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- Antibody Data
- Antigen structure
- References [75]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 22362-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- BRCA1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BRCA1 antibody (Cat. #22362-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SERBP1 is required for efficient HR repair and cisplatin chemoresistance in lung adenocarcinoma.
Discovery of Novel and Potent Dual PARP1/ERK Inhibitors as a Promising Strategy for Cancer Therapy.
Low-dose X-ray-activated radiodynamic therapy via a lutetium-coordinated nanoplatform synergizing PARP inhibition and ferroptosis.
A Novel Human Cellular System for Studying Normal Aging and for Anti-Aging Discovery.
LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance.
CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation.
Multi-target modulation of the homologous recombination pathway by resveratrol promotes DNA damage repair in POI: integrated network pharmacology, molecular dynamics simulation, and experimental validation.
POLA1 mediates hexavalent chromium-induced ovarian tumor progression through replication stress and DNA damage response.
Development of the first-in-class RNF4 PROTAC degrader as potential therapeutics for hepatocellular carcinoma.
Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture.
Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes.
THE GID COMPLEX REGULATES DNA END PROCESSING DURING DNA DOUBLE-STRAND BREAK REPAIR BY NONHOMOLOGOUS END JOINING.
Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting function.
Ferroptosis contributing to spermatocyte injury induced by silica nanoparticles via BRCA1/GPX4 signaling.
Targeting MTPN sensitizes pancreatic cancer of wild-type BRCA1/2 to Cisplatin-based chemotherapy.
GX15-070 enhances niraparib efficacy in ovarian cancer by promoting a shift in Mcl1-mediated DNA repair pathway from HR to NHEJ.
Phospho-TRIM21 orchestrates RPA2 ubiquitination switch to promote homologous recombination and tumor radio/chemo-resistance.
Establishment and transcriptomic characteristics of radio-resistant meningioma cell lines.
Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma.
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma.
Anemarchalconyn, a natural alkyne ketone compound, inhibits HCC cell growth by suppressing Polθ and inducing synthetic lethality in Homologous recombination deficiency cells.
FOXD3 promotes homologous recombination repair and genomic stability by facilitating MRE11-mediated DNA end resection.
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
Olaparib promotes FABP4 expression and reduces antitumor effect in ovarian cancer cells with a BRCA1 mutation.
ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancer.
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.
Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells.
Oncoproteins E6 and E7 upregulate topoisomerase I to activate the cGAS-PD-L1 pathway in cervical cancer development.
A novel molecular target, superoxide dismutase 1, in ALK inhibitor-resistant lung cancer cells, detected through proteomic analysis.
Metabolically inducing defects in DNA repair sensitizes BRCA-wild-type cancer cells to replication stress.
SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21 and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells.
YY1 is involved in homologous recombination inhibition at guanine quadruplex sites in human cells.
Ailanthone synergizes with PARP1 inhibitor in tumour growth inhibition through crosstalk of DNA repair pathways in gastric cancer.
FANCJ DNA helicase is recruited to the replisome by AND-1 to ensure genome stability.
Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients.
A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation.
Design, synthesis, and evaluation of novel stilbene derivatives that degrade acidic nucleoplasmic DNA-binding protein 1 (And1) and synergize with PARP1 inhibitor in NSCLC cells.
Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1.
Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke.
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers.
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.
Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition.
Dual RNA sequencing of Helicobacter pylori and host cell transcriptomes reveals ontologically distinct host-pathogen interaction.
ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint.
Deubiquitinase BAP1 regulates stability of BRCA1 protein and inactivates the NF-κB signaling to protect mice from sepsis-induced acute kidney injury.
DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic vulnerabilities.
Discovery of dual PARP and CDK6 inhibitors for triple-negative breast cancer with wild-type BRCA.
Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51.
Identification of a luminescent platinum(II) complex with BODIPY derivative as novel photodynamic therapy agent for triple negative breast cancer cells.
HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression.
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner.
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Inhibition of PKM2 Enhances Sensitivity of Olaparib to Ovarian Cancer Cells and Induces DNA Damage.
