21207-1-AP

antibody from Proteintech Group

Targeting: TET2 FLJ20032, KIAA1546

Provider product page for 21207-1-AP

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Immunohistochemistry

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Antibody Data
Antigen structure
References [89]
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Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 21207-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21207-1-AP, RRID:AB_10734584
Product name: TET2 antibody
Antibody type: Polyclonal
Description: KD/KO validated TET2 antibody (Cat. #21207-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TET2 protein structure - 21207-1-AP shown in red.

Submitted references Targeting CPS1 attenuates lung cancer metastasis by regulating EMT through an epigenetic mechanism.

Ding Y, Tian Y, Li M, Fu Y, Wang T, Du X, Wang M, Dong L, Gao F, Liu B, Lu Y, Zhang C, Mao L, Jiang J, Li L, Liao L, Li K
Theranostics 2026;16(4):1740-1761

Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pathogenesis of polycystic ovary syndrome.

Liu K, Hong Y, Gao Q, Huang J, Liu L, Li Y, Liang Y, Zhang S, He X, Nie X
Cellular and molecular life sciences : CMLS 2026 Mar 11;83(1)

LncRNA FENDRR Inhibits Mitochondrial Apoptosis via TET2-Mediated DNA Demethylation of MFN1 in NSCPO.

Wu C, Liu H, Shan Z, Xia Y, Zhao P, Zhang Z, Yueguang G, Ma J
Oral diseases 2026 Jan;32(1):183-200

Loss of ten-eleven translocation 2 (TET2) facilitates aggressive behaviour in cutaneous melanoma by inducing peroxisome proliferator-activated receptor-γ coactivator 1α expression and oxidative phosphorylation.

Fischer GM, Fang R, Xu S, Karkempetzaki AI, Migayron L, Draper E, Wang J, Schatton T, Mandinova A, Murphy GF, Lian CG
The British journal of dermatology 2026 Jan 6;194(1):111-124

TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway.

Xia L, Wang Z, Chen X
Journal of inflammation research 2025;18:8719-8733

Histone lactylation-derived TET2 enhanced Arg1-mediated MDSC immunosuppression.

Da W, Dai Y, Shen B, Zhang Y, Bao P, Zhu W, Wang D, Wang S, Ma J
Frontiers in immunology 2025;16:1677780

Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model.

Chu Y, Shen H, Li Q, Shen B, Zhang Y, Wang D, Zhu W, Wang S, Ma J
Frontiers in cell and developmental biology 2025;13:1565993

Deletion of EP3 prostaglandin receptor in murine macrophages aggravates diet-induced obesity by suppressing SPARC.

Shang W, Li Y, Wang L, Liu J, Ren H, Liu Q, Guo S, Wang Y, Ma Y, You T, Shen Y, Zhou Y, Tian D, Yu Y
The EMBO journal 2025 Sep;44(18):4962-4983

Oxytocin Enhances Demethylation Through TET Enzyme Expression in Neurons of Aged Mice: Oxytocin as a Potential Antiaging Peptide.

Maejima Y, Yokota S, Yamachi M, Hidema S, Ono T, Taira S, Nishimori K, de Wet H, Shimomura K
Aging cell 2025 Oct;24(10):e70198

IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1.

Chai L, Li C, Wang X, Qin Y, Sun H, Du J, Yang L, Hu D, Xiong J, Zhao Z, Gong R, Wu T, Wu M, Nie M, Gao J, Jia J, Gao C, Zhao W, Zhou H, Kang D, Jia M
Cell reports 2025 Oct 28;44(10):116336

PRAME Expression in Melanoma is Negatively Regulated by TET2-Mediated DNA Hydroxymethylation.

Fang R, Vallius T, Zhang A, Van Cura D, Alicandri F, Fischer G, Draper E, Xu S, Pelletier R, Wang J, Mandinova A, Katsyv I, Sorger PK, Murphy GF, Lian CG
Laboratory investigation; a journal of technical methods and pathology 2025 May;105(5):104123

Effects of polystyrene microparticles exposures on spermatogenic cell differentiation and reproductive endpoints in male mice.

