20795-1-AP

antibody from Proteintech Group

Targeting: HMGA2 BABL, HMGIC, LIPO

Provider product page for 20795-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [38]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 20795-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20795-1-AP, RRID:AB_2665377
Product name: HMGA2 antibody
Antibody type: Polyclonal
Description: KD/KO validated HMGA2 antibody (Cat. #20795-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HMGA2 protein structure - 20795-1-AP shown in red.

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Cancer research 2024 Mar 4;84(5):659-674

HMGA2 overexpression activates IGF2BP2 to stabilize APLP2 via m6A modification and promote pancreatic cancer progression.

Liu K, Wei C, Yu H, Zhang Q, Du Z
Heliyon 2024 Mar 15;10(5):e27268

OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1.

Song C, Xu Z, Liang Q, Mu Y, Liu M, Wu Z, Li X, Li J, Chen H, Wang Y, Gao S, Li A, Yao W, Liu G
International immunopharmacology 2024 Jan 5;126:111148

Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis.

Cheng C, Yao H, Li H, Liu J, Liu Z, Wu Y, Zhu L, Hu H, Fang Z, Wu L
Acta pharmaceutica Sinica. B 2024 Apr;14(4):1624-1643

Platinum-Based Regimens Are Active in Advanced Pediatric-Type Rhabdomyosarcoma in Adults and Depending on HMGB1 Expression.

Hindi N, Carrillo-García J, Blanco-Alcaina E, Renshaw M, Luna P, Durán J, Jiménez N, Sancho P, Ramos R, Moura DS, Martín-Broto J
International journal of molecular sciences 2023 Jan 3;24(1)

Effect and Mechanism of lncRNA CERS6-AS1 on the Biological Behavior of Prostate Cancer Cell.

Huang F, Zhou LQ
Applied bionics and biomechanics 2022;2022:9292538

NUF2 Drives Clear Cell Renal Cell Carcinoma by Activating HMGA2 Transcription through KDM2A-mediated H3K36me2 Demethylation.

Lin J, Chen X, Yu H, Min S, Chen Y, Li Z, Xie X
International journal of biological sciences 2022;18(9):3621-3635

A novel HCC prognosis predictor PDSS1 affects the cell cycle through the STAT3 signaling pathway in HCC.

Rao Z, Li H, Yao W, Wang Q, Ma B, Xue D, Meng X
Frontiers in oncology 2022;12:927468

Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia.

Wang Z, Huang Y, Chu F, Ji S, Liao K, Cui Z, Chen J, Tang S
Journal of inflammation research 2021;14:5901-5918

ER-α36 Promotes the Malignant Progression of Cervical Cancer Mediated by Estrogen via HMGA2.

Wang C, Zhang T, Wang K, Zhang S, Sun Q, Yang X
Frontiers in oncology 2021;11:712849

A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.

Hasenbilige, Mei J, Dlamini MB, Gao Z, Jiang L, Li Q, Geng C, Shi X, Liu Y, Kong Y, Cao J
Toxicology 2021 Oct;462:152928

Layered Double Hydroxide Nanoparticles with Osteogenic Effects as miRNA Carriers to Synergistically Promote Osteogenesis of MSCs.

Yang L, He X, Jing G, Wang H, Niu J, Qian Y, Wang S
ACS applied materials & interfaces 2021 Oct 20;13(41):48386-48402

YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.

Pi J, Wang W, Ji M, Wang X, Wei X, Jin J, Liu T, Qiang J, Qi Z, Li F, Liu Y, Ma Y, Si Y, Huo Y, Gao Y, Chen Y, Dong L, Su R, Chen J, Rao S, Yi P, Yu S, Wang F, Yu J
Cancer research 2021 May 15;81(10):2651-2665

MicroRNA-9-5p increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating high mobility group A2 expression.

Zheng H, Yan B, Wu Q, Zhang J
Oncology letters 2021 Mar;21(3):235

CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization.

Xia Y, Lv J, Jiang T, Li B, Li Y, He Z, Xuan Z, Sun G, Wang S, Li Z, Wang W, Wang L, Xu Z
Journal of experimental & clinical cancer research : CR 2021 Mar 17;40(1):103

In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma.

Chen H, Sa G, Li L, He S, Wu T
European journal of pharmacology 2021 Jan 15;891:173757

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.

Taftaf R, Liu X, Singh S, Jia Y, Dashzeveg NK, Hoffmann AD, El-Shennawy L, Ramos EK, Adorno-Cruz V, Schuster EJ, Scholten D, Patel D, Zhang Y, Davis AA, Reduzzi C, Cao Y, D'Amico P, Shen Y, Cristofanilli M, Muller WA, Varadan V, Liu H
Nature communications 2021 Aug 11;12(1):4867

Alterations in TGF-β signaling leads to high HMGA2 levels potentially through modulation of PJA1/SMAD3 in HCC cells.

Ohshiro K, Chen J, Srivastav J, Mishra L, Mishra B
Genes & cancer 2020;11(1-2):43-52

Cr (VI) induced mitophagy via the interaction of HMGA2 and PARK2.

Gao Z, Mei J, Yan X, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J
Toxicology letters 2020 Oct 15;333:261-268

LncRNA ZEB2-AS1 promotes the proliferation, migration and invasion of esophageal squamous cell carcinoma cell through miR-574-3p/HMGA2 axis.

Xu JH, Chen RZ, Liu LY, Li XM, Wu CP, Zhou YT, Yan JD, Zhang ZY
European review for medical and pharmacological sciences 2020 May;24(10):5391-5403

OLR1 Promotes Pancreatic Cancer Metastasis via Increased c-Myc Expression and Transcription of HMGA2.

Yang G, Xiong G, Feng M, Zhao F, Qiu J, Liu Y, Cao Z, Wang H, Yang J, You L, Zheng L, Zhang T, Zhao Y
Molecular cancer research : MCR 2020 May;18(5):685-697

Protein phosphatase 6 is a key factor regulating spermatogenesis.

Lei WL, Han F, Hu MW, Liang QX, Meng TG, Zhou Q, Ouyang YC, Hou Y, Schatten H, Wang ZB, Sun QY
Cell death and differentiation 2020 Jun;27(6):1952-1964

Molecular mechanism of targeted inhibition of HMGA2 via miRNAlet-7a in proliferation and metastasis of laryngeal squamous cell carcinoma.

Ma LJ, Wu J, Zhou E, Yin J, Xiao XP
Bioscience reports 2020 Jun 26;40(6)

MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.

Sun C, Cao W, Qiu C, Li C, Dongol S, Zhang Z, Dong R, Song K, Yang X, Zhang Q, Kong B
Journal of hematology & oncology 2020 Jan 31;13(1):9

High mobility group AT-hook 2 and c-MYC as potential prognostic factors in pancreatic ductal adenocarcinoma.

Li K, Yang J, Chen J, Shi Y, Zhang Z, Chen W
Oncology letters 2020 Feb;19(2):1584-1592

Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells.

Chen W, Lin J, Li B, Cao S, Li H, Zhao J, Liu K, Li Y, Li Y, Sun S
Journal of cellular and molecular medicine 2020 Apr;24(8):4762-4772

Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer.

Chen CH, Hsieh YC, Yang PM, Liu YR, Cho EC
Biochemical and biophysical research communications 2020 Apr 16;524(4):1003-1009

N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.

Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, Wang F, Ma NF, Guan X, Yun JP, Wang FW, Xu RH, Dan Xie
Nature communications 2019 Oct 16;10(1):4695

H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas.

Cao T, Jiang Y, Wang Z, Zhang N, Al-Hendy A, Mamillapalli R, Kallen AN, Kodaman P, Taylor HS, Li D, Huang Y
Oncogene 2019 Jul;38(27):5356-5366

Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women.

Jiang Y, Zhu C, He D, Gao Q, Tian X, Ma X, Wu J, Das BC, Severinov K, Hitzeroth II, Debata PR, Liu R, Zou L, Shi L, Xu H, Wang K, Bao Y, Ka-Kit LR, You Z, Cui Z, Hu Z
Translational oncology 2019 Jul;12(7):959-967

The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.

Li M, Zhao H, Zhao SG, Wei DM, Zhao YR, Huang T, Muhammad T, Yan L, Gao F, Li L, Lu G, Chan WY, Leung PCK, Dunaif A, Liu HB, Chen ZJ
The Journal of clinical endocrinology and metabolism 2019 Apr 1;104(4):1049-1059

Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells.

Xia C, Liang S, He Z, Zhu X, Chen R, Chen J
European journal of pharmacology 2018 Jul 5;830:59-67

Tumor suppressive role of miR-569 in lung cancer.

Zheng YP, Wu L, Gao J, Wang Y
Oncology letters 2018 Apr;15(4):4087-4092

TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.

Zhuang J, Shen L, Yang L, Huang X, Lu Q, Cui Y, Zheng X, Zhao X, Zhang D, Huang R, Guo H, Yan J
Theranostics 2017;7(12):3053-3067

Lin28B facilitates the progression and metastasis of pancreatic ductal adenocarcinoma.

Wang Y, Li J, Guo S, Ouyang Y, Yin L, Liu S, Zhao Z, Yang J, Huang W, Qin H, Zhao X, Ni B, Wang H
Oncotarget 2017 Sep 1;8(36):60414-60428

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids.

Nikolić MZ, Caritg O, Jeng Q, Johnson JA, Sun D, Howell KJ, Brady JL, Laresgoiti U, Allen G, Butler R, Zilbauer M, Giangreco A, Rawlins EL
eLife 2017 Jun 30;6

XIAP 3'-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma.

Wu WY, Tao SQ, Wang XN, Lobie PE, Wu ZS
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317719578

Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML.

Tan L, Wei X, Zheng L, Zeng J, Liu H, Yang S, Tan H
Journal of cancer research and clinical oncology 2016 Feb;142(2):389-99

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 20795-1-AP( HMGA2 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The HMGA2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human HMGA2. This antibody recognizes human, mouse antigen. The HMGA2 antibody has been validated for the following applications: ELISA, WB, IF analysis.
Appendix: 20795-1-AP.pdf

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