Increased co-expression of MEST and BRCA1 is associated with worse prognosis and immune infiltration in ovarian cancer.
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.
FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathways.
Chemotherapeutic drugs induce oxidative stress associated with DNA repair and metabolism modulation.
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer.
CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition.
Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.
Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway.
Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stability.
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.
Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production.
Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.
FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair.
Slowly Repaired Bulky DNA Damages Modulate Cellular Redox Environment Leading to Premature Senescence.
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
BRCA1 protects cardiac microvascular endothelial cells against irradiation by regulating p21-mediated cell cycle arrest.
USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.
Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity.
PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.
Xie Y, Chen Q, Tang N, Zeng Y, Zhao J, Yang Y, Li C, Li J, Zhu J, Huang JA, Liu Z
Cell death discovery 2026 Mar 19;12(1)
Cell death discovery 2026 Mar 19;12(1)
Discovery of Novel and Potent Dual PARP1/ERK Inhibitors as a Promising Strategy for Cancer Therapy.
Bai Y, Wu S, Zhang W, Chen Y, Yan W, Huang L, Liu J, Guan Z, Su Y, Guo D, Bian Y, Cong K, Zou Y, Hao H, Zhu Q, Wang H, Xu Y
Journal of medicinal chemistry 2026 Mar 12;69(5):6230-6253
Journal of medicinal chemistry 2026 Mar 12;69(5):6230-6253
Low-dose X-ray-activated radiodynamic therapy via a lutetium-coordinated nanoplatform synergizing PARP inhibition and ferroptosis.
Song W, Zhao C, Mai Y, Zhang G, Kang W, Zheng X, Yuan Q, Chen Z, Zhong C, Tang J, Fu D, Zhai T, Ling K, Jiang H
Journal of nanobiotechnology 2026 Jan 16;24(1):148
Journal of nanobiotechnology 2026 Jan 16;24(1):148
A Novel Human Cellular System for Studying Normal Aging and for Anti-Aging Discovery.
Feng Z, Li CS, Fu H, Jiang W, Zhang W, Huang Y, Huang Y, Tam TTKK, Li Y, Liu F, Lu L, Lee YL, Yeung WSB, Dougan G, Liu P
Aging cell 2026 Feb;25(2):e70352
Aging cell 2026 Feb;25(2):e70352
LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance.
Li Q, Zhou Z, Li X, Lan Q
Non-coding RNA research 2026 Feb;16:57-69
Non-coding RNA research 2026 Feb;16:57-69
CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation.
Shi J, Li Q, Li J, Bai J, Xi J, He Q, Zhou J, Wang X, Song X, Li X, Yue X, Zhang X, Sun Z, Li J, Yang W, Cui Y, Shu W, Guo L, Wang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e10275
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e10275
Multi-target modulation of the homologous recombination pathway by resveratrol promotes DNA damage repair in POI: integrated network pharmacology, molecular dynamics simulation, and experimental validation.
Yu Z, Peng W, Li M, Li F, Zhang T, Nong Y, Liu C, Liu W, Ding H, Lv X, Wang J, Zhang X, Liu F, Wu H
International journal of surgery (London, England) 2026 Feb 5;112(4):9404-26
International journal of surgery (London, England) 2026 Feb 5;112(4):9404-26
POLA1 mediates hexavalent chromium-induced ovarian tumor progression through replication stress and DNA damage response.
Guo H, Sun Z, Li M, Yao S, Yan L
Toxicology 2026 Aug;524:154465
Toxicology 2026 Aug;524:154465
Development of the first-in-class RNF4 PROTAC degrader as potential therapeutics for hepatocellular carcinoma.
Wan H, Liu Y, Chang H, Zhang K, Li Z, Ni H, Xu J, Pan B, Zhu K, Hu J, Wang S, Yang D, Wang X, Dang Y, Zhu S
European journal of medicinal chemistry 2026 Apr 5;307:118668
European journal of medicinal chemistry 2026 Apr 5;307:118668
Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture.
Soetomo SA, Sharp MF, Crismani W
PloS one 2025;20(9):e0332860
PloS one 2025;20(9):e0332860
Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes.