Shen R, Xia P, Guo Y, Ji P, Yuan X, Wang L, Shuang S, Zhou L, Tong R, Zhang L, Liu D, Wang D
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126200

Trained immunity driven by Enterococcus faecalis ribosomal protein S11 enhances antigen presentation and boosts influenza vaccine efficacy via nanoparticle delivery.

Zhang JG, Zhou CK, Gao Y, Zhang XM, Ma K, Peng ZR, Luo XY, Liu ZZ, Lin XQ, Chen W, Yang YJ
International journal of biological macromolecules 2025 Jun;315(Pt 1):144179

Maternal exercise prevents metabolic disorders in offspring mice through SERPINA3C.

Li Y, Li RY, Zhu JY, Chen M, Mu WJ, Luo HY, Li S, Yan LJ, Yin MT, Li X, Chen HM, Guo L
Nature metabolism 2025 Feb;7(2):401-420

Trimethylamine N-oxide induces pyroptosis in HTR8-S/Vneo cells through the ten-eleven translocation 2-cytochrome b-reactive oxygen species pathway.

Liang L, Rao Y, Wang J, Zhao J, He L, Meng J, Wu P, Wang Z
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16237

Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells.

Chatterjee B, Majumder P, Chen CC, Wang JP, Su PH, Lai HC, Liu CC, Lin HN, Yu CA, Yuan HS, Shen CJ
Cellular & molecular biology letters 2025 Aug 5;30(1):95

Vitamin C-Dependent Intergenerational Inheritance of Enhanced Endurance Performance Following Maternal Exercise.

Shi H, Li J, Li F, Yu H, Zhang F, Wu T, Yang L, Li Y, Hu R, Chen M, Sg N, Zhuang X, Feng S, Zhu L, Duan R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2408912

Endogenous IL-22 contributes to the pathogenesis of salivary gland dysfunction in the non-obese diabetic model of Sjögren's syndrome.

Felix FA, Zhou J, Li D, Onodera S, Yu Q
Molecular immunology 2024 Sep;173:20-29

HSP90β shapes the fate of Th17 cells with the help of glycolysis-controlled methylation modification.

Yang L, Zhu JC, Li SJ, Zeng X, Xue XR, Dai Y, Wei ZF
British journal of pharmacology 2024 Oct;181(20):3886-3907

CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.

Waarts MR, Mowla S, Boileau M, Martinez Benitez AR, Sango J, Bagish M, Fernández-Maestre I, Shan Y, Eisman SE, Park YC, Wereski M, Csete I, O'Connor K, Romero-Vega AC, Miles LA, Xiao W, Wu X, Koche RP, Armstrong SA, Shih AH, Papapetrou EP, Butler JM, Cai SF, Bowman RL, Levine RL
Cancer discovery 2024 Oct 4;14(10):1860-1878

5-Hydroxymethylcytosine in circulating cell-free DNA as a potential diagnostic biomarker for SLE.

Tong X, Chen W, Ye L, Xiong Y, Xu Y, Luo Y, Xia X, Xu Z, Lin Y, Zhu X, Wang N, Xue X, Zhang H, Guo G
Lupus science & medicine 2024 Oct 4;11(2)

TET3-overexpressing macrophages promote endometriosis.

Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael GG, Li D, Taylor HS, Huang Y
The Journal of clinical investigation 2024 Nov 1;134(21)

Decreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions.

Zhang H, Jia T, Che D, Peng B, Chu Z, Song X, Zeng W, Geng S
Journal of dermatological science 2024 Mar;113(3):103-112

PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation.

Fang R, Vallius T, Zhang A, Van Cura D, Alicandri F, Fischer G, Draper E, Xu S, Pelletier R, Katsyv I, Sorger PK, Murphy GF, Lian CG
bioRxiv : the preprint server for biology 2024 Jul 26;

DNA demethylase TET2-mediated reduction of HADHB expression contributes to cadmium-induced malignant progression of colorectal cancer.

