15323-1-AP

antibody from Proteintech Group

Targeting: STT3B FLJ90106, SIMP, STT3-B

Provider product page for 15323-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [26]
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Validations
Western blot [1]

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Product number: 15323-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15323-1-AP, RRID:AB_2198046
Product name: STT3B antibody
Antibody type: Polyclonal
Description: KD/KO validated STT3B antibody (Cat. #15323-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

STT3B protein structure - 15323-1-AP shown in red.

Submitted references HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis.

Han W, Chen H, Cui B, Chen J, Zhang P, Feng Y
Molecular medicine reports 2026 Mar;33(3)

Structural basis of regulated N-glycosylation at the secretory translocon.

Yamsek M, Ma M, Jha R, Wan Y, Li Q, Zhong F, DeLong K, Ji Z, Rohatgi R, Keenan RJ
Nature 2026 Jan;649(8097):777-784

Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions.

Beauchemin KS, Kun J, Groveman B, Williams K, Salerno F, Francomacaro LM, Robison P, Haigh CL, Supattapone S
PLoS pathogens 2026 Jan;22(1):e1013867

Integrated screening identifies GPR31 as a key driver and druggable target for metabolic dysfunction-associated steatohepatitis.

Zhang XJ, Fu J, Cheng X, Shen H, Yang H, Wang K, Li W, Tian H, Tian T, Zhou J, Tian S, Wang Z, Wan J, Bai L, Duan H, Zhang X, Tian R, Xu H, Liao R, Zou T, Shi J, Qu W, Fang L, Cai J, Zhang P, She ZG, Jiang J, Hu Y, Wang Y, Li H
The Journal of clinical investigation 2025 Sep 2;135(17)

Unveiling the Role of Oligosaccharyltransferase STT3B in Colorectal Cancer Tissues: Clinical significance and Molecular Mechanisms Driving the Formation of Tertiary Lymphoid Structures.

Zhang C, Wang B, Bian X, Zhao Y, Yang X, Zhao W
Immunobiology 2025 May;230(3):152886

STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein.

Zhu H, Lou J, Yang Z, Bai J, Jiang P, Wang X, Liu X
Journal of virology 2025 Mar 18;99(3):e0001825

N-glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer.

Xiong N, Du Y, Huang C, Yan Q, Zhao L, Yang C, Sun Q, Gao Z, Wang C, Zhan J, Zhang H, Wang S, Ye Y, Li Y, Shen Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2411740

Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation.

Wang S, Li W, Wen J, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM
mBio 2025 Dec 10;16(12):e0293025

STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer.

Wang J, Zhang HM, Zhu GH, Zhao LL, Shi J, Dai ZT, Li JP, Li XR, Sun F, Wu Y, Chen SY, Li HN, Liao XH, Xiang Y
Acta pharmacologica Sinica 2025 Apr;46(4):1097-1110

Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation.

Wang S, Li W, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM
bioRxiv : the preprint server for biology 2024 May 3;

Proteomic profiling of FFPE specimens: Discovery of HNRNPA2/B1 and STT3B as biomarkers for determining formalin fixation durations.

Kobayashi G, Ito R, Taga M, Koyama K, Yano S, Endo T, Kai T, Yamamoto T, Hiratsuka T, Tsuruyama T
Journal of proteomics 2024 Jun 15;301:105196

Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma.

Xu S, Wang H, Zhu Y, Han Y, Liu L, Zhang X, Hu J, Zhang W, Duan S, Deng J, Zhang Z, Liu S
International journal of oral science 2024 Jul 1;16(1):47

MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning.

Wang Q, Su Y, Sun R, Xiong X, Guo K, Wei M, Yang G, Ru Y, Zhang Z, Li J, Zhang J, Qiao Q, Li X
Cell & bioscience 2024 Jan 20;14(1):12

STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1.

Song D, Jia X, Gao Y, Xiao T, Dan J, Shen R, Cai J, Liang J, Zhu W, Hu J, Yan G, Zhang Q, Lin Y
Oncogene 2023 Nov;42(48):3575-3588

Signal recognition particle receptor-β (SR-β) coordinates cotranslational N-glycosylation.

Phoomak C, Rinis N, Baro M, Shrimal S, Bennett D, Shaffer SA, Lehrman M, Gilmore R, Contessa JN
Science advances 2023 Mar 17;9(11):eade8079

MITA oligomerization upon viral infection is dependent on its N-glycosylation mediated by DDOST.

Tu Y, Yin XJ, Liu Q, Zhang S, Wang J, Ji BZ, Zhang J, Sun MS, Yang Y, Wang CH, Yin L, Liu Y
PLoS pathogens 2022 Nov;18(11):e1010989

Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis.

Wright MT, Kouba L, Plate L
Molecular & cellular proteomics : MCP 2021;20:100008

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro.

Huang HC, Lai YJ, Liao CC, Yang WF, Huang KB, Lee IJ, Chou WC, Wang SH, Wang LH, Hsu JM, Sun CP, Kuo CT, Wang J, Hsiao TC, Yang PJ, Lee TA, Huang W, Li FA, Shen CY, Lin YL, Tao MH, Li CW
EBioMedicine 2021 Dec;74:103712

N-Glycosylation Regulates Chitinase 3-like-1 and IL-13 Ligand Binding to IL-13 Receptor α2.

He CH, Lee CG, Ma B, Kamle S, Choi AMK, Elias JA
American journal of respiratory cell and molecular biology 2020 Sep;63(3):386-395

Comparative proteomic analyses of Duchenne muscular dystrophy and Becker muscular dystrophy muscles: changes contributing to preserve muscle function in Becker muscular dystrophy patients.

Capitanio D, Moriggi M, Torretta E, Barbacini P, De Palma S, Viganò A, Lochmüller H, Muntoni F, Ferlini A, Mora M, Gelfi C
Journal of cachexia, sarcopenia and muscle 2020 Apr;11(2):547-563

Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.

Rinis N, Golden JE, Marceau CD, Carette JE, Van Zandt MC, Gilmore R, Contessa JN
Cell chemical biology 2018 Oct 18;25(10):1231-1241.e4

Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex.

Lin DL, Cherepanova NA, Bozzacco L, MacDonald MR, Gilmore R, Tai AW
mBio 2017 Jul 18;8(4)

TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans.

Capitanio D, Fania C, Torretta E, Viganò A, Moriggi M, Bravatà V, Caretti A, Levett DZH, Grocott MPW, Samaja M, Cerretelli P, Gelfi C
Scientific reports 2017 Aug 29;7(1):9723

Changes in cellular glycosylation of leukemia cells upon treatment with acridone derivatives yield insight into drug action.

Wang Y, Park D, Galermo AG, Gao D, Liu H, Lebrilla CB
Proteomics 2016 Dec;16(23):2977-2988

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.

Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN
Nature chemical biology 2016 Dec;12(12):1023-1030

TUSC3 loss alters the ER stress response and accelerates prostate cancer growth in vivo.

Horak P, Tomasich E, Vaňhara P, Kratochvílová K, Anees M, Marhold M, Lemberger CE, Gerschpacher M, Horvat R, Sibilia M, Pils D, Krainer M
Scientific reports 2014 Jan 17;4:3739

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The STT3B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human STT3B. This antibody recognizes human, mouse, rat antigen. The STT3B antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 15323-1-AP.pdf

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