Zhong J, Liang L, Zhao N, Wang J, Shu P
Frontiers in pharmacology 2025;16:1562244
Frontiers in pharmacology 2025;16:1562244
THE GID COMPLEX REGULATES DNA END PROCESSING DURING DNA DOUBLE-STRAND BREAK REPAIR BY NONHOMOLOGOUS END JOINING.
Sleckman BP, Chen BR
Transactions of the American Clinical and Climatological Association 2025;135:281-293
Transactions of the American Clinical and Climatological Association 2025;135:281-293
Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting function.
Peng X, Zhou P, Zhang K, Chen L, Tang M, Zhou Q, Peng J, Yang L
Cell death & disease 2025 Oct 21;16(1):743
Cell death & disease 2025 Oct 21;16(1):743
Ferroptosis contributing to spermatocyte injury induced by silica nanoparticles via BRCA1/GPX4 signaling.
Liu J, Zhang E, Su S, Xie S, Liu R, Ren L, Yin C
Toxicology 2025 Nov;517:154231
Toxicology 2025 Nov;517:154231
Targeting MTPN sensitizes pancreatic cancer of wild-type BRCA1/2 to Cisplatin-based chemotherapy.
Wang Z, Huang X, Bai T, Jin Y, Gong T, Wu W, Kouken B, Wang Q, Wang L
Cancer gene therapy 2025 Nov;32(11):1245-1258
Cancer gene therapy 2025 Nov;32(11):1245-1258
GX15-070 enhances niraparib efficacy in ovarian cancer by promoting a shift in Mcl1-mediated DNA repair pathway from HR to NHEJ.
Sheng JJ, He Y, Liu PW, Zheng SA, Wu N, Sui HY, Cheng Q, Li H
Journal of translational medicine 2025 Nov 11;23(1):1262
Journal of translational medicine 2025 Nov 11;23(1):1262
Phospho-TRIM21 orchestrates RPA2 ubiquitination switch to promote homologous recombination and tumor radio/chemo-resistance.
Zhang J, Chen B, Xu F, Wang R, Zhao X, Yao Z, Zhang J, Zhou S, Xu A, Wu L, Zhao G
Oncogene 2025 May;44(16):1106-1117
Oncogene 2025 May;44(16):1106-1117
Establishment and transcriptomic characteristics of radio-resistant meningioma cell lines.
Yu J, Ren L, Wu T, Hua L, Wang D, Wang Y, Xie Q, Deng J, Gong Y
Journal of neuro-oncology 2025 May;173(1):105-119
Journal of neuro-oncology 2025 May;173(1):105-119
Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma.
Mi L, Cai Y, Qi J, Chen L, Li Y, Zhang S, Ran H, Qi Q, Zhang C, Wu H, Cao S, Huang H, Xiao D, Wang X, Li B, Xie J, Li F, Han Q, Wu Q, Li T, Li A, Rich JN, Zhou T, Man J
Nature communications 2025 May 28;16(1):4941
Nature communications 2025 May 28;16(1):4941
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma.
Liu B, Li W, Zhang W, Feng C, Wan L, He S, Xu R, Fu Z, Liu Z, Xu H, Jin X, Tu C, Li Z
Signal transduction and targeted therapy 2025 May 21;10(1):165
Signal transduction and targeted therapy 2025 May 21;10(1):165
Anemarchalconyn, a natural alkyne ketone compound, inhibits HCC cell growth by suppressing Polθ and inducing synthetic lethality in Homologous recombination deficiency cells.
Li J, Deng W, Zhou T, Zhang X, Hu L, Fan S, Zou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156679
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156679
FOXD3 promotes homologous recombination repair and genomic stability by facilitating MRE11-mediated DNA end resection.
