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- References [17]
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- Product number
- 16735-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16735-1-AP, RRID:AB_2180166
- Product name
- MRPS16 antibody
- Antibody type
- Polyclonal
- Description
- MRPS16 antibody (Cat. #16735-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tetracycline-dependent inhibition of mitoribosome protein elongation in mitochondrial disease mutant cells suppresses IRE1α to promote cell survival.
Multi-omics identifies large mitoribosomal subunit instability caused by pathogenic MRPL39 variants as a cause of pediatric onset mitochondrial disease.
Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan.
Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.
Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis.
MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.
Fidelity of translation initiation is required for coordinated respiratory complex assembly.
Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation.
The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.
Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z.
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.
Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice.
Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.
Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction.
Ronayne CT, Bennett CF, Perry EA, Kantorovich N, Puigserver P
bioRxiv : the preprint server for biology 2023 Mar 21;
bioRxiv : the preprint server for biology 2023 Mar 21;
Multi-omics identifies large mitoribosomal subunit instability caused by pathogenic MRPL39 variants as a cause of pediatric onset mitochondrial disease.
Amarasekera SSC, Hock DH, Lake NJ, Calvo SE, Grønborg SW, Krzesinski EI, Amor DJ, Fahey MC, Simons C, Wibrand F, Mootha VK, Lek M, Lunke S, Stark Z, Østergaard E, Christodoulou J, Thorburn DR, Stroud DA, Compton AG
Human molecular genetics 2023 Jul 20;32(15):2441-2454
Human molecular genetics 2023 Jul 20;32(15):2441-2454
Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival.
Ronayne CT, Jackson TD, Bennett CF, Perry EA, Kantorovic N, Puigserver P
EMBO reports 2023 Dec 6;24(12):e57228
EMBO reports 2023 Dec 6;24(12):e57228
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan.
Richman TR, Ermer JA, Siira SJ, Kuznetsova I, Brosnan CA, Rossetti G, Baker J, Perks KL, Cserne Szappanos H, Viola HM, Gray N, Larance M, Hool LC, Zuryn S, Rackham O, Filipovska A
Aging cell 2021 Jul;20(7):e13408
Aging cell 2021 Jul;20(7):e13408
Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.
Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P
eLife 2021 Dec 31;10
eLife 2021 Dec 31;10
Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis.
Lee RG, Gao J, Siira SJ, Shearwood AM, Ermer JA, Hofferek V, Mathews JC, Zheng M, Reid GE, Rackham O, Filipovska A
Journal of cell science 2020 Jul 24;133(14)
Journal of cell science 2020 Jul 24;133(14)
MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.
Busch JD, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schöndorf T, Li X, Pearce SF, Milenkovic D, Rorbach J, Larsson NG
Cell reports 2019 Nov 5;29(6):1728-1738.e9
Cell reports 2019 Nov 5;29(6):1728-1738.e9
Fidelity of translation initiation is required for coordinated respiratory complex assembly.
Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A
Science advances 2019 Dec;5(12):eaay2118
Science advances 2019 Dec;5(12):eaay2118
Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation.
Ferreira N, Perks KL, Rossetti G, Rudler DL, Hughes LA, Ermer JA, Scott LH, Kuznetsova I, Richman TR, Narayana VK, Abudulai LN, Shearwood AJ, Cserne Szappanos H, Tull D, Yeoh GC, Hool LC, Filipovska A, Rackham O
The EMBO journal 2019 Dec 16;38(24):e102155
The EMBO journal 2019 Dec 16;38(24):e102155
The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.
Lavdovskaia E, Kolander E, Steube E, Mai MM, Urlaub H, Richter-Dennerlein R
Nucleic acids research 2018 Sep 19;46(16):8471-8482
Nucleic acids research 2018 Sep 19;46(16):8471-8482
Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z.
Siira SJ, Rossetti G, Richman TR, Perks K, Ermer JA, Kuznetsova I, Hughes L, Shearwood AJ, Viola HM, Hool LC, Rackham O, Filipovska A
EMBO reports 2018 Oct;19(10)
EMBO reports 2018 Oct;19(10)
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Perks KL, Ferreira N, Richman TR, Ermer JA, Kuznetsova I, Shearwood AJ, Lee RG, Viola HM, Johnstone VPA, Matthews V, Hool LC, Rackham O, Filipovska A
Science advances 2017 Aug;3(8):e1700677
Science advances 2017 Aug;3(8):e1700677
Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.
Lake NJ, Webb BD, Stroud DA, Richman TR, Ruzzenente B, Compton AG, Mountford HS, Pulman J, Zangarelli C, Rio M, Boddaert N, Assouline Z, Sherpa MD, Schadt EE, Houten SM, Byrnes J, McCormick EM, Zolkipli-Cunningham Z, Haude K, Zhang Z, Retterer K, Bai R, Calvo SE, Mootha VK, Christodoulou J, Rötig A, Filipovska A, Cristian I, Falk MJ, Metodiev MD, Thorburn DR
American journal of human genetics 2017 Aug 3;101(2):239-254
American journal of human genetics 2017 Aug 3;101(2):239-254
Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice.
Richman TR, Spåhr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A
Nature communications 2016 Jun 20;7:11884
Nature communications 2016 Jun 20;7:11884
Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.
Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A
Cell reports 2016 Aug 16;16(7):1874-90
Cell reports 2016 Aug 16;16(7):1874-90
Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction.
Richman TR, Ermer JA, Davies SM, Perks KL, Viola HM, Shearwood AM, Hool LC, Rackham O, Filipovska A
PLoS genetics 2015 Mar;11(3):e1005089
PLoS genetics 2015 Mar;11(3):e1005089
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The MRPS16 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MRPS16. This antibody recognizes human, mouse, rat antigen. The MRPS16 antibody has been validated for the following applications: ELISA, WB analysis.
