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- References [30]
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- Product number
- 20795-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20795-1-AP, RRID:AB_2665377
- Product name
- HMGA2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HMGA2 antibody (Cat. #20795-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia.
ER-α36 Promotes the Malignant Progression of Cervical Cancer Mediated by Estrogen via HMGA2.
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.
Layered Double Hydroxide Nanoparticles with Osteogenic Effects as miRNA Carriers to Synergistically Promote Osteogenesis of MSCs.
YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.
MicroRNA-9-5p increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating high mobility group A2 expression.
CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization.
In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma.
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.
Alterations in TGF-β signaling leads to high HMGA2 levels potentially through modulation of PJA1/SMAD3 in HCC cells.
Cr (VI) induced mitophagy via the interaction of HMGA2 and PARK2.
LncRNA ZEB2-AS1 promotes the proliferation, migration and invasion of esophageal squamous cell carcinoma cell through miR-574-3p/HMGA2 axis.
OLR1 Promotes Pancreatic Cancer Metastasis via Increased c-Myc Expression and Transcription of HMGA2.
Protein phosphatase 6 is a key factor regulating spermatogenesis.
Molecular mechanism of targeted inhibition of HMGA2 via miRNAlet-7a in proliferation and metastasis of laryngeal squamous cell carcinoma.
MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.
High mobility group AT-hook 2 and c-MYC as potential prognostic factors in pancreatic ductal adenocarcinoma.
Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells.
Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer.
N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.
H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas.
Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women.
The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.
Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells.
Tumor suppressive role of miR-569 in lung cancer.
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.
Lin28B facilitates the progression and metastasis of pancreatic ductal adenocarcinoma.
Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids.
XIAP 3'-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma.
Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML.
Wang Z, Huang Y, Chu F, Ji S, Liao K, Cui Z, Chen J, Tang S
Journal of inflammation research 2021;14:5901-5918
Journal of inflammation research 2021;14:5901-5918
ER-α36 Promotes the Malignant Progression of Cervical Cancer Mediated by Estrogen via HMGA2.
Wang C, Zhang T, Wang K, Zhang S, Sun Q, Yang X
Frontiers in oncology 2021;11:712849
Frontiers in oncology 2021;11:712849
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.
Hasenbilige, Mei J, Dlamini MB, Gao Z, Jiang L, Li Q, Geng C, Shi X, Liu Y, Kong Y, Cao J
Toxicology 2021 Oct;462:152928
Toxicology 2021 Oct;462:152928
Layered Double Hydroxide Nanoparticles with Osteogenic Effects as miRNA Carriers to Synergistically Promote Osteogenesis of MSCs.
Yang L, He X, Jing G, Wang H, Niu J, Qian Y, Wang S
ACS applied materials & interfaces 2021 Oct 20;13(41):48386-48402
ACS applied materials & interfaces 2021 Oct 20;13(41):48386-48402
YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.
Pi J, Wang W, Ji M, Wang X, Wei X, Jin J, Liu T, Qiang J, Qi Z, Li F, Liu Y, Ma Y, Si Y, Huo Y, Gao Y, Chen Y, Dong L, Su R, Chen J, Rao S, Yi P, Yu S, Wang F, Yu J
Cancer research 2021 May 15;81(10):2651-2665
Cancer research 2021 May 15;81(10):2651-2665
MicroRNA-9-5p increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating high mobility group A2 expression.
Zheng H, Yan B, Wu Q, Zhang J
Oncology letters 2021 Mar;21(3):235
Oncology letters 2021 Mar;21(3):235
CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization.
Xia Y, Lv J, Jiang T, Li B, Li Y, He Z, Xuan Z, Sun G, Wang S, Li Z, Wang W, Wang L, Xu Z
Journal of experimental & clinical cancer research : CR 2021 Mar 17;40(1):103
Journal of experimental & clinical cancer research : CR 2021 Mar 17;40(1):103
In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma.
Chen H, Sa G, Li L, He S, Wu T
European journal of pharmacology 2021 Jan 15;891:173757
European journal of pharmacology 2021 Jan 15;891:173757
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.
Taftaf R, Liu X, Singh S, Jia Y, Dashzeveg NK, Hoffmann AD, El-Shennawy L, Ramos EK, Adorno-Cruz V, Schuster EJ, Scholten D, Patel D, Zhang Y, Davis AA, Reduzzi C, Cao Y, D'Amico P, Shen Y, Cristofanilli M, Muller WA, Varadan V, Liu H
Nature communications 2021 Aug 11;12(1):4867
Nature communications 2021 Aug 11;12(1):4867
Alterations in TGF-β signaling leads to high HMGA2 levels potentially through modulation of PJA1/SMAD3 in HCC cells.
Ohshiro K, Chen J, Srivastav J, Mishra L, Mishra B
Genes & cancer 2020;11(1-2):43-52
Genes & cancer 2020;11(1-2):43-52
Cr (VI) induced mitophagy via the interaction of HMGA2 and PARK2.
Gao Z, Mei J, Yan X, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J
Toxicology letters 2020 Oct 15;333:261-268
Toxicology letters 2020 Oct 15;333:261-268
LncRNA ZEB2-AS1 promotes the proliferation, migration and invasion of esophageal squamous cell carcinoma cell through miR-574-3p/HMGA2 axis.
Xu JH, Chen RZ, Liu LY, Li XM, Wu CP, Zhou YT, Yan JD, Zhang ZY
European review for medical and pharmacological sciences 2020 May;24(10):5391-5403
European review for medical and pharmacological sciences 2020 May;24(10):5391-5403
OLR1 Promotes Pancreatic Cancer Metastasis via Increased c-Myc Expression and Transcription of HMGA2.