Xu S, Zhang J, Gao C, Xiong Z, Gong Y, Chai B, Chen H, Xu X
Acta biochimica et biophysica Sinica 2025 Jun 13;57(10):1601-1610
Acta biochimica et biophysica Sinica 2025 Jun 13;57(10):1601-1610
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
Xu F, Xia Q, Chen B, Wang R, Zhang J, Zhao X, Zhang Z, Yao Z, Zhang J, Zhou S, Li X, Chen B, Xu A, Wu L, Zhao G
Cell death and differentiation 2025 Jul;32(7):1303-1316
Cell death and differentiation 2025 Jul;32(7):1303-1316
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
Wu Y, Zhang Y, Yu Y, Wang X, Zhen Z, Yuan Y, Xie B, Han M, Wang M, Zhang X, Sun X, Wen X, Hashimoto K, Shang Y, Yuan S, Zhang J
Nature communications 2025 Jul 23;16(1):6779
Nature communications 2025 Jul 23;16(1):6779
Olaparib promotes FABP4 expression and reduces antitumor effect in ovarian cancer cells with a BRCA1 mutation.
Huang W, Meng H, Xu Y, Huang L, Lou G
Oncology letters 2025 Feb;29(2):67
Oncology letters 2025 Feb;29(2):67
ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancer.
Fu X, Zhu Y, Lu X, Gao X, Xin L, Ren Y, Liu X, Ge L, Hao J, Yao Z, Shi L, Yang J
Cell death & disease 2025 Dec 18;17(1):119
Cell death & disease 2025 Dec 18;17(1):119
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.
Benedetti R, Di Crosta M, Gilardini Montani MS, D'Orazi G, Cirone M
Cell death discovery 2025 Apr 10;11(1):162
Cell death discovery 2025 Apr 10;11(1):162
Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells.
Li P, Zhu X, Qu H, Han Z, Yao X, Wei Y, Li B, Chen H
OncoTargets and therapy 2024;17:741-753
OncoTargets and therapy 2024;17:741-753
Oncoproteins E6 and E7 upregulate topoisomerase I to activate the cGAS-PD-L1 pathway in cervical cancer development.
Luo Y, Niu M, Liu Y, Zhang M, Deng Y, Mu D, Xu J, Hong S
Frontiers in pharmacology 2024;15:1450875
Frontiers in pharmacology 2024;15:1450875
A novel molecular target, superoxide dismutase 1, in ALK inhibitor-resistant lung cancer cells, detected through proteomic analysis.
Miyake N, Ochi N, Takeyama M, Isozaki H, Ichihara E, Yamane H, Fukazawa T, Nagasaki Y, Kawahara T, Nakanishi H, Hiraki A, Kiura K, Takigawa N
Experimental cell research 2024 Oct 1;442(2):114266
Experimental cell research 2024 Oct 1;442(2):114266
Metabolically inducing defects in DNA repair sensitizes BRCA-wild-type cancer cells to replication stress.
Watanabe K, Yamamoto T, Fujita T, Hino S, Hino Y, Yamazaki K, Ohashi Y, Sakuraba S, Kono H, Nakao M, Ochiai K, Dan S, Saitoh N
Science signaling 2024 Nov 12;17(862):eadl6445
Science signaling 2024 Nov 12;17(862):eadl6445
SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21 and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells.
Di Crosta M, Ragone FC, Benedetti R, D'Orazi G, Gilardini Montani MS, Cirone M
International journal of molecular sciences 2024 Jun 27;25(13)
International journal of molecular sciences 2024 Jun 27;25(13)
YY1 is involved in homologous recombination inhibition at guanine quadruplex sites in human cells.
Cui X, Zhang C, Fu C, Hu J, Li T, Li L
Nucleic acids research 2024 Jul 22;52(13):7401-7413
Nucleic acids research 2024 Jul 22;52(13):7401-7413
Ailanthone synergizes with PARP1 inhibitor in tumour growth inhibition through crosstalk of DNA repair pathways in gastric cancer.
Wang C, Yi T, Li X, Cui J, Li B, Qin Y, Tang S, Zhang J
Journal of cellular and molecular medicine 2024 Jan;28(2):e18033
Journal of cellular and molecular medicine 2024 Jan;28(2):e18033
FANCJ DNA helicase is recruited to the replisome by AND-1 to ensure genome stability.
Boavida A, Napolitano LM, Santos D, Cortone G, Jegadesan NK, Onesti S, Branzei D, Pisani FM
EMBO reports 2024 Feb;25(2):876-901
EMBO reports 2024 Feb;25(2):876-901
Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients.
