Antibody data
- Antibody Data
- Antigen structure
- References [39]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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Validation data
Reference
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- Product number
- 55187-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55187-1-AP, RRID:AB_10859261
- Product name
- ATP1A1-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ATP1A1-Specific antibody (Cat. #55187-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 150ul
Submitted references LAPTM4B Confers Resistance to EGFR-TKIs by Suppressing the Proteasomal Degradation of ATP1A1 in Non-small Cell Lung Cancer.
Phenylephrine attenuates LPS-induced lung injury via Foxh1/GSK-3β/β-catenin-mediated alveolar epithelial cell differentiation in ARDS.
BIN1 Interacts with Tau Fragments to Inhibit TrkB Signaling Endosome Recycling in a Mouse Model of Alzheimer's Disease.
Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming.
The extracellular domain of mGluR6 regulates targeting to the conventional secretion pathway.
The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.
Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability.
RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism.
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Corilagin regulates antigen processing and presentation by directly binding to inhibit ERAP1.
Neutrophil extracellular traps-STC1 positive feedback loop promotes immune evasion and metastasis in bladder cancer.
The local anesthetic, lidocaine, suppresses the growth of colon cancer SW480 cells by decreasing the voltage-gated sodium channel subunit Na(v)1.5.
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation.
Protein S-glutathionylation confers cellular resistance to ferroptosis induced by glutathione depletion.
Glycerophospholipid metabolism licenses IgE-mediated mast cell degranulation.
Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells.
Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1.
Targeted Degradation of sGRP78 Alleviates the Immunosuppressive Tumor Microenvironment.
ENT3: A lysosomal urate transporter regulating urate disposition and macrophage inflammation.
d-serine prevents cognitive impairment in a mouse model of NMDAR encephalitis.
Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling.
Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink.
Brain Slice Derived Nerve Fibers Grow along Microcontact Prints and are Stimulated by Beta-Amyloid(42).
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells.
Carnosic Acid: A Novel Selective Inhibitor of ERAP1 by Direct Binding and Its Modulation of Antigen Processing and Presentation.
Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury.
Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis.
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation.
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1.
HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABA(A)R-mediated inhibitory synaptic transmission in pentylenetetrazole rat model.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Hepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue.
Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
The metabolic changes in the hippocampus of an atherosclerotic rat model and the regulation of aerobic training.
Identification of the retinoschisin-binding site on the retinal Na/K-ATPase.
CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation.
Retinoschisin is linked to retinal Na/K-ATPase signaling and localization.
A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice.
Fluorescence- and magnetic-activated cell sorting strategies to separate spermatozoa involving plural contributors from biological mixtures for human identification.
Liu D, Liu M, Lv D, Li Y, Guo H, Lu B, Leng H, Yan R, Yu H, Blom T, Zhou K
International journal of biological sciences 2026;22(1):1-24
International journal of biological sciences 2026;22(1):1-24
Phenylephrine attenuates LPS-induced lung injury via Foxh1/GSK-3β/β-catenin-mediated alveolar epithelial cell differentiation in ARDS.
Zeng Z, Yin Y, Cong Z, Wei S, Wei X, Shen Z, Ge Q, Zhu X
International immunopharmacology 2026 May 15;177:116541
International immunopharmacology 2026 May 15;177:116541
BIN1 Interacts with Tau Fragments to Inhibit TrkB Signaling Endosome Recycling in a Mouse Model of Alzheimer's Disease.
Wei Y, Xi Y, Li H, Zhang X, Wang Y, Li Y, Fang R, Xiang J, Wu S
Neuroscience bulletin 2026 Mar;42(3):525-538
Neuroscience bulletin 2026 Mar;42(3):525-538
Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming.
Xu H, Mi H, Cheng R, Gui T, Hu F, Yang Y, Cheng J, Xue Q
CNS neuroscience & therapeutics 2026 Mar;32(3):e70815
CNS neuroscience & therapeutics 2026 Mar;32(3):e70815
The extracellular domain of mGluR6 regulates targeting to the conventional secretion pathway.