Yang G, Xiong G, Feng M, Zhao F, Qiu J, Liu Y, Cao Z, Wang H, Yang J, You L, Zheng L, Zhang T, Zhao Y
Molecular cancer research : MCR 2020 May;18(5):685-697
Molecular cancer research : MCR 2020 May;18(5):685-697
Protein phosphatase 6 is a key factor regulating spermatogenesis.
Lei WL, Han F, Hu MW, Liang QX, Meng TG, Zhou Q, Ouyang YC, Hou Y, Schatten H, Wang ZB, Sun QY
Cell death and differentiation 2020 Jun;27(6):1952-1964
Cell death and differentiation 2020 Jun;27(6):1952-1964
Molecular mechanism of targeted inhibition of HMGA2 via miRNAlet-7a in proliferation and metastasis of laryngeal squamous cell carcinoma.
Ma LJ, Wu J, Zhou E, Yin J, Xiao XP
Bioscience reports 2020 Jun 26;40(6)
Bioscience reports 2020 Jun 26;40(6)
MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.
Sun C, Cao W, Qiu C, Li C, Dongol S, Zhang Z, Dong R, Song K, Yang X, Zhang Q, Kong B
Journal of hematology & oncology 2020 Jan 31;13(1):9
Journal of hematology & oncology 2020 Jan 31;13(1):9
High mobility group AT-hook 2 and c-MYC as potential prognostic factors in pancreatic ductal adenocarcinoma.
Li K, Yang J, Chen J, Shi Y, Zhang Z, Chen W
Oncology letters 2020 Feb;19(2):1584-1592
Oncology letters 2020 Feb;19(2):1584-1592
Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells.
Chen W, Lin J, Li B, Cao S, Li H, Zhao J, Liu K, Li Y, Li Y, Sun S
Journal of cellular and molecular medicine 2020 Apr;24(8):4762-4772
Journal of cellular and molecular medicine 2020 Apr;24(8):4762-4772
Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer.
Chen CH, Hsieh YC, Yang PM, Liu YR, Cho EC
Biochemical and biophysical research communications 2020 Apr 16;524(4):1003-1009
Biochemical and biophysical research communications 2020 Apr 16;524(4):1003-1009
N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.
Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, Wang F, Ma NF, Guan X, Yun JP, Wang FW, Xu RH, Dan Xie
Nature communications 2019 Oct 16;10(1):4695
Nature communications 2019 Oct 16;10(1):4695
H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas.
Cao T, Jiang Y, Wang Z, Zhang N, Al-Hendy A, Mamillapalli R, Kallen AN, Kodaman P, Taylor HS, Li D, Huang Y
Oncogene 2019 Jul;38(27):5356-5366
Oncogene 2019 Jul;38(27):5356-5366
Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women.
Jiang Y, Zhu C, He D, Gao Q, Tian X, Ma X, Wu J, Das BC, Severinov K, Hitzeroth II, Debata PR, Liu R, Zou L, Shi L, Xu H, Wang K, Bao Y, Ka-Kit LR, You Z, Cui Z, Hu Z
Translational oncology 2019 Jul;12(7):959-967
Translational oncology 2019 Jul;12(7):959-967
The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.
Li M, Zhao H, Zhao SG, Wei DM, Zhao YR, Huang T, Muhammad T, Yan L, Gao F, Li L, Lu G, Chan WY, Leung PCK, Dunaif A, Liu HB, Chen ZJ
The Journal of clinical endocrinology and metabolism 2019 Apr 1;104(4):1049-1059
The Journal of clinical endocrinology and metabolism 2019 Apr 1;104(4):1049-1059
Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells.
Xia C, Liang S, He Z, Zhu X, Chen R, Chen J
European journal of pharmacology 2018 Jul 5;830:59-67
European journal of pharmacology 2018 Jul 5;830:59-67
Tumor suppressive role of miR-569 in lung cancer.
Zheng YP, Wu L, Gao J, Wang Y
Oncology letters 2018 Apr;15(4):4087-4092
Oncology letters 2018 Apr;15(4):4087-4092
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.
Zhuang J, Shen L, Yang L, Huang X, Lu Q, Cui Y, Zheng X, Zhao X, Zhang D, Huang R, Guo H, Yan J
Theranostics 2017;7(12):3053-3067
Theranostics 2017;7(12):3053-3067
Lin28B facilitates the progression and metastasis of pancreatic ductal adenocarcinoma.
Wang Y, Li J, Guo S, Ouyang Y, Yin L, Liu S, Zhao Z, Yang J, Huang W, Qin H, Zhao X, Ni B, Wang H
Oncotarget 2017 Sep 1;8(36):60414-60428
Oncotarget 2017 Sep 1;8(36):60414-60428
Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids.
Nikolić MZ, Caritg O, Jeng Q, Johnson JA, Sun D, Howell KJ, Brady JL, Laresgoiti U, Allen G, Butler R, Zilbauer M, Giangreco A, Rawlins EL
eLife 2017 Jun 30;6
eLife 2017 Jun 30;6
XIAP 3'-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma.
Wu WY, Tao SQ, Wang XN, Lobie PE, Wu ZS
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317719578
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317719578
Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML.
Tan L, Wei X, Zheng L, Zeng J, Liu H, Yang S, Tan H
Journal of cancer research and clinical oncology 2016 Feb;142(2):389-99
Journal of cancer research and clinical oncology 2016 Feb;142(2):389-99
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 20795-1-AP( HMGA2 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HMGA2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human HMGA2. This antibody recognizes human, mouse antigen. The HMGA2 antibody has been validated for the following applications: ELISA, WB, IF analysis.