Li L, Jiang M, Wang W, Cao X, Ma Q, Han J, Liu Z, Huang Y, Chen Y
Ecotoxicology and environmental safety 2024 Jul 15;280:116579

Downregulation of TET2 Contributes to Nasal Polypogenesis Through Hypoxia-Inducible Factor 1α-Mediated Epithelial-to-Mesenchymal Transition.

Liu K, Xu Y
Clinical and experimental otorhinolaryngology 2024 Feb;17(1):64-77

Exploring the importance of m5c in the diagnosis and subtype classification of COPD using the GEO database.

Wu J, Li X, Kong D, Zheng X, Du W, Zhang Y, Jiao Y, Li X
Gene 2024 Feb 15;895:147987

Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.

Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett AM, Diano S, Huang Y
Diabetologia 2024 Apr;67(4):724-737

A negative feedback loop between TET2 and leptin in adipocyte regulates body weight.

Zeng Q, Song J, Sun X, Wang D, Liao X, Ding Y, Hu W, Jiao Y, Mai W, Aini W, Wang F, Zhou H, Xie L, Mei Y, Tang Y, Xie Z, Wu H, Liu W, Deng T
Nature communications 2024 Apr 1;15(1):2825

Differential expression of epigenetic modifiers in early and late cardiotoxic heart failure reveals DNA methylation as a key regulator of cardiotoxicity.

Robinson EL, Ameri P, Delrue L, Vanderheyden M, Bartunek J, Altieri P, Heymans S, Heggermont WA
Frontiers in cardiovascular medicine 2023;10:884174

LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.

Chen D, Wang J, Li Y, Xu C, Fanzheng M, Zhang P, Liu L
Clinical and translational medicine 2023 Sep;13(9):e1418

DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell.

Zeng Z, Li T, Liu X, Ma Y, Luo L, Wang Z, Zhao Z, Li H, He X, Zeng H, Tao Y, Chen Y
Redox biology 2023 Nov;67:102916

TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice.

Gao Z, Lv H, Wang Y, Xie Y, Guan M, Xu Y
Molecular medicine (Cambridge, Mass.) 2023 Nov 27;29(1):160

Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication.

Hu Y, Chen X, Ling Y, Zhou K, Han M, Wang X, Yue M, Li Y
PLoS pathogens 2023 Jul;19(7):e1011550

The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy.

Zhao L, Xu H, Liu X, Cheng Y, Xie J
Journal of translational medicine 2023 Jul 10;21(1):455

Enhanced BPGM/2,3-DPG pathway activity suppresses glycolysis in hypoxic astrocytes via FIH-1 and TET2.

E G, Sun B, Liu B, Xu G, He S, Wang Y, Feng L, Wei H, Zhang J, Chen J, Gao Y, Zhang E
Brain research bulletin 2023 Jan;192:36-46

m(5)C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization.

Wang N, Chen RX, Deng MH, Wei WS, Zhou ZH, Ning K, Li YH, Li XD, Ye YL, Wen JH, Dong B, Zhang XP, Liu ZW, Zhou FJ
Cell death & disease 2023 Feb 18;14(2):139

Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage.

Lv H, Gao Z, Wang Y, Chen S, Liu P, Xie Y, Guan M, Cong J, Xu Y
Neurochemical research 2023 Dec;48(12):3639-3651

Mutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells.

Gao J, Wang H, Shen J, Liu X, Zhu X, Huang C, Li G, Sun Y, Liu Z, Sun YE, Liu H
Journal of cellular physiology 2023 Dec;238(12):2827-2840

m6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia.

Wu Z, Zuo X, Zhang W, Li Y, Gui R, Leng J, Shen H, Pan B, Fan L, Li J, Jin H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2304895

TET2 confers a mechanistic link of microRNA-210 and mtROS in hypoxia-suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep.

