FNab08515

antibody from FineTest Biotech
Targeting: TBC1D5 KIAA0210
Provider product page for FNab08515
Western blot
ELISA
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
FNab08515 - Provider product page
Provider
FineTest Biotech
Product name
TBC1D5 antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
May act as a GTPase-activating protein(GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity(PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy(PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes(PubMed:24603492).
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
TBC1 domain family, member 5
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
TBC1D5 protein structure - FNab08515 shown in red.