu Y, Song X
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.
Huo L, Gao Y, Zhang D, Wang S, Han Y, Men H, Yang Z, Qin X, Wang R, Kong D, Bai H, Zhang H, Zhang W, Jia Z
Pharmacological research 2021 Feb;164:105391
Pharmacological research 2021 Feb;164:105391
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension.
Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, Ravellette KS, Wu L, Balistrieri F, Tang H, Wu X, Zhao T, Black SM, Desai AA, Garcia JGN, Sun X, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Wang J, Yuan JX
American journal of physiology. Cell physiology 2021 Dec 1;321(6):C1010-C1027
American journal of physiology. Cell physiology 2021 Dec 1;321(6):C1010-C1027
Upregulation of Piezo1 Is a Novel Prognostic Indicator in Glioma Patients.
Qu S, Li S, Hu Z
Cancer management and research 2020;12:3527-3536
Cancer management and research 2020;12:3527-3536
Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells.
Kuntze A, Goetsch O, Fels B, Najder K, Unger A, Wilhelmi M, Sargin S, Schimmelpfennig S, Neumann I, Schwab A, Pethő Z
Frontiers in physiology 2020;11:89
Frontiers in physiology 2020;11:89
Tubeimoside I Antagonizes Yoda1-Evoked Piezo1 Channel Activation.
Liu S, Pan X, Cheng W, Deng B, He Y, Zhang L, Ning Y, Li J
Frontiers in pharmacology 2020;11:768
Frontiers in pharmacology 2020;11:768
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice.
Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S
Nature communications 2020 May 8;11(1):2303
Nature communications 2020 May 8;11(1):2303
Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure.
MacKay CE, Leo MD, Fernández-Peña C, Hasan R, Yin W, Mata-Daboin A, Bulley S, Gammons J, Mancarella S, Jaggar JH
eLife 2020 May 4;9
eLife 2020 May 4;9
Functional Expression of Piezo1 in Dorsal Root Ganglion (DRG) Neurons.
Roh J, Hwang SM, Lee SH, Lee K, Kim YH, Park CK
International journal of molecular sciences 2020 May 28;21(11)
International journal of molecular sciences 2020 May 28;21(11)
Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling.
Mousawi F, Peng H, Li J, Ponnambalam S, Roger S, Zhao H, Yang X, Jiang LH
Stem cells (Dayton, Ohio) 2020 Mar;38(3):410-421
Stem cells (Dayton, Ohio) 2020 Mar;38(3):410-421
PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cells.
Caulier A, Jankovsky N, Demont Y, Ouled-Haddou H, Demagny J, Guitton C, Merlusca L, Lebon D, Vong P, Aubry A, Lahary A, Rose C, Gréaume S, Cardon E, Platon J, Ouadid-Ahidouch H, Rochette J, Marolleau JP, Picard V, Garçon L
Haematologica 2020 Mar;105(3):610-622
Haematologica 2020 Mar;105(3):610-622
Piezo1 is required for outflow tract and aortic valve development.
Faucherre A, Moha Ou Maati H, Nasr N, Pinard A, Theron A, Odelin G, Desvignes JP, Salgado D, Collod-Béroud G, Avierinos JF, Lebon G, Zaffran S, Jopling C
Journal of molecular and cellular cardiology 2020 Jun;143:51-62
Journal of molecular and cellular cardiology 2020 Jun;143:51-62
Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier.
Zhong M, Wu W, Kang H, Hong Z, Xiong S, Gao X, Rehman J, Komarova YA, Malik AB
American journal of respiratory cell and molecular biology 2020 Feb;62(2):168-177
American journal of respiratory cell and molecular biology 2020 Feb;62(2):168-177
RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis.
Sugisawa E, Takayama Y, Takemura N, Kondo T, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, Maruyama K
Cell 2020 Aug 6;182(3):609-624.e21
Cell 2020 Aug 6;182(3):609-624.e21
Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle.
Han Y, Liu C, Zhang D, Men H, Huo L, Geng Q, Wang S, Gao Y, Zhang W, Zhang Y, Jia Z
International journal of oncology 2019 Sep;55(3):629-644
International journal of oncology 2019 Sep;55(3):629-644
A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-β1 expression.
Saleh A, Marhuenda E, Fabre C, Hassani Z, Weille J, Boukhaddaoui H, Guelfi S, Maldonado IL, Hugnot JP, Duffau H, Bauchet L, Cornu D, Bakalara N
Scientific reports 2019 Oct 10;9(1):14612
Scientific reports 2019 Oct 10;9(1):14612
The Mechanosensitive Ion Channel Piezo1 Significantly Mediates In Vitro Ultrasonic Stimulation of Neurons.
Qiu Z, Guo J, Kala S, Zhu J, Xian Q, Qiu W, Li G, Zhu T, Meng L, Zhang R, Chan HC, Zheng H, Sun L
iScience 2019 Nov 22;21:448-457
iScience 2019 Nov 22;21:448-457
Mechanically Defined Microenvironment Promotes Stabilization of Microvasculature, Which Correlates with the Enrichment of a Novel Piezo-1(+) Population of Circulating CD11b(+) /CD115(+) Monocytes.
Forget A, Gianni-Barrera R, Uccelli A, Sarem M, Kohler E, Fogli B, Muraro MG, Bichet S, Aumann K, Banfi A, Shastri VP
Advanced materials (Deerfield Beach, Fla.) 2019 May;31(21):e1808050
Advanced materials (Deerfield Beach, Fla.) 2019 May;31(21):e1808050
Rapid flow-induced activation of Gα(q/11) is independent of Piezo1 activation.
Dela Paz NG, Frangos JA
American journal of physiology. Cell physiology 2019 May 1;316(5):C741-C752
American journal of physiology. Cell physiology 2019 May 1;316(5):C741-C752
Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries.