Hu XQ, Song R, Dasgupta C, Blood AB, Zhang L
The Journal of physiology 2023 Apr;601(8):1501-1514

A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model.

Lv H, Catarino J, Li D, Liu B, Gao XB, Horvath TL, Huang Y
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 18;120(16):e2300015120

m(6)A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement.

Qu W, Li Q, Wang M, Zhao X, Wu J, Liu D, Hong S, Yang Y, Shu Q, Li X
Frontiers in cell and developmental biology 2022;10:903179

RNA 5-Methylcytosine Regulators Contribute to Metabolism Heterogeneity and Predict Prognosis in Ovarian Cancer.

Xu J, Liu X, Chen Y, Wang Y, Liu T, Yi P
Frontiers in cell and developmental biology 2022;10:807786

ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells.

Wang L, Mao B, Fan K, Sun R, Zhang J, Liang H, Liu Y
Fluids and barriers of the CNS 2022 Sep 8;19(1):73

TET2 Regulates 5-Hydroxymethylcytosine Signature and CD4(+) T-Cell Balance in Allergic Rhinitis.

Tan L, Fu L, Zheng L, Fan W, Tan H, Tao Z, Xu Y
Allergy, asthma & immunology research 2022 Mar;14(2):254-272

Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing.

Yi Y, Wu M, Zhou X, Xiong M, Tan Y, Yu H, Liu Z, Wu Y, Zhang Q
Stem cell research & therapy 2022 Mar 21;13(1):119

HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.

Liu D, Sun H, Li K, Zhao Z, Liu Z, Zhang G, Ge Y, Zhang J, Wang D, Leng Y
Biochemical and biophysical research communications 2022 Aug 27;618:15-23

Ascorbic acid induces salivary gland function through TET2/acetylcholine receptor signaling in aging SAMP1/Klotho (-/-) mice.

Toan NK, Kim SA, Ahn SG
Aging 2022 Aug 11;14(15):6028-6046

TET2 regulates immune tolerance in chronically activated mast cells.

Rigo R, Chelbi R, Agopian J, Letard S, Griffon A, Ghamlouch H, Vernerey J, Ladopoulos V, Voisset E, De Sepulveda P, Guittard G, Nunès JA, Bidaut G, Göttgens B, Weber M, Bernard OA, Dubreuil P, Soucie E
JCI insight 2022 Apr 8;7(7)

Epigenetic Landscape of HIV-1 Infection in Primary Human Macrophage.

Lu F, Zankharia U, Vladimirova O, Yi Y, Collman RG, Lieberman PM
Journal of virology 2022 Apr 13;96(7):e0016222

MgFe-LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self-Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells.

He X, Zhu Y, Yang L, Wang Z, Wang Z, Feng J, Wen X, Cheng L, Zhu R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(9):2003535

Loss of ten-eleven translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway.

Tao H, Xu W, Qu W, Gao H, Zhang J, Cheng X, Liu N, Chen J, Xu GL, Li X, Shu Q
Human molecular genetics 2021 May 29;30(10):865-879

DNA demethylase Tet2 suppresses cisplatin-induced acute kidney injury.

Bao Y, Bai M, Zhu H, Yuan Y, Wang Y, Zhang Y, Wang J, Xie X, Yao X, Mao J, Fu X, Chen J, Yang Y, Lin W
Cell death discovery 2021 Jun 17;7(1):167

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons.

Traube FR, Özdemir D, Sahin H, Scheel C, Glück AF, Geserich AS, Oganesian S, Kostidis S, Iwan K, Rahimoff R, Giorgio G, Müller M, Spada F, Biel M, Cox J, Giera M, Michalakis S, Carell T
Nature communications 2021 Jul 2;12(1):4100

The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins.

Huang Z, Yu J, Cui W, Johnson BK, Kim K, Pfeifer GP
Science advances 2021 Jan;7(4)

Inhibition of NF-κB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.

