22362-1-AP

antibody from Proteintech Group

Targeting: BRCA1 BRCC1, FANCS, PPP1R53, RNF53

Provider product page for 22362-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [39]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 22362-1-AP - Provider product page
Provider: Proteintech Group
Product name: BRCA1 antibody
Antibody type: Polyclonal
Description: KD/KO validated BRCA1 antibody (Cat. #22362-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

BRCA1 protein structure - 22362-1-AP shown in red.

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Wang C, Yi T, Li X, Cui J, Li B, Qin Y, Tang S, Zhang J
Journal of cellular and molecular medicine 2024 Jan;28(2):e18033

FANCJ DNA helicase is recruited to the replisome by AND-1 to ensure genome stability.

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EMBO reports 2024 Feb;25(2):876-901

Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients.

Ma Z, Wang Y, Yu Y, Fu F, Zhang Y
Journal of thoracic disease 2024 Feb 29;16(2):911-923

A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation.

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eLife 2024 Feb 23;12

BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers.

Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B
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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.

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Molecular cell 2024 Apr 4;84(7):1206-1223.e15

Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition.

Zhang Z, Liu Y, Xu Y, Xu Z, Jia J, Jin Y, Wang W, Liu L
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):576-585

Dual RNA sequencing of Helicobacter pylori and host cell transcriptomes reveals ontologically distinct host-pathogen interaction.

Hu W, Zhai ZY, Huang ZY, Chen ZM, Zhou P, Li XX, Yang GH, Bao CJ, You LJ, Cui XB, Xia GL, Ou Yang MP, Zhang L, Wu WKK, Li LF, Zhang YX, Xiao ZG, Gong W
mSystems 2024 Apr 16;9(4):e0020624

ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint.

Fan W, Xiong R, Zhou Z, Zhang C, Han Y, Shi T, Qiu J, Zhang R
Journal of Cancer 2023;14(11):2039-2050

Deubiquitinase BAP1 regulates stability of BRCA1 protein and inactivates the NF-κB signaling to protect mice from sepsis-induced acute kidney injury.

Luo S, Gong J, Zhao S, Li M, Li R
Chemico-biological interactions 2023 Sep 1;382:110621

DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic vulnerabilities.

Zhao N, Zhang Z, Wang Q, Li L, Wei Z, Chen H, Zhou M, Liu Z, Su J
EBioMedicine 2023 Oct;96:104801

Discovery of dual PARP and CDK6 inhibitors for triple-negative breast cancer with wild-type BRCA.

Wang C, Luo H, Chen X, Zhang Y, Lu D, Liu X, Yin F, Li S, Kong L, Wang X
Bioorganic chemistry 2023 Oct;139:106683

Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51.

Tao L, Zhou Y, Pan X, Luo Y, Qiu J, Zhou X, Chen Z, Li Y, Xu L, Zhou Y, Zuo Z, Liu C, Wang L, Liu X, Tian X, Su N, Yang Z, Zhang Y, Gou K, Sang N, Liu H, Zou J, Xiao Y, Zhong X, Xu J, Yang X, Xiao K, Liu Y, Yang S, Peng Y, Han J, Cen X, Zhao Y
Nature communications 2023 Nov 16;14(1):7430

Identification of a luminescent platinum(II) complex with BODIPY derivative as novel photodynamic therapy agent for triple negative breast cancer cells.

Wang Y, Wang S, Wang Q, Tang W, Lin L, Zhang T, Hu M, Wang X
Journal of inorganic biochemistry 2023 May;242:112160

HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression.

Refaat AM, Nakata M, Husain A, Kosako H, Honjo T, Begum NA
Cell reports 2023 Mar 28;42(3):112284

Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.

Wei Y, Xiao G, Xu H, Sun X, Shi Y, Wang F, Kang J, Peng J, Zhou F
The FEBS journal 2023 Jul;290(14):3629-3645

GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner.

Shi M, Hou J, Liang W, Li Q, Shao S, Ci S, Shu C, Zhao X, Zhao S, Huang M, Wu C, Hu Z, He L, Guo Z, Pan F
EMBO reports 2023 Aug 3;24(8):e56437

Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.

Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486

Inhibition of PKM2 Enhances Sensitivity of Olaparib to Ovarian Cancer Cells and Induces DNA Damage.

Zhou S, Li D, Xiao D, Wu T, Hu X, Zhang Y, Deng J, Long J, Xu S, Wu J, Li G, Peng M, Yang X
International journal of biological sciences 2022;18(4):1555-1568

Increased co-expression of MEST and BRCA1 is associated with worse prognosis and immune infiltration in ovarian cancer.

