20877-1-AP

antibody from Proteintech Group

Targeting: PRKCE

Provider product page for 20877-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [25]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 20877-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20877-1-AP, RRID:AB_10697812
Product name: PKC Epsilon antibody
Antibody type: Polyclonal
Description: KD/KO validated PKC Epsilon antibody (Cat. #20877-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PRKCE protein structure - 20877-1-AP shown in red.

Submitted references Deletion of the SHORT Syndrome Gene Prkce Results in Brain Atrophy and Cognitive and Motor Behavior Deficits in Mice.

Bao YL, Duan WP, Yang Y, Lin Z, Shen Y, Zheng R, Wang XT
Neuroscience bulletin 2026 May;42(5):976-988

GPER Enhances Chronic Burn Pain via PKC-Mediated Mu-Opioid Receptor Phosphorylation in the Rostral Ventromedial Medulla.

Zhu X, Zhang Y, Zhang Q, Zhang Z
Journal of pain research 2025;18:3859-3878

Desmoplakin loss leads to PKC-dependent insertion of series sarcomeres and contractile dysfunction in cardiomyocytes.

Gokhan I, Li X, Sendek JM, Mora Pagan AJ, Akar FG, Campbell SG
bioRxiv : the preprint server for biology 2025 May 19;

Roles for PKC signaling in chromaffin cell exocytosis.

Chen X, Bell NA, Coffman BL, Giovannucci DR, Anantharam A
Biophysical journal 2025 Jun 3;124(11):1785-1797

Combining metabolomics and network pharmacology to investigate the protective effect of Jiawei Xinglou Chengqi Granules in ischemic stroke.

Wang R, Mao L, Liang P, Gan Y, Gao Q, Liang S, Zhang D, Luo G, Yang S
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2024;57:e13388

Reduction of TRPV1 expression on neurons due to downregulation of P2X7R in neonatal rat dorsal root ganglion satellite glial cells under co-culture conditions.

Wang H, Chen L, Xing J, Shi X, Xu C
Biology of the cell 2024 Oct;116(10):e2400021

Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence.

Fox ME, Wulff AB, Franco D, Choi EY, Calarco CA, Engeln M, Turner MD, Chandra R, Rhodes VM, Thompson SM, Ament SA, Lobo MK
Biological psychiatry 2023 Mar 15;93(6):489-501

Thromboxane A(2)-TP axis promotes adipose tissue macrophages M1 polarization leading to insulin resistance in obesity.

Xu R, Dai Y, Zheng X, Yan Y, He Z, Zhang H, Li H, Chen W
Biochemical pharmacology 2023 Apr;210:115465

cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning.

Wang XT, Zhou L, Dong BB, Xu FX, Wang DJ, Shen EW, Cai XY, Wang Y, Wang N, Ji SJ, Chen W, Schonewille M, Zhu JJ, De Zeeuw CI, Shen Y
eLife 2023 Apr 26;12

PKC signal amplification suppresses non-small cell lung cancer growth by promoting p21 expression and phosphorylation.

Liu S, Zhang Y, Yang Q, Zhang Y, Liu H, Huang MH, Wang R, Lu F
Heliyon 2022 Sep;8(9):e10657

Silencing P2X7R Alleviates Diabetic Neuropathic Pain Involving TRPV1 via PKCε/P38MAPK/NF-κB Signaling Pathway in Rats.

Chen L, Wang H, Xing J, Shi X, Huang H, Huang J, Xu C
International journal of molecular sciences 2022 Nov 16;23(22)

In vivo study of a novel protein kinase C that mediates immunocompetence and catecholamine biosynthesis in hemocytes of Litopenaeus vannamei by using its potential competitive inhibitor, bisindolylmaleimide I.

Chang ZW, Chang CC
Fish & shellfish immunology 2022 Mar;122:87-97

Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.

Li R, Qi Y, Yuan Q, Xu L, Gao M, Xu Y, Han X, Yin L, Liu C
European journal of pharmacology 2021 Sep 15;907:174277

LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.

Su X, Wei J, Qi H, Jin M, Zhang Q, Zhang Y, Zhang C, Yang R
Inflammatory bowel diseases 2021 Jul 27;27(8):1302-1315

Delta Opioid Receptor Activation with Delta Opioid Peptide [d-Ala2, d-Leu5] Enkephalin Contributes to Synaptic Improvement in Rat Hippocampus against Global Ischemia.

Zhang G, Lai Z, Gu L, Xu K, Wang Z, Duan Y, Chen H, Zhang M, Zhang J, Zhao Z, Wang S
Cell transplantation 2021 Jan-Dec;30:9636897211041585

PKCε SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain.

Zhao X, Xia B, Cheng J, Zhu MX, Li Y
Cell reports 2020 Oct 6;33(1):108191

Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.

Liu YC, Tsai JJ, Weng YS, Hsu FT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319

Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.

Liu P, Li Y, Qi X, Xu J, Liu D, Ji X, Chi T, Liu H, Zou L
Journal of cellular and molecular medicine 2019 Sep;23(9):6343-6354

Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.

Dąbrowska K, Zielińska M
International journal of molecular sciences 2019 Jan 9;20(2)

Phosphorylation of ELAVL1 (Ser219/Ser316) mediated by PKC is required for erythropoiesis.

Zhou X, Wang S, Zheng M, Kuver A, Wan X, Dai K, Li X
Biochimica et biophysica acta. Molecular cell research 2019 Feb;1866(2):214-224

p66Shc Mediates Mitochondrial Dysfunction Dependent on PKC Activation in Airway Epithelial Cells Induced by Cigarette Smoke.

Zhang M, Tang J, Shan H, Zhang Q, Yang X, Zhang J, Li Y
Oxidative medicine and cellular longevity 2018;2018:5837123

Chronic stress causes protein kinase C epsilon-aldehyde dehydrogenase 2 signaling pathway perturbation in the rat hippocampus and prefrontal cortex, but not in the myocardium.

Zhang WY, Wang KY, Li YJ, Li YR, Lu RZ
Neural regeneration research 2018 Jul;13(7):1225-1230

Berberine alleviates hepatic lipid accumulation by increasing ABCA1 through the protein kinase C δ pathway.

Liang H, Wang Y
Biochemical and biophysical research communications 2018 Apr 6;498(3):473-480

Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.

Hu Y, Tao X, Han X, Xu L, Yin L, Qi Y, Zhao Y, Xu Y, Wang C, Peng J
Chemico-biological interactions 2016 Oct 25;258:234-44

MiR-34a regulates blood-tumor barrier function by targeting protein kinase Cε.

Zhao W, Wang P, Ma J, Liu YH, Li Z, Li ZQ, Wang ZH, Chen LY, Xue YX
Molecular biology of the cell 2015 May 15;26(10):1786-96

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 20877-1-AP(PRKCE antibody) at dilution of 1:800
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human thyroid cancer using 20877-1-AP(PRKCE antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PKC epsilon antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PKC epsilon. This antibody recognizes human,mouse,rat antigen. The PKC epsilon antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 20877-1-AP.pdf

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