Lu X, Li Y, Yang W, Tao M, Dai Y, Xu J, Xu Q
Journal of biochemical and molecular toxicology 2021 Jan;35(1):e22621

Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway.

Chen J, Zhang J, Wu J, Zhang S, Liang Y, Zhou B, Wu P, Wei D
Free radical biology & medicine 2021 Jan;162:582-591

Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice.

Kawakubo-Yasukochi T, Yano E, Kimura S, Nishinakagawa T, Mizokami A, Hayashi Y, Hatakeyama Y, Ohe K, Yasukochi A, Nakamura S, Jimi E, Hirata M
Molecular metabolism 2021 Dec;54:101360

Experimental eye research / short communication format characterization of DNA hydroxymethylation in the ocular choroid.

Pomerleau J, Weidmann C, Coutant K, Lowry CM, Veilleux MP, Bérubé J, Wagner JR, Landreville S
Experimental eye research 2021 Apr;205:108473

Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro.

Li T, Fang T, Xu L, Liu X, Li X, Xue M, Yu X, Sun B, Chen L
Frontiers in pharmacology 2020;11:622153

Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.

Sivalingam K, Samikkannu T
Brain sciences 2020 Sep 5;10(9)

Proteases Activate Pregnancy Neutrophils by a Protease-Activated Receptor 1 Pathway: Epigenetic Implications for Preeclampsia.

Walsh SW, Nugent WH, Al Dulaimi M, Washington SL, Dacha P, Strauss JF 3rd
Reproductive sciences (Thousand Oaks, Calif.) 2020 Nov;27(11):2115-2127

Restoration of TET2 deficiency inhibits tumor growth in head neck squamous cell carcinoma.

Huang R, Wang Y, Ge H, Wang D, Wang Y, Zhang W, Yang J, Cheng J
Annals of translational medicine 2020 Mar;8(6):329

Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice.

Buck JM, O'Neill HC, Stitzel JA
Epigenetics & chromatin 2020 Mar 5;13(1):13

TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.

Morin A, Goncalves J, Moog S, Castro-Vega LJ, Job S, Buffet A, Fontenille MJ, Woszczyk J, Gimenez-Roqueplo AP, Letouzé E, Favier J
Cell reports 2020 Mar 31;30(13):4551-4566.e7

Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2×Tg-AD mice.

Li L, Qiu Y, Miao M, Liu Z, Li W, Zhu Y, Wang Q
Human molecular genetics 2020 Jul 21;29(11):1833-1852

Protease Amplification of the Inflammatory Response Induced by Commensal Bacteria: Implications for Racial Disparity in Term and Preterm Birth.

Walsh SW, Nugent WH, Alam SMK, Washington SL, Teves M, Jefferson KK, Strauss JF 3rd
Reproductive sciences (Thousand Oaks, Calif.) 2020 Jan;27(1):246-259

Demethylation of HACE1 gene promoter by propofol promotes autophagy of human A549 cells.

Li S, Yang H, Zhao M, Gong L, Wang Y, Lv Z, Quan Y, Wang Z
Oncology letters 2020 Dec;20(6):280

Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation.

Hahn MA, Jin SG, Li AX, Liu J, Huang Z, Wu X, Kim BW, Johnson J, Bilbao AV, Tao S, Yim JA, Fong Y, Goebbels S, Schwab MH, Lu Q, Pfeifer GP
Science advances 2019 Oct;5(10):eaax0080

Aanat Knockdown and Melatonin Supplementation in Embryo Development: Involvement of Mitochondrial Function and DNA Methylation.

Yang M, Tao J, Wu H, Guan S, Liu L, Zhang L, Deng S, He C, Ji P, Liu J, Liu G
Antioxidants & redox signaling 2019 Jun 20;30(18):2050-2065

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.

Sun X, Cui Y, Feng H, Liu H, Liu X
The Journal of experimental medicine 2019 Dec 2;216(12):2819-2837

m(6)A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.

