15958-1-AP

antibody from Proteintech Group

Targeting: SEC24A

Provider product page for 15958-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 15958-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15958-1-AP, RRID:AB_2186118
Product name: SEC24A antibody
Antibody type: Polyclonal
Description: KD/KO validated SEC24A antibody (Cat. #15958-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat, Simian
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SEC24A protein structure - 15958-1-AP shown in red.

Submitted references STING signaling modulation by COPII cargo recognition.

Lyu H, Xing C, Huai W, Song K, Jeltema D, Zhang H, Zhang X, Yan N
Cell 2026 May 14;189(10):2971-2987.e19

Defective anterograde protein-trafficking contributes to endoplasmic reticulum-stress in a CLN1 disease model.

Plavelil N, Appu AP, Gopal KC, Mondal A, Perkins N, Mukherjee AB
Neurobiology of disease 2025 Jun 1;209:106890

The COPII Transport Complex Participates in HPV16 Infection.

Day PM, Thompson CD, Weisberg AS, Schiller JT
Viruses 2025 Apr 25;17(5)

SEC31a-ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation.

Nie J, Ma S, Wu L, Li Y, Cao J, Li M, Mei P, Cooper PR, Li A, Pei D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2405127

Zosuquidar Promotes Antitumor Immunity by Inducing Autophagic Degradation of PD-L1.

Ding L, Guo H, Zhang J, Zheng M, Zhang W, Wang L, Du Q, Zhou C, Xu Y, Wu H, He Q, Yang B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2400340

V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation.

Sun Y, Wang X, Yang X, Wang L, Ding J, Wang CC, Zhang H, Wang X
Developmental cell 2023 Dec 4;58(23):2761-2775.e5

A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis.

Stomberski CT, Venetos NM, Zhou HL, Qian Z, Collison BR, Field SJ, Premont RT, Stamler JS
Cell reports 2022 Oct 25;41(4):111538

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.

You M, Wu F, Gao M, Chen M, Zeng S, Zhang Y, Zhao W, Li D, Wei L, Ruan XZ, Chen Y
Redox biology 2022 Nov;57:102500

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.

Lu CL, Ortmeier S, Brudvig J, Moretti T, Cain J, Boyadjiev SA, Weimer JM, Kim J
Traffic (Copenhagen, Denmark) 2022 Jan;23(1):81-93

Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.

Liu Z, Yan M, Lei W, Jiang R, Dai W, Chen J, Wang C, Li L, Wu M, Nian X, Li D, Sun D, Lv X, Wang C, Xie C, Yao L, Wu C, Hu J, Xiao N, Mo W, Wang Z, Zhang L
The Journal of clinical investigation 2022 Apr 1;132(7)

THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.

Li C, Chi H, Deng S, Wang H, Yao H, Wang Y, Chen D, Guo X, Fang JY, He F, Xu J
Journal for immunotherapy of cancer 2021 Aug;9(8)

SEC24A stimulates oncogenicity of human gastric cancer cells.

Lu M, Wang W, Zhang S, Li Y
International journal of clinical and experimental pathology 2018;11(8):4044-4051

The COPII cargo adapter SEC24C is essential for neuronal homeostasis.

Wang B, Joo JH, Mount R, Teubner BJW, Krenzer A, Ward AL, Ichhaporia VP, Adams EJ, Khoriaty R, Peters ST, Pruett-Miller SM, Zakharenko SS, Ginsburg D, Kundu M
The Journal of clinical investigation 2018 Aug 1;128(8):3319-3332

Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection.

Möllerherm H, Branitzki-Heinemann K, Brogden G, Elamin AA, Oehlmann W, Fuhrmann H, Singh M, Naim HY, von Köckritz-Blickwede M
Frontiers in immunology 2017;8:541

Yip1A, a novel host factor for the activation of the IRE1 pathway of the unfolded protein response during Brucella infection.

Taguchi Y, Imaoka K, Kataoka M, Uda A, Nakatsu D, Horii-Okazaki S, Kunishige R, Kano F, Murata M
PLoS pathogens 2015 Mar;11(3):e1004747

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.

Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, Deng H, Wang Y
Nature 2015 Aug 13;524(7564):243-6

The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.

Gustafsen C, Kjolby M, Nyegaard M, Mattheisen M, Lundhede J, Buttenschøn H, Mors O, Bentzon JF, Madsen P, Nykjaer A, Glerup S
Cell metabolism 2014 Feb 4;19(2):310-8

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human liver tissue were subjected to SDS PAGE followed by western blot with 15958-1-AP(SEC24A antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using SEC24A antibody 15958-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line