Rideout AP, Abuelatta OW, Agosto MA
Molecular and cellular neurosciences 2026 Mar;136:104068
Molecular and cellular neurosciences 2026 Mar;136:104068
The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.
Zhang H, Fu J, Guo Y, Liu S, Mei X, Zeng X, Ren W
Cell chemical biology 2026 Feb 19;33(2):169-182.e5
Cell chemical biology 2026 Feb 19;33(2):169-182.e5
Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability.
Clark CJ, Anderson CE, Dou A, Dierdorff JM, Galpin JD, Gissot L, Thompson SG, Choi H, Yoon JY, Infield DT, McLendon JM, Hoeger JM, Rabab'h O, Bronk P, Leeds K, Kutschke WJ, Paradee WJ, Boudreau RL, Choi BR, London B, Ahern CA
Circulation research 2026 Apr 24;138(9):e328159
Circulation research 2026 Apr 24;138(9):e328159
RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism.
Huo Y, Zhao D, Zhu X, Zheng N, Yang D, Meng J, Chen Y, Zhang YW
Theranostics 2025;15(4):1338-1352
Theranostics 2025;15(4):1338-1352
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Zhang M, Liu S, Wu Z, Wang C, Zhang H, Yang J, Guo C, Dai M, Wang X, Ren W
Science China. Life sciences 2025 Oct;68(10):3037-3050
Science China. Life sciences 2025 Oct;68(10):3037-3050
Corilagin regulates antigen processing and presentation by directly binding to inhibit ERAP1.
Sun X, Zhou Y, Yu S, Liu X, Wu J, Zhou Y, Bai J, Li D, Xu H, Cao H
International immunopharmacology 2025 Oct 10;163:115180
International immunopharmacology 2025 Oct 10;163:115180
Neutrophil extracellular traps-STC1 positive feedback loop promotes immune evasion and metastasis in bladder cancer.
Cai T, Feng T, Zhang W, Ge Q, Peng L, Wang Y, Xie J, Deng X, Zhu W, Jin S, Wang J, Ye D, Zhu Y
Journal for immunotherapy of cancer 2025 Nov 28;13(11)
Journal for immunotherapy of cancer 2025 Nov 28;13(11)
The local anesthetic, lidocaine, suppresses the growth of colon cancer SW480 cells by decreasing the voltage-gated sodium channel subunit Na(v)1.5.
Haraguchi-Suzuki K, Suzuki T, Nakasone C, Kawabata-Iwakawa R, Saito S
Scientific reports 2025 Nov 22;15(1):45018
Scientific reports 2025 Nov 22;15(1):45018
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation.
Wang Z, Hou Y, Liu P, Wu R, Yang J, Fan S, Peng Z, Han X, Su B, Zhang C
Immunity 2025 Nov 11;58(11):2670-2684.e10
Immunity 2025 Nov 11;58(11):2670-2684.e10
Protein S-glutathionylation confers cellular resistance to ferroptosis induced by glutathione depletion.
Ju Y, Zhang Y, Tian X, Zhu N, Zheng Y, Qiao Y, Yang T, Niu B, Li X, Yu L, Liu Z, Wu Y, Zhi Y, Dong Y, Xu Q, Yang X, Wang X, Wang X, Deng H, Mao Y, Li X
Redox biology 2025 Jun;83:103660
Redox biology 2025 Jun;83:103660
Glycerophospholipid metabolism licenses IgE-mediated mast cell degranulation.
Xia Y, Bin P, Zhou Y, Zhao M, Zhang J, Zhong W, Wang N, Wang B, Ren W
Cell reports 2025 Jun 24;44(6):115742
Cell reports 2025 Jun 24;44(6):115742
Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells.
de Weerd S, Ma X, Zohali Z, Oudejans LL, Kyrloglou E, Stuart MCA, Roos WH, Schuringa JJ, Salvati A
Advanced healthcare materials 2025 Jul;14(19):e2500667
Advanced healthcare materials 2025 Jul;14(19):e2500667
Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1.