Chen J, Zhang YC, Huang C, Shen H, Sun B, Cheng X, Zhang YJ, Yang YG, Shu Q, Yang Y, Li X
Genomics, proteomics & bioinformatics 2019 Apr;17(2):154-168

Pregnancy-Induced Physiologic Adaptation of the Abdominal Aorta Is Associated with Changes in Gene Expression and Genomic Methylation.

Gelinne A, Brown L, Ko NL, Osol G, Brown S
Journal of vascular research 2018;55(5):319-327

Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation.

Zhong W, Li B, Xu Y, Yang P, Chen R, Wang Z, Shao C, Song J, Yan J
JACC. Basic to translational science 2018 Oct;3(5):604-624

Ten-eleven translocation 2 demethylates the MMP9 promoter, and its down-regulation in preeclampsia impairs trophoblast migration and invasion.

Li X, Wu C, Shen Y, Wang K, Tang L, Zhou M, Yang M, Pan T, Liu X, Xu W
The Journal of biological chemistry 2018 Jun 29;293(26):10059-10070

Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.

Barazeghi E, Prabhawa S, Norlén O, Hellman P, Stålberg P, Westin G
BMC cancer 2018 Jul 25;18(1):764

The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.

Zhang J, Cao H, Xie J, Fan C, Xie Y, He X, Liao M, Zhang S, Wang H
Cell death & disease 2018 Feb 14;9(2):224

TET2 facilitates PPARγ agonist-mediated gene regulation and insulin sensitization in adipocytes.

Bian F, Ma X, Villivalam SD, You D, Choy LR, Paladugu A, Fung S, Kang S
Metabolism: clinical and experimental 2018 Dec;89:39-47

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H(2)S System.

Peng J, Tang ZH, Ren Z, He B, Zeng Y, Liu LS, Wang Z, Wei DH, Zheng XL, Jiang ZS
Frontiers in pharmacology 2017;8:486

Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.

Wang X, Wang Z, Wang Q, Wang H, Liang H, Liu D
Research in veterinary science 2017 Oct;114:363-369

Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.

Lu F, Wiedmer A, Martin KA, Wickramasinghe PJMS, Kossenkov AV, Lieberman PM
Journal of virology 2017 Oct 15;91(20)

Restricted TET2 Expression in Germinal Center Type B Cells Promotes Stringent Epstein-Barr Virus Latency.

Wille CK, Li Y, Rui L, Johannsen EC, Kenney SC
Journal of virology 2017 Mar 1;91(5)

A role for TET2 in parathyroid carcinoma.

Barazeghi E, Gill AJ, Sidhu S, Norlén O, Dina R, Palazzo FF, Hellman P, Stålberg P, Westin G
Endocrine-related cancer 2017 Jul;24(7):329-338

Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells.

Gao J, Ma Y, Fu HL, Luo Q, Wang Z, Xiao YH, Yang H, Cui DX, Jin WL
Protein & cell 2016 May;7(5):351-61

A Novel Function of TET2 in CNS: Sustaining Neuronal Survival.

Mi Y, Gao X, Dai J, Ma Y, Xu L, Jin W
International journal of molecular sciences 2015 Sep 10;16(9):21846-57

Oxidized low-density lipoprotein inhibits THP-1-derived macrophage autophagy via TET2 down-regulation.

Li G, Peng J, Liu Y, Li X, Yang Q, Li Y, Tang Z, Wang Z, Jiang Z, Wei D
Lipids 2015 Feb;50(2):177-83

Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.

Zhao X, Dai J, Ma Y, Mi Y, Cui D, Ju G, Macklin WB, Jin W
Glia 2014 Jun;62(6):914-26

TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.

Fu HL, Ma Y, Lu LG, Hou P, Li BJ, Jin WL, Cui DX
Journal of biomedical nanotechnology 2014 Jul;10(7):1217-30

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 21207-1-AP(TET2 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TET2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TET2. This antibody recognizes human, mouse antigen. The TET2 antibody has been validated for the following applications: ELISA, WB, IP analysis.
Appendix: 21207-1-AP.pdf

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