Antibody data
- Antibody Data
- Antigen structure
- References [28]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 15004-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15004-1-AP, RRID:AB_10644442
- Product name
- TCTN1 antibody
- Antibody type
- Polyclonal
- Description
- TCTN1 antibody (Cat. #15004-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Circular RNA circCHSY1 silencing inhibits the malignant progression of esophageal squamous cell carcinoma.
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.
Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone.
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome.
Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.
ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
NUP98 Sets the Size-Exclusion Diffusion Limit through the Ciliary Base.
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Loss of OCRL increases ciliary PI(4,5)P(2) in Lowe oculocerebrorenal syndrome.
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.
INPP5E regulates phosphoinositide-dependent cilia transition zone function.
Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.
Immunofluorescent staining of septins in primary cilia.
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
CCDC41 is required for ciliary vesicle docking to the mother centriole.
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.
He H, Chen Y, Liang H, Che W, Chen H, Chen Y, Peng F, Wu B
Discover oncology 2024 Mar 21;15(1):84
Discover oncology 2024 Mar 21;15(1):84
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.
Schembs L, Willems A, Hasenpusch-Theil K, Cooper JD, Whiting K, Burr K, Bøstrand SMK, Selvaraj BT, Chandran S, Theil T
Cell reports 2022 May 17;39(7):110811
Cell reports 2022 May 17;39(7):110811
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.
Wang J, Thomas HR, Thompson RG, Waldrep SC, Fogerty J, Song P, Li Z, Ma Y, Santra P, Hoover JD, Yeo NC, Drummond IA, Yoder BK, Amack JD, Perkins B, Parant JM
Disease models & mechanisms 2022 Dec 1;15(12)
Disease models & mechanisms 2022 Dec 1;15(12)
Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone.
Conduit SE, Davies EM, Fulcher AJ, Oorschot V, Mitchell CA
Frontiers in cell and developmental biology 2021;9:634649
Frontiers in cell and developmental biology 2021;9:634649
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Chen C, Xu Q, Zhang Y, Davies BA, Huang Y, Katzmann DJ, Harris PC, Hu J, Ling K
Science advances 2021 Jun;7(26)
Science advances 2021 Jun;7(26)
Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome.
Luo M, Lin Z, Zhu T, Jin M, Meng D, He R, Cao Z, Shen Y, Lu C, Cai R, Zhao Y, Wang X, Li H, Wu S, Zou X, Luo G, Cao L, Huang M, Jiao H, Gao H, Sui R, Zhao C, Ma X, Cao M
Genetics in medicine : official journal of the American College of Medical Genetics 2021 Jun;23(6):1041-1049
Genetics in medicine : official journal of the American College of Medical Genetics 2021 Jun;23(6):1041-1049
Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.
Qiu H, Fujisawa S, Nozaki S, Katoh Y, Nakayama K
Biology open 2021 Jan 25;10(1)
Biology open 2021 Jan 25;10(1)
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J
Developmental cell 2020 May 4;53(3):287-299.e5
Developmental cell 2020 May 4;53(3):287-299.e5
TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.
Yan H, Chen C, Chen H, Hong H, Huang Y, Ling K, Hu J, Wei Q
Nature communications 2020 May 4;11(1):2196
Nature communications 2020 May 4;11(1):2196
ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.
Jung E, Choi TI, Lee JE, Kim CH, Kim J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1331-1344
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1331-1344
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Vuolo L, Stevenson NL, Heesom KJ, Stephens DJ
eLife 2018 Oct 16;7
eLife 2018 Oct 16;7
NUP98 Sets the Size-Exclusion Diffusion Limit through the Ciliary Base.
