Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 22362-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- BRCA1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BRCA1 antibody (Cat. #22362-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stability.
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.
Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production.
Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.
FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair.
Slowly Repaired Bulky DNA Damages Modulate Cellular Redox Environment Leading to Premature Senescence.
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
BRCA1 protects cardiac microvascular endothelial cells against irradiation by regulating p21-mediated cell cycle arrest.
USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.
Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity.
PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.
Cao C, Han P, Liu L, Tang Y, Tian S, Zhang K, Shi L, Liu Z, Zhuo D, Ge W, Gong W
The Journal of biological chemistry 2021 Sep;297(3):101036
The Journal of biological chemistry 2021 Sep;297(3):101036
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.
Wang C, Qu L, Li S, Yin F, Ji L, Peng W, Luo H, Lu D, Liu X, Chen X, Kong L, Wang X
Journal of medicinal chemistry 2021 Sep 9;64(17):12630-12650
Journal of medicinal chemistry 2021 Sep 9;64(17):12630-12650
Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production.
Zhou S, Liu Y, Jin L, Guo P, Liu Q, Shan J, Luo X, He H, Ma W, Zhang T
The Journal of steroid biochemistry and molecular biology 2021 May;209:105853
The Journal of steroid biochemistry and molecular biology 2021 May;209:105853
Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.
McMahon KA, Stroud DA, Gambin Y, Tillu V, Bastiani M, Sierecki E, Polinkovsky ME, Hall TE, Gomez GA, Wu Y, Parat MO, Martel N, Lo HP, Khanna KK, Alexandrov K, Daly R, Yap A, Ryan MT, Parton RG
eLife 2021 Jun 18;10
eLife 2021 Jun 18;10
FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair.
Wang SP, Wu SQ, Huang SH, Tang YX, Meng LQ, Liu F, Zhu QH, Xu YG
Cell death & disease 2021 Dec 8;12(12):1138
Cell death & disease 2021 Dec 8;12(12):1138
Slowly Repaired Bulky DNA Damages Modulate Cellular Redox Environment Leading to Premature Senescence.
Zhang Y, Guo P, Xiang W, Liu Q, Liu X, Ma N, Zhou S, He H, Wlaschek M, Scharffetter-Kochanek K, Zhang TC, Ma W
Oxidative medicine and cellular longevity 2020;2020:5367102
Oxidative medicine and cellular longevity 2020;2020:5367102
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
BRCA1 protects cardiac microvascular endothelial cells against irradiation by regulating p21-mediated cell cycle arrest.
Zeng ZM, Du HY, Xiong L, Zeng XL, Zhang P, Cai J, Huang L, Liu AW
Life sciences 2020 Mar 1;244:117342
Life sciences 2020 Mar 1;244:117342
USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.
Ting X, Xia L, Yang J, He L, Si W, Shang Y, Sun L
Nucleic acids research 2019 Oct 10;47(18):9721-9740
Nucleic acids research 2019 Oct 10;47(18):9721-9740
Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity.
Li S, Wei Y
Oncology letters 2018 Jun;15(6):9572-9576
Oncology letters 2018 Jun;15(6):9572-9576
PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.
Bian X, Gao J, Luo F, Rui C, Zheng T, Wang D, Wang Y, Roberts TM, Liu P, Zhao JJ, Cheng H
Oncogene 2018 Jan 18;37(3):341-351
Oncogene 2018 Jan 18;37(3):341-351
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.
Li L, Shi L, Yang S, Yan R, Zhang D, Yang J, He L, Li W, Yi X, Sun L, Liang J, Cheng Z, Shi L, Shang Y, Yu W
Nature communications 2016 Jul 20;7:12235
Nature communications 2016 Jul 20;7:12235
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 22362-1-AP( BRCA1 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BRCA1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human BRCA1. This antibody recognizes human antigen. The BRCA1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.