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- Antibody Data
- Antigen structure
- References [26]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 21090-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21090-1-AP, RRID:AB_10734583
- Product name
- CHCHD4 antibody
- Antibody type
- Polyclonal
- Description
- CHCHD4 antibody (Cat. #21090-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway.
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression.
Autoregulatory control of mitochondrial glutathione homeostasis.
NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space.
Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension.
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation.
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway.
Flow-induced endothelial mitochondrial remodeling mitigates mitochondrial reactive oxygen species production and promotes mitochondrial DNA integrity in a p53-dependent manner.
Moschamindole induces glioma cell apoptosis by blocking Mia40-dependent mitochondrial intermembrane space assembly and oxidative respiration.
Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus.
Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8.
Dependence of PINK1 accumulation on mitochondrial redox system.
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway.
A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.
A disease-associated Aifm1 variant induces severe myopathy in knockin mice.
CHTM1, a novel metabolic marker deregulated in human malignancies.
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
The Level of ALR is Regulated by the Quantity of Mitochondrial DNA.
Loss of apoptosis-inducing factor critically affects MIA40 function.
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.
Bi PY, Killackey SA, Schweizer L, Arnoult D, Philpott DJ, Girardin SE
Communications biology 2024 Mar 30;7(1):391
Communications biology 2024 Mar 30;7(1):391
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
Huang D, Chen L, Ji Q, Xiang Y, Zhou Q, Chen K, Zhang X, Zou F, Zhang X, Zhao Z, Wang T, Zheng G, Meng X
Redox biology 2024 Feb;69:102990
Redox biology 2024 Feb;69:102990
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression.
Kramer NJ, Prakash G, Isaac RS, Choquet K, Soto I, Petrova B, Merens HE, Kanarek N, Churchman LS
Nature cell biology 2023 Nov;25(11):1575-1589
Nature cell biology 2023 Nov;25(11):1575-1589
Autoregulatory control of mitochondrial glutathione homeostasis.
Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, Molina H, Allwein B, Kenny TC, Possemato RL, Zhao L, Hite RK, Vinogradova EV, Mansy SS, Birsoy K
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.
Pandey J, Larson-Casey JL, Patil MH, Joshi R, Jiang CS, Zhou Y, He C, Carter AB
The Journal of biological chemistry 2023 May;299(5):104695
The Journal of biological chemistry 2023 May;299(5):104695
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space.
Adriaenssens E, Asselbergh B, Rivera-Mejías P, Bervoets S, Vendredy L, De Winter V, Spaas K, de Rycke R, van Isterdael G, Impens F, Langer T, Timmerman V
Nature cell biology 2023 Mar;25(3):467-480
Nature cell biology 2023 Mar;25(3):467-480
Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension.
Wang Y, Zeng Z, Zeng Z, Chu G, Shan X
Journal of translational medicine 2023 Jul 12;21(1):464
Journal of translational medicine 2023 Jul 12;21(1):464
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
Mao J, Wang D, Wang D, Wu Q, Shang Q, Gao C, Wang H, Wang H, Du M, Peng P, Jia H, Xu X, Wang J, Yang L, Luo Z
Experimental & molecular medicine 2023 Jan;55(1):253-268
Experimental & molecular medicine 2023 Jan;55(1):253-268
Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation.
Nedara K, Reinhardt C, Lebraud E, Arena G, Gracia C, Buard V, Pioche-Durieu C, Castelli F, Colsch B, Bénit P, Rustin P, Albaud B, Gestraud P, Baulande S, Servant N, Deutsch E, Verbavatz JM, Brenner C, Milliat F, Modjtahedi N
Frontiers in oncology 2022;12:958155
Frontiers in oncology 2022;12:958155
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
Aaltonen MJ, Alecu I, König T, Bennett SA, Shoubridge EA
Life science alliance 2022 Feb;5(2)
Life science alliance 2022 Feb;5(2)
USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway.
Zhou Y, Zhao Y, Ma W, Zhang L, Jiang Y, Dong W
Discover oncology 2022 Dec 8;13(1):136
Discover oncology 2022 Dec 8;13(1):136
Flow-induced endothelial mitochondrial remodeling mitigates mitochondrial reactive oxygen species production and promotes mitochondrial DNA integrity in a p53-dependent manner.
