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Western blotAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- RA0724 - Provider product page
- Provider
- Oursmab
- Product name
- Livmoniplimab (Biosimilar Reference Antibody) (TGFB1 and LRRC32)
- Antibody type
- Monoclonal
- Description
- Livmoniplimab is a humanized monoclonal antibody that targets a complex involving Leucine-rich repeat-containing protein 32 (LRRC32, also known as GARP) and latent transforming growth factor-beta 1 (TGF¦Â1). It specifically binds to the LRRC32-latent TGF¦Â1 complex on the surface of regulatory T cells (Tregs) and platelets, thereby blocking the LRRC32-mediated activation and release of mature TGF¦Â1. By inhibiting this localized, cell-surface activation of TGF¦Â1, livmoniplimab aims to selectively dampen the immunosuppressive tumor microenvironment without causing systemic TGF¦Â blockade. It is being investigated as an immuno-oncology agent for the treatment of advanced solid tumors, often in combination with other immunotherapies.
- Reactivity
- Human
- Isotype
- IgG
- Vial size
- 100 ¦Ìg,1 mg,5 mg-500,10 mg,25 mg,50 mg,221 mg
- Concentration
- Bottled at the concentration indicated on the vial.
- Storage
- Store at -20¡ãC or -91¡ãC. Avoid repeated freeze.
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Supportive validation
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- Oursmab (provider)
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- Experimental details
- Livmoniplimab (Biosimilar Reference Antibody) (TGFB1 and LRRC32)-RA0724-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
