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- Antigen structure
- References [15]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 16331-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16331-1-AP, RRID:AB_2191406
- Product name
- OCTN2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OCTN2 antibody (Cat. #16331-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dissection of immunotherapeutic predictive versus prognostic transcriptional programs identifies SLC22A5-centric carnitine metabolism-driven resistance to anti-PD-(L)1 treatment in non-small cell lung cancer.
Levocarnitine improves cardiac energy metabolic remodeling in myocarditis mice.
Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD-MASH Transition by Disrupting Carnitine Biosynthesis.
Aging-associated intestinal dysfunction impairs 5-heptadecylresorcinol absorption: Mechanistic insights into transporter-mediated uptake, barrier integrity and inflammatory regulation.
Involvement of impaired carnitine-induced fatty acid oxidation in experimental and human diabetic kidney disease.
Targeting long-chain acylcarnitine accumulation to protect cardiac mitochondrial homeostasis after complete revascularization.
The propensity of fructose to induce metabolic dysfunction is dependent on the baseline diet, length of the dietary exposure, and sex of the mice.
L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy.
The Enhancement of Acylcarnitine Metabolism by 5-Heptadecylresorcinol in Brown Adipose Tissue Contributes to Improving Glucose and Lipid Levels in Aging Male Mice.
Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation.
Ferulic acid supplementation alleviates hyperuricemia in high-fructose/fat diet-fed rats via promoting uric acid excretion and mediating the gut microbiota.
Lenvatinib causes reduced expression of carnitine/organic cation transporter 2 and carnitine deficiency in the skeletal muscle of rats.
The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion.
Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy.
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.
Wang YZ, Gao N, Lin Z, Wang SH, Ai S, Wei Z, Zhang S, Cai J, Yang W, Ma SC, Cheng C
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Jan;84:101313
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Jan;84:101313
Levocarnitine improves cardiac energy metabolic remodeling in myocarditis mice.
Yang S, Li X, Lu Z, Xu X, Guo Z, He B
Frontiers in pharmacology 2025;16:1706936
Frontiers in pharmacology 2025;16:1706936
Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD-MASH Transition by Disrupting Carnitine Biosynthesis.
Lian S, Lu M, Jiajing L, Zhang B, Fang Y, Wang X, Zheng M, Ni Y, Xu G, Yang Y, Jiang R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2410602
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2410602
Aging-associated intestinal dysfunction impairs 5-heptadecylresorcinol absorption: Mechanistic insights into transporter-mediated uptake, barrier integrity and inflammatory regulation.
Zhang K, Zhang H, Sun Y, Zhou P, Xue L, Wang Y, Fan M, Qian H, Li Y, Wang L
Food research international (Ottawa, Ont.) 2025 Jun;211:116499
Food research international (Ottawa, Ont.) 2025 Jun;211:116499
Involvement of impaired carnitine-induced fatty acid oxidation in experimental and human diabetic kidney disease.
Ito S, Taguchi K, Kodama G, Kubo S, Moriyama T, Yamashita Y, Yokota Y, Nakayama Y, Kaida Y, Shinohara M, Tashiro K, Ohta K, Yamagishi SI, Fukami K
JCI insight 2025 Jul 8;10(13)
JCI insight 2025 Jul 8;10(13)
Targeting long-chain acylcarnitine accumulation to protect cardiac mitochondrial homeostasis after complete revascularization.
Lin R, Li Y, Yang S, Gao H, Li F, Wang X, Tan X, Wang Z, Chen W, Ren L, Wang X, Wang L, Qin J, Yin W, Du J, Wang Y
Cell reports. Medicine 2025 Dec 16;6(12):102507
Cell reports. Medicine 2025 Dec 16;6(12):102507
The propensity of fructose to induce metabolic dysfunction is dependent on the baseline diet, length of the dietary exposure, and sex of the mice.
Fadhul T, Park SH, Ali H, Alsiraj Y, Wali JA, Simpson SJ, Softic S
bioRxiv : the preprint server for biology 2024 Nov 26;
bioRxiv : the preprint server for biology 2024 Nov 26;
L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy.
Jing Z, Iba T, Naito H, Xu P, Morishige JI, Nagata N, Okubo H, Ando H
Frontiers in pharmacology 2023;14:1182788
Frontiers in pharmacology 2023;14:1182788
The Enhancement of Acylcarnitine Metabolism by 5-Heptadecylresorcinol in Brown Adipose Tissue Contributes to Improving Glucose and Lipid Levels in Aging Male Mice.
Zhang K, Jiang L, Xue L, Wang Y, Sun Y, Fan M, Qian H, Wang L, Li Y
Nutrients 2023 Oct 29;15(21)
Nutrients 2023 Oct 29;15(21)
Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation.
Helsley RN, Park SH, Vekaria HJ, Sullivan PG, Conroy LR, Sun RC, Romero MDM, Herrero L, Bons J, King CD, Rose J, Meyer JG, Schilling B, Kahn CR, Softic S
Journal of hepatology 2023 Jul;79(1):25-42
Journal of hepatology 2023 Jul;79(1):25-42
Ferulic acid supplementation alleviates hyperuricemia in high-fructose/fat diet-fed rats via promoting uric acid excretion and mediating the gut microbiota.
Zhang N, Zhou J, Zhao L, Zhao Z, Wang S, Zhang L, Zhou F
Food & function 2023 Feb 6;14(3):1710-1725
Food & function 2023 Feb 6;14(3):1710-1725
Lenvatinib causes reduced expression of carnitine/organic cation transporter 2 and carnitine deficiency in the skeletal muscle of rats.
Jing Z, Okubo H, Morishige JI, Xu P, Hasan N, Nagata N, Ando H
Toxicology letters 2022 Aug 1;366:17-25
Toxicology letters 2022 Aug 1;366:17-25
The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion.
Wang S, Fang Y, Yu X, Guo L, Zhang X, Xia D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Mar;111:162-168
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Mar;111:162-168
Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy.
Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I
Journal of neurochemistry 2019 Feb;148(3):373-385
Journal of neurochemistry 2019 Feb;148(3):373-385
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.
Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ
Cell metabolism 2017 Sep 5;26(3):509-522.e6
Cell metabolism 2017 Sep 5;26(3):509-522.e6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse small intestine tissue were subjected to SDS PAGE followed by western blot with 16331-1-AP(SLC22A5 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The OCTN2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human OCTN2. This antibody recognizes human,mouse,rat antigen. The OCTN2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
