28511-1-AP

antibody from Proteintech Group

Targeting: PIEZO1 FAM38A, KIAA0233

Provider product page for 28511-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [36]
Comments [0]
Validations [0]

Submit

Product number: 28511-1-AP - Provider product page
Provider: Proteintech Group
Product name: Piezo1 (extracellular domain) antibody
Antibody type: Polyclonal
Description: KD/KO validated Piezo1 (extracellular domain) antibody (Cat. #28511-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PIEZO1 protein structure - 28511-1-AP shown in red.

Submitted references Spatiotemporal Regulation of Ligand Trafficking and TLR9 Activation by PIEZO1 in Human Plasmacytoid Dendritic Cells.

Pattanayak S, Raychaudhuri D, Bandopadhyay P, Mukhopadhyay U, Mandal T, Liu CSC, Kalidas N, Roychowdhury S, Chattopadhyay K, Ashish F, Sinha B, Ganguly D
Research (Washington, D.C.) 2026;9:1067

Stiff matrix drives microglial cell migration through Piezo1/Ca(2+)/AKT/cofilin signaling axis-regulated F-actin reassembly.

Chen X, Li Z, Men J, Shao H, Bai J, Guo Y, Chen X, Fan Y, Jiang LH, Jia X
Regenerative biomaterials 2026;13:rbaf124

Dynamically responsive hydrogel with mechanical stimulation enhances diabetic wound healing via activation of Piezo1-mediated efferocytosis.

Tao Z, Li Z, Shao Y, Xiao Y, Fan X, Yang L, Sun Z, Cui T, Sun Z, Jiang J, Lian X, Guo X, Liu S, Ma X
Bioactive materials 2026 Jun;60:607-625

The mechanosensitive ion channel Piezo1 promotes colitis by modulating oxidative stress and ferroptosis-related markers.

Zhou J, Lu P, He H, Yang D, Zhu W, Liu Q, Liu Q, Zhang G, Liu M
Cellular signalling 2026 Jul;143:112507

Piezo1 Upregulation in Monocyte-Derived Macrophages Impairs Post-Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis.

Peng L, Xia Y, Zhao H, Guo Y, Xu X, Han X, Wang S, Ding F, Liu Q, Li C, He Y, Luo Z, Wang Q, Zhang X, Gao F, Wang Y, Li Y, Wang S, Tao L, Yan W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e10991

Gear-like MOF microrobots for single cell mechanotransduction of microvilli.

Liu X, Wang Y, Lin L, Liu N, Yang Z, Wang P, Yan X, Guo J, Jin D, Ma X
Nature communications 2026 Feb 26;17(1)

Targeting Piezo1 can improve endometrial fibrosis by inhibiting ferroptosis in endothelial cells.

Yang H, Dou C, Pan R, Xu Y, Zeng K, Huang J, Sun L, Yao Y, Wang J
iScience 2026 Feb 20;29(2):114540

Long-range chemical signalling in vivo is regulated by mechanical signals.

Pillai EK, Mukherjee S, Gampl N, McGinn RJ, Mooslehner KA, Becker JM, Winkel AK, Thompson AJ, Franze K
Nature materials 2026 Apr;25(4):687-697

Kaempferol regulating macrophage foaming and atherosclerosis through Piezo1-mediated MAPK/NF-κB and Nrf2/HO-1 signaling pathway.

Chu T, Wang Y, Wang S, Li J, Li Z, Wei Z, Li J, Bian Y
Journal of advanced research 2025 Sep;75:635-650

Mechanosensitive Channels Mediate Pancreatic β Cells Reactive Oxygen Species Formation and Downregulation of Essential Genes During Therapeutic Ultrasound Treatment.

Brayer M, Zderic V, Jeremic A
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2025 Sep;44(9):1577-1593

TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy.

Luo R, Miao Y, Hu R, Lin F, Yan J, Yang T, Xiao L, Sun Z, Wang Y, Chen J
Genes & diseases 2025 Sep;12(5):101707

FSS in CTE triggers neuronal apoptosis through Piezo1-induced Ca(2+) homeostasis disruption.

Gao T, Zhao J, Shao S, Yang Y, Li N, Yuan H, Liu B
Archives of biochemistry and biophysics 2025 Nov;773:110587

Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression.

Huang C, Chen X, Wu D, Chen J, Wang J, Li S, Hu J, Yan Z, Zhu Y, Zhang Y
International journal of biological macromolecules 2025 Nov;330(Pt 1):147928

Environmental stiffness regulates neuronal maturation via Piezo1-mediated transthyretin activity.

Kreysing E, Gautier HOB, Mukherjee S, Mooslehner KA, Muresan L, Haarhoff D, Zhao X, Winkel AK, Borić T, Vásquez-Sepúlveda S, Gampl N, Dimitracopoulos A, Pillai EK, Humphrey R, Káradóttir RT, Franze K
Nature communications 2025 Nov 7;16(1):9842

Mechanosensitive Piezo1 channel is highly expressed in the age-induced fibrotic uterus.

Wang Y, Liu X, Wang M, Kang J, Zhang Y
Molecular biology reports 2025 May 28;52(1):510

Trimethylamine N-oxide induces cardiac diastolic dysfunction by down-regulating Piezo1 in mice with heart failure with preserved ejection fraction.

Chen Q, Zhang H, Chen Y, Peng Y, Yao Y, Xue H, Guo Q, Tian D, Xiao L, Teng X, Zheng M, Xiao B, Wu Y, Jin S
Life sciences 2025 May 15;369:123554

Static Topographical Cue Combined with Dynamic Fluid Stimulation Enhances the Macrophage Extracellular Vesicle Yield and Therapeutic Potential for Bone Defects.