Ma Z, Wang Y, Yu Y, Fu F, Zhang Y
Journal of thoracic disease 2024 Feb 29;16(2):911-923
Journal of thoracic disease 2024 Feb 29;16(2):911-923
A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation.
Ascenção C, Sims JR, Dziubek A, Comstock W, Fogarty EA, Badar J, Freire R, Grimson A, Weiss RS, Cohen PE, Smolka MB
eLife 2024 Feb 23;12
eLife 2024 Feb 23;12
Design, synthesis, and evaluation of novel stilbene derivatives that degrade acidic nucleoplasmic DNA-binding protein 1 (And1) and synergize with PARP1 inhibitor in NSCLC cells.
Chen L, Ren Z, Zhang Y, Hou W, Li Y
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2383886
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2383886
Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1.
Wang PH, Wang Y, Guo YY, Ma ZH, Wu C, Xing L
International immunopharmacology 2024 Dec 25;143(Pt 3):113502
International immunopharmacology 2024 Dec 25;143(Pt 3):113502
Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke.
Guo H, Li Y, Wang S, Yang Y, Xu T, Zhao J, Wang J, Zuo W, Wang P, Zhao G, Wang H, Hou W, Dong H, Cai Y
Redox biology 2024 Aug;74:103234
Redox biology 2024 Aug;74:103234
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers.
Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B
Cancer discovery 2024 Aug 2;14(8):1476-1495
Cancer discovery 2024 Aug 2;14(8):1476-1495
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.
Bao K, Ma Y, Li Y, Shen X, Zhao J, Tian S, Zhang C, Liang C, Zhao Z, Yang Y, Zhang K, Yang N, Meng FL, Hao J, Yang J, Liu T, Yao Z, Ai D, Shi L
Molecular cell 2024 Apr 4;84(7):1206-1223.e15
Molecular cell 2024 Apr 4;84(7):1206-1223.e15
Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition.
Zhang Z, Liu Y, Xu Y, Xu Z, Jia J, Jin Y, Wang W, Liu L
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):576-585
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):576-585
Dual RNA sequencing of Helicobacter pylori and host cell transcriptomes reveals ontologically distinct host-pathogen interaction.
Hu W, Zhai ZY, Huang ZY, Chen ZM, Zhou P, Li XX, Yang GH, Bao CJ, You LJ, Cui XB, Xia GL, Ou Yang MP, Zhang L, Wu WKK, Li LF, Zhang YX, Xiao ZG, Gong W
mSystems 2024 Apr 16;9(4):e0020624
mSystems 2024 Apr 16;9(4):e0020624
ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint.
Fan W, Xiong R, Zhou Z, Zhang C, Han Y, Shi T, Qiu J, Zhang R
Journal of Cancer 2023;14(11):2039-2050
Journal of Cancer 2023;14(11):2039-2050
Deubiquitinase BAP1 regulates stability of BRCA1 protein and inactivates the NF-κB signaling to protect mice from sepsis-induced acute kidney injury.
Luo S, Gong J, Zhao S, Li M, Li R
Chemico-biological interactions 2023 Sep 1;382:110621
Chemico-biological interactions 2023 Sep 1;382:110621
DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic vulnerabilities.
Zhao N, Zhang Z, Wang Q, Li L, Wei Z, Chen H, Zhou M, Liu Z, Su J
EBioMedicine 2023 Oct;96:104801
EBioMedicine 2023 Oct;96:104801
Discovery of dual PARP and CDK6 inhibitors for triple-negative breast cancer with wild-type BRCA.
Wang C, Luo H, Chen X, Zhang Y, Lu D, Liu X, Yin F, Li S, Kong L, Wang X
Bioorganic chemistry 2023 Oct;139:106683
Bioorganic chemistry 2023 Oct;139:106683
Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51.