Zhang J, Yu S, Li Q, Wang Q, Zhang J
Gynecologic oncology 2022 Mar;164(3):566-576

A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.

Zhao J, Tian S, Guo Q, Bao K, Yu G, Wang X, Shen X, Zhang J, Chen J, Yang Y, Liu L, Li X, Hao J, Yang N, Liu Z, Ai D, Yang J, Zhu Y, Yao Z, Ma S, Zhang K, Shi L
Molecular cell 2022 Jul 21;82(14):2571-2587.e9

FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathways.

Wu SQ, Huang SH, Lin QW, Tang YX, Huang L, Xu YG, Wang SP
Pharmacological research 2022 Jan;175:106040

Chemotherapeutic drugs induce oxidative stress associated with DNA repair and metabolism modulation.

Zhang Y, Ding C, Zhu W, Li X, Chen T, Liu Q, Zhou S, Zhang TC, Ma W
Life sciences 2022 Jan 15;289:120242

Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer.

Xue W, Li X, Li W, Wang Y, Jiang C, Zhou L, Gao J, Yu Y, Shen Y, Xu Q
Signal transduction and targeted therapy 2022 Feb 4;7(1):35

CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition.

Zhang T, Wu DM, Luo PW, Liu T, Han R, Deng SH, He M, Zhao YY, Xu Y
Cell death & disease 2022 Feb 21;13(2):167

Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.

Zhang X, Li T, Yang M, Du Q, Wang R, Fu B, Tan Y, Cao M, Chen Y, Wang Q, Hu R
Cell death & disease 2022 Feb 10;13(2):138

Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway.

Xu Y, Zhang L, Wang Q, Zheng M
Cellular signalling 2022 Apr;92:110273

Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stability.

Cao C, Han P, Liu L, Tang Y, Tian S, Zhang K, Shi L, Liu Z, Zhuo D, Ge W, Gong W
The Journal of biological chemistry 2021 Sep;297(3):101036

Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.

Wang C, Qu L, Li S, Yin F, Ji L, Peng W, Luo H, Lu D, Liu X, Chen X, Kong L, Wang X
Journal of medicinal chemistry 2021 Sep 9;64(17):12630-12650

Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production.

Zhou S, Liu Y, Jin L, Guo P, Liu Q, Shan J, Luo X, He H, Ma W, Zhang T
The Journal of steroid biochemistry and molecular biology 2021 May;209:105853

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.

McMahon KA, Stroud DA, Gambin Y, Tillu V, Bastiani M, Sierecki E, Polinkovsky ME, Hall TE, Gomez GA, Wu Y, Parat MO, Martel N, Lo HP, Khanna KK, Alexandrov K, Daly R, Yap A, Ryan MT, Parton RG
eLife 2021 Jun 18;10

FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair.

Wang SP, Wu SQ, Huang SH, Tang YX, Meng LQ, Liu F, Zhu QH, Xu YG
Cell death & disease 2021 Dec 8;12(12):1138

Slowly Repaired Bulky DNA Damages Modulate Cellular Redox Environment Leading to Premature Senescence.

Zhang Y, Guo P, Xiang W, Liu Q, Liu X, Ma N, Zhou S, He H, Wlaschek M, Scharffetter-Kochanek K, Zhang TC, Ma W
Oxidative medicine and cellular longevity 2020;2020:5367102

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.

Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222

BRCA1 protects cardiac microvascular endothelial cells against irradiation by regulating p21-mediated cell cycle arrest.

Zeng ZM, Du HY, Xiong L, Zeng XL, Zhang P, Cai J, Huang L, Liu AW
Life sciences 2020 Mar 1;244:117342

USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.

Ting X, Xia L, Yang J, He L, Si W, Shang Y, Sun L
Nucleic acids research 2019 Oct 10;47(18):9721-9740

Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity.

Li S, Wei Y
Oncology letters 2018 Jun;15(6):9572-9576

PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.

Bian X, Gao J, Luo F, Rui C, Zheng T, Wang D, Wang Y, Roberts TM, Liu P, Zhao JJ, Cheng H
Oncogene 2018 Jan 18;37(3):341-351

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.

Li L, Shi L, Yang S, Yan R, Zhang D, Yang J, He L, Li W, Yi X, Sun L, Liang J, Cheng Z, Shi L, Shang Y, Yu W
Nature communications 2016 Jul 20;7:12235

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 22362-1-AP( BRCA1 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The BRCA1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human BRCA1. This antibody recognizes human antigen. The BRCA1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 22362-1-AP.pdf

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