Yang Z, Liu X, Zhu J, Chai Y, Cong B, Li B, Gao W, Hu Y, Wen M, Liu Y, Fu L, Cao X
Cancer cell 2025 Jan 13;43(1):86-102.e10
Cancer cell 2025 Jan 13;43(1):86-102.e10
Targeted Degradation of sGRP78 Alleviates the Immunosuppressive Tumor Microenvironment.
Wu Z, Zheng P, Xiao Y, Wang Q, Pan X, Zhou X, Lv Y, Xiao J, He Y, Huang T, Lei P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e09921
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e09921
ENT3: A lysosomal urate transporter regulating urate disposition and macrophage inflammation.
Matake I, Yasujima T, Matsuo H, Nakayama A, Toyoda Y, Takada T, Inoue K, Yamashiro T, Yuasa H
iScience 2025 Dec 19;28(12):114249
iScience 2025 Dec 19;28(12):114249
d-serine prevents cognitive impairment in a mouse model of NMDAR encephalitis.
Luo H, Han Z, Yang J, Yang X, Li Y, Huang D, Ding R, Cheng L, Ma J, Jiang L
Journal of neuroimmunology 2025 Dec 15;409:578768
Journal of neuroimmunology 2025 Dec 15;409:578768
Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling.
Wang Y, Zhang X, Hung I, Liu C, Ren W, Ge L, Wang H
Research (Washington, D.C.) 2024;7:0418
Research (Washington, D.C.) 2024;7:0418
Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink.
Grönroos P, Mörö A, Puistola P, Hopia K, Huuskonen M, Viheriälä T, Ilmarinen T, Skottman H
Stem cell research & therapy 2024 Mar 14;15(1):81
Stem cell research & therapy 2024 Mar 14;15(1):81
Brain Slice Derived Nerve Fibers Grow along Microcontact Prints and are Stimulated by Beta-Amyloid(42).
Steiner K, Humpel C
Frontiers in bioscience (Landmark edition) 2024 Jun 24;29(6):232
Frontiers in bioscience (Landmark edition) 2024 Jun 24;29(6):232
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells.
Tan X, He Y, Yu P, Deng Y, Xie Z, Guo J, Hou Q, Li P, Lin X, Ouyang S, Ma W, Xie Y, Guo Z, Chen D, Zhang Z, Zhu Y, Huang F, Zhao Z, Zhang C, Guo Z, Chen X, Peng T, Li L, Xie W
Molecular medicine (Cambridge, Mass.) 2024 Jul 15;30(1):102
Molecular medicine (Cambridge, Mass.) 2024 Jul 15;30(1):102
Carnosic Acid: A Novel Selective Inhibitor of ERAP1 by Direct Binding and Its Modulation of Antigen Processing and Presentation.
Wu J, Li Z, Liu X, Feng D, Liang R, Su X, Li D, Hua H, Cao H
Journal of agricultural and food chemistry 2024 Aug 7;72(31):17343-17355
Journal of agricultural and food chemistry 2024 Aug 7;72(31):17343-17355
Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury.
Li Y, Xu J, Chen W, Wang X, Zhao Z, Li Y, Zhang L, Jiao J, Yang Q, Ding Q, Yang P, Wei L, Chen Y, Chen Y, Ruan XZ, Zhao L
Autophagy 2023 Sep;19(9):2504-2519
Autophagy 2023 Sep;19(9):2504-2519
Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis.
Zheng ZG, Xu YY, Liu WP, Zhang Y, Zhang C, Liu HL, Zhang XY, Liu RZ, Zhang YP, Shi MY, Yang H, Li P
Cell metabolism 2023 Jan 3;35(1):101-117.e11
Cell metabolism 2023 Jan 3;35(1):101-117.e11
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation.
