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- References [18]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 20877-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20877-1-AP, RRID:AB_10697812
- Product name
- PKC Epsilon antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PKC Epsilon antibody (Cat. #20877-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Thromboxane A(2)-TP axis promotes adipose tissue macrophages M1 polarization leading to insulin resistance in obesity.
cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning.
PKC signal amplification suppresses non-small cell lung cancer growth by promoting p21 expression and phosphorylation.
Silencing P2X7R Alleviates Diabetic Neuropathic Pain Involving TRPV1 via PKCε/P38MAPK/NF-κB Signaling Pathway in Rats.
In vivo study of a novel protein kinase C that mediates immunocompetence and catecholamine biosynthesis in hemocytes of Litopenaeus vannamei by using its potential competitive inhibitor, bisindolylmaleimide I.
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.
Delta Opioid Receptor Activation with Delta Opioid Peptide [d-Ala2, d-Leu5] Enkephalin Contributes to Synaptic Improvement in Rat Hippocampus against Global Ischemia.
PKCε SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain.
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.
Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.
Phosphorylation of ELAVL1 (Ser219/Ser316) mediated by PKC is required for erythropoiesis.
p66Shc Mediates Mitochondrial Dysfunction Dependent on PKC Activation in Airway Epithelial Cells Induced by Cigarette Smoke.
Chronic stress causes protein kinase C epsilon-aldehyde dehydrogenase 2 signaling pathway perturbation in the rat hippocampus and prefrontal cortex, but not in the myocardium.
Berberine alleviates hepatic lipid accumulation by increasing ABCA1 through the protein kinase C δ pathway.
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
MiR-34a regulates blood-tumor barrier function by targeting protein kinase Cε.
Xu R, Dai Y, Zheng X, Yan Y, He Z, Zhang H, Li H, Chen W
Biochemical pharmacology 2023 Apr;210:115465
Biochemical pharmacology 2023 Apr;210:115465
cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning.
Wang XT, Zhou L, Dong BB, Xu FX, Wang DJ, Shen EW, Cai XY, Wang Y, Wang N, Ji SJ, Chen W, Schonewille M, Zhu JJ, De Zeeuw CI, Shen Y
eLife 2023 Apr 26;12
eLife 2023 Apr 26;12
PKC signal amplification suppresses non-small cell lung cancer growth by promoting p21 expression and phosphorylation.
Liu S, Zhang Y, Yang Q, Zhang Y, Liu H, Huang MH, Wang R, Lu F
Heliyon 2022 Sep;8(9):e10657
Heliyon 2022 Sep;8(9):e10657
Silencing P2X7R Alleviates Diabetic Neuropathic Pain Involving TRPV1 via PKCε/P38MAPK/NF-κB Signaling Pathway in Rats.
Chen L, Wang H, Xing J, Shi X, Huang H, Huang J, Xu C
International journal of molecular sciences 2022 Nov 16;23(22)
International journal of molecular sciences 2022 Nov 16;23(22)
In vivo study of a novel protein kinase C that mediates immunocompetence and catecholamine biosynthesis in hemocytes of Litopenaeus vannamei by using its potential competitive inhibitor, bisindolylmaleimide I.
Chang ZW, Chang CC
Fish & shellfish immunology 2022 Mar;122:87-97
Fish & shellfish immunology 2022 Mar;122:87-97
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
Li R, Qi Y, Yuan Q, Xu L, Gao M, Xu Y, Han X, Yin L, Liu C
European journal of pharmacology 2021 Sep 15;907:174277
European journal of pharmacology 2021 Sep 15;907:174277
LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.
Su X, Wei J, Qi H, Jin M, Zhang Q, Zhang Y, Zhang C, Yang R
Inflammatory bowel diseases 2021 Jul 27;27(8):1302-1315
Inflammatory bowel diseases 2021 Jul 27;27(8):1302-1315
Delta Opioid Receptor Activation with Delta Opioid Peptide [d-Ala2, d-Leu5] Enkephalin Contributes to Synaptic Improvement in Rat Hippocampus against Global Ischemia.
Zhang G, Lai Z, Gu L, Xu K, Wang Z, Duan Y, Chen H, Zhang M, Zhang J, Zhao Z, Wang S
Cell transplantation 2021 Jan-Dec;30:9636897211041585
Cell transplantation 2021 Jan-Dec;30:9636897211041585
PKCε SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain.
Zhao X, Xia B, Cheng J, Zhu MX, Li Y
Cell reports 2020 Oct 6;33(1):108191
Cell reports 2020 Oct 6;33(1):108191
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Liu YC, Tsai JJ, Weng YS, Hsu FT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.
Liu P, Li Y, Qi X, Xu J, Liu D, Ji X, Chi T, Liu H, Zou L
Journal of cellular and molecular medicine 2019 Sep;23(9):6343-6354
Journal of cellular and molecular medicine 2019 Sep;23(9):6343-6354
Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.
Dąbrowska K, Zielińska M
International journal of molecular sciences 2019 Jan 9;20(2)
International journal of molecular sciences 2019 Jan 9;20(2)
Phosphorylation of ELAVL1 (Ser219/Ser316) mediated by PKC is required for erythropoiesis.
Zhou X, Wang S, Zheng M, Kuver A, Wan X, Dai K, Li X
Biochimica et biophysica acta. Molecular cell research 2019 Feb;1866(2):214-224
Biochimica et biophysica acta. Molecular cell research 2019 Feb;1866(2):214-224
p66Shc Mediates Mitochondrial Dysfunction Dependent on PKC Activation in Airway Epithelial Cells Induced by Cigarette Smoke.
Zhang M, Tang J, Shan H, Zhang Q, Yang X, Zhang J, Li Y
Oxidative medicine and cellular longevity 2018;2018:5837123
Oxidative medicine and cellular longevity 2018;2018:5837123
Chronic stress causes protein kinase C epsilon-aldehyde dehydrogenase 2 signaling pathway perturbation in the rat hippocampus and prefrontal cortex, but not in the myocardium.
Zhang WY, Wang KY, Li YJ, Li YR, Lu RZ
Neural regeneration research 2018 Jul;13(7):1225-1230
Neural regeneration research 2018 Jul;13(7):1225-1230
Berberine alleviates hepatic lipid accumulation by increasing ABCA1 through the protein kinase C δ pathway.
Liang H, Wang Y
Biochemical and biophysical research communications 2018 Apr 6;498(3):473-480
Biochemical and biophysical research communications 2018 Apr 6;498(3):473-480
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
Hu Y, Tao X, Han X, Xu L, Yin L, Qi Y, Zhao Y, Xu Y, Wang C, Peng J
Chemico-biological interactions 2016 Oct 25;258:234-44
Chemico-biological interactions 2016 Oct 25;258:234-44
MiR-34a regulates blood-tumor barrier function by targeting protein kinase Cε.
Zhao W, Wang P, Ma J, Liu YH, Li Z, Li ZQ, Wang ZH, Chen LY, Xue YX
Molecular biology of the cell 2015 May 15;26(10):1786-96
Molecular biology of the cell 2015 May 15;26(10):1786-96
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 20877-1-AP(PRKCE antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human thyroid cancer using 20877-1-AP(PRKCE antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PKC epsilon antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PKC epsilon. This antibody recognizes human,mouse,rat antigen. The PKC epsilon antibody has been validated for the following applications: ELISA, WB, IHC analysis.
