Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- AF346 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal BMPR-IA/ALK-3 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human BMPR-IA in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant mouse BMPR-IA is observed and less than 5% cross-reactivity with recombinant human BMPR-IB is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references A new signaling cascade linking BMP4, BMPR1A, ΔNp73 and NANOG impacts on stem-like human cell properties and patient outcome.
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.
The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis.
BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity.
Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling.
Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro.
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.
Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells.
Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain.
Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach.
Voeltzel T, Flores-Violante M, Zylbersztejn F, Lefort S, Billandon M, Jeanpierre S, Joly S, Fossard G, Milenkov M, Mazurier F, Nehme A, Belhabri A, Paubelle E, Thomas X, Michallet M, Louache F, Nicolini FE, Caron de Fromentel C, Maguer-Satta V
Cell death & disease 2018 Sep 27;9(10):1011
Cell death & disease 2018 Sep 27;9(10):1011
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.
Toofan P, Busch C, Morrison H, O'Brien S, Jørgensen H, Copland M, Wheadon H
Cell death & disease 2018 Sep 11;9(9):927
Cell death & disease 2018 Sep 11;9(9):927
The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis.
Martínez VG, Sacedón R, Hidalgo L, Valencia J, Fernández-Sevilla LM, Hernández-López C, Vicente A, Varas A
PloS one 2015;10(6):e0131453
PloS one 2015;10(6):e0131453
BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity.
Cao Y, Slaney CY, Bidwell BN, Parker BS, Johnstone CN, Rautela J, Eckhardt BL, Anderson RL
Cancer research 2014 Sep 15;74(18):5091-102
Cancer research 2014 Sep 15;74(18):5091-102
Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling.
Robson NC, Hidalgo L, Mc Alpine T, Wei H, Martínez VG, Entrena A, Melen GJ, MacDonald AS, Phythian-Adams A, Sacedón R, Maraskovsky E, Cebon J, Ramírez M, Vicente A, Varas A
Cancer research 2014 Sep 15;74(18):5019-5031
Cancer research 2014 Sep 15;74(18):5019-5031
Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro.
Fong D, Bisson M, Laberge G, McManus S, Grenier G, Faucheux N, Roux S
Cellular signalling 2013 Apr;25(4):717-28
Cellular signalling 2013 Apr;25(4):717-28
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH, Kotliarova S, Kotliarov Y, Walling J, Ahn S, Kim M, Totonchy M, Cusack T, Ene C, Ma H, Su Q, Zenklusen JC, Zhang W, Maric D, Fine HA
Cancer cell 2008 Jan;13(1):69-80
Cancer cell 2008 Jan;13(1):69-80
Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.
Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R
The Journal of biological chemistry 2007 Aug 10;282(32):23337-47
The Journal of biological chemistry 2007 Aug 10;282(32):23337-47
Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells.
Gossrau G, Thiele J, Konang R, Schmandt T, Brüstle O
Stem cells (Dayton, Ohio) 2007 Apr;25(4):939-49
Stem cells (Dayton, Ohio) 2007 Apr;25(4):939-49
Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain.
Lopez-Coviella I, Mellott TM, Kovacheva VP, Berse B, Slack BE, Zemelko V, Schnitzler A, Blusztajn JK
Brain research 2006 May 9;1088(1):49-56
Brain research 2006 May 9;1088(1):49-56
Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach.
Bleuming SA, Kodach LL, Garcia Leon MJ, Richel DJ, Peppelenbosch MP, Reitsma PH, Hardwick JC, van den Brink GR
The Journal of pathology 2006 Jun;209(2):190-7
The Journal of pathology 2006 Jun;209(2):190-7
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human BMPR-IA/ALK-3 by Western Blot. Western blot shows lysates of human prostate tissue. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human BMPR-IA/ALK-3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF346) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for BMPR-IA/ALK-3 at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- BMPR-IA/ALK-3 in Human Prostate Cancer Tissue.