SLC4A7

This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]

Description

Solute carrier family 4 member 7

Tissue specificity

Tissue enhanced (intestine, retina)

Subcell location

Plasma membrane, Focal adhesion sites, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

3 (27372721 - 27484420)

Ensembl ID

ENSG00000033867  (ver. 103.38)

Orthologs

Mouse Slc4a7: ENSMUSG00000021733

UniProt

Q9Y6M7

neXtProt

NX_Q9Y6M7

Human splice variants
Mouse splice variants

Protein structure