BS6423

antibody from Bioworld Technology, Inc
Targeting: BRCA1 BRCC1, FANCS, PPP1R53, RNF53
Provider product page for BS6423
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6423 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BRCA1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human BRCA1.
Description
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BRCA1 protein structure - BS6423 shown in red.