Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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Validation data
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- Product number
- ALX-804-867FI-0100 - Provider product page
- Provider
- Enzo Life Sciences
- Product name
- LRRC32 monoclonal antibody (Plato-1) (FITC conjugate)
- Antibody type
- Monoclonal
- Antigen
- Recombinant protein fragment
- Description
- Protein G-affinity purified.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- Plato-1
- Vial size
- 100 μg
- Storage
- +4°C
- Handling
- Keep conjugated formats at +4¡C. Do not freeze. Protect from light.
Submitted references Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency.
Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy.
Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).
Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells.
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.
Miller MM, Fogle JE, Ross P, Tompkins MB
AIDS research and human retroviruses 2013 Apr;29(4):641-51
AIDS research and human retroviruses 2013 Apr;29(4):641-51
Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy.
Presicce P, Orsborn K, King E, Pratt J, Fichtenbaum CJ, Chougnet CA
PloS one 2011;6(12):e28118
PloS one 2011;6(12):e28118
Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).
Chan DV, Somani AK, Young AB, Massari JV, Ohtola J, Sugiyama H, Garaczi E, Babineau D, Cooper KD, McCormick TS
BMC biochemistry 2011 May 26;12:27
BMC biochemistry 2011 May 26;12:27
Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells.
Tran DQ, Shevach EM
Human immunology 2009 May;70(5):294-9
Human immunology 2009 May;70(5):294-9
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 11;106(32):13445-50
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 11;106(32):13445-50
Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.
Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 11;106(32):13439-44
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 11;106(32):13439-44
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Supportive validation
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Flow cytometry analysis, intracellular staining, of 10E6 Jurkat cells using LRRC32, mAb (Plato-1) (FITC conjugate) at a concentration of 50_g/ml.