Cheng Q, Wu J, Xia Y, Cheng Q, Zhao Y, Zhu P, Zhang W, Zhang S, Zhang L, Yuan Y, Li C, Chen G, Xue B
Molecular brain 2023 Feb 13;16(1):24
Molecular brain 2023 Feb 13;16(1):24
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1.
She X, Shen S, Chen G, Gao Y, Ma J, Gao Y, Liu Y, Gao G, Zhao Y, Wang C, Jiang C, Wang P, Qin H, Gao H
The EMBO journal 2023 Apr 3;42(7):e111112
The EMBO journal 2023 Apr 3;42(7):e111112
HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABA(A)R-mediated inhibitory synaptic transmission in pentylenetetrazole rat model.
Wen Y, Zhang G, Liu L, Zhang P, Lin L, Mei R, Zhang F, Chen Y, Li R
Neuroscience research 2022 Sep;182:7-14
Neuroscience research 2022 Sep;182:7-14
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Wang Y, Jin C, Tian H, Xu J, Chen J, Hu S, Li Q, Lu L, Ou Q, Xu GT, Cui H
Experimental eye research 2022 Jun;219:108939
Experimental eye research 2022 Jun;219:108939
Hepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue.
Lin J, Jiang X, Dong M, Liu X, Shen Q, Huang Y, Zhang H, Ye R, Zhou H, Yan C, Yuan S, Wu X, Chen L, Wang Y, He M, Tao Y, Zhang Z, Jin W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(21):e2101991
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(21):e2101991
Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
Shao S, Li XD, Lu YY, Li SJ, Chen XH, Zhou HD, He S, Guo YT, Lu X, Gao PJ, Wang JG
Hypertension (Dallas, Tex. : 1979) 2021 Mar 3;77(3):868-881
Hypertension (Dallas, Tex. : 1979) 2021 Mar 3;77(3):868-881
The metabolic changes in the hippocampus of an atherosclerotic rat model and the regulation of aerobic training.
Liu B, Li J, Lin X, Hu J, Lou S
Metabolic brain disease 2020 Aug;35(6):1017-1034
Metabolic brain disease 2020 Aug;35(6):1017-1034
Identification of the retinoschisin-binding site on the retinal Na/K-ATPase.
Plössl K, Straub K, Schmid V, Strunz F, Wild J, Merkl R, Weber BHF, Friedrich U
PloS one 2019;14(5):e0216320
PloS one 2019;14(5):e0216320
CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation.
Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, Cui J, Bai L, Wang J, Jiang W, Zhou R
Nature communications 2017 Aug 4;8(1):202
Nature communications 2017 Aug 4;8(1):202
Retinoschisin is linked to retinal Na/K-ATPase signaling and localization.
Plössl K, Royer M, Bernklau S, Tavraz NN, Friedrich T, Wild J, Weber BHF, Friedrich U
Molecular biology of the cell 2017 Aug 1;28(16):2178-2189
Molecular biology of the cell 2017 Aug 1;28(16):2178-2189
A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice.
Liu M, Feng LX, Sun P, Liu W, Wu WY, Jiang BH, Yang M, Hu LH, Guo DA, Liu X
PloS one 2016;11(7):e0159789
PloS one 2016;11(7):e0159789
Fluorescence- and magnetic-activated cell sorting strategies to separate spermatozoa involving plural contributors from biological mixtures for human identification.
Xu Y, Xie J, Chen R, Cao Y, Ping Y, Xu Q, Hu W, Wu D, Gu L, Zhou H, Chen X, Zhao Z, Zhong J, Li R
Scientific reports 2016 Nov 18;6:36515
Scientific reports 2016 Nov 18;6:36515
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 55187-1-AP(ATP1A1 antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 55187-1-AP(ATP1A1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 55187-1-AP(ATP1A1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The ATP1A1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ATP1A1. This antibody recognizes human, mouse antigen. The ATP1A1 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.