Tao L, Zhou Y, Pan X, Luo Y, Qiu J, Zhou X, Chen Z, Li Y, Xu L, Zhou Y, Zuo Z, Liu C, Wang L, Liu X, Tian X, Su N, Yang Z, Zhang Y, Gou K, Sang N, Liu H, Zou J, Xiao Y, Zhong X, Xu J, Yang X, Xiao K, Liu Y, Yang S, Peng Y, Han J, Cen X, Zhao Y
Nature communications 2023 Nov 16;14(1):7430
Nature communications 2023 Nov 16;14(1):7430
Identification of a luminescent platinum(II) complex with BODIPY derivative as novel photodynamic therapy agent for triple negative breast cancer cells.
Wang Y, Wang S, Wang Q, Tang W, Lin L, Zhang T, Hu M, Wang X
Journal of inorganic biochemistry 2023 May;242:112160
Journal of inorganic biochemistry 2023 May;242:112160
HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression.
Refaat AM, Nakata M, Husain A, Kosako H, Honjo T, Begum NA
Cell reports 2023 Mar 28;42(3):112284
Cell reports 2023 Mar 28;42(3):112284
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
Wei Y, Xiao G, Xu H, Sun X, Shi Y, Wang F, Kang J, Peng J, Zhou F
The FEBS journal 2023 Jul;290(14):3629-3645
The FEBS journal 2023 Jul;290(14):3629-3645
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner.
Shi M, Hou J, Liang W, Li Q, Shao S, Ci S, Shu C, Zhao X, Zhao S, Huang M, Wu C, Hu Z, He L, Guo Z, Pan F
EMBO reports 2023 Aug 3;24(8):e56437
EMBO reports 2023 Aug 3;24(8):e56437
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486
The Prostate 2023 Apr;83(5):470-486
Inhibition of PKM2 Enhances Sensitivity of Olaparib to Ovarian Cancer Cells and Induces DNA Damage.
Zhou S, Li D, Xiao D, Wu T, Hu X, Zhang Y, Deng J, Long J, Xu S, Wu J, Li G, Peng M, Yang X
International journal of biological sciences 2022;18(4):1555-1568
International journal of biological sciences 2022;18(4):1555-1568
Increased co-expression of MEST and BRCA1 is associated with worse prognosis and immune infiltration in ovarian cancer.
Zhang J, Yu S, Li Q, Wang Q, Zhang J
Gynecologic oncology 2022 Mar;164(3):566-576
Gynecologic oncology 2022 Mar;164(3):566-576
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.
Zhao J, Tian S, Guo Q, Bao K, Yu G, Wang X, Shen X, Zhang J, Chen J, Yang Y, Liu L, Li X, Hao J, Yang N, Liu Z, Ai D, Yang J, Zhu Y, Yao Z, Ma S, Zhang K, Shi L
Molecular cell 2022 Jul 21;82(14):2571-2587.e9
Molecular cell 2022 Jul 21;82(14):2571-2587.e9
FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathways.
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Wang C, Qu L, Li S, Yin F, Ji L, Peng W, Luo H, Lu D, Liu X, Chen X, Kong L, Wang X
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Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production.
Zhou S, Liu Y, Jin L, Guo P, Liu Q, Shan J, Luo X, He H, Ma W, Zhang T
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Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.
McMahon KA, Stroud DA, Gambin Y, Tillu V, Bastiani M, Sierecki E, Polinkovsky ME, Hall TE, Gomez GA, Wu Y, Parat MO, Martel N, Lo HP, Khanna KK, Alexandrov K, Daly R, Yap A, Ryan MT, Parton RG
eLife 2021 Jun 18;10
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UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
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USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.
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Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity.
Li S, Wei Y
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PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.
Bian X, Gao J, Luo F, Rui C, Zheng T, Wang D, Wang Y, Roberts TM, Liu P, Zhao JJ, Cheng H
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SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.
Li L, Shi L, Yang S, Yan R, Zhang D, Yang J, He L, Li W, Yi X, Sun L, Liang J, Cheng Z, Shi L, Shang Y, Yu W
Nature communications 2016 Jul 20;7:12235
Nature communications 2016 Jul 20;7:12235
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 22362-1-AP( BRCA1 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BRCA1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human BRCA1. This antibody recognizes human antigen. The BRCA1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