Lhomme A, Gilbert G, Pele T, Deweirdt J, Henrion D, Baudrimont I, Campagnac M, Marthan R, Guibert C, Ducret T, Savineau JP, Quignard JF
American journal of respiratory cell and molecular biology 2019 Jun;60(6):650-658
American journal of respiratory cell and molecular biology 2019 Jun;60(6):650-658
The mechanosensitive Piezo1 channel is required for bone formation.
Sun W, Chi S, Li Y, Ling S, Tan Y, Xu Y, Jiang F, Li J, Liu C, Zhong G, Cao D, Jin X, Zhao D, Gao X, Liu Z, Xiao B, Li Y
eLife 2019 Jul 10;8
eLife 2019 Jul 10;8
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.
Kang H, Hong Z, Zhong M, Klomp J, Bayless KJ, Mehta D, Karginov AV, Hu G, Malik AB
American journal of physiology. Cell physiology 2019 Jan 1;316(1):C92-C103
American journal of physiology. Cell physiology 2019 Jan 1;316(1):C92-C103
Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.
Tao H, Zhu M, Lau K, Whitley OKW, Samani M, Xiao X, Chen XX, Hahn NA, Liu W, Valencia M, Wu M, Wang X, Fenelon KD, Pasiliao CC, Hu D, Wu J, Spring S, Ferguson J, Karuna EP, Henkelman RM, Dunn A, Huang H, Ho HH, Atit R, Goyal S, Sun Y, Hopyan S
Nature communications 2019 Apr 12;10(1):1703
Nature communications 2019 Apr 12;10(1):1703
PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis.
Zhang J, Zhou Y, Huang T, Wu F, Liu L, Kwan JSH, Cheng ASL, Yu J, To KF, Kang W
Molecular carcinogenesis 2018 Sep;57(9):1144-1155
Molecular carcinogenesis 2018 Sep;57(9):1144-1155
Piezo1 and G(q)/G(11) promote endothelial inflammation depending on flow pattern and integrin activation.
Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S
The Journal of experimental medicine 2018 Oct 1;215(10):2655-2672
The Journal of experimental medicine 2018 Oct 1;215(10):2655-2672
A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.
Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan JJ, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida MM, Dirks PB, Song Y, Hui CC, Sun Y, Wang LY, Li X, Huang X
Neuron 2018 Nov 21;100(4):799-815.e7
Neuron 2018 Nov 21;100(4):799-815.e7
Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII.
Liang J, Huang B, Yuan G, Chen Y, Liang F, Zeng H, Zheng S, Cao L, Geng D, Zhou S
American journal of translational research 2017;9(6):2945-2955
American journal of translational research 2017;9(6):2945-2955
Mechanical stretch triggers rapid epithelial cell division through Piezo1.
Gudipaty SA, Lindblom J, Loftus PD, Redd MJ, Edes K, Davey CF, Krishnegowda V, Rosenblatt J
Nature 2017 Mar 2;543(7643):118-121
Nature 2017 Mar 2;543(7643):118-121
Evidence for shear-mediated Ca(2+) entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.
Ilkan Z, Wright JR, Goodall AH, Gibbins JM, Jones CI, Mahaut-Smith MP
The Journal of biological chemistry 2017 Jun 2;292(22):9204-9217
The Journal of biological chemistry 2017 Jun 2;292(22):9204-9217
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S
The Journal of clinical investigation 2016 Dec 1;126(12):4527-4536
The Journal of clinical investigation 2016 Dec 1;126(12):4527-4536
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.
Fotiou E, Martin-Almedina S, Simpson MA, Lin S, Gordon K, Brice G, Atton G, Jeffery I, Rees DC, Mignot C, Vogt J, Homfray T, Snyder MP, Rockson SG, Jeffery S, Mortimer PS, Mansour S, Ostergaard P
Nature communications 2015 Sep 3;6:8085
Nature communications 2015 Sep 3;6:8085
Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis).
Andolfo I, Russo R, Manna F, Shmukler BE, Gambale A, Vitiello G, De Rosa G, Brugnara C, Alper SL, Snyder LM, Iolascon A
American journal of hematology 2015 Oct;90(10):921-6
American journal of hematology 2015 Oct;90(10):921-6
Piezo1 integration of vascular architecture with physiological force.
Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ
Nature 2014 Nov 13;515(7526):279-282
Nature 2014 Nov 13;515(7526):279-282
Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures.
Miyamoto T, Mochizuki T, Nakagomi H, Kira S, Watanabe M, Takayama Y, Suzuki Y, Koizumi S, Takeda M, Tominaga M
The Journal of biological chemistry 2014 Jun 6;289(23):16565-75
The Journal of biological chemistry 2014 Jun 6;289(23):16565-75
Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.
Andolfo I, Alper SL, De Franceschi L, Auriemma C, Russo R, De Falco L, Vallefuoco F, Esposito MR, Vandorpe DH, Shmukler BE, Narayan R, Montanaro D, D'Armiento M, Vetro A, Limongelli I, Zuffardi O, Glader BE, Schrier SL, Brugnara C, Stewart GW, Delaunay J, Iolascon A
Blood 2013 May 9;121(19):3925-35, S1-12
Blood 2013 May 9;121(19):3925-35, S1-12
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
Eisenhoffer GT, Loftus PD, Yoshigi M, Otsuna H, Chien CB, Morcos PA, Rosenblatt J
Nature 2012 Apr 15;484(7395):546-9
Nature 2012 Apr 15;484(7395):546-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Piezo1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Piezo1. This antibody recognizes human antigen. The Piezo1 antibody has been validated for the following applications: ELISA, WB analysis.