Endicott SJ, Brueckner M
Current biology : CB 2018 May 21;28(10):1643-1650.e3
Current biology : CB 2018 May 21;28(10):1643-1650.e3
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Wiegering A, Dildrop R, Kalfhues L, Spychala A, Kuschel S, Lier JM, Zobel T, Dahmen S, Leu T, Struchtrup A, Legendre F, Vesque C, Schneider-Maunoury S, Saunier S, Rüther U, Gerhardt C
The EMBO journal 2018 May 15;37(10)
The EMBO journal 2018 May 15;37(10)
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY
Nature communications 2018 Dec 11;9(1):5277
Nature communications 2018 Dec 11;9(1):5277
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, Taylor MD, Mitchell CA, Dyson JM
Oncogene 2017 Oct 26;36(43):5969-5984
Oncogene 2017 Oct 26;36(43):5969-5984
Loss of OCRL increases ciliary PI(4,5)P(2) in Lowe oculocerebrorenal syndrome.
Prosseda PP, Luo N, Wang B, Alvarado JA, Hu Y, Sun Y
Journal of cell science 2017 Oct 15;130(20):3447-3454
Journal of cell science 2017 Oct 15;130(20):3447-3454
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.
Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Brüchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wühl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C
Nature genetics 2017 Jul;49(7):1025-1034
Nature genetics 2017 Jul;49(7):1025-1034
INPP5E regulates phosphoinositide-dependent cilia transition zone function.
Dyson JM, Conduit SE, Feeney SJ, Hakim S, DiTommaso T, Fulcher AJ, Sriratana A, Ramm G, Horan KA, Gurung R, Wicking C, Smyth I, Mitchell CA
The Journal of cell biology 2017 Jan 2;216(1):247-263
The Journal of cell biology 2017 Jan 2;216(1):247-263
Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.
Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, Busso C, Olieric N, Sorzano COS, Steinmetz MO, Guichard P, Gönczy P
Current biology : CB 2017 Aug 21;27(16):2486-2498.e6
Current biology : CB 2017 Aug 21;27(16):2486-2498.e6
Immunofluorescent staining of septins in primary cilia.
Kim MS, Froese CD, Xie H, Trimble WS
Methods in cell biology 2016;136:269-83
Methods in cell biology 2016;136:269-83
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Fu W, Wang L, Kim S, Li J, Dynlacht BD
Cell reports 2016 Nov 1;17(6):1505-1517
Cell reports 2016 Nov 1;17(6):1505-1517
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.
Xu Q, Zhang Y, Wei Q, Huang Y, Hu J, Ling K
Nature communications 2016 Feb 26;7:10777
Nature communications 2016 Feb 26;7:10777
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
Lu H, Toh MT, Narasimhan V, Thamilselvam SK, Choksi SP, Roy S
Developmental biology 2015 Jan 15;397(2):225-36
Developmental biology 2015 Jan 15;397(2):225-36
Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.
Barbelanne M, Hossain D, Chan DP, Peränen J, Tsang WY
Human molecular genetics 2015 Apr 15;24(8):2185-200
Human molecular genetics 2015 Apr 15;24(8):2185-200
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
Wang WJ, Tay HG, Soni R, Perumal GS, Goll MG, Macaluso FP, Asara JM, Amack JD, Tsou MF
Nature cell biology 2013 Jun;15(6):591-601
Nature cell biology 2013 Jun;15(6):591-601
CCDC41 is required for ciliary vesicle docking to the mother centriole.
Joo K, Kim CG, Lee MS, Moon HY, Lee SH, Kim MJ, Kweon HS, Park WY, Kim CH, Gleeson JG, Kim J
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):5987-92
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):5987-92
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS, Ramaswami G, Otto EA, Noriega TR, Seol AD, Robinson JF, Bennett CL, Josifova DJ, García-Verdugo JM, Katsanis N, Hildebrandt F, Reiter JF
Nature genetics 2011 Jul 3;43(8):776-84
Nature genetics 2011 Jul 3;43(8):776-84
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.
Chih B, Liu P, Chinn Y, Chalouni C, Komuves LG, Hass PE, Sandoval W, Peterson AS
Nature cell biology 2011 Dec 18;14(1):61-72
Nature cell biology 2011 Dec 18;14(1):61-72
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse embryo tissue were subjected to SDS PAGE followed by western blot with 15004-1-AP(TCTN1 antibody) at dilution of 1:800
- Sample type
- tissue