Huang H, Xiao L, Fang L, Lei M, Liu Z, Gao S, Lei Q, Lei J, Wei R, Lei Y, Xue L, Geng Z, Cai L, Yan F
ACS nano 2025 Mar 11;19(9):8667-8691

Piezo1 promotes double-directional differentiation from human periodontal ligament progenitor cells.

Kono Y, Kajiya H, Nagano R, Tominaga C, Maeda H, Fujita T, Tamaoki S
Journal of oral biosciences 2025 Jun;67(2):100651

Tissue geometry spatiotemporally drives bacterial infections.

Han Y, Liu X, Qu S, Duan X, Xiang Y, Jiang N, Yang S, Fang X, Xu L, Wen H, Yu Y, Huang S, Huang J, Zhu K
Cell 2025 Jun 26;188(13):3459-3476.e21

Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma.

Mo J, Zhang Y, Cao C, Zheng W, Zheng L, Wang X, Wang S, Wu J, Bao Y
Cell communication and signaling : CCS 2025 Jun 13;23(1):280

PIEZO1-mediated mechanotransduction regulates collagen synthesis on nanostructured 2D and 3D models of fibrosis.

Rashidi N, Harasymowicz NS, Savadipour A, Steward N, Tang R, Oswald S, Guilak F
Acta biomaterialia 2025 Jan 24;193:242-254

The mRNA Stability of PIEZO1, Regulated by Methyltransferase-Like 3 via N(6)-Methylation of Adenosine Modification in a YT521-B Homology Domain Family 2-Dependent Manner, Facilitates the Progression of Diabetic Retinopathy.

Han N, Yu N, Yu L
The American journal of pathology 2025 Feb;195(2):265-280

Talin1 modulates the Piezo1-YAP axis to regulate endothelial cell inflammation and atherosclerosis.

Wang Y, Huang H, Liu Z, Gao Z, Liao B, Long Y, Yu F, Nie Y
Cellular and molecular life sciences : CMLS 2025 Dec 26;83(1):40

Unravelling the Role of PIEZO1 in Adipogenesis of Fibrogenic/Adipogenic Progenitors for Muscle Fat Infiltration After Rotator Cuff Tear.

Lin X, Song Q, Kuati A, Li Z, Zhou H, Feng S, Wang M, Zhu S, Cui G, Wang J, Shao X
Journal of cachexia, sarcopenia and muscle 2025 Aug;16(4):e70004

Hyperosmotic stress-induced NLRP3 inflammasome activation via the mechanosensitive PIEZO1 channel in dry eye corneal epithelium.

Lian L, Ye X, Wang Z, Li J, Wang J, Chen L, Reinach PS, Ma X, Chen W, Zheng Q
The ocular surface 2025 Apr;36:106-118

Wada H, Abe M, Wada N, Yoshimoto S, Fujii S, Moriyama M, Mori Y, Kido MA, Kiyoshima T
Journal of cellular physiology 2025 Apr;240(4):e70036

Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro.

Moneme C, Olutoye OO 2nd, Sobstel MF, Zhang Y, Zhou X, Kaminer JL, Hsu BA, Shen C, Mandal A, Li H, Yu L, Balaji S, Keswani SG, Cheng LS
Frontiers in molecular neuroscience 2024;17:1474025

Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis.

Zhang N, Wu P, Mu M, Niu C, Hu S
Molecular neurobiology 2024 Sep;61(9):6556-6571

Piezo activity levels need to be tightly regulated to maintain normal morphology and function in pericardial nephrocytes.

Schulz K, Hazelton-Cavill P, Alornyo KK, Edenhofer I, Lindenmeyer M, Lohr C, Huber TB, Denholm B, Koehler S
Scientific reports 2024 Nov 16;14(1):28254

High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1.

Deng BL, Lin DX, Li ZP, Li K, Wei PY, Luo CC, Zhang MY, Zhou Q, Yang ZL, Chen Z
Current medical science 2024 Aug;44(4):718-725

The role of Piezo1 mechanotransduction in high-grade serous ovarian cancer: Insights from an in vitro model of collective detachment.

Micek HM, Yang N, Dutta M, Rosenstock L, Ma Y, Hielsberg C, McCord M, Notbohm J, McGregor S, Kreeger PK
Science advances 2024 Apr 26;10(17):eadl4463

Mechanosensitive channel Piezo1 is an essential regulator in cell cycle progression of optic nerve head astrocytes.

Wan Y, Wang H, Fan X, Bao J, Wu S, Liu Q, Yan X, Zhang J, Jin ZB, Xiao B, Wang N
Glia 2023 May;71(5):1233-1246

Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease.

Hu J, Chen Q, Zhu H, Hou L, Liu W, Yang Q, Shen H, Chai G, Zhang B, Chen S, Cai Z, Wu C, Hong F, Li H, Chen S, Xiao N, Wang ZX, Zhang X, Wang B, Zhang L, Mo W
Neuron 2023 Jan 4;111(1):15-29.e8

The function of Piezo1 in hepatoblastoma metastasis and its potential transduction mechanism.

Ye X, Xia Y, Zheng Y, Chen W, Chen Z, Cheng Z, Wang B
Heliyon 2022 Sep;8(9):e10301

Mechanosensitive Piezo1 channels mediate renal fibrosis.

Zhao X, Kong Y, Liang B, Xu J, Lin Y, Zhou N, Li J, Jiang B, Cheng J, Li C, Wang W
JCI insight 2022 Apr 8;7(7)

Mechanical stretch activates piezo1 in caveolae of alveolar type I cells to trigger ATP release and paracrine stimulation of surfactant secretion from alveolar type II cells.

Diem K, Fauler M, Fois G, Hellmann A, Winokurow N, Schumacher S, Kranz C, Frick M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sep;34(9):12785-12804

No comments: Submit comment

No validations: Submit validation data