Shin J, Hong SG, Choi SY, Rath ME, Saredy J, Jovin DG, Sayoc J, Park HS, Eguchi S, Rizzo V, Scalia R, Wang H, Houser SR, Park JY
Redox biology 2022 Apr;50:102252
Redox biology 2022 Apr;50:102252
Moschamindole induces glioma cell apoptosis by blocking Mia40-dependent mitochondrial intermembrane space assembly and oxidative respiration.
Huang GD, Chen FF, Yang JH, Ma GX, Liao ZJ, Li WP, Li ZY, Chen L
Phytotherapy research : PTR 2021 Jun;35(6):3390-3405
Phytotherapy research : PTR 2021 Jun;35(6):3390-3405
Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus.
Goyal S, Tiwari S, Seth B, Tandon A, Shankar J, Sinha M, Singh SJ, Priya S, Chaturvedi RK
Neurotoxicology 2021 Jul;85:18-32
Neurotoxicology 2021 Jul;85:18-32
Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8.
Chang HC, Shapiro JS, Jiang X, Senyei G, Sato T, Geier J, Sawicki KT, Ardehali H
eLife 2021 Apr 9;10
eLife 2021 Apr 9;10
Dependence of PINK1 accumulation on mitochondrial redox system.
Gao F, Zhang Y, Hou X, Tao Z, Ren H, Wang G
Aging cell 2020 Sep;19(9):e13211
Aging cell 2020 Sep;19(9):e13211
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Singh RP, Jeyaraju DV, Voisin V, Hurren R, Xu C, Hawley JR, Barghout SH, Khan DH, Gronda M, Wang X, Jitkova Y, Sharon D, Liyanagae S, MacLean N, Seneviratene AK, Mirali S, Borenstein A, Thomas GE, Soriano J, Orouji E, Minden MD, Arruda A, Chan SM, Bader GD, Lupien M, Schimmer AD
Cell stem cell 2020 Jun 4;26(6):926-937.e10
Cell stem cell 2020 Jun 4;26(6):926-937.e10
CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway.
Babbar M, Huang Y, Curtiss CM, Sheikh MS
Journal of experimental & clinical cancer research : CR 2019 Jun 20;38(1):271
Journal of experimental & clinical cancer research : CR 2019 Jun 20;38(1):271
A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.
Lehmer C, Schludi MH, Ransom L, Greiling J, Junghänel M, Exner N, Riemenschneider H, van der Zee J, Van Broeckhoven C, Weydt P, Heneka MT, Edbauer D
EMBO molecular medicine 2018 Jun;10(6)
EMBO molecular medicine 2018 Jun;10(6)
A disease-associated Aifm1 variant induces severe myopathy in knockin mice.
Wischhof L, Gioran A, Sonntag-Bensch D, Piazzesi A, Stork M, Nicotera P, Bano D
Molecular metabolism 2018 Jul;13:10-23
Molecular metabolism 2018 Jul;13:10-23
CHTM1, a novel metabolic marker deregulated in human malignancies.
Babbar M, Huang Y, An J, Landas SK, Sheikh MS
Oncogene 2018 Apr;37(15):2052-2066
Oncogene 2018 Apr;37(15):2052-2066
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.
Télot L, Rousseau E, Lesuisse E, Garcia C, Morlet B, Léger T, Camadro JM, Serre V
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):997-1009
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):997-1009
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Song G, Napoli E, Wong S, Hagerman R, Liu S, Tassone F, Giulivi C
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
The Level of ALR is Regulated by the Quantity of Mitochondrial DNA.
Balogh T, Lőrincz T, Stiller I, Mandl J, Bánhegyi G, Szarka A
Pathology oncology research : POR 2016 Apr;22(2):431-7
Pathology oncology research : POR 2016 Apr;22(2):431-7
Loss of apoptosis-inducing factor critically affects MIA40 function.
Meyer K, Buettner S, Ghezzi D, Zeviani M, Bano D, Nicotera P
Cell death & disease 2015 Jul 9;6(7):e1814
Cell death & disease 2015 Jul 9;6(7):e1814
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.
Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman LI
Mitochondrion 2015 Jan;20:43-51
Mitochondrion 2015 Jan;20:43-51
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- L02 cells were subjected to SDS PAGE followed by western blot with 21090-1-AP(CHCHD4 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CHCHD4 antibody 21090-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 21090-1-AP(CHCHD4 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 21090-1-AP(CHCHD4 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
