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- Antibody Data
- Antigen structure
- References [16]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 20649-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20649-1-AP, RRID:AB_10697668
- Product name
- BRCA1 antibody
- Antibody type
- Polyclonal
- Description
- BRCA1 antibody (Cat. #20649-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references RBM14 promotes DNA end resection during homologous recombination repair.
Comparison of DNA stability and its related genes of neurons derived from induced pluripotent stem cells and primary retinal neurons.
Brca1 Is Regulated by the Transcription Factor Gata3, and Its Silencing Promotes Neural Differentiation in Retinal Neurons.
Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1.
N6-methyladenosine regulates ATM expression and downstream signaling.
WNT inhibition creates a BRCA-like state in Wnt-addicted cancer.
Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1.
RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer.
Noncoding RNA Ginir functions as an oncogene by associating with centrosomal proteins.
Brca1 Is Upregulated by 5-Aza-CdR and Promotes DNA Repair and Cell Survival, and Inhibits Neurite Outgrowth in Rat Retinal Neurons.
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening.
Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair.
Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Li Z, Liao Y, Tang C, Xu L, Peng B, Xu X
Acta biochimica et biophysica Sinica 2023 Dec 25;55(12):1864-1873
Acta biochimica et biophysica Sinica 2023 Dec 25;55(12):1864-1873
Comparison of DNA stability and its related genes of neurons derived from induced pluripotent stem cells and primary retinal neurons.
Yu N, Qiu J, Li K, Luo Q, Liu X, Yang Y, Jiang Z, He S, He A, Chen S, Chen X, Li Y, Ge J, Zhuang J, Yu K
Cell biology international 2022 Oct;46(10):1625-1636
Cell biology international 2022 Oct;46(10):1625-1636
Brca1 Is Regulated by the Transcription Factor Gata3, and Its Silencing Promotes Neural Differentiation in Retinal Neurons.
Zhuang J, Chen P, Wu Y, Luo Q, Wang Q, Chen S, Chen X, Jiang Z, Qiu J, Li Y, Yuan Z, Zhuang J
International journal of molecular sciences 2022 Nov 10;23(22)
International journal of molecular sciences 2022 Nov 10;23(22)
Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1.
Zeng F, Peng Y, Qin Y, Wang J, Jiang G, Feng W, Yuan Y
Cell communication and signaling : CCS 2022 Dec 27;20(1):199
Cell communication and signaling : CCS 2022 Dec 27;20(1):199
N6-methyladenosine regulates ATM expression and downstream signaling.
Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051
Journal of Cancer 2021;12(23):7041-7051
WNT inhibition creates a BRCA-like state in Wnt-addicted cancer.
Kaur A, Lim JYS, Sepramaniam S, Patnaik S, Harmston N, Lee MA, Petretto E, Virshup DM, Madan B
EMBO molecular medicine 2021 Apr 9;13(4):e13349
EMBO molecular medicine 2021 Apr 9;13(4):e13349
Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1.
Xiao M, Guo J, Xie L, Yang C, Gong L, Wang Z, Cai J
Molecular cancer research : MCR 2020 Mar;18(3):436-447
Molecular cancer research : MCR 2020 Mar;18(3):436-447
RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer.
Yu Y, Chen L, Zhao G, Li H, Guo Q, Zhu S, Li P, Min L, Zhang S
Oncogene 2020 Feb;39(6):1273-1289
Oncogene 2020 Feb;39(6):1273-1289
Noncoding RNA Ginir functions as an oncogene by associating with centrosomal proteins.
Panda S, Setia M, Kaur N, Shepal V, Arora V, Singh DK, Mondal A, Teli A, Tathode M, Gajula R, Padhy LC, Shiras A
PLoS biology 2018 Oct;16(10):e2004204
PLoS biology 2018 Oct;16(10):e2004204
Brca1 Is Upregulated by 5-Aza-CdR and Promotes DNA Repair and Cell Survival, and Inhibits Neurite Outgrowth in Rat Retinal Neurons.
Wang Q, Xu L, Chen P, Xu Z, Qiu J, Ge J, Yu K, Zhuang J
International journal of molecular sciences 2018 Apr 17;19(4)
International journal of molecular sciences 2018 Apr 17;19(4)
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Dai C, Lei L, Li B, Lin Y, Xiao X, Tang S
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening.
Zhou S, Xiao Y, Zhuang Y, Liu Y, Zhao H, Yang H, Xie C, Zhou F, Zhou Y
Oncology reports 2017 Jul;38(1):515-521
Oncology reports 2017 Jul;38(1):515-521
Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair.
Xiao M, Cai J, Cai L, Jia J, Xie L, Zhu Y, Huang B, Jin D, Wang Z
Journal of ovarian research 2017 Apr 4;10(1):24
Journal of ovarian research 2017 Apr 4;10(1):24
Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.
Wang D, Li C, Zhang Y, Wang M, Jiang N, Xiang L, Li T, Roberts TM, Zhao JJ, Cheng H, Liu P
Gynecologic oncology 2016 Sep;142(3):548-56
Gynecologic oncology 2016 Sep;142(3):548-56
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Gao X, Wang W, Yang H, Wu L, He Z, Zhou S, Zhao H, Fu Z, Zhou F, Zhou Y
Oncotarget 2016 May 31;7(22):32543-53
Oncotarget 2016 May 31;7(22):32543-53
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Wang D, Wang M, Jiang N, Zhang Y, Bian X, Wang X, Roberts TM, Zhao JJ, Liu P, Cheng H
Oncotarget 2016 Mar 15;7(11):13153-66
Oncotarget 2016 Mar 15;7(11):13153-66
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human testis tissue were subjected to SDS PAGE followed by western blot with 20649-1-AP(BRCA1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 20649-1-AP(BRCA1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BRCA1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human BRCA1. This antibody recognizes human, mouse, rat antigen